SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ypo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 4ypo KETOL-ACID
REDUCTOISOMERASE
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 159
GLY A 156
LEU A 163
SER A 164
 None
 0.88A 3aiaA-4ypoA:
undetectable		 3aiaA-4ypoA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4ypo KETOL-ACID
REDUCTOISOMERASE
(Mycobacterium
tuberculosis) 		4 / 8 PRO A  64
ALA A  68
ALA A  71
ILE A  91
 None
 0.51A 3dtuC-4ypoA:
undetectable
3dtuD-4ypoA:
undetectable		 3dtuC-4ypoA:
20.63
3dtuD-4ypoA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 4ypo KETOL-ACID
REDUCTOISOMERASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 292
GLY A 294
LYS A 297
 None
 0.67A 4k50I-4ypoA:
undetectable		 4k50I-4ypoA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 4ypo KETOL-ACID
REDUCTOISOMERASE
(Mycobacterium
tuberculosis) 		4 / 5 VAL A  76
LEU A 101
VAL A 122
PHE A 103
 None
 0.99A 4lb0B-4ypoA:
undetectable		 4lb0B-4ypoA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 4ypo KETOL-ACID
REDUCTOISOMERASE
(Mycobacterium
tuberculosis) 		5 / 9 LEU A 161
ALA A   7
ASP A   6
GLY A 171
ILE A 169
 None
 1.01A 5kr0B-4ypoA:
undetectable		 5kr0B-4ypoA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 4ypo KETOL-ACID
REDUCTOISOMERASE
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 161
ALA A   7
ASP A   6
GLY A 171
ILE A 169
 None
 0.97A 5kr1A-4ypoA:
undetectable		 5kr1A-4ypoA:
14.84