SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yqx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 4yqx JES6-1 VH DOMAIN
JES6-1 VL DOMAIN
(Rattus
norvegicus) 		4 / 7 ALA L  43
TYR L  45
TYR H 109
PHE L 107
 None
 1.18A 2ajvH-4yqxL:
14.5
2ajvL-4yqxL:
21.1		 2ajvH-4yqxL:
21.03
2ajvL-4yqxL:
60.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4yqx JES6-1 VH DOMAIN
JES6-1 VL DOMAIN
(Rattus
norvegicus;
Rattus
norvegicus) 		4 / 7 HIS H  42
TYR L  45
PRO L  53
TYR L  96
 None
 1.20A 2ombC-4yqxH:
14.6
2ombD-4yqxH:
14.8		 2ombC-4yqxH:
20.80
2ombD-4yqxH:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 4yqx JES6-1 VH DOMAIN
JES6-1 VL DOMAIN
(Rattus
norvegicus) 		4 / 7 PHE H 111
TYR L  58
PRO H 110
TRP L  44
 None
 1.41A 2q6kA-4yqxH:
undetectable		 2q6kA-4yqxH:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_E_C2FE995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 4yqx JES6-1 VH DOMAIN
(Rattus
norvegicus) 		5 / 11 GLN H   9
GLN H  85
LEU H  23
THR H 118
LEU H  73
 None
 1.46A 3fsuE-4yqxH:
undetectable		 3fsuE-4yqxH:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4yqx JES6-1 VL DOMAIN
(Rattus
norvegicus) 		3 / 3 SER L  35
GLY L  36
GLN L  38
 None
 0.64A 3v4tH-4yqxL:
undetectable		 3v4tH-4yqxL:
14.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WFH_B_P2EB301_1
(MAB FAB H FRAGMENT
MAB FAB L FRAGMENT)		 4yqx JES6-1 VH DOMAIN
JES6-1 VL DOMAIN
(Rattus
norvegicus) 		5 / 12 HIS H  38
VAL H  40
TRP H  53
TRP H 114
LEU L  98
 None
 0.61A 3wfhA-4yqxH:
20.9
3wfhB-4yqxH:
15.4		 3wfhA-4yqxH:
56.15
3wfhB-4yqxH:
21.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WHX_B_XPGB301_1
(MAB FAB H FRAGMENT
MAB FAB L FRAGMENT)		 4yqx JES6-1 VH DOMAIN
JES6-1 VL DOMAIN
(Rattus
norvegicus) 		5 / 12 HIS H  38
VAL H  40
TRP H  53
TRP H 114
LEU L  98
 None
 0.63A 3whxA-4yqxH:
21.0
3whxB-4yqxH:
15.4		 3whxA-4yqxH:
56.15
3whxB-4yqxH:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4yqx JES6-1 VH DOMAIN
(Rattus
norvegicus) 		4 / 7 ALA H  95
THR H  94
VAL H 120
GLU H  92
 None
 0.83A 5ecoD-4yqxH:
undetectable		 5ecoD-4yqxH:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 4yqx JES6-1 VH DOMAIN
JES6-1 VL DOMAIN
(Rattus
norvegicus;
Rattus
norvegicus) 		4 / 7 TYR L  41
TYR L  59
GLN L  99
HIS H  38
 None
 1.33A 5ov9B-4yqxL:
undetectable		 5ov9B-4yqxL:
13.35