SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ynv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 4ynv ACL4
(Chaetomium
thermophilum) 		4 / 5 GLY A  68
LEU A  71
THR A  72
VAL A  97
 None
 0.97A 1ekjF-4ynvA:
undetectable
1ekjG-4ynvA:
undetectable		 1ekjF-4ynvA:
21.10
1ekjG-4ynvA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ynv ACL4
(Chaetomium
thermophilum) 		6 / 12 ILE A  46
ALA A  49
ALA A  50
LEU A  74
LEU A  41
ALA A  37
 None
 1.25A 1fm9A-4ynvA:
undetectable		 1fm9A-4ynvA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4ynv ACL4
(Chaetomium
thermophilum) 		5 / 12 LEU A 263
ALA A 233
SER A 237
GLY A 239
LEU A 238
 None
 1.04A 1igxA-4ynvA:
undetectable		 1igxA-4ynvA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ynv ACL4
(Chaetomium
thermophilum) 		6 / 12 ILE A  46
ALA A  49
ALA A  50
LEU A  74
LEU A  41
ALA A  37
 None
 1.25A 1k74A-4ynvA:
undetectable		 1k74A-4ynvA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4ynv ACL4
(Chaetomium
thermophilum) 		3 / 3 ARG A 298
VAL A 290
TRP A 291
 None
 0.96A 1qw6A-4ynvA:
undetectable		 1qw6A-4ynvA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4ynv ACL4
(Chaetomium
thermophilum) 		3 / 3 ARG A 298
VAL A 290
TRP A 291
 None
 0.93A 1qwcA-4ynvA:
undetectable		 1qwcA-4ynvA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4ynv ACL4
(Chaetomium
thermophilum) 		3 / 3 ARG A 298
VAL A 290
TRP A 291
 None
 0.93A 1vagA-4ynvA:
undetectable		 1vagA-4ynvA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ynv ACL4
(Chaetomium
thermophilum) 		6 / 12 ILE A  46
ALA A  49
ALA A  50
LEU A  74
LEU A  41
ALA A  37
 None
 1.19A 1xlsA-4ynvA:
undetectable		 1xlsA-4ynvA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ynv ACL4
(Chaetomium
thermophilum) 		6 / 12 ILE A  46
ALA A  49
ALA A  50
LEU A  74
LEU A  41
ALA A  37
 None
 1.19A 1xlsB-4ynvA:
undetectable		 1xlsB-4ynvA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ynv ACL4
(Chaetomium
thermophilum) 		6 / 12 ILE A  46
ALA A  49
ALA A  50
LEU A  74
LEU A  41
ALA A  37
 None
 1.19A 1xlsC-4ynvA:
undetectable		 1xlsC-4ynvA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ynv ACL4
(Chaetomium
thermophilum) 		6 / 12 ILE A  46
ALA A  49
ALA A  50
LEU A  74
LEU A  41
ALA A  37
 None
 1.19A 1xlsD-4ynvA:
undetectable		 1xlsD-4ynvA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4ynv ACL4
(Chaetomium
thermophilum) 		3 / 3 ARG A 298
VAL A 290
TRP A 291
 None
 0.84A 1zviA-4ynvA:
3.3		 1zviA-4ynvA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ynv ACL4
(Chaetomium
thermophilum) 		5 / 12 ALA A  49
ALA A  50
LEU A  74
LEU A  41
ALA A  37
 None
 0.97A 2aclA-4ynvA:
undetectable
2aclE-4ynvA:
undetectable		 2aclA-4ynvA:
25.16
2aclE-4ynvA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ynv ACL4
(Chaetomium
thermophilum) 		5 / 11 ILE A  46
ALA A  49
ALA A  50
LEU A  74
ALA A  37
 None
 0.85A 2aclE-4ynvA:
undetectable		 2aclE-4ynvA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ynv ACL4
(Chaetomium
thermophilum) 		6 / 12 ILE A  46
ALA A  49
ALA A  50
LEU A  74
LEU A  41
ALA A  37
 None
 1.29A 2aclG-4ynvA:
undetectable		 2aclG-4ynvA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 4ynv ACL4
(Chaetomium
thermophilum) 		3 / 3 ARG A 169
VAL A 179
THR A 216
 None
 0.72A 2nmzA-4ynvA:
undetectable		 2nmzA-4ynvA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 4ynv ACL4
(Chaetomium
thermophilum) 		4 / 8 VAL A 251
PRO A 252
PRO A 211
SER A 237
 None
 0.84A 2v32C-4ynvA:
undetectable
2v32D-4ynvA:
undetectable		 2v32C-4ynvA:
20.70
2v32D-4ynvA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ynv ACL4
(Chaetomium
thermophilum) 		5 / 12 ALA A  49
ALA A  50
LEU A  74
LEU A  41
ALA A  37
 None
 0.99A 3fc6C-4ynvA:
undetectable		 3fc6C-4ynvA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 4ynv ACL4
(Chaetomium
thermophilum) 		3 / 3 ARG A 169
VAL A 179
THR A 216
 None
 0.58A 3k4vD-4ynvA:
undetectable		 3k4vD-4ynvA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ynv ACL4
(Chaetomium
thermophilum) 		3 / 3 LEU A 103
PRO A 104
LEU A 107
 None
 0.45A 3w1wB-4ynvA:
undetectable		 3w1wB-4ynvA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 4ynv ACL4
(Chaetomium
thermophilum) 		4 / 7 GLU A 212
GLN A 215
ASN A 219
ILE A 200
 None
 1.10A 4ii8A-4ynvA:
undetectable		 4ii8A-4ynvA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ynv ACL4
(Chaetomium
thermophilum) 		5 / 12 ALA A  49
ALA A  50
LEU A  74
LEU A  41
ALA A  37
 None
 0.91A 4k6iA-4ynvA:
undetectable		 4k6iA-4ynvA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ynv ACL4
(Chaetomium
thermophilum) 		5 / 12 ILE A  46
ALA A  49
ALA A  50
LEU A  41
ALA A  37
 None
 1.05A 4k6iA-4ynvA:
undetectable		 4k6iA-4ynvA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4ynv ACL4
(Chaetomium
thermophilum) 		4 / 6 GLU A 212
GLN A 215
VAL A 276
THR A 277
 None
 1.28A 4lnxA-4ynvA:
undetectable		 4lnxA-4ynvA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ynv ACL4
(Chaetomium
thermophilum) 		5 / 12 ALA A  49
ALA A  50
LEU A  41
ALA A  37
ILE A  84
 None
 1.04A 4nqaH-4ynvA:
undetectable		 4nqaH-4ynvA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ynv ACL4
(Chaetomium
thermophilum) 		5 / 12 ILE A  46
ALA A  49
ALA A  50
LEU A  41
ALA A  37
 None
 1.15A 4nqaH-4ynvA:
undetectable		 4nqaH-4ynvA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 4ynv ACL4
(Chaetomium
thermophilum) 		5 / 11 ARG A 231
LEU A 234
ARG A 235
SER A 237
LEU A 260
 None
 1.32A 4or0A-4ynvA:
2.2		 4or0A-4ynvA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 4ynv ACL4
(Chaetomium
thermophilum) 		5 / 11 LEU A  40
ALA A  37
GLY A  75
HIS A  78
LEU A  74
 None
 1.19A 4pxmB-4ynvA:
undetectable		 4pxmB-4ynvA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4ynv ACL4
(Chaetomium
thermophilum) 		5 / 10 LEU A  40
ALA A  37
GLY A  75
HIS A  78
LEU A  74
 None
 1.22A 5dx3A-4ynvA:
undetectable		 5dx3A-4ynvA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 4ynv ACL4
(Chaetomium
thermophilum) 		5 / 11 LEU A  40
ALA A  37
GLY A  75
HIS A  78
LEU A  74
 None
 1.23A 5dxgB-4ynvA:
undetectable		 5dxgB-4ynvA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ynv ACL4
(Chaetomium
thermophilum) 		3 / 3 ARG A 298
VAL A 290
TRP A 291
 None
 0.86A 5fvoA-4ynvA:
undetectable		 5fvoA-4ynvA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4ynv ACL4
(Chaetomium
thermophilum) 		4 / 5 LEU A  33
ALA A  37
LEU A  40
LEU A  73
 None
 0.84A 5vkqA-4ynvA:
3.6
5vkqD-4ynvA:
3.6		 5vkqA-4ynvA:
11.04
5vkqD-4ynvA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4ynv ACL4
(Chaetomium
thermophilum) 		4 / 5 LEU A  73
LEU A  33
ALA A  37
LEU A  40
 None
 0.85A 5vkqA-4ynvA:
3.6
5vkqB-4ynvA:
3.6		 5vkqA-4ynvA:
11.04
5vkqB-4ynvA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4ynv ACL4
(Chaetomium
thermophilum) 		4 / 5 LEU A  73
LEU A  33
ALA A  37
LEU A  40
 None
 0.81A 5vkqB-4ynvA:
3.6
5vkqC-4ynvA:
3.6		 5vkqB-4ynvA:
11.04
5vkqC-4ynvA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4ynv ACL4
(Chaetomium
thermophilum) 		4 / 5 LEU A  73
LEU A  33
ALA A  37
LEU A  40
 None
 0.87A 5vkqC-4ynvA:
3.6
5vkqD-4ynvA:
3.6		 5vkqC-4ynvA:
11.04
5vkqD-4ynvA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ynv ACL4
(Chaetomium
thermophilum) 		6 / 12 ILE A  46
ALA A  49
ALA A  50
LEU A  74
LEU A  41
ALA A  37
 None
 1.18A 5z12B-4ynvA:
undetectable		 5z12B-4ynvA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ynv ACL4
(Chaetomium
thermophilum) 		5 / 12 ILE A  46
ALA A  49
ALA A  50
LEU A  41
ALA A  37
 None
 1.16A 6a5zD-4ynvA:
undetectable		 6a5zD-4ynvA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ynv ACL4
(Chaetomium
thermophilum) 		5 / 12 ILE A  46
ALA A  49
ALA A  50
LEU A  74
ALA A  37
 None
 0.88A 6a60D-4ynvA:
undetectable		 6a60D-4ynvA:
13.41