SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ypt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 4ypt REPLICASE
POLYPROTEIN 1AB
(Murine
coronavirus) 		4 / 7 ARG A1604
VAL A1600
SER A1601
LYS A1635
 None
 1.37A 1hwiC-4yptA:
undetectable		 1hwiC-4yptA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 4ypt REPLICASE
POLYPROTEIN 1AB
(Murine
coronavirus) 		4 / 5 ASP A1666
SER A1665
LEU A1637
GLY A1638
 None
 1.16A 2j2pA-4yptA:
undetectable
2j2pB-4yptA:
undetectable		 2j2pA-4yptA:
23.74
2j2pB-4yptA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 4ypt REPLICASE
POLYPROTEIN 1AB
(Murine
coronavirus) 		4 / 4 ALA A1674
VAL A1620
PHE A1679
THR A1616
 None
 1.41A 2pkkA-4yptA:
undetectable		 2pkkA-4yptA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4ypt REPLICASE
POLYPROTEIN 1AB
(Murine
coronavirus) 		4 / 5 SER A1582
PHE A1595
VAL A1566
TYR A1571
 None
 1.46A 2x7hA-4yptA:
undetectable		 2x7hA-4yptA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4ypt REPLICASE
POLYPROTEIN 1AB
(Murine
coronavirus) 		4 / 5 SER A1582
PHE A1595
VAL A1566
TYR A1571
 None
 1.47A 2x7hB-4yptA:
undetectable		 2x7hB-4yptA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ypt REPLICASE
POLYPROTEIN 1AB
(Murine
coronavirus) 		5 / 12 THR A1814
LEU A1790
VAL A1835
PHE A1840
CYH A1788
 None
 1.40A 3u9fB-4yptA:
undetectable
3u9fC-4yptA:
undetectable		 3u9fB-4yptA:
18.49
3u9fC-4yptA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ypt REPLICASE
POLYPROTEIN 1AB
(Murine
coronavirus) 		5 / 12 THR A1814
LEU A1790
VAL A1835
PHE A1840
CYH A1788
 None
 1.47A 3u9fD-4yptA:
undetectable
3u9fE-4yptA:
undetectable		 3u9fD-4yptA:
18.49
3u9fE-4yptA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ypt REPLICASE
POLYPROTEIN 1AB
(Murine
coronavirus) 		5 / 12 THR A1814
LEU A1790
VAL A1835
PHE A1840
CYH A1788
 None
 1.40A 3u9fG-4yptA:
undetectable
3u9fH-4yptA:
undetectable		 3u9fG-4yptA:
18.49
3u9fH-4yptA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 4ypt REPLICASE
POLYPROTEIN 1AB
(Murine
coronavirus) 		4 / 6 ARG A1751
TYR A1690
TYR A1689
LEU A1686
 GOL  A2002 ( 4.6A)
None
GOL  A2002 (-4.8A)
None
 1.13A 4f8yA-4yptA:
undetectable
4f8yB-4yptA:
undetectable		 4f8yA-4yptA:
19.76
4f8yB-4yptA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4ypt REPLICASE
POLYPROTEIN 1AB
(Murine
coronavirus) 		3 / 3 PRO A1857
LEU A1856
HIS A1876
 None
 0.51A 4pevA-4yptA:
undetectable		 4pevA-4yptA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 4ypt REPLICASE
POLYPROTEIN 1AB
(Murine
coronavirus) 		4 / 5 TYR A1874
PHE A1709
HIS A1876
LEU A1725
 None
 1.13A 5csyB-4yptA:
undetectable		 5csyB-4yptA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 4ypt REPLICASE
POLYPROTEIN 1AB
(Murine
coronavirus) 		4 / 5 ILE A1603
PHE A1595
SER A1582
ALA A1598
 None
 1.23A 5msdA-4yptA:
undetectable		 5msdA-4yptA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ypt REPLICASE
POLYPROTEIN 1AB
(Murine
coronavirus) 		4 / 6 LEU A1845
TYR A1906
PHE A1840
GLY A1818
 None
 0.91A 6hd4B-4yptA:
undetectable		 6hd4B-4yptA:
12.07