SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yo2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_K_EF2K501_1
(PROTEIN CEREBLON)		 4yo2 TRANSCRIPTION FACTOR
E2F8
(Homo
sapiens) 		4 / 7 HIS A 181
TRP A 180
PHE A 125
THR A 189
 None
 1.48A 5yizk-4yo2A:
undetectable
5yizt-4yo2A:
undetectable		 5yizk-4yo2A:
14.73
5yizt-4yo2A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_Y_EF2Y501_1
(PROTEIN CEREBLON)		 4yo2 TRANSCRIPTION FACTOR
E2F8
(Homo
sapiens) 		4 / 7 THR A 189
HIS A 181
TRP A 180
PHE A 125
 None
 1.49A 5yizG-4yo2A:
undetectable
5yizY-4yo2A:
undetectable		 5yizG-4yo2A:
14.73
5yizY-4yo2A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_K_EF2K501_1
(PROTEIN CEREBLON)		 4yo2 TRANSCRIPTION FACTOR
E2F8
(Homo
sapiens) 		4 / 7 HIS A 181
TRP A 180
PHE A 125
THR A 189
 None
 1.49A 5yj0k-4yo2A:
undetectable
5yj0t-4yo2A:
undetectable		 5yj0k-4yo2A:
14.73
5yj0t-4yo2A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_Y_EF2Y501_1
(PROTEIN CEREBLON)		 4yo2 TRANSCRIPTION FACTOR
E2F8
(Homo
sapiens) 		4 / 7 THR A 189
HIS A 181
TRP A 180
PHE A 125
 None
 1.49A 5yj0G-4yo2A:
undetectable
5yj0Y-4yo2A:
undetectable		 5yj0G-4yo2A:
14.73
5yj0Y-4yo2A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_K_6ELK501_0
(PROTEIN CEREBLON)		 4yo2 TRANSCRIPTION FACTOR
E2F8
(Homo
sapiens) 		4 / 7 HIS A 181
TRP A 180
PHE A 125
THR A 189
 None
 1.48A 5yj1k-4yo2A:
undetectable
5yj1t-4yo2A:
undetectable		 5yj1k-4yo2A:
17.81
5yj1t-4yo2A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_Y_6ELY501_0
(PROTEIN CEREBLON)		 4yo2 TRANSCRIPTION FACTOR
E2F8
(Homo
sapiens) 		4 / 7 THR A 189
HIS A 181
TRP A 180
PHE A 125
 None
 1.49A 5yj1G-4yo2A:
undetectable
5yj1Y-4yo2A:
undetectable		 5yj1G-4yo2A:
17.81
5yj1Y-4yo2A:
17.81