SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yqz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 4yqz PUTATIVE
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 12 ALA A 116
GLY A 119
GLY A 118
LEU A   9
LEU A  72
 None
 0.99A 1eizA-4yqzA:
10.1		 1eizA-4yqzA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 4yqz PUTATIVE
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 12 ALA A 116
GLY A 119
GLY A 118
LEU A   9
LEU A  72
 None
 0.99A 1ej0A-4yqzA:
10.1		 1ej0A-4yqzA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 4yqz PUTATIVE
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 11 ALA A  13
LEU A  33
LYS A   7
ILE A  63
LEU A  69
 None
 1.07A 1jomA-4yqzA:
undetectable		 1jomA-4yqzA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4yqz PUTATIVE
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 12 SER A 127
ALA A 129
VAL A 134
TYR A 140
THR A 172
 None
 0.59A 2japA-4yqzA:
30.0		 2japA-4yqzA:
29.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4yqz PUTATIVE
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 12 SER A 127
ALA A 129
VAL A 134
TYR A 140
THR A 172
 None
 0.56A 2japB-4yqzA:
30.0		 2japB-4yqzA:
29.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4yqz PUTATIVE
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 12 SER A 127
ALA A 129
VAL A 134
TYR A 140
THR A 172
 None
 0.59A 2japC-4yqzA:
16.3		 2japC-4yqzA:
29.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4yqz PUTATIVE
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 12 SER A 127
ALA A 129
VAL A 134
TYR A 140
THR A 172
 None
 0.59A 2japD-4yqzA:
30.0		 2japD-4yqzA:
29.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 4yqz PUTATIVE
OXIDOREDUCTASE
(Thermus
thermophilus) 		3 / 3 GLY A 218
ARG A 164
TYR A 212
 None
 0.78A 2opxA-4yqzA:
4.6		 2opxA-4yqzA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4yqz PUTATIVE
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 10 LEU A 111
VAL A 163
GLY A 120
GLY A 118
GLN A 117
 None
 1.21A 2wd9C-4yqzA:
3.0		 2wd9C-4yqzA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 4yqz PUTATIVE
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 12 ILE A 206
ALA A  22
ALA A 214
ALA A  75
ASN A 124
 None
 1.08A 3jb3A-4yqzA:
5.3		 3jb3A-4yqzA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4yqz PUTATIVE
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 12 SER A 215
LEU A   3
ILE A 168
ILE A 123
VAL A  71
 None
 1.11A 3w67D-4yqzA:
2.4		 3w67D-4yqzA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 4yqz PUTATIVE
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 11 ILE A  21
ILE A  17
GLY A  16
VAL A 228
GLY A 201
 None
 0.93A 4ac9B-4yqzA:
6.7
4ac9C-4yqzA:
4.2		 4ac9B-4yqzA:
21.35
4ac9C-4yqzA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4yqz PUTATIVE
OXIDOREDUCTASE
(Thermus
thermophilus) 		4 / 8 GLU A 157
ILE A  63
VAL A  59
PHE A  60
 None
 1.02A 4dx7B-4yqzA:
3.0		 4dx7B-4yqzA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4yqz PUTATIVE
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 11 GLU A  23
GLY A  18
VAL A  32
ALA A  48
GLN A  26
 None
 0.96A 5o96A-4yqzA:
3.4
5o96B-4yqzA:
2.7		 5o96A-4yqzA:
21.98
5o96B-4yqzA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4yqz PUTATIVE
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 10 GLN A  26
GLY A  14
GLY A  18
VAL A  32
ALA A  48
 None
 0.91A 5o96E-4yqzA:
2.9
5o96F-4yqzA:
undetectable		 5o96E-4yqzA:
21.98
5o96F-4yqzA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 4yqz PUTATIVE
OXIDOREDUCTASE
(Thermus
thermophilus) 		4 / 4 LYS A 101
LEU A  97
ALA A 100
LEU A  98
 None
 1.45A 6gnrA-4yqzA:
undetectable		 6gnrA-4yqzA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 4yqz PUTATIVE
OXIDOREDUCTASE
(Thermus
thermophilus) 		4 / 4 LYS A 101
LEU A  97
ALA A 100
LEU A  98
 None
 1.44A 6gnrB-4yqzA:
undetectable		 6gnrB-4yqzA:
18.99