SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ynq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ynq THREE-PRIME REPAIR
EXONUCLEASE 1
(Mus
musculus) 		5 / 12 ILE A 106
LEU A  69
LEU A 147
PHE A 111
LEU A 112
 None
 1.17A 1g5yB-4ynqA:
undetectable		 1g5yB-4ynqA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 4ynq THREE-PRIME REPAIR
EXONUCLEASE 1
(Mus
musculus) 		6 / 12 PHE A 226
LEU A  36
LEU A  17
ILE A  15
LEU A 112
LEU A  34
 None
 1.40A 1xdkF-4ynqA:
undetectable		 1xdkF-4ynqA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_1
(MINERALOCORTICOID
RECEPTOR)		 4ynq THREE-PRIME REPAIR
EXONUCLEASE 1
(Mus
musculus) 		5 / 12 LEU A 121
LEU A  37
ALA A  38
LEU A  44
THR A 150
 None
 1.41A 1ya3A-4ynqA:
undetectable		 1ya3A-4ynqA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 4ynq THREE-PRIME REPAIR
EXONUCLEASE 1
(Mus
musculus) 		5 / 12 LEU A 121
LEU A  37
ALA A  38
LEU A  44
THR A 150
 None
 1.39A 2aa5B-4ynqA:
undetectable		 2aa5B-4ynqA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 4ynq THREE-PRIME REPAIR
EXONUCLEASE 1
(Mus
musculus) 		4 / 5 LEU A 159
GLN A 164
LEU A 162
GLU A 163
 None
 1.10A 3h5gA-4ynqA:
undetectable
3h5gB-4ynqA:
undetectable		 3h5gA-4ynqA:
10.21
3h5gB-4ynqA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4ynq THREE-PRIME REPAIR
EXONUCLEASE 1
(Mus
musculus) 		6 / 11 ALA A 105
LEU A 108
GLU A 137
LEU A  34
LEU A  69
LEU A  67
 None
 1.45A 4wg0C-4ynqA:
undetectable
4wg0D-4ynqA:
undetectable
4wg0E-4ynqA:
undetectable		 4wg0C-4ynqA:
6.70
4wg0D-4ynqA:
6.70
4wg0E-4ynqA:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4ynq THREE-PRIME REPAIR
EXONUCLEASE 1
(Mus
musculus) 		6 / 11 ALA A 105
LEU A 108
GLU A 137
LEU A  34
LEU A  69
LEU A  67
 None
 1.48A 4wg0E-4ynqA:
undetectable
4wg0F-4ynqA:
undetectable
4wg0G-4ynqA:
undetectable		 4wg0E-4ynqA:
6.70
4wg0F-4ynqA:
6.70
4wg0G-4ynqA:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4ynq THREE-PRIME REPAIR
EXONUCLEASE 1
(Mus
musculus) 		5 / 11 ALA A 105
LEU A 108
GLU A 137
LEU A  34
LEU A  67
 None
 1.19A 4wg0G-4ynqA:
undetectable
4wg0H-4ynqA:
undetectable
4wg0I-4ynqA:
undetectable		 4wg0G-4ynqA:
6.70
4wg0H-4ynqA:
6.70
4wg0I-4ynqA:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4ynq THREE-PRIME REPAIR
EXONUCLEASE 1
(Mus
musculus) 		5 / 11 LEU A  67
GLU A  33
LEU A  69
LEU A 104
LEU A 107
 None
 1.16A 4wg0G-4ynqA:
undetectable
4wg0H-4ynqA:
undetectable
4wg0I-4ynqA:
undetectable		 4wg0G-4ynqA:
6.70
4wg0H-4ynqA:
6.70
4wg0I-4ynqA:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4ynq THREE-PRIME REPAIR
EXONUCLEASE 1
(Mus
musculus) 		3 / 3 HIS A 222
GLU A 221
TRP A 218
 None
 0.90A 5odiD-4ynqA:
undetectable		 5odiD-4ynqA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4ynq THREE-PRIME REPAIR
EXONUCLEASE 1
(Mus
musculus) 		3 / 3 HIS A 222
GLU A 221
TRP A 218
 None
 0.83A 5odqD-4ynqA:
undetectable		 5odqD-4ynqA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4ynq THREE-PRIME REPAIR
EXONUCLEASE 1
(Mus
musculus) 		3 / 3 HIS A 222
GLU A 221
TRP A 218
 None
 0.84A 5odrD-4ynqA:
undetectable		 5odrD-4ynqA:
17.87