SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ypl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		5 / 12 LEU A 610
ALA A 639
ALA A 637
VAL A 667
MET A 633
 4KZ  A 801 (-4.2A)
None
None
None
4KZ  A 801 (-3.6A)
 1.26A 1kt4A-4yplA:
undetectable		 1kt4A-4yplA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M00_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.29A 1m00A-4yplA:
undetectable
1m00B-4yplA:
undetectable		 1m00A-4yplA:
21.32
1m00B-4yplA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M00_B_H4BB1760_1
(NITRIC-OXIDE
SYNTHASE)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 GLU A 705
MET A 713
ARG A 709
VAL A 762
 None
 1.28A 1m00A-4yplA:
undetectable
1m00B-4yplA:
undetectable		 1m00A-4yplA:
21.32
1m00B-4yplA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6I_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.31A 1p6iA-4yplA:
undetectable
1p6iB-4yplA:
undetectable		 1p6iA-4yplA:
21.32
1p6iB-4yplA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		5 / 12 ALA A 724
LEU A 600
PRO A 736
ASN A 739
LEU A 743
 None
 1.04A 1u72A-4yplA:
undetectable		 1u72A-4yplA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.28A 1zzqA-4yplA:
undetectable
1zzqB-4yplA:
undetectable		 1zzqA-4yplA:
21.24
1zzqB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 GLU A 705
MET A 713
ARG A 709
VAL A 762
 None
 1.26A 1zzqA-4yplA:
undetectable
1zzqB-4yplA:
undetectable		 1zzqA-4yplA:
21.24
1zzqB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		3 / 3 ARG A 272
ASP A 457
ASP A 453
 None
 0.75A 2ejtA-4yplA:
undetectable		 2ejtA-4yplA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 5 LEU A 420
ALA A 369
ILE A 368
SER A 367
 None
 0.87A 2othA-4yplA:
undetectable		 2othA-4yplA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		5 / 12 ALA A 724
LEU A 600
PRO A 736
ASN A 739
LEU A 743
 None
 1.04A 2w3bB-4yplA:
undetectable		 2w3bB-4yplA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		5 / 12 ALA A 724
LEU A 600
PRO A 736
ASN A 739
LEU A 743
 None
 1.07A 2w3mA-4yplA:
undetectable		 2w3mA-4yplA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		5 / 12 GLY A 710
GLY A 680
SER A 707
VAL A 665
ILE A 687
 None
 1.13A 2wa2A-4yplA:
undetectable		 2wa2A-4yplA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		5 / 12 ILE A 687
PHE A 657
LEU A 663
ALA A 616
LEU A 766
 None
 1.12A 3dzyA-4yplA:
undetectable		 3dzyA-4yplA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		5 / 12 ALA A 724
GLU A 745
PRO A 736
ASN A 739
LEU A 743
 None
 1.25A 3eigA-4yplA:
undetectable		 3eigA-4yplA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		5 / 12 ALA A 724
LEU A 600
GLU A 745
PRO A 736
LEU A 743
 None
 1.20A 3eigA-4yplA:
undetectable		 3eigA-4yplA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.22A 3jt4A-4yplA:
undetectable
3jt4B-4yplA:
undetectable		 3jt4A-4yplA:
21.24
3jt4B-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.25A 3jt6A-4yplA:
undetectable
3jt6B-4yplA:
undetectable		 3jt6A-4yplA:
21.24
3jt6B-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWS_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.22A 3jwsA-4yplA:
undetectable
3jwsB-4yplA:
undetectable		 3jwsA-4yplA:
21.24
3jwsB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWS_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 GLU A 705
MET A 713
ARG A 709
VAL A 762
 None
 1.26A 3jwsA-4yplA:
undetectable
3jwsB-4yplA:
undetectable		 3jwsA-4yplA:
21.24
3jwsB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.28A 3jwtA-4yplA:
undetectable
3jwtB-4yplA:
undetectable		 3jwtA-4yplA:
21.24
3jwtB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 GLU A 705
MET A 713
ARG A 709
VAL A 762
 None
 1.29A 3jwtA-4yplA:
undetectable
3jwtB-4yplA:
undetectable		 3jwtA-4yplA:
21.24
3jwtB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWU_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.23A 3jwuA-4yplA:
undetectable
3jwuB-4yplA:
undetectable		 3jwuA-4yplA:
21.24
3jwuB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWU_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 GLU A 705
MET A 713
ARG A 709
VAL A 762
 None
 1.28A 3jwuA-4yplA:
undetectable
3jwuB-4yplA:
undetectable		 3jwuA-4yplA:
21.24
3jwuB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWV_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.25A 3jwvA-4yplA:
undetectable
3jwvB-4yplA:
undetectable		 3jwvA-4yplA:
21.24
3jwvB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWV_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 GLU A 705
MET A 713
ARG A 709
VAL A 762
 None
 1.25A 3jwvA-4yplA:
undetectable
3jwvB-4yplA:
undetectable		 3jwvA-4yplA:
21.24
3jwvB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX0_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.22A 3jx0A-4yplA:
undetectable
3jx0B-4yplA:
undetectable		 3jx0A-4yplA:
21.24
3jx0B-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.25A 3jx1A-4yplA:
undetectable
3jx1B-4yplA:
undetectable		 3jx1A-4yplA:
21.24
3jx1B-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		5 / 12 LEU A 663
VAL A 665
LEU A 653
ALA A 686
ALA A 640
 None
 0.95A 3mdvB-4yplA:
undetectable		 3mdvB-4yplA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLK_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.26A 3nlkA-4yplA:
undetectable
3nlkB-4yplA:
undetectable		 3nlkA-4yplA:
21.24
3nlkB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLM_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.29A 3nlmA-4yplA:
undetectable
3nlmB-4yplA:
undetectable		 3nlmA-4yplA:
21.24
3nlmB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLM_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 GLU A 705
MET A 713
ARG A 709
VAL A 762
 None
 1.33A 3nlmA-4yplA:
undetectable
3nlmB-4yplA:
undetectable		 3nlmA-4yplA:
21.24
3nlmB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLN_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.28A 3nlnA-4yplA:
undetectable
3nlnB-4yplA:
undetectable		 3nlnA-4yplA:
21.24
3nlnB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLN_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 GLU A 705
MET A 713
ARG A 709
VAL A 762
 None
 1.28A 3nlnA-4yplA:
undetectable
3nlnB-4yplA:
undetectable		 3nlnA-4yplA:
21.24
3nlnB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.29A 3nloA-4yplA:
undetectable
3nloB-4yplA:
undetectable		 3nloA-4yplA:
21.24
3nloB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLO_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 GLU A 705
MET A 713
ARG A 709
VAL A 762
 None
 1.33A 3nloA-4yplA:
undetectable
3nloB-4yplA:
undetectable		 3nloA-4yplA:
21.24
3nloB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLV_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.23A 3nlvA-4yplA:
undetectable
3nlvB-4yplA:
undetectable		 3nlvA-4yplA:
21.24
3nlvB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLX_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.26A 3nlxA-4yplA:
undetectable
3nlxB-4yplA:
undetectable		 3nlxA-4yplA:
21.24
3nlxB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLX_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 GLU A 705
MET A 713
ARG A 709
VAL A 762
 None
 1.29A 3nlxA-4yplA:
undetectable
3nlxB-4yplA:
undetectable		 3nlxA-4yplA:
21.24
3nlxB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLZ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.30A 3nlzA-4yplA:
undetectable
3nlzB-4yplA:
undetectable		 3nlzA-4yplA:
21.24
3nlzB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NM0_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.27A 3nm0A-4yplA:
undetectable
3nm0B-4yplA:
undetectable		 3nm0A-4yplA:
21.24
3nm0B-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNY_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.30A 3nnyA-4yplA:
undetectable
3nnyB-4yplA:
undetectable		 3nnyA-4yplA:
21.24
3nnyB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNZ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.24A 3nnzA-4yplA:
undetectable
3nnzB-4yplA:
undetectable		 3nnzA-4yplA:
21.24
3nnzB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNZ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 GLU A 705
MET A 713
ARG A 709
VAL A 762
 None
 1.27A 3nnzA-4yplA:
undetectable
3nnzB-4yplA:
undetectable		 3nnzA-4yplA:
21.24
3nnzB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNF_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.28A 3pnfA-4yplA:
undetectable
3pnfB-4yplA:
undetectable		 3pnfA-4yplA:
21.24
3pnfB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQJ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 GLU A 705
MET A 713
ARG A 709
VAL A 762
 None
 1.31A 3rqjA-4yplA:
undetectable
3rqjB-4yplA:
undetectable		 3rqjA-4yplA:
21.24
3rqjB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQM_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.29A 3rqmA-4yplA:
undetectable
3rqmB-4yplA:
undetectable		 3rqmA-4yplA:
21.24
3rqmB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQN_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.29A 3rqnA-4yplA:
undetectable
3rqnB-4yplA:
undetectable		 3rqnA-4yplA:
21.24
3rqnB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQN_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 GLU A 705
MET A 713
ARG A 709
VAL A 762
 None
 1.30A 3rqnA-4yplA:
undetectable
3rqnB-4yplA:
undetectable		 3rqnA-4yplA:
21.24
3rqnB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFU_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.30A 3ufuA-4yplA:
undetectable
3ufuB-4yplA:
undetectable		 3ufuA-4yplA:
21.24
3ufuB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFU_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 GLU A 705
MET A 713
ARG A 709
VAL A 762
 None
 1.29A 3ufuA-4yplA:
undetectable
3ufuB-4yplA:
undetectable		 3ufuA-4yplA:
21.24
3ufuB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.23A 4capA-4yplA:
0.9
4capB-4yplA:
undetectable		 4capA-4yplA:
21.24
4capB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTV_A_H4BA1718_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.30A 4ctvA-4yplA:
undetectable
4ctvB-4yplA:
undetectable		 4ctvA-4yplA:
21.24
4ctvB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTW_A_H4BA1718_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.24A 4ctwA-4yplA:
undetectable
4ctwB-4yplA:
undetectable		 4ctwA-4yplA:
21.24
4ctwB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTW_B_H4BB1720_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 GLU A 705
MET A 713
ARG A 709
VAL A 762
 None
 1.26A 4ctwA-4yplA:
undetectable
4ctwB-4yplA:
undetectable		 4ctwA-4yplA:
21.24
4ctwB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTX_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.27A 4ctxA-4yplA:
undetectable
4ctxB-4yplA:
undetectable		 4ctxA-4yplA:
21.24
4ctxB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.26A 4cx5A-4yplA:
undetectable
4cx5B-4yplA:
undetectable		 4cx5A-4yplA:
21.24
4cx5B-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 GLU A 705
MET A 713
ARG A 709
VAL A 762
 None
 1.30A 4cx5A-4yplA:
undetectable
4cx5B-4yplA:
undetectable		 4cx5A-4yplA:
21.24
4cx5B-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1N_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.25A 4d1nA-4yplA:
undetectable
4d1nB-4yplA:
undetectable		 4d1nA-4yplA:
22.22
4d1nB-4yplA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D2Y_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.27A 4d2yA-4yplA:
undetectable
4d2yB-4yplA:
undetectable		 4d2yA-4yplA:
21.24
4d2yB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D2Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 GLU A 705
MET A 713
ARG A 709
VAL A 762
 None
 1.26A 4d2yA-4yplA:
undetectable
4d2yB-4yplA:
undetectable		 4d2yA-4yplA:
21.24
4d2yB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D2Z_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.28A 4d2zA-4yplA:
undetectable
4d2zB-4yplA:
undetectable		 4d2zA-4yplA:
21.24
4d2zB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D2Z_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 GLU A 705
MET A 713
ARG A 709
VAL A 762
 None
 1.32A 4d2zA-4yplA:
undetectable
4d2zB-4yplA:
undetectable		 4d2zA-4yplA:
21.24
4d2zB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D30_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.34A 4d30A-4yplA:
undetectable
4d30B-4yplA:
undetectable		 4d30A-4yplA:
21.24
4d30B-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.27A 4d32A-4yplA:
undetectable
4d32B-4yplA:
undetectable		 4d32A-4yplA:
21.24
4d32B-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D3B_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.23A 4d3bA-4yplA:
undetectable
4d3bB-4yplA:
undetectable		 4d3bA-4yplA:
21.24
4d3bB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D3B_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 GLU A 705
MET A 713
ARG A 709
VAL A 762
 None
 1.24A 4d3bA-4yplA:
undetectable
4d3bB-4yplA:
undetectable		 4d3bA-4yplA:
21.24
4d3bB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7O_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.26A 4d7oA-4yplA:
undetectable
4d7oB-4yplA:
undetectable		 4d7oA-4yplA:
21.24
4d7oB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7O_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 GLU A 705
MET A 713
ARG A 709
VAL A 762
 None
 1.28A 4d7oA-4yplA:
undetectable
4d7oB-4yplA:
undetectable		 4d7oA-4yplA:
21.24
4d7oB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVW_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.28A 4fvwA-4yplA:
undetectable
4fvwB-4yplA:
undetectable		 4fvwA-4yplA:
21.24
4fvwB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.28A 4fvxA-4yplA:
undetectable
4fvxB-4yplA:
undetectable		 4fvxA-4yplA:
21.24
4fvxB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FW0_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.27A 4fw0A-4yplA:
undetectable
4fw0B-4yplA:
undetectable		 4fw0A-4yplA:
21.24
4fw0B-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GQE_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.28A 4gqeA-4yplA:
undetectable
4gqeB-4yplA:
undetectable		 4gqeA-4yplA:
21.24
4gqeB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		5 / 12 TYR A 505
GLY A 360
ILE A 490
ARG A 378
SER A 363
 None
 1.14A 4iv0B-4yplA:
undetectable		 4iv0B-4yplA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSJ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.24A 4jsjA-4yplA:
undetectable
4jsjB-4yplA:
undetectable		 4jsjA-4yplA:
21.24
4jsjB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSJ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 GLU A 705
MET A 713
ARG A 709
VAL A 762
 None
 1.28A 4jsjA-4yplA:
undetectable
4jsjB-4yplA:
undetectable		 4jsjA-4yplA:
21.24
4jsjB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 LEU A 322
LYS A 498
GLU A 497
TYR A 505
 None
 0.81A 4lb2A-4yplA:
undetectable		 4lb2A-4yplA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		5 / 11 ILE A 687
PHE A 657
LEU A 663
ALA A 616
LEU A 766
 None
 1.19A 4nqaA-4yplA:
undetectable		 4nqaA-4yplA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH1_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.30A 4uh1A-4yplA:
undetectable
4uh1B-4yplA:
undetectable		 4uh1A-4yplA:
21.24
4uh1B-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPM_A_H4BA760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.28A 4upmA-4yplA:
undetectable
4upmB-4yplA:
undetectable		 4upmA-4yplA:
21.24
4upmB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.23A 4uppA-4yplA:
undetectable
4uppB-4yplA:
undetectable		 4uppA-4yplA:
21.24
4uppB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 GLU A 705
MET A 713
ARG A 709
VAL A 762
 None
 1.27A 4uppA-4yplA:
undetectable
4uppB-4yplA:
undetectable		 4uppA-4yplA:
21.24
4uppB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3X_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.33A 4v3xA-4yplA:
undetectable
4v3xB-4yplA:
undetectable		 4v3xA-4yplA:
21.24
4v3xB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.25A 4v3yA-4yplA:
undetectable
4v3yB-4yplA:
undetectable		 4v3yA-4yplA:
21.24
4v3yB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 8 GLU A 705
MET A 713
ARG A 709
VAL A 762
 None
 1.30A 4v3yA-4yplA:
undetectable
4v3yB-4yplA:
undetectable		 4v3yA-4yplA:
21.24
4v3yB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		5 / 6 LEU A 293
ILE A 253
LEU A 290
GLU A 269
TYR A 289
 None
 1.43A 4w5nA-4yplA:
undetectable		 4w5nA-4yplA:
22.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPM_A_BO2A801_1
(LON PROTEASE)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		12 / 12 ALA A 601
THR A 603
THR A 608
LEU A 610
MET A 633
THR A 672
LYS A 674
GLY A 676
PRO A 677
SER A 678
ALA A 679
LYS A 721
 4KZ  A 801 (-3.3A)
4KZ  A 801 ( 4.5A)
None
4KZ  A 801 (-4.2A)
4KZ  A 801 (-3.6A)
None
None
4KZ  A 801 (-3.3A)
4KZ  A 801 (-4.3A)
4KZ  A 801 (-1.4A)
4KZ  A 801 (-3.5A)
4KZ  A 801 (-3.4A)
 0.57A 4ypmA-4yplA:
34.6		 4ypmA-4yplA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		5 / 10 ALA A 684
LEU A 769
ALA A 597
SER A 678
ALA A 679
 None
None
None
4KZ  A 801 (-1.4A)
4KZ  A 801 (-3.5A)
 1.12A 4zbrA-4yplA:
2.2		 4zbrA-4yplA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGK_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.31A 5agkA-4yplA:
undetectable
5agkB-4yplA:
undetectable		 5agkA-4yplA:
21.24
5agkB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGL_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.27A 5aglA-4yplA:
undetectable
5aglB-4yplA:
undetectable		 5aglA-4yplA:
21.24
5aglB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGM_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.27A 5agmA-4yplA:
undetectable
5agmB-4yplA:
undetectable		 5agmA-4yplA:
21.24
5agmB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		3 / 3 GLY A 716
GLN A 742
LYS A 721
 None
None
4KZ  A 801 (-3.4A)
 0.84A 5imsB-4yplA:
undetectable		 5imsB-4yplA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		5 / 11 ILE A 687
PHE A 657
LEU A 663
ALA A 616
LEU A 766
 None
 1.23A 5ji0A-4yplA:
undetectable		 5ji0A-4yplA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		5 / 12 VAL A 530
LEU A 543
GLY A 548
SER A 514
ILE A 550
 None
 1.16A 5vooA-4yplA:
undetectable		 5vooA-4yplA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		5 / 12 VAL A 530
LEU A 543
GLY A 548
SER A 514
ILE A 550
 None
 1.15A 5vooB-4yplA:
undetectable		 5vooB-4yplA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		5 / 12 VAL A 530
LEU A 543
GLY A 548
SER A 514
ILE A 550
 None
 1.18A 5vooC-4yplA:
undetectable		 5vooC-4yplA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUL_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.25A 5vulA-4yplA:
undetectable
5vulB-4yplA:
undetectable		 5vulA-4yplA:
21.24
5vulB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUL_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 GLU A 705
MET A 713
ARG A 709
VAL A 762
 None
 1.28A 5vulA-4yplA:
undetectable
5vulB-4yplA:
undetectable		 5vulA-4yplA:
21.24
5vulB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.25A 5vunA-4yplA:
undetectable
5vunB-4yplA:
undetectable		 5vunA-4yplA:
21.24
5vunB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUP_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.25A 5vupA-4yplA:
undetectable
5vupB-4yplA:
undetectable		 5vupA-4yplA:
21.24
5vupB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUP_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 GLU A 705
MET A 713
ARG A 709
VAL A 762
 None
 1.25A 5vupA-4yplA:
undetectable
5vupB-4yplA:
undetectable		 5vupA-4yplA:
21.24
5vupB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUT_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 MET A 713
ARG A 709
VAL A 762
GLU A 705
 None
 1.27A 5vutA-4yplA:
undetectable
5vutB-4yplA:
undetectable		 5vutA-4yplA:
21.24
5vutB-4yplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 4ypl LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 6 MET A 683
THR A 682
MET A 633
LEU A 735
 None
None
4KZ  A 801 (-3.6A)
None
 1.21A 6mvxA-4yplA:
undetectable
6mvxB-4yplA:
undetectable
6mvxC-4yplA:
undetectable		 6mvxA-4yplA:
20.00
6mvxB-4yplA:
20.00
6mvxC-4yplA:
20.00