SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ynn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 10 ALA A 101
LEU A 103
LEU A  88
GLU A  61
ALA A  86
 None
 1.09A 1ie4A-4ynnA:
undetectable
1ie4C-4ynnA:
undetectable		 1ie4A-4ynnA:
13.73
1ie4C-4ynnA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		4 / 7 SER A 168
ASP A 169
GLU A 176
GLU A 109
 None
 1.05A 1knyA-4ynnA:
undetectable
1knyB-4ynnA:
undetectable		 1knyA-4ynnA:
20.61
1knyB-4ynnA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		4 / 8 GLU A 109
SER A 168
ASP A 169
GLU A 176
 None
 1.10A 1knyA-4ynnA:
undetectable
1knyB-4ynnA:
undetectable		 1knyA-4ynnA:
20.61
1knyB-4ynnA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 11 ALA A 231
ILE A 104
GLY A 105
GLY A 106
ILE A  77
 None
 0.85A 1sduA-4ynnA:
undetectable		 1sduA-4ynnA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_C_T44C601_1
(TRANSTHYRETIN)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 9 ALA A 101
LEU A 103
LEU A  88
GLU A  61
ALA A  86
 None
 1.03A 1sn0A-4ynnA:
undetectable
1sn0C-4ynnA:
undetectable		 1sn0A-4ynnA:
18.71
1sn0C-4ynnA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 ALA A 101
LEU A 103
LEU A  88
GLU A  61
ALA A  86
 None
 1.09A 1sn5B-4ynnA:
undetectable
1sn5D-4ynnA:
undetectable		 1sn5B-4ynnA:
18.71
1sn5D-4ynnA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 LEU A  88
GLU A  61
ALA A  86
ALA A 101
LEU A 103
 None
 1.08A 1sn5B-4ynnA:
undetectable
1sn5D-4ynnA:
undetectable		 1sn5B-4ynnA:
18.71
1sn5D-4ynnA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 LEU A 194
ASN A 205
ALA A 190
LEU A 112
THR A 181
 None
 1.37A 2oaxC-4ynnA:
undetectable		 2oaxC-4ynnA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A  66
GLY A 192
GLY A 188
ILE A  76
VAL A  22
 None
 0.95A 2oxtA-4ynnA:
undetectable		 2oxtA-4ynnA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A  66
GLY A 192
GLY A 188
ILE A  76
VAL A  22
 None
 0.94A 2oxtC-4ynnA:
undetectable		 2oxtC-4ynnA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.77A 2pxcA-4ynnA:
undetectable		 2pxcA-4ynnA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		3 / 3 ARG A  84
ASN A 189
THR A  78
 None
 0.88A 2q63A-4ynnA:
undetectable		 2q63A-4ynnA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.91A 2wa2B-4ynnA:
undetectable		 2wa2B-4ynnA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 11 ALA A 193
ALA A 141
GLY A 188
GLY A  66
ILE A  21
 None
 1.09A 2x1lA-4ynnA:
undetectable		 2x1lA-4ynnA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 11 ALA A 193
ALA A 141
GLY A 188
GLY A  66
ILE A  21
 None
 1.04A 2x1lC-4ynnA:
undetectable		 2x1lC-4ynnA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 11 LEU A 194
GLY A 191
VAL A  67
ILE A 179
ALA A 221
 None
 1.18A 2yy8A-4ynnA:
undetectable
2yy8B-4ynnA:
undetectable		 2yy8A-4ynnA:
18.78
2yy8B-4ynnA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 11 LEU A 194
GLY A 192
VAL A  67
ILE A 179
ALA A 221
 None
 0.96A 2yy8A-4ynnA:
undetectable
2yy8B-4ynnA:
undetectable		 2yy8A-4ynnA:
18.78
2yy8B-4ynnA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		4 / 4 THR A 158
VAL A 195
GLY A 191
THR A  78
 None
 1.07A 3cflA-4ynnA:
undetectable		 3cflA-4ynnA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.77A 3embA-4ynnA:
undetectable		 3embA-4ynnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		4 / 4 GLY A 288
VAL A 271
GLY A 268
THR A 300
 None
 0.88A 3ib2A-4ynnA:
undetectable		 3ib2A-4ynnA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 10 GLY A 284
ARG A 324
LEU A 285
LEU A 331
ILE A 322
 None
 1.29A 3kvrA-4ynnA:
undetectable		 3kvrA-4ynnA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 10 GLY A 284
ARG A 324
LEU A 285
LEU A 331
ILE A 322
 None
 1.22A 3kvrB-4ynnA:
undetectable		 3kvrB-4ynnA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		3 / 3 ARG A  84
VAL A  24
THR A  78
 None
 0.76A 3ndtA-4ynnA:
undetectable		 3ndtA-4ynnA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.73A 3p97A-4ynnA:
undetectable		 3p97A-4ynnA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_C_SAMC263_0
(NON-STRUCTURAL
PROTEIN 5)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.82A 3p97C-4ynnA:
undetectable		 3p97C-4ynnA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 9 GLY A 377
ASP A 393
ILE A 395
GLY A 384
ILE A 406
 None
 0.91A 3s53A-4ynnA:
undetectable		 3s53A-4ynnA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 HIS A  81
ASP A 111
GLY A 188
ALA A 190
ALA A 207
 None
 0.27A 3sudA-4ynnA:
13.0		 3sudA-4ynnA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 HIS A  81
ASP A 111
GLY A 188
ALA A 190
ALA A 207
 None
 0.23A 3sudB-4ynnA:
13.1		 3sudB-4ynnA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 HIS A  81
ASP A 111
GLY A 188
ALA A 190
ALA A 207
 None
 0.28A 3sudC-4ynnA:
12.6		 3sudC-4ynnA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 HIS A  81
ASP A 111
GLY A 188
ALA A 190
ALA A 207
 None
 0.29A 3sudD-4ynnA:
8.5		 3sudD-4ynnA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 HIS A  81
ASP A 111
GLY A 188
ALA A 190
THR A 206
 None
 1.01A 3sugA-4ynnA:
13.1		 3sugA-4ynnA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 ILE A 204
LEU A 115
LEU A 112
ALA A 231
ILE A  21
 None
 0.92A 3vrmA-4ynnA:
undetectable		 3vrmA-4ynnA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 ILE A  77
ILE A 202
ASN A 205
ASN A 189
LEU A 125
 None
 1.21A 4a81A-4ynnA:
undetectable		 4a81A-4ynnA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.73A 4ctjA-4ynnA:
undetectable		 4ctjA-4ynnA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_C_SAMC1263_0
(NON-STRUCTURAL
PROTEIN 5)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.83A 4ctjC-4ynnA:
undetectable		 4ctjC-4ynnA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_A_SAMA1263_0
(POLYPROTEIN)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.72A 4ctkA-4ynnA:
undetectable		 4ctkA-4ynnA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_C_SAMC1263_0
(POLYPROTEIN)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.82A 4ctkC-4ynnA:
undetectable		 4ctkC-4ynnA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 11 ALA A 184
GLY A 188
GLY A 143
ILE A 185
ASN A 186
 None
 1.09A 4dcmA-4ynnA:
undetectable		 4dcmA-4ynnA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 10 VAL A 139
ALA A 141
SER A 130
LEU A 165
VAL A 162
 None
 1.36A 4eilB-4ynnA:
undetectable		 4eilB-4ynnA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 ILE A  69
GLY A 192
GLY A  66
ALA A  20
ALA A 141
 None
 0.99A 4kicB-4ynnA:
undetectable		 4kicB-4ynnA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 9 ASN A  79
ALA A 190
ILE A  21
ILE A  83
VAL A  82
 None
 1.06A 4nptA-4ynnA:
2.1		 4nptA-4ynnA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 ILE A 161
LEU A 125
GLY A 203
ASN A 205
ILE A 202
 None
 1.11A 4o1eB-4ynnA:
undetectable		 4o1eB-4ynnA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 ALA A 190
GLY A 191
GLY A 192
ILE A  63
ASN A 144
 None
 1.06A 4obwB-4ynnA:
undetectable		 4obwB-4ynnA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		4 / 7 LEU A 434
ILE A 396
ILE A 395
VAL A 403
 None
 0.73A 4ojbA-4ynnA:
undetectable		 4ojbA-4ynnA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 LEU A 112
GLY A 106
LEU A 103
VAL A  82
ILE A  75
 None
 1.14A 4ok1A-4ynnA:
undetectable		 4ok1A-4ynnA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 9 ILE A  21
GLY A 192
ALA A 190
SER A  62
ILE A  83
 None
 1.05A 4r21B-4ynnA:
undetectable		 4r21B-4ynnA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		4 / 6 PHE A 351
SER A 382
ALA A 383
LEU A 355
 None
 1.32A 5dzkg-4ynnA:
undetectable
5dzku-4ynnA:
undetectable		 5dzkg-4ynnA:
20.85
5dzku-4ynnA:
0.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.71A 5e9qA-4ynnA:
undetectable		 5e9qA-4ynnA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.88A 5e9qC-4ynnA:
undetectable		 5e9qC-4ynnA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.70A 5ec8A-4ynnA:
undetectable		 5ec8A-4ynnA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_C_SAMC4000_0
(GENOME POLYPROTEIN)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.80A 5ec8C-4ynnA:
undetectable		 5ec8C-4ynnA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.70A 5ehgA-4ynnA:
undetectable		 5ehgA-4ynnA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.82A 5ehgC-4ynnA:
undetectable		 5ehgC-4ynnA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.72A 5ehiA-4ynnA:
undetectable		 5ehiA-4ynnA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.83A 5ehiC-4ynnA:
undetectable		 5ehiC-4ynnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.73A 5eifA-4ynnA:
undetectable		 5eifA-4ynnA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_C_SAMC4000_0
(GENOME POLYPROTEIN)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.84A 5eifC-4ynnA:
undetectable		 5eifC-4ynnA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.70A 5eiwA-4ynnA:
undetectable		 5eiwA-4ynnA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.72A 5ekxA-4ynnA:
undetectable		 5ekxA-4ynnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_B_SAMB4000_0
(NS5
METHYLTRANSFERASE)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.75A 5ekxB-4ynnA:
undetectable		 5ekxB-4ynnA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.79A 5ikmA-4ynnA:
undetectable		 5ikmA-4ynnA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.76A 5kqrA-4ynnA:
undetectable		 5kqrA-4ynnA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.75A 5kqsA-4ynnA:
undetectable		 5kqsA-4ynnA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.82A 5m5bA-4ynnA:
undetectable		 5m5bA-4ynnA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 ILE A 204
GLY A 191
VAL A  24
ALA A 193
ILE A 127
 None
 1.07A 5n0tB-4ynnA:
undetectable		 5n0tB-4ynnA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_A_SAMA301_0
(NS5)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.76A 5njvA-4ynnA:
undetectable		 5njvA-4ynnA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_B_SAMB301_0
(NS5)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.74A 5njvB-4ynnA:
undetectable		 5njvB-4ynnA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.79A 5njvC-4ynnA:
undetectable		 5njvC-4ynnA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_D_SAMD301_0
(NS5)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.84A 5njvD-4ynnA:
undetectable		 5njvD-4ynnA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.77A 5vimA-4ynnA:
undetectable		 5vimA-4ynnA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.73A 5vimB-4ynnA:
undetectable		 5vimB-4ynnA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_B_SAMB601_0
(NS5
METHYLTRANSFERASE)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.79A 5wz1B-4ynnA:
undetectable		 5wz1B-4ynnA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_A_SAMA601_0
(NS5 MTASE)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.72A 5wz2A-4ynnA:
undetectable		 5wz2A-4ynnA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_B_SAMB601_0
(NS5 MTASE)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.70A 5wz2B-4ynnA:
undetectable		 5wz2B-4ynnA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_C_SAMC601_0
(NS5 MTASE)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.72A 5wz2C-4ynnA:
undetectable		 5wz2C-4ynnA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 10 LEU A  93
THR A  92
ILE A  21
ILE A  68
ILE A  76
 None
 1.08A 6ebpD-4ynnA:
undetectable		 6ebpD-4ynnA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4ynn PROTEASE DO
(Legionella
pneumophila) 		5 / 11 LEU A  93
THR A  92
ILE A  21
ILE A  68
ILE A  76
 None
 1.08A 6ebzB-4ynnA:
undetectable		 6ebzB-4ynnA:
10.94