SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yod'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)
4yod THIOREDOXIN-LIKE
PROTEIN

(Bacteroides
caccae)
5 / 12 ILE A 206
ALA A 281
ASP A 298
THR A 217
LEU A 203
None
1.14A 1ddsA-4yodA:
undetectable
1ddsA-4yodA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)
4yod THIOREDOXIN-LIKE
PROTEIN

(Bacteroides
caccae)
4 / 4 LYS A 292
LEU A 202
ALA A 179
LEU A 204
None
1.31A 1f86B-4yodA:
undetectable
1f86B-4yodA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)
4yod THIOREDOXIN-LIKE
PROTEIN

(Bacteroides
caccae)
5 / 12 ILE A 206
ALA A 281
ASP A 298
THR A 217
LEU A 203
None
1.10A 1tdrA-4yodA:
undetectable
1tdrA-4yodA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_A_T44A128_1
(TRANSTHYRETIN)
4yod THIOREDOXIN-LIKE
PROTEIN

(Bacteroides
caccae)
4 / 4 LYS A 292
LEU A 202
ALA A 179
LEU A 204
None
1.29A 2roxA-4yodA:
undetectable
2roxA-4yodA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)
4yod THIOREDOXIN-LIKE
PROTEIN

(Bacteroides
caccae)
5 / 9 LEU A 285
PHE A 205
VAL A 238
ILE A 218
ALA A 224
None
1.09A 3mdtA-4yodA:
undetectable
3mdtA-4yodA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)
4yod THIOREDOXIN-LIKE
PROTEIN

(Bacteroides
caccae)
3 / 3 CYH A  89
MET A 136
ASN A 138
None
1.27A 5qh8A-4yodA:
undetectable
5qh8A-4yodA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)
4yod THIOREDOXIN-LIKE
PROTEIN

(Bacteroides
caccae)
4 / 4 LYS A 292
LEU A 202
ALA A 179
LEU A 204
None
1.32A 6gnrA-4yodA:
undetectable
6gnrA-4yodA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)
4yod THIOREDOXIN-LIKE
PROTEIN

(Bacteroides
caccae)
4 / 4 LYS A 292
LEU A 202
ALA A 179
LEU A 204
None
1.31A 6gnrB-4yodA:
undetectable
6gnrB-4yodA:
17.24