SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yot'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 4yot 3-5 EXONUCLEASE
PHOEXO I
(Pyrococcus
horikoshii) 		5 / 12 VAL A  76
ALA A   5
ALA A   6
LEU A 119
LEU A  79
 None
 1.03A 3p2kD-4yotA:
undetectable		 3p2kD-4yotA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4yot 3-5 EXONUCLEASE
PHOEXO I
(Pyrococcus
horikoshii) 		5 / 12 LEU A  79
LEU A 112
LEU A  91
ILE A 101
GLY A 105
 None
 1.29A 4j26A-4yotA:
undetectable		 4j26A-4yotA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 4yot 3-5 EXONUCLEASE
PHOEXO I
(Pyrococcus
horikoshii) 		4 / 7 ARG A 142
VAL A 139
LEU A 195
SER A 187
 None
 1.09A 4zphA-4yotA:
undetectable
4zphB-4yotA:
undetectable		 4zphA-4yotA:
21.57
4zphB-4yotA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 4yot 3-5 EXONUCLEASE
PHOEXO I
(Pyrococcus
horikoshii) 		4 / 8 ALA A 120
ILE A  62
ALA A  65
ILE A  66
 None
 0.47A 5mvmA-4yotA:
undetectable
5mvmB-4yotA:
undetectable		 5mvmA-4yotA:
16.29
5mvmB-4yotA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 4yot 3-5 EXONUCLEASE
PHOEXO I
(Pyrococcus
horikoshii) 		4 / 7 PHE A 123
ARG A  89
ALA A  69
GLN A 117
 None
 1.11A 6b89A-4yotA:
undetectable		 6b89A-4yotA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 4yot 3-5 EXONUCLEASE
PHOEXO I
(Pyrococcus
horikoshii) 		5 / 12 ILE A 150
GLY A 149
ILE A 178
VAL A 203
ILE A 183
 None
 1.01A 6emuB-4yotA:
undetectable		 6emuB-4yotA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 4yot 3-5 EXONUCLEASE
PHOEXO I
(Pyrococcus
horikoshii) 		5 / 12 ILE A 150
GLY A 149
ILE A 178
VAL A 203
ILE A 183
 None
 1.00A 6emuC-4yotA:
undetectable		 6emuC-4yotA:
25.00