SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yqy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4yqy PUTATIVE
DEHYDROGENASE
(Sulfitobacter
sp.
NAS-14.1) 		4 / 6 ARG A 167
ARG A 145
GLY A 144
ALA A 143
 None
 0.94A 1wmqA-4yqyA:
undetectable		 1wmqA-4yqyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4yqy PUTATIVE
DEHYDROGENASE
(Sulfitobacter
sp.
NAS-14.1) 		4 / 6 ARG A 167
ARG A 145
GLY A 144
ALA A 143
 None
 0.94A 1wmqB-4yqyA:
undetectable		 1wmqB-4yqyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4yqy PUTATIVE
DEHYDROGENASE
(Sulfitobacter
sp.
NAS-14.1) 		4 / 6 ARG A 167
ARG A 145
GLY A 144
ALA A 143
 None
 0.94A 1wpuA-4yqyA:
undetectable		 1wpuA-4yqyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4yqy PUTATIVE
DEHYDROGENASE
(Sulfitobacter
sp.
NAS-14.1) 		4 / 6 ARG A 167
ARG A 145
GLY A 144
ALA A 143
 None
 0.94A 1wpuB-4yqyA:
undetectable		 1wpuB-4yqyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4yqy PUTATIVE
DEHYDROGENASE
(Sulfitobacter
sp.
NAS-14.1) 		4 / 6 ARG A 167
ARG A 145
GLY A 144
ALA A 143
 None
 0.97A 1wrqA-4yqyA:
undetectable		 1wrqA-4yqyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4yqy PUTATIVE
DEHYDROGENASE
(Sulfitobacter
sp.
NAS-14.1) 		4 / 6 ARG A 167
ARG A 145
GLY A 144
ALA A 143
 None
 0.95A 1wrqB-4yqyA:
undetectable		 1wrqB-4yqyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 4yqy PUTATIVE
DEHYDROGENASE
(Sulfitobacter
sp.
NAS-14.1) 		5 / 12 GLY A  18
GLY A  13
GLY A  42
ASP A  16
ILE A  17
 None
 0.92A 3eluA-4yqyA:
4.5		 3eluA-4yqyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4yqy PUTATIVE
DEHYDROGENASE
(Sulfitobacter
sp.
NAS-14.1) 		5 / 12 LEU A 127
LEU A 173
VAL A 179
LEU A 165
PHE A 119
 None
 1.12A 3fl9B-4yqyA:
undetectable		 3fl9B-4yqyA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4yqy PUTATIVE
DEHYDROGENASE
(Sulfitobacter
sp.
NAS-14.1) 		5 / 10 LEU A 127
LEU A 173
VAL A 179
LEU A 165
PHE A 119
 None
 1.10A 3fl9E-4yqyA:
undetectable		 3fl9E-4yqyA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4yqy PUTATIVE
DEHYDROGENASE
(Sulfitobacter
sp.
NAS-14.1) 		5 / 12 LEU A 127
LEU A 173
VAL A 179
LEU A 165
PHE A 119
 None
 1.10A 3fl9G-4yqyA:
2.1		 3fl9G-4yqyA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4yqy PUTATIVE
DEHYDROGENASE
(Sulfitobacter
sp.
NAS-14.1) 		5 / 12 ALA A 143
GLY A 156
GLY A 149
ALA A 140
HIS A 192
 None
 1.12A 3ou6B-4yqyA:
5.8		 3ou6B-4yqyA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4yqy PUTATIVE
DEHYDROGENASE
(Sulfitobacter
sp.
NAS-14.1) 		5 / 12 ALA A 143
GLY A 156
GLY A 149
ALA A 140
HIS A 192
 None
 1.15A 3ou7B-4yqyA:
5.7		 3ou7B-4yqyA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 4yqy PUTATIVE
DEHYDROGENASE
(Sulfitobacter
sp.
NAS-14.1) 		5 / 11 ALA A  20
VAL A  10
GLY A  13
LEU A  25
LEU A  23
 None
 0.98A 3sm2B-4yqyA:
undetectable		 3sm2B-4yqyA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_C_SAMC1263_0
(NON-STRUCTURAL
PROTEIN 5)		 4yqy PUTATIVE
DEHYDROGENASE
(Sulfitobacter
sp.
NAS-14.1) 		5 / 12 GLY A  18
GLY A  13
GLY A  42
ASP A  16
ILE A  17
 None
 0.92A 4ctjC-4yqyA:
4.2		 4ctjC-4yqyA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 4yqy PUTATIVE
DEHYDROGENASE
(Sulfitobacter
sp.
NAS-14.1) 		4 / 7 VAL A 224
SER A 135
LEU A   3
ASP A   2
 None
 1.25A 4hxyB-4yqyA:
19.7		 4hxyB-4yqyA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 4yqy PUTATIVE
DEHYDROGENASE
(Sulfitobacter
sp.
NAS-14.1) 		3 / 3 ASP A 146
TRP A 108
SER A 141
 None
 0.98A 4lrhA-4yqyA:
undetectable		 4lrhA-4yqyA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4yqy PUTATIVE
DEHYDROGENASE
(Sulfitobacter
sp.
NAS-14.1) 		4 / 8 ARG A  97
SER A 158
ALA A 143
SER A 141
 None
 1.17A 4lv9A-4yqyA:
undetectable
4lv9B-4yqyA:
undetectable		 4lv9A-4yqyA:
19.16
4lv9B-4yqyA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4yqy PUTATIVE
DEHYDROGENASE
(Sulfitobacter
sp.
NAS-14.1) 		4 / 6 LYS A 159
GLY A 148
GLY A 147
ASP A 146
 None
 0.93A 5a06D-4yqyA:
4.8		 5a06D-4yqyA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 4yqy PUTATIVE
DEHYDROGENASE
(Sulfitobacter
sp.
NAS-14.1) 		5 / 12 GLY A  18
GLY A  13
GLY A  42
ASP A  16
ILE A  17
 None
 0.90A 5ehgA-4yqyA:
4.8		 5ehgA-4yqyA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 4yqy PUTATIVE
DEHYDROGENASE
(Sulfitobacter
sp.
NAS-14.1) 		5 / 12 GLY A  18
GLY A  13
GLY A  42
ASP A  16
ILE A  17
 None
 0.89A 5ehgC-4yqyA:
4.7		 5ehgC-4yqyA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 4yqy PUTATIVE
DEHYDROGENASE
(Sulfitobacter
sp.
NAS-14.1) 		5 / 12 GLY A  18
GLY A  13
GLY A  42
ASP A  16
ILE A  17
 None
 0.91A 5ehiC-4yqyA:
2.2		 5ehiC-4yqyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 4yqy PUTATIVE
DEHYDROGENASE
(Sulfitobacter
sp.
NAS-14.1) 		5 / 12 GLY A  18
GLY A  13
GLY A  42
ASP A  16
ILE A  17
 None
 0.90A 5eiwA-4yqyA:
4.8		 5eiwA-4yqyA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 4yqy PUTATIVE
DEHYDROGENASE
(Sulfitobacter
sp.
NAS-14.1) 		5 / 12 GLY A  18
GLY A  13
GLY A  42
ASP A  16
ILE A  17
 None
 0.90A 5ekxA-4yqyA:
4.5		 5ekxA-4yqyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_B_SAMB4000_0
(NS5
METHYLTRANSFERASE)		 4yqy PUTATIVE
DEHYDROGENASE
(Sulfitobacter
sp.
NAS-14.1) 		5 / 12 GLY A  18
GLY A  13
GLY A  42
ASP A  16
ILE A  17
 None
 0.90A 5ekxB-4yqyA:
4.9		 5ekxB-4yqyA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)		 4yqy PUTATIVE
DEHYDROGENASE
(Sulfitobacter
sp.
NAS-14.1) 		5 / 12 GLY A  18
GLY A  13
GLY A  42
ASP A  16
ILE A  17
 None
 0.92A 5ikmA-4yqyA:
3.6		 5ikmA-4yqyA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 4yqy PUTATIVE
DEHYDROGENASE
(Sulfitobacter
sp.
NAS-14.1) 		5 / 12 GLY A  18
GLY A  13
GLY A  42
ASP A  16
ILE A  17
 None
 0.91A 5njvC-4yqyA:
undetectable		 5njvC-4yqyA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_A_SAMA601_0
(NS5 MTASE)		 4yqy PUTATIVE
DEHYDROGENASE
(Sulfitobacter
sp.
NAS-14.1) 		5 / 12 GLY A  18
GLY A  13
GLY A  42
ASP A  16
ILE A  17
 None
 0.91A 5wz2A-4yqyA:
undetectable		 5wz2A-4yqyA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_B_SAMB601_0
(NS5 MTASE)		 4yqy PUTATIVE
DEHYDROGENASE
(Sulfitobacter
sp.
NAS-14.1) 		5 / 12 GLY A  18
GLY A  13
GLY A  42
ASP A  16
ILE A  17
 None
 0.89A 5wz2B-4yqyA:
5.6		 5wz2B-4yqyA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_C_SAMC601_0
(NS5 MTASE)		 4yqy PUTATIVE
DEHYDROGENASE
(Sulfitobacter
sp.
NAS-14.1) 		5 / 12 GLY A  18
GLY A  13
GLY A  42
ASP A  16
ILE A  17
 None
 0.91A 5wz2C-4yqyA:
5.4		 5wz2C-4yqyA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4yqy PUTATIVE
DEHYDROGENASE
(Sulfitobacter
sp.
NAS-14.1) 		5 / 12 ASP A  16
ALA A 220
GLY A  12
GLY A  18
VAL A  88
 None
 1.27A 6clxA-4yqyA:
6.2		 6clxA-4yqyA:
27.05