SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yo0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 4yo0 HEAVY CHAIN OF
ANTIGEN BINDING
FRAGMENT, FAB
(Rattus
norvegicus) 		3 / 3 TRP A 211
VAL A 234
PRO A 235
 None
 0.97A 1rg1A-4yo0A:
undetectable		 1rg1A-4yo0A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 4yo0 HEAVY CHAIN OF
ANTIGEN BINDING
FRAGMENT, FAB
(Rattus
norvegicus) 		3 / 3 TRP A 211
VAL A 234
PRO A 235
 None
 0.97A 1rh0A-4yo0A:
undetectable		 1rh0A-4yo0A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 4yo0 LIGHT CHAIN OF
ANTIGEN BINDING
FRAGMENT, FAB
(Rattus
norvegicus) 		3 / 3 THR B 136
SER B 159
PHE B 140
 None
 0.86A 3d4sA-4yo0B:
undetectable		 3d4sA-4yo0B:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4yo0 LIGHT CHAIN OF
ANTIGEN BINDING
FRAGMENT, FAB
(Rattus
norvegicus) 		4 / 7 VAL B 127
ARG B  81
VAL B  37
GLU B 105
 None
 1.26A 3jx2A-4yo0B:
undetectable
3jx2B-4yo0B:
undetectable		 3jx2A-4yo0B:
20.56
3jx2B-4yo0B:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBR_A_ASDA129_1
(STEROID
DELTA-ISOMERASE)		 4yo0 HEAVY CHAIN OF
ANTIGEN BINDING
FRAGMENT, FAB
LIGHT CHAIN OF
ANTIGEN BINDING
FRAGMENT, FAB
(Rattus
norvegicus) 		5 / 12 PHE A 189
VAL B 216
VAL B 166
PRO B 135
PHE B 161
 None
 1.41A 3nbrA-4yo0A:
undetectable		 3nbrA-4yo0A:
24.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		 4yo0 LIGHT CHAIN OF
ANTIGEN BINDING
FRAGMENT, FAB
(Rattus
norvegicus) 		4 / 7 TYR B  52
TYR B  56
TYR B  69
PRO B  75
 None
 0.53A 5aclA-4yo0B:
19.3		 5aclA-4yo0B:
55.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUO_D_PFLD402_1
(PROTON-GATED ION
CHANNEL)		 4yo0 HEAVY CHAIN OF
ANTIGEN BINDING
FRAGMENT, FAB
LIGHT CHAIN OF
ANTIGEN BINDING
FRAGMENT, FAB
(Rattus
norvegicus) 		5 / 9 SER A 203
THR B 138
THR B 136
SER B 159
ILE B 194
 None
 1.05A 5muoA-4yo0A:
undetectable
5muoB-4yo0A:
2.2
5muoC-4yo0A:
undetectable
5muoD-4yo0A:
undetectable
5muoE-4yo0A:
undetectable		 5muoA-4yo0A:
14.35
5muoB-4yo0A:
14.35
5muoC-4yo0A:
14.35
5muoD-4yo0A:
14.35
5muoE-4yo0A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUO_D_PFLD402_1
(PROTON-GATED ION
CHANNEL)		 4yo0 HEAVY CHAIN OF
ANTIGEN BINDING
FRAGMENT, FAB
LIGHT CHAIN OF
ANTIGEN BINDING
FRAGMENT, FAB
(Rattus
norvegicus) 		5 / 9 THR B 138
THR B 136
SER B 159
ILE B 194
THR A 205
 None
 1.24A 5muoA-4yo0B:
undetectable
5muoB-4yo0B:
undetectable
5muoC-4yo0B:
undetectable
5muoD-4yo0B:
undetectable
5muoE-4yo0B:
undetectable		 5muoA-4yo0B:
16.13
5muoB-4yo0B:
16.13
5muoC-4yo0B:
16.13
5muoD-4yo0B:
16.13
5muoE-4yo0B:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 4yo0 LIGHT CHAIN OF
ANTIGEN BINDING
FRAGMENT, FAB
(Rattus
norvegicus) 		4 / 7 GLY B  84
PHE B  82
ARG B  70
ASN B  54
 None
 0.94A 5n5dB-4yo0B:
undetectable		 5n5dB-4yo0B:
20.16