SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ypg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2J0D_A_ERYA1498_0 (CYTOCHROME P450 3A4)	4ypg	INTERFERON ALPHA-2 (Homo sapiens)	5 / 12	SER C 150 ILE C 147 PHE C 36 ALA C 118 GLU C 58	None	0.97A	2j0dA-4ypgC: undetectable	2j0dA-4ypgC: 15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WRK_D_CAMD502_0 (CAMPHOR 5-MONOOXYGENASE)	4ypg	INTERFERON ALPHA-2 (Homo sapiens)	4 / 5	PHE C 38 GLY C 44 THR C 52 VAL C 55	None	1.03A	3wrkD-4ypgC: undetectable	3wrkD-4ypgC: 16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAQ_A_2GMA2001_2 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	4ypg	INTERFERON ALPHA-2 (Homo sapiens)	4 / 6	TRP C 76 THR C 14 VAL C 142 SER C 152	None	1.09A	4iaqA-4ypgC: undetectable	4iaqA-4ypgC: 16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HRQ_K_IPHK101_0 (INSULIN A-CHAIN INSULIN B-CHAIN)	4ypg	INTERFERON ALPHA-2 (Homo sapiens)	4 / 6	VAL C 142 CYH C 138 CYH C 29 HIS C 34	None	1.47A	5hrqH-4ypgC: undetectable 5hrqK-4ypgC: undetectable 5hrqL-4ypgC: undetectable	5hrqH-4ypgC: 15.52 5hrqK-4ypgC: 7.33 5hrqL-4ypgC: 15.52

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2J0D_A_ERYA1498_0","CYTOCHROME P450 3A4","4ypg","INTERFERON ALPHA-2","Homo sapiens",5,"SER C 150;ILE C 147;PHE C  36;ALA C 118;GLU C  58","None","0.97A","2j0dA-4ypgC:undetectable","2j0dA-4ypgC:15.60"],["3WRK_D_CAMD502_0","CAMPHOR 5-MONOOXYGENASE","4ypg","INTERFERON ALPHA-2","Homo sapiens",4,"PHE C  38;GLY C  44;THR C  52;VAL C  55","None","1.03A","3wrkD-4ypgC:undetectable","3wrkD-4ypgC:16.63"],["4IAQ_A_2GMA2001_2","CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562","4ypg","INTERFERON ALPHA-2","Homo sapiens",4,"TRP C  76;THR C  14;VAL C 142;SER C 152","None","1.09A","4iaqA-4ypgC:undetectable","4iaqA-4ypgC:16.37"],["5HRQ_K_IPHK101_0","INSULIN A-CHAIN;INSULIN B-CHAIN","4ypg","INTERFERON ALPHA-2","Homo sapiens",4,"VAL C 142;CYH C 138;CYH C  29;HIS C  34","None","1.47A","5hrqH-4ypgC:undetectable;5hrqK-4ypgC:undetectable;5hrqL-4ypgC:undetectable","5hrqH-4ypgC:15.52;5hrqK-4ypgC:7.33;5hrqL-4ypgC:15.52"]]