SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yr1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 4yr1 ALKALINE PHOSPHATASE
(Escherichia
coli) 		4 / 5 ASP A 327
HIS A 331
HIS A 370
HIS A 412
 ZN  A 502 (-1.7A)
ZN  A 502 ( 3.3A)
ZN  A 501 ( 3.2A)
ZN  A 502 ( 3.3A)
 0.42A 1ei6A-4yr1A:
15.3		 1ei6A-4yr1A:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 4yr1 ALKALINE PHOSPHATASE
(Escherichia
coli) 		5 / 8 ASP A  51
ASP A 327
HIS A 331
HIS A 370
HIS A 412
 ZN  A 501 ( 2.5A)
ZN  A 502 (-1.7A)
ZN  A 502 ( 3.3A)
ZN  A 501 ( 3.2A)
ZN  A 502 ( 3.3A)
 0.39A 1ei6C-4yr1A:
15.7		 1ei6C-4yr1A:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4yr1 ALKALINE PHOSPHATASE
(Escherichia
coli) 		3 / 3 SER A 405
GLU A 406
GLU A 407
 None
 0.68A 1eqbD-4yr1A:
undetectable		 1eqbD-4yr1A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4yr1 ALKALINE PHOSPHATASE
(Escherichia
coli) 		3 / 3 SER A 405
GLU A 406
GLU A 407
 None
 0.67A 1eqbB-4yr1A:
undetectable		 1eqbB-4yr1A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4yr1 ALKALINE PHOSPHATASE
(Escherichia
coli) 		4 / 5 GLU A 322
GLY A  50
SER A 147
THR A 148
 None
 1.32A 1icrA-4yr1A:
undetectable
1icrB-4yr1A:
undetectable		 1icrA-4yr1A:
18.65
1icrB-4yr1A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 4yr1 ALKALINE PHOSPHATASE
(Escherichia
coli) 		5 / 12 HIS A  86
ALA A  88
GLU A  57
ILE A 326
HIS A 331
 None
None
None
None
ZN  A 502 ( 3.3A)
 1.17A 1kxhA-4yr1A:
undetectable		 1kxhA-4yr1A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 4yr1 ALKALINE PHOSPHATASE
(Escherichia
coli) 		4 / 7 HIS A 162
ASN A 181
THR A 107
GLY A 121
 None
 1.05A 2f6dA-4yr1A:
undetectable		 2f6dA-4yr1A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 4yr1 ALKALINE PHOSPHATASE
(Escherichia
coli) 		4 / 5 ILE A  46
LEU A 319
ASP A 304
ALA A 352
 None
 1.01A 2opxA-4yr1A:
undetectable		 2opxA-4yr1A:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 4yr1 ALKALINE PHOSPHATASE
(Escherichia
coli) 		5 / 12 THR A 192
ALA A 157
PHE A 211
ALA A 149
GLY A 257
 None
 1.11A 2ve3A-4yr1A:
undetectable		 2ve3A-4yr1A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 4yr1 ALKALINE PHOSPHATASE
(Escherichia
coli) 		5 / 12 THR A 192
ALA A 157
PHE A 211
ALA A 149
GLY A 257
 None
 1.11A 2ve3B-4yr1A:
undetectable		 2ve3B-4yr1A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4yr1 ALKALINE PHOSPHATASE
(Escherichia
coli) 		5 / 12 LEU A 120
ALA A 157
VAL A 160
LEU A 310
LEU A 255
 None
 1.22A 3b0wB-4yr1A:
undetectable		 3b0wB-4yr1A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 4yr1 ALKALINE PHOSPHATASE
(Escherichia
coli) 		4 / 6 GLN A 194
LEU A 196
GLU A 193
LEU A 225
 None
 0.82A 3h5gA-4yr1A:
undetectable
3h5gC-4yr1A:
undetectable		 3h5gA-4yr1A:
5.91
3h5gC-4yr1A:
5.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 4yr1 ALKALINE PHOSPHATASE
(Escherichia
coli) 		3 / 3 ARG A 166
LEU A 120
THR A 174
 GOL  A 505 (-4.8A)
None
None
 0.80A 3oxcA-4yr1A:
undetectable		 3oxcA-4yr1A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 4yr1 ALKALINE PHOSPHATASE
(Escherichia
coli) 		5 / 11 VAL A 321
LEU A  48
GLU A 347
ALA A 348
THR A 303
 None
 1.21A 4e0fA-4yr1A:
undetectable		 4e0fA-4yr1A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 4yr1 ALKALINE PHOSPHATASE
(Escherichia
coli) 		5 / 11 GLY A  74
LEU A 353
GLN A 350
ALA A 300
ASP A 304
 None
 1.28A 4wnuC-4yr1A:
undetectable		 4wnuC-4yr1A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 4yr1 ALKALINE PHOSPHATASE
(Escherichia
coli) 		5 / 12 SER A 409
HIS A 412
ASP A 369
ASP A  51
GLY A  52
 None
ZN  A 502 ( 3.3A)
ZN  A 501 ( 2.3A)
ZN  A 501 ( 2.5A)
ZN  A 501 ( 4.9A)
 0.98A 5eenA-4yr1A:
undetectable		 5eenA-4yr1A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 4yr1 ALKALINE PHOSPHATASE
(Escherichia
coli) 		4 / 5 GLY A 170
THR A 174
GLN A 194
THR A 192
 None
 1.29A 5h5fA-4yr1A:
undetectable		 5h5fA-4yr1A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 4yr1 ALKALINE PHOSPHATASE
(Escherichia
coli) 		5 / 9 ILE A 419
TYR A  84
LEU A 438
ILE A  49
GLY A  50
 None
 1.37A 5ifuB-4yr1A:
undetectable		 5ifuB-4yr1A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 4yr1 ALKALINE PHOSPHATASE
(Escherichia
coli) 		4 / 6 ILE A 365
GLY A 144
ASN A 145
ILE A  45
 None
 0.91A 5j4nB-4yr1A:
undetectable		 5j4nB-4yr1A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_A_ACTA301_0
(ANTIBODY FAB HEAVY
CHAIN)		 4yr1 ALKALINE PHOSPHATASE
(Escherichia
coli) 		4 / 4 THR A 107
VAL A 113
PRO A 130
THR A 111
 None
None
GOL  A 506 ( 4.8A)
None
 1.49A 5mthA-4yr1A:
undetectable
5mthH-4yr1A:
undetectable		 5mthA-4yr1A:
19.51
5mthH-4yr1A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4yr1 ALKALINE PHOSPHATASE
(Escherichia
coli) 		5 / 12 LEU A  48
ILE A 307
VAL A 202
THR A 362
LEU A 363
 None
 1.22A 6djzB-4yr1A:
undetectable		 6djzB-4yr1A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 4yr1 ALKALINE PHOSPHATASE
(Escherichia
coli) 		5 / 10 ALA A  77
LEU A  78
VAL A 364
THR A 303
ALA A 348
 None
 1.20A 6h1lA-4yr1A:
undetectable		 6h1lA-4yr1A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 4yr1 ALKALINE PHOSPHATASE
(Escherichia
coli) 		4 / 6 THR A 433
LEU A 432
THR A 436
LEU A 417
 None
 1.06A 6mvxA-4yr1A:
undetectable
6mvxB-4yr1A:
undetectable
6mvxC-4yr1A:
undetectable		 6mvxA-4yr1A:
19.83
6mvxB-4yr1A:
19.83
6mvxC-4yr1A:
19.83