SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ypj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H1D_A_SAMA301_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		5 / 12 ASN A 179
GLY A 132
TYR A 134
ASN A 380
TYR A 153
 None
 1.46A 1h1dA-4ypjA:
2.3		 1h1dA-4ypjA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		4 / 6 LEU A 386
ILE A 439
GLU A 400
ARG A 432
 None
 1.05A 1mt1A-4ypjA:
undetectable
1mt1F-4ypjA:
undetectable		 1mt1A-4ypjA:
5.37
1mt1F-4ypjA:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		4 / 6 ILE A 439
GLU A 400
ARG A 432
LEU A 386
 None
 0.84A 1mt1B-4ypjA:
undetectable
1mt1C-4ypjA:
undetectable		 1mt1B-4ypjA:
8.50
1mt1C-4ypjA:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		4 / 7 LEU A 814
VAL A 790
GLY A 789
VAL A 781
 None
 0.98A 1t88A-4ypjA:
undetectable		 1t88A-4ypjA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		4 / 7 ALA A 401
SER A 443
ILE A 444
ILE A 448
 None
 0.87A 1yc5A-4ypjA:
undetectable		 1yc5A-4ypjA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		5 / 9 THR A 483
LEU A 509
VAL A 507
GLY A 508
ILE A 500
 None
 1.36A 2a1oB-4ypjA:
undetectable		 2a1oB-4ypjA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		5 / 11 ASN A 446
GLU A 447
TYR A 511
GLU A 532
TRP A 593
 None
 0.74A 2v3dB-4ypjA:
14.1		 2v3dB-4ypjA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		4 / 5 PHE A 322
PHE A 330
LEU A 339
PHE A 591
 None
 1.22A 3ag3C-4ypjA:
undetectable
3ag3J-4ypjA:
undetectable		 3ag3C-4ypjA:
14.16
3ag3J-4ypjA:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		3 / 3 LEU A 348
TRP A 186
TYR A 193
 None
 1.01A 3aicB-4ypjA:
4.1		 3aicB-4ypjA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		3 / 3 LEU A 348
TRP A 186
TYR A 193
 None
 1.01A 3aicE-4ypjA:
2.2		 3aicE-4ypjA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		3 / 3 LEU A 348
TRP A 186
TYR A 193
 None
 0.96A 3aicG-4ypjA:
2.6		 3aicG-4ypjA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		3 / 3 LEU A 348
TRP A 186
TYR A 193
 None
 1.00A 3aicH-4ypjA:
3.2		 3aicH-4ypjA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		5 / 10 THR A 483
LEU A 509
GLY A 508
THR A 477
VAL A 504
 None
 1.31A 3lxiA-4ypjA:
undetectable		 3lxiA-4ypjA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		5 / 11 THR A 483
LEU A 509
GLY A 508
THR A 477
VAL A 504
 None
 1.27A 3lxiB-4ypjA:
undetectable		 3lxiB-4ypjA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		4 / 8 HIS A 346
SER A 188
LEU A  89
ASP A  84
 None
 1.23A 3n2oC-4ypjA:
8.5
3n2oD-4ypjA:
8.4		 3n2oC-4ypjA:
21.66
3n2oD-4ypjA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		4 / 5 GLN A 685
THR A 686
GLU A 694
THR A 700
 None
 1.49A 3n58A-4ypjA:
undetectable		 3n58A-4ypjA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		4 / 6 ILE A 160
ASN A 142
LEU A 146
ASP A 159
 None
 1.26A 3oi8A-4ypjA:
undetectable		 3oi8A-4ypjA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		4 / 7 PHE A 317
VAL A 229
ILE A 283
SER A 249
 None
 0.95A 3pglA-4ypjA:
undetectable		 3pglA-4ypjA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		5 / 12 VAL A 619
ILE A 375
PHE A 596
ILE A 366
THR A 594
 None
 1.20A 3qfxA-4ypjA:
undetectable		 3qfxA-4ypjA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		4 / 7 VAL A  39
PHE A  49
LEU A 164
ILE A 126
 None
 0.92A 3rfmA-4ypjA:
undetectable		 3rfmA-4ypjA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		5 / 12 PHE A 596
GLY A 623
ASP A 791
GLY A 617
ALA A 795
 None
 1.25A 3sueD-4ypjA:
undetectable		 3sueD-4ypjA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		3 / 3 ASN A 154
GLU A 428
ARG A 432
 None
 1.06A 3wxoA-4ypjA:
undetectable		 3wxoA-4ypjA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		4 / 4 ASN A 453
ALA A 455
GLY A 456
THR A 459
 None
 1.32A 4bboC-4ypjA:
undetectable		 4bboC-4ypjA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		5 / 9 VAL A 748
VAL A 747
ILE A 826
GLY A 824
ALA A 750
 None
 0.96A 4fwdA-4ypjA:
undetectable		 4fwdA-4ypjA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		3 / 3 LEU A 288
ARG A 320
MET A 441
 None
 0.91A 4m11C-4ypjA:
undetectable		 4m11C-4ypjA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		3 / 3 SER A 665
ALA A 717
VAL A 716
 None
 0.59A 4o2bA-4ypjA:
2.3		 4o2bA-4ypjA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		4 / 7 ASN A 391
ILE A 375
ILE A 397
VAL A 377
 None
 0.82A 4ojbA-4ypjA:
undetectable		 4ojbA-4ypjA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		4 / 6 ASN A 391
ILE A 375
ILE A 397
VAL A 377
 None
 0.84A 4olmA-4ypjA:
undetectable		 4olmA-4ypjA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		3 / 3 SER A 665
ALA A 717
VAL A 716
 None
 0.44A 4x1iA-4ypjA:
undetectable		 4x1iA-4ypjA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		3 / 3 ASP A 597
GLY A 793
ASP A 791
 None
 0.64A 4xdtA-4ypjA:
undetectable		 4xdtA-4ypjA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		4 / 7 SER A 512
TYR A 511
ARG A 376
SER A 531
 None
 1.45A 4xzkA-4ypjA:
undetectable		 4xzkA-4ypjA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		3 / 3 SER A 665
ALA A 717
VAL A 716
 None
 0.45A 5eypA-4ypjA:
2.9		 5eypA-4ypjA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		4 / 6 ILE A  87
GLY A 793
ASN A 792
ILE A 599
 None
 0.99A 5j4nB-4ypjA:
undetectable		 5j4nB-4ypjA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		5 / 11 ILE A 826
VAL A 842
ASP A 838
ILE A 758
ALA A 815
 None
 1.04A 5lg3A-4ypjA:
3.4		 5lg3A-4ypjA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		5 / 11 ILE A 826
VAL A 842
THR A 840
ILE A 758
ALA A 815
 None
 1.06A 5lg3A-4ypjA:
3.4		 5lg3A-4ypjA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		5 / 12 ILE A 826
VAL A 842
THR A 840
ILE A 758
ALA A 815
 None
 1.05A 5lg3E-4ypjA:
3.4		 5lg3E-4ypjA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		4 / 5 PHE A 322
PHE A 330
LEU A 339
PHE A 591
 None
 1.21A 5wauc-4ypjA:
undetectable
5wauj-4ypjA:
undetectable		 5wauc-4ypjA:
14.16
5wauj-4ypjA:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		4 / 5 PHE A 322
PHE A 330
LEU A 339
PHE A 591
 None
 1.20A 5xdqP-4ypjA:
undetectable
5xdqW-4ypjA:
undetectable		 5xdqP-4ypjA:
14.16
5xdqW-4ypjA:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		3 / 3 ARG A  54
ARG A 112
ASP A  73
 None
 0.98A 6d8pA-4ypjA:
3.7		 6d8pA-4ypjA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		4 / 6 MET A 344
ALA A 390
LEU A 395
ALA A 374
 None
 1.11A 6fosB-4ypjA:
undetectable		 6fosB-4ypjA:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4ypj BETA GALACTOSIDASE
(Bacillus
circulans) 		4 / 7 TRP A 593
HIS A 379
THR A 378
GLU A 447
 None
 0.93A 6mn4E-4ypjA:
undetectable		 6mn4E-4ypjA:
15.51