SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yoo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 4yoo RETINOBLASTOMA-LIKE
PROTEIN
1,RETINOBLASTOMA-LIK
E PROTEIN 1
(Homo
sapiens) 		4 / 7 LEU A 810
HIS A 839
ASP A 805
HIS A 877
 None
 1.17A 1v55C-4yooA:
2.1
1v55N-4yooA:
1.4
1v55P-4yooA:
2.1		 1v55C-4yooA:
21.08
1v55N-4yooA:
20.71
1v55P-4yooA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 4yoo RETINOBLASTOMA-LIKE
PROTEIN
1,RETINOBLASTOMA-LIK
E PROTEIN 1
(Homo
sapiens) 		4 / 6 TYR A 849
PHE A 848
THR A 860
GLU A 858
 None
 1.48A 2dttB-4yooA:
undetectable
2dttC-4yooA:
1.9		 2dttB-4yooA:
15.48
2dttC-4yooA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4yoo RETINOBLASTOMA-LIKE
PROTEIN
1,RETINOBLASTOMA-LIK
E PROTEIN 1
(Homo
sapiens) 		3 / 3 LYS A 958
TYR A 949
PRO A 959
 None
 1.38A 2j9cC-4yooA:
undetectable		 2j9cC-4yooA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 4yoo RETINOBLASTOMA-LIKE
PROTEIN
1,RETINOBLASTOMA-LIK
E PROTEIN 1
(Homo
sapiens) 		4 / 8 MET A 835
LEU A 828
ARG A 802
SER A 572
 None
 1.03A 2qd2A-4yooA:
undetectable		 2qd2A-4yooA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 4yoo RETINOBLASTOMA-LIKE
PROTEIN
1,RETINOBLASTOMA-LIK
E PROTEIN 1
(Homo
sapiens) 		4 / 8 MET A 835
LEU A 828
ARG A 802
SER A 572
 None
 0.95A 2qd5A-4yooA:
undetectable		 2qd5A-4yooA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4yoo RETINOBLASTOMA-LIKE
PROTEIN
1,RETINOBLASTOMA-LIK
E PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 427
ILE A 400
ILE A 466
VAL A 509
LEU A 501
 None
 1.20A 2qo5A-4yooA:
undetectable		 2qo5A-4yooA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yoo RETINOBLASTOMA-LIKE
PROTEIN
1,RETINOBLASTOMA-LIK
E PROTEIN 1
(Homo
sapiens) 		4 / 8 HIS A 839
ASP A 805
HIS A 877
LEU A 810
 None
 1.10A 3ablA-4yooA:
undetectable
3ablC-4yooA:
2.3
3ablP-4yooA:
2.1		 3ablA-4yooA:
20.71
3ablC-4yooA:
21.08
3ablP-4yooA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yoo RETINOBLASTOMA-LIKE
PROTEIN
1,RETINOBLASTOMA-LIK
E PROTEIN 1
(Homo
sapiens) 		4 / 8 LEU A 810
HIS A 839
ASP A 805
HIS A 877
 None
 1.15A 3ablC-4yooA:
2.3
3ablN-4yooA:
undetectable
3ablP-4yooA:
2.1		 3ablC-4yooA:
21.08
3ablN-4yooA:
20.71
3ablP-4yooA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4yoo RETINOBLASTOMA-LIKE
PROTEIN
1,RETINOBLASTOMA-LIK
E PROTEIN 1
(Homo
sapiens) 		4 / 7 MET A 835
LEU A 828
ARG A 802
SER A 572
 None
 1.09A 3hcnA-4yooA:
undetectable		 3hcnA-4yooA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yoo RETINOBLASTOMA-LIKE
PROTEIN
1,RETINOBLASTOMA-LIK
E PROTEIN 1
(Homo
sapiens) 		4 / 8 HIS A 839
ASP A 805
HIS A 877
LEU A 810
 None
 1.11A 3x2qA-4yooA:
undetectable
3x2qC-4yooA:
2.1
3x2qP-4yooA:
2.1		 3x2qA-4yooA:
20.71
3x2qC-4yooA:
21.08
3x2qP-4yooA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP308_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yoo RETINOBLASTOMA-LIKE
PROTEIN
1,RETINOBLASTOMA-LIK
E PROTEIN 1
(Homo
sapiens) 		4 / 8 LEU A 810
HIS A 839
ASP A 805
HIS A 877
 None
 1.17A 3x2qC-4yooA:
2.1
3x2qN-4yooA:
undetectable
3x2qP-4yooA:
2.1		 3x2qC-4yooA:
21.08
3x2qN-4yooA:
20.71
3x2qP-4yooA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 4yoo RETINOBLASTOMA-LIKE
PROTEIN
1,RETINOBLASTOMA-LIK
E PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 506
ILE A 427
ILE A 430
HIS A 498
LEU A 501
 None
 1.27A 4j24C-4yooA:
undetectable		 4j24C-4yooA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4yoo RETINOBLASTOMA-LIKE
PROTEIN
1,RETINOBLASTOMA-LIK
E PROTEIN 1
(Homo
sapiens) 		4 / 7 ARG A 793
SER A 572
VAL A 795
TRP A 568
 None
 1.15A 4klaA-4yooA:
undetectable		 4klaA-4yooA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4yoo RETINOBLASTOMA-LIKE
PROTEIN
1,RETINOBLASTOMA-LIK
E PROTEIN 1
(Homo
sapiens) 		4 / 5 MET A 835
LEU A 828
ARG A 802
SER A 572
 None
 0.85A 4kmmB-4yooA:
undetectable		 4kmmB-4yooA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1008_1
(SERUM ALBUMIN)		 4yoo RETINOBLASTOMA-LIKE
PROTEIN
1,RETINOBLASTOMA-LIK
E PROTEIN 1
(Homo
sapiens) 		5 / 9 PHE A 531
ALA A 573
VAL A 580
SER A 787
LEU A 788
 None
None
None
SO4  A1002 (-3.1A)
None
 1.48A 4z69A-4yooA:
undetectable		 4z69A-4yooA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yoo RETINOBLASTOMA-LIKE
PROTEIN
1,RETINOBLASTOMA-LIK
E PROTEIN 1
(Homo
sapiens) 		4 / 8 HIS A 839
ASP A 805
HIS A 877
LEU A 810
 None
 1.11A 5b1bA-4yooA:
undetectable
5b1bC-4yooA:
2.4
5b1bP-4yooA:
2.4		 5b1bA-4yooA:
20.71
5b1bC-4yooA:
21.08
5b1bP-4yooA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yoo RETINOBLASTOMA-LIKE
PROTEIN
1,RETINOBLASTOMA-LIK
E PROTEIN 1
(Homo
sapiens) 		4 / 8 LEU A 810
HIS A 839
ASP A 805
HIS A 877
 None
 1.09A 5iy5C-4yooA:
2.1
5iy5N-4yooA:
undetectable
5iy5P-4yooA:
2.3		 5iy5C-4yooA:
21.13
5iy5N-4yooA:
20.71
5iy5P-4yooA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yoo RETINOBLASTOMA-LIKE
PROTEIN
1,RETINOBLASTOMA-LIK
E PROTEIN 1
(Homo
sapiens) 		4 / 8 HIS A 839
ASP A 805
HIS A 877
LEU A 810
 None
 1.11A 5w97A-4yooA:
1.2
5w97C-4yooA:
2.0
5w97c-4yooA:
2.0		 5w97A-4yooA:
20.71
5w97C-4yooA:
21.08
5w97c-4yooA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yoo RETINOBLASTOMA-LIKE
PROTEIN
1,RETINOBLASTOMA-LIK
E PROTEIN 1
(Homo
sapiens) 		4 / 7 LEU A 810
HIS A 839
ASP A 805
HIS A 877
 None
 1.13A 5w97C-4yooA:
2.0
5w97a-4yooA:
undetectable
5w97c-4yooA:
2.0		 5w97C-4yooA:
21.08
5w97a-4yooA:
20.71
5w97c-4yooA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yoo RETINOBLASTOMA-LIKE
PROTEIN
1,RETINOBLASTOMA-LIK
E PROTEIN 1
(Homo
sapiens) 		4 / 8 HIS A 839
ASP A 805
HIS A 877
LEU A 810
 None
 1.12A 5wauA-4yooA:
undetectable
5wauC-4yooA:
2.3
5wauc-4yooA:
2.3		 5wauA-4yooA:
20.71
5wauC-4yooA:
21.08
5wauc-4yooA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yoo RETINOBLASTOMA-LIKE
PROTEIN
1,RETINOBLASTOMA-LIK
E PROTEIN 1
(Homo
sapiens) 		4 / 7 LEU A 810
HIS A 839
ASP A 805
HIS A 877
 None
 1.09A 5wauC-4yooA:
2.3
5waua-4yooA:
undetectable
5wauc-4yooA:
2.3		 5wauC-4yooA:
21.08
5waua-4yooA:
20.71
5wauc-4yooA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yoo RETINOBLASTOMA-LIKE
PROTEIN
1,RETINOBLASTOMA-LIK
E PROTEIN 1
(Homo
sapiens) 		4 / 8 HIS A 839
ASP A 805
HIS A 877
LEU A 810
 None
 1.09A 5x19A-4yooA:
undetectable
5x19C-4yooA:
2.0
5x19P-4yooA:
2.0		 5x19A-4yooA:
20.71
5x19C-4yooA:
21.08
5x19P-4yooA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yoo RETINOBLASTOMA-LIKE
PROTEIN
1,RETINOBLASTOMA-LIK
E PROTEIN 1
(Homo
sapiens) 		4 / 7 HIS A 839
ASP A 805
HIS A 877
LEU A 810
 None
 1.05A 5x1bA-4yooA:
1.5
5x1bC-4yooA:
undetectable
5x1bP-4yooA:
undetectable		 5x1bA-4yooA:
20.71
5x1bC-4yooA:
21.08
5x1bP-4yooA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yoo RETINOBLASTOMA-LIKE
PROTEIN
1,RETINOBLASTOMA-LIK
E PROTEIN 1
(Homo
sapiens) 		4 / 7 HIS A 839
ASP A 805
HIS A 877
LEU A 810
 None
 1.06A 5x1fA-4yooA:
undetectable
5x1fC-4yooA:
2.0
5x1fP-4yooA:
2.0		 5x1fA-4yooA:
20.71
5x1fC-4yooA:
21.08
5x1fP-4yooA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yoo RETINOBLASTOMA-LIKE
PROTEIN
1,RETINOBLASTOMA-LIK
E PROTEIN 1
(Homo
sapiens) 		4 / 8 HIS A 839
ASP A 805
HIS A 877
LEU A 810
 None
 1.13A 5xdqA-4yooA:
undetectable
5xdqC-4yooA:
2.4
5xdqP-4yooA:
2.4		 5xdqA-4yooA:
20.71
5xdqC-4yooA:
21.08
5xdqP-4yooA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yoo RETINOBLASTOMA-LIKE
PROTEIN
1,RETINOBLASTOMA-LIK
E PROTEIN 1
(Homo
sapiens) 		4 / 8 LEU A 810
HIS A 839
ASP A 805
HIS A 877
 None
 1.14A 5xdqC-4yooA:
2.4
5xdqN-4yooA:
undetectable
5xdqP-4yooA:
2.4		 5xdqC-4yooA:
21.08
5xdqN-4yooA:
20.71
5xdqP-4yooA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yoo RETINOBLASTOMA-LIKE
PROTEIN
1,RETINOBLASTOMA-LIK
E PROTEIN 1
(Homo
sapiens) 		4 / 8 LEU A 810
HIS A 839
ASP A 805
HIS A 877
 None
 1.16A 5xdxC-4yooA:
2.3
5xdxN-4yooA:
undetectable
5xdxP-4yooA:
2.1		 5xdxC-4yooA:
21.13
5xdxN-4yooA:
20.71
5xdxP-4yooA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yoo RETINOBLASTOMA-LIKE
PROTEIN
1,RETINOBLASTOMA-LIK
E PROTEIN 1
(Homo
sapiens) 		4 / 7 LEU A 810
HIS A 839
ASP A 805
HIS A 877
 None
 1.17A 5z84C-4yooA:
2.3
5z84N-4yooA:
undetectable
5z84P-4yooA:
2.3		 5z84C-4yooA:
21.08
5z84N-4yooA:
20.71
5z84P-4yooA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yoo RETINOBLASTOMA-LIKE
PROTEIN
1,RETINOBLASTOMA-LIK
E PROTEIN 1
(Homo
sapiens) 		4 / 8 LEU A 810
HIS A 839
ASP A 805
HIS A 877
 None
 1.17A 5z86C-4yooA:
2.4
5z86N-4yooA:
undetectable
5z86P-4yooA:
2.4		 5z86C-4yooA:
21.08
5z86N-4yooA:
20.71
5z86P-4yooA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yoo RETINOBLASTOMA-LIKE
PROTEIN
1,RETINOBLASTOMA-LIK
E PROTEIN 1
(Homo
sapiens) 		4 / 8 LEU A 810
HIS A 839
ASP A 805
HIS A 877
 None
 1.11A 6nknC-4yooA:
2.2
6nknN-4yooA:
undetectable
6nknP-4yooA:
undetectable		 6nknC-4yooA:
21.08
6nknN-4yooA:
20.71
6nknP-4yooA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4yoo RETINOBLASTOMA-LIKE
PROTEIN
1,RETINOBLASTOMA-LIK
E PROTEIN 1
(Homo
sapiens) 		4 / 7 HIS A 839
ASP A 805
HIS A 877
LEU A 810
 None
 1.00A 6nmfA-4yooA:
undetectable
6nmfC-4yooA:
undetectable
6nmfP-4yooA:
undetectable		 6nmfA-4yooA:
20.71
6nmfC-4yooA:
21.08
6nmfP-4yooA:
21.08