SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yog'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 4yog 3C-LIKE PROTEINASE
(Tylonycteris
bat
coronavirus
HKU4) 		4 / 4 SER A 150
VAL A  13
PHE A 129
VAL A 131
 None
 1.34A 1o86A-4yogA:
undetectable		 1o86A-4yogA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4yog 3C-LIKE PROTEINASE
(Tylonycteris
bat
coronavirus
HKU4) 		4 / 7 TYR A 164
THR A 126
GLU A  14
VAL A 131
 None
None
ACT  A 401 (-4.3A)
None
 1.06A 1tv8B-4yogA:
undetectable		 1tv8B-4yogA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 4yog 3C-LIKE PROTEINASE
(Tylonycteris
bat
coronavirus
HKU4) 		4 / 8 SER A 147
TYR A 164
HIS A 175
HIS A 166
 None
None
None
4F5  A 405 (-4.2A)
 1.37A 2v0gA-4yogA:
undetectable		 2v0gA-4yogA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 4yog 3C-LIKE PROTEINASE
(Tylonycteris
bat
coronavirus
HKU4) 		5 / 12 GLY A 177
SER A 179
GLY A 186
CYH A 148
PHE A 143
 None
None
None
4F5  A 405 (-3.1A)
None
 1.42A 3r24A-4yogA:
undetectable		 3r24A-4yogA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 4yog 3C-LIKE PROTEINASE
(Tylonycteris
bat
coronavirus
HKU4) 		3 / 3 ARG A 134
ASP A 200
TYR A 202
 ACT  A 404 ( 4.4A)
ACT  A 404 ( 4.6A)
ACT  A 404 (-4.0A)
 0.35A 4yo9B-4yogA:
44.6		 4yo9B-4yogA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 4yog 3C-LIKE PROTEINASE
(Tylonycteris
bat
coronavirus
HKU4) 		3 / 3 MET A  25
HIS A  41
GLY A 146
 4F5  A 405 (-3.4A)
4F5  A 405 (-3.6A)
None
 0.86A 5gwzB-4yogA:
40.4		 5gwzB-4yogA:
47.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 4yog 3C-LIKE PROTEINASE
(Tylonycteris
bat
coronavirus
HKU4) 		5 / 12 ILE A 251
THR A 204
ALA A 209
LEU A 254
VAL A 296
 None
 1.02A 5hw4A-4yogA:
undetectable		 5hw4A-4yogA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 4yog 3C-LIKE PROTEINASE
(Tylonycteris
bat
coronavirus
HKU4) 		5 / 12 ILE A 251
THR A 204
ALA A 209
LEU A 254
VAL A 296
 None
 1.02A 5hw4C-4yogA:
undetectable		 5hw4C-4yogA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 4yog 3C-LIKE PROTEINASE
(Tylonycteris
bat
coronavirus
HKU4) 		5 / 12 LEU A 133
VAL A 131
VAL A 117
GLY A 152
LEU A  89
 None
 1.18A 5x24A-4yogA:
undetectable		 5x24A-4yogA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4yog 3C-LIKE PROTEINASE
(Tylonycteris
bat
coronavirus
HKU4) 		5 / 12 SER A 107
THR A 108
VAL A  86
GLY A 182
SER A 179
 None
 1.20A 6a94B-4yogA:
undetectable		 6a94B-4yogA:
22.47