SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yom'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4yom SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		4 / 8 ALA A 573
ASP A 550
ILE A 551
ILE A 594
 None
 0.87A 1p7lD-4yomA:
undetectable		 1p7lD-4yomA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4yom SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		4 / 8 ALA A 573
ASP A 550
ILE A 551
ILE A 594
 None
 0.87A 1p7lC-4yomA:
undetectable		 1p7lC-4yomA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4yom SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		4 / 8 ALA A 573
ASP A 550
ILE A 551
ILE A 594
 None
 0.87A 1rg9B-4yomA:
undetectable		 1rg9B-4yomA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4yom SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		4 / 8 ALA A 573
ASP A 550
ILE A 551
ILE A 594
 None
 0.88A 1rg9A-4yomA:
undetectable		 1rg9A-4yomA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4yom SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		4 / 8 ALA A 573
ASP A 550
ILE A 551
ILE A 594
 None
 0.87A 1rg9D-4yomA:
undetectable		 1rg9D-4yomA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4yom SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		4 / 8 ALA A 573
ASP A 550
ILE A 551
ILE A 594
 None
 0.87A 1rg9C-4yomA:
undetectable		 1rg9C-4yomA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 4yom SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		5 / 12 LEU A 561
ILE A 630
PHE A 623
ILE A 594
PHE A 555
 None
 1.08A 2ygoA-4yomA:
undetectable		 2ygoA-4yomA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4yom SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		4 / 7 ILE A 551
PHE A 555
ARG A 572
THR A 614
 None
 1.04A 3ag2N-4yomA:
undetectable
3ag2W-4yomA:
undetectable		 3ag2N-4yomA:
13.44
3ag2W-4yomA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4yom SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		4 / 7 ILE A 551
PHE A 555
ARG A 572
THR A 614
 None
 0.97A 3ag4N-4yomA:
undetectable
3ag4W-4yomA:
undetectable		 3ag4N-4yomA:
13.44
3ag4W-4yomA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 4yom SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		5 / 12 ASP A 593
LEU A 634
ILE A 551
PHE A 590
PHE A 623
 None
 1.27A 3ko0G-4yomA:
undetectable
3ko0H-4yomA:
undetectable
3ko0I-4yomA:
undetectable
3ko0J-4yomA:
undetectable		 3ko0G-4yomA:
18.44
3ko0H-4yomA:
18.44
3ko0I-4yomA:
18.44
3ko0J-4yomA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4yom SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		4 / 8 ALA A 573
ASP A 550
ILE A 551
ILE A 594
 None
 0.94A 4ndnB-4yomA:
undetectable		 4ndnB-4yomA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4yom SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		4 / 8 ALA A 573
ASP A 550
ILE A 551
ILE A 594
 None
 0.93A 4ndnD-4yomA:
undetectable		 4ndnD-4yomA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4yom SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		4 / 7 VAL A 626
PHE A 555
HIS A 563
GLU A 574
 None
 1.26A 5ad9A-4yomA:
undetectable
5ad9B-4yomA:
undetectable		 5ad9A-4yomA:
16.11
5ad9B-4yomA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4yom SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		4 / 8 ALA A 573
ASP A 550
ILE A 551
ILE A 594
 None
 0.94A 5t8sA-4yomA:
undetectable		 5t8sA-4yomA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 4yom SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		5 / 12 GLN A 633
ALA A 632
ILE A 547
VAL A 537
ASP A 541
 None
 1.23A 5vlmG-4yomA:
undetectable		 5vlmG-4yomA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4yom SERINE/THREONINE-PRO
TEIN KINASE BRSK2
(Mus
musculus) 		4 / 5 ILE A 551
PHE A 555
ARG A 572
THR A 614
 None
 0.99A 5z84N-4yomA:
undetectable
5z84W-4yomA:
undetectable		 5z84N-4yomA:
13.44
5z84W-4yomA:
21.58