SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yo1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 12 GLU A 200
ASP A 137
ILE A 179
LEU A 165
ILE A 202
 CD  A 401 (-2.1A)
None
None
None
None
 1.19A 2e7fA-4yo1A:
undetectable		 2e7fA-4yo1A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.80A 2pxcA-4yo1A:
undetectable		 2pxcA-4yo1A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_2
(PROTEASE RETROPEPSIN)		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 12 LEU A 112
GLY A 192
ILE A  69
ILE A 202
ILE A  77
 None
 0.85A 2rkgB-4yo1A:
undetectable		 2rkgB-4yo1A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 4yo1 DEGQ
(Legionella
pneumophila) 		4 / 7 VAL A  67
GLY A 128
VAL A 195
ASP A 129
 None
 0.87A 2y05A-4yo1A:
undetectable
2y05B-4yo1A:
undetectable		 2y05A-4yo1A:
23.38
2y05B-4yo1A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 11 LEU A 194
GLY A 192
VAL A  67
ILE A 179
ALA A 221
 None
 0.92A 2yy8A-4yo1A:
undetectable
2yy8B-4yo1A:
undetectable		 2yy8A-4yo1A:
19.72
2yy8B-4yo1A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 11 LEU A 331
ILE A 294
GLY A 243
ILE A 322
ILE A 320
 None
 0.91A 3ebzA-4yo1A:
undetectable		 3ebzA-4yo1A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 4yo1 DEGQ
(Legionella
pneumophila) 		4 / 4 GLY A 288
VAL A 271
GLY A 268
THR A 300
 None
 0.88A 3ib2A-4yo1A:
undetectable		 3ib2A-4yo1A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_2
(PROTEASE)		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 9 LEU A 112
GLY A 192
ILE A  69
ILE A 202
ILE A  77
 None
 0.88A 3nu4B-4yo1A:
undetectable		 3nu4B-4yo1A:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.77A 3p97A-4yo1A:
undetectable		 3p97A-4yo1A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_2
(PROTEASE)		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 11 LEU A 331
ILE A 294
GLY A 243
ILE A 322
ILE A 320
 None
 0.80A 3s53B-4yo1A:
undetectable		 3s53B-4yo1A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 4yo1 DEGQ
(Legionella
pneumophila) 		4 / 7 ILE A 204
LYS A 132
LYS A 198
GLY A 199
 None
CD  A 401 (-3.4A)
None
None
 1.21A 3sj0X-4yo1A:
undetectable		 3sj0X-4yo1A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.79A 4ctjA-4yo1A:
undetectable		 4ctjA-4yo1A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_C_SAMC1263_0
(NON-STRUCTURAL
PROTEIN 5)		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.90A 4ctjC-4yo1A:
undetectable		 4ctjC-4yo1A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_A_SAMA1263_0
(POLYPROTEIN)		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.77A 4ctkA-4yo1A:
undetectable		 4ctkA-4yo1A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 10 VAL A 139
ALA A 141
SER A 130
LEU A 165
VAL A 162
 None
 1.49A 4eilB-4yo1A:
undetectable		 4eilB-4yo1A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 12 ILE A 161
LEU A 125
GLY A 203
ASN A 205
ILE A 202
 None
 1.19A 4o1eB-4yo1A:
undetectable		 4o1eB-4yo1A:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 4yo1 DEGQ
(Legionella
pneumophila) 		6 / 12 THR A 206
ALA A 221
LEU A 194
LEU A 201
ILE A  21
GLY A 143
 None
 1.46A 4xi3B-4yo1A:
undetectable		 4xi3B-4yo1A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 11 ALA A 221
LEU A 194
LEU A 201
ILE A  21
GLY A 143
 None
 1.24A 5dxbB-4yo1A:
undetectable		 5dxbB-4yo1A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_1
(PROTEASE)		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 12 LEU A 331
ILE A 294
GLY A 243
ILE A 322
ILE A 320
 None
 0.75A 5e5jA-4yo1A:
undetectable		 5e5jA-4yo1A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_2
(HIV-1 PROTEASE)		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 12 LEU A 112
GLY A 192
ILE A  69
ILE A 202
ILE A  77
 None
 0.83A 5e5kB-4yo1A:
undetectable		 5e5kB-4yo1A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_2
(HIV-1 PROTEASE)		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 12 LEU A 331
ILE A 294
GLY A 243
ILE A 322
ILE A 320
 None
 0.78A 5e5kB-4yo1A:
undetectable		 5e5kB-4yo1A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.77A 5e9qA-4yo1A:
undetectable		 5e9qA-4yo1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.73A 5ec8A-4yo1A:
undetectable		 5ec8A-4yo1A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_C_SAMC4000_0
(GENOME POLYPROTEIN)		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.87A 5ec8C-4yo1A:
undetectable		 5ec8C-4yo1A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.75A 5ehgA-4yo1A:
undetectable		 5ehgA-4yo1A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.89A 5ehgC-4yo1A:
undetectable		 5ehgC-4yo1A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.80A 5eifA-4yo1A:
undetectable		 5eifA-4yo1A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_B_SAMB4000_0
(NS5
METHYLTRANSFERASE)		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.82A 5ekxB-4yo1A:
undetectable		 5ekxB-4yo1A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.82A 5ikmA-4yo1A:
undetectable		 5ikmA-4yo1A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.83A 5kqrA-4yo1A:
undetectable		 5kqrA-4yo1A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.81A 5kqsA-4yo1A:
undetectable		 5kqsA-4yo1A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 10 ILE A  69
ILE A  77
ILE A 234
ILE A 235
ILE A 104
 None
 0.90A 5murE-4yo1A:
undetectable		 5murE-4yo1A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 12 ILE A 204
GLY A 191
VAL A  24
ALA A 193
ILE A 127
 None
 1.03A 5n0tB-4yo1A:
undetectable		 5n0tB-4yo1A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_A_SAMA301_0
(NS5)		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.83A 5njvA-4yo1A:
undetectable		 5njvA-4yo1A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_B_SAMB301_0
(NS5)		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.81A 5njvB-4yo1A:
undetectable		 5njvB-4yo1A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.77A 5njvC-4yo1A:
undetectable		 5njvC-4yo1A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.83A 5vimA-4yo1A:
undetectable		 5vimA-4yo1A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.80A 5vimB-4yo1A:
undetectable		 5vimB-4yo1A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_B_SAMB601_0
(NS5
METHYLTRANSFERASE)		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.84A 5wz1B-4yo1A:
undetectable		 5wz1B-4yo1A:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_A_SAMA601_0
(NS5 MTASE)		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.77A 5wz2A-4yo1A:
undetectable		 5wz2A-4yo1A:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_B_SAMB601_0
(NS5 MTASE)		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.75A 5wz2B-4yo1A:
undetectable		 5wz2B-4yo1A:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_C_SAMC601_0
(NS5 MTASE)		 4yo1 DEGQ
(Legionella
pneumophila) 		5 / 12 GLY A 203
GLY A  66
GLY A 191
VAL A  91
ILE A  76
 None
 0.74A 5wz2C-4yo1A:
undetectable		 5wz2C-4yo1A:
25.21