SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ynz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		6 / 9 LEU A  26
GLY A  27
VAL A  34
ALA A  47
LEU A  80
LEU A 149
 None
 0.70A 1muoA-4ynzA:
15.9		 1muoA-4ynzA:
29.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		5 / 12 THR A  31
LEU A 149
VAL A  99
VAL A  46
ALA A  47
 None
 1.12A 1q23H-4ynzA:
undetectable
1q23I-4ynzA:
undetectable		 1q23H-4ynzA:
18.16
1q23I-4ynzA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		5 / 9 LEU A  26
VAL A  34
LYS A  49
LEU A  82
LEU A  94
 None
 0.42A 1xkkA-4ynzA:
21.7		 1xkkA-4ynzA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		6 / 12 GLY A  27
VAL A  34
ALA A  47
LEU A  80
LEU A  96
ALA A 159
 None
 0.72A 2wgjA-4ynzA:
20.7		 2wgjA-4ynzA:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		5 / 11 GLY A  32
GLY A  29
ILE A  50
VAL A  34
ASP A 160
 None
 0.88A 3dxyA-4ynzA:
undetectable		 3dxyA-4ynzA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		3 / 3 VAL A  60
LYS A  63
HIS A 140
 None
 0.96A 3elzA-4ynzA:
undetectable		 3elzA-4ynzA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		4 / 6 VAL A  79
ILE A 138
HIS A 140
ILE A 158
 None
 0.49A 3hegA-4ynzA:
22.0		 3hegA-4ynzA:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		6 / 9 LEU A  26
VAL A  34
ALA A  47
LEU A  96
LEU A 149
ALA A 159
 None
 0.74A 4anqA-4ynzA:
20.1		 4anqA-4ynzA:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		8 / 12 LEU A  26
GLY A  27
VAL A  34
ALA A  47
LYS A  49
LEU A  94
LEU A 149
ASP A 160
 None
 0.70A 4i22A-4ynzA:
21.3		 4i22A-4ynzA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		7 / 12 GLY A  27
VAL A  34
ALA A  47
LYS A  49
LEU A  82
LEU A  94
LEU A 149
 None
 0.53A 4ifgA-4ynzA:
26.9		 4ifgA-4ynzA:
28.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		8 / 11 GLY A  27
VAL A  34
ALA A  47
LYS A  49
LEU A  80
ASN A 147
LEU A 149
ASP A 160
 None
 0.87A 4o0sA-4ynzA:
27.7		 4o0sA-4ynzA:
28.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		8 / 11 LEU A  26
GLY A  27
VAL A  34
ALA A  47
LYS A  49
LEU A  80
ASN A 147
ASP A 160
 None
 0.85A 4o0sA-4ynzA:
27.7		 4o0sA-4ynzA:
28.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		5 / 6 VAL A  34
ALA A  47
LYS A  49
LEU A  80
LEU A 149
 None
 0.66A 4o0uA-4ynzA:
16.1		 4o0uA-4ynzA:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		5 / 12 GLY A  27
VAL A  34
ALA A  47
LYS A  49
LEU A  80
 None
 0.46A 5hieC-4ynzA:
22.1		 5hieC-4ynzA:
26.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		6 / 12 GLY A  27
VAL A  34
ALA A  47
HIS A  98
LEU A 149
ALA A 159
 None
 0.97A 5l2tA-4ynzA:
12.2		 5l2tA-4ynzA:
30.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		6 / 11 GLY A  27
VAL A  34
ALA A  47
LEU A  96
GLU A 146
LEU A 149
 None
 0.52A 5lvnA-4ynzA:
25.8		 5lvnA-4ynzA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		6 / 11 LEU A  26
GLY A  27
VAL A  34
ALA A  47
LEU A  96
GLU A 146
 None
 0.55A 5lvnA-4ynzA:
25.8		 5lvnA-4ynzA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		5 / 12 GLY A 162
THR A  31
VAL A  51
ASN A 147
LEU A 143
 None
 1.25A 5nz0A-4ynzA:
undetectable		 5nz0A-4ynzA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		5 / 12 LEU A  26
GLY A  27
VAL A  34
ALA A  47
ALA A 159
 None
 0.42A 5xv7A-4ynzA:
21.8		 5xv7A-4ynzA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		7 / 12 LEU A  26
GLY A  27
VAL A  34
ALA A  47
LYS A  49
LEU A  80
ASP A 160
 None
 1.45A 5yu9A-4ynzA:
21.1		 5yu9A-4ynzA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		8 / 12 LEU A  26
GLY A  27
VAL A  34
ALA A  47
LYS A  49
LEU A  94
LEU A 149
ASP A 160
 None
 0.68A 5yu9A-4ynzA:
21.1		 5yu9A-4ynzA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		7 / 12 GLY A  27
VAL A  34
ALA A  47
LYS A  49
LEU A  94
LEU A 149
ASP A 160
 None
 0.71A 5yu9B-4ynzA:
21.3		 5yu9B-4ynzA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		5 / 12 VAL A  34
ALA A  47
LYS A  49
LEU A  94
ASP A 160
 None
 0.57A 5yu9C-4ynzA:
21.3		 5yu9C-4ynzA:
12.87