SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yra'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus
musculus)
5 / 10 ALA A 326
THR A 236
GLY A 172
THR A 193
SER A 330
None
1.04A 1c9sN-4yraA:
undetectable
1c9sO-4yraA:
undetectable
1c9sN-4yraA:
12.91
1c9sO-4yraA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus
musculus)
5 / 11 ALA A 326
THR A 236
GLY A 172
THR A 193
SER A 330
None
1.04A 1c9sP-4yraA:
undetectable
1c9sQ-4yraA:
undetectable
1c9sP-4yraA:
12.91
1c9sQ-4yraA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus
musculus)
5 / 9 ALA A 326
THR A 236
GLY A 172
THR A 193
SER A 330
None
1.03A 1c9sQ-4yraA:
undetectable
1c9sR-4yraA:
undetectable
1c9sQ-4yraA:
12.91
1c9sR-4yraA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus
musculus)
5 / 10 GLY A 172
THR A 193
SER A 330
ALA A 326
THR A 236
None
1.04A 1c9sL-4yraA:
undetectable
1c9sV-4yraA:
undetectable
1c9sL-4yraA:
12.91
1c9sV-4yraA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus
musculus)
5 / 9 GLY A 172
THR A 193
SER A 330
ALA A 326
THR A 236
None
1.06A 1gtfD-4yraA:
undetectable
1gtfE-4yraA:
undetectable
1gtfD-4yraA:
12.91
1gtfE-4yraA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus
musculus)
5 / 10 GLY A 172
THR A 193
SER A 330
ALA A 326
THR A 236
None
1.08A 1gtfJ-4yraA:
undetectable
1gtfK-4yraA:
undetectable
1gtfJ-4yraA:
12.91
1gtfK-4yraA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus
musculus)
5 / 11 ALA A 326
THR A 236
GLY A 172
THR A 193
SER A 330
None
1.03A 1gtfQ-4yraA:
undetectable
1gtfR-4yraA:
undetectable
1gtfQ-4yraA:
12.91
1gtfR-4yraA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus
musculus)
5 / 9 ALA A 326
THR A 236
GLY A 172
THR A 193
SER A 330
None
1.02A 1gtfR-4yraA:
undetectable
1gtfS-4yraA:
undetectable
1gtfR-4yraA:
12.91
1gtfS-4yraA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus
musculus)
5 / 11 ALA A 326
THR A 236
GLY A 172
THR A 193
SER A 330
None
1.02A 1gtfS-4yraA:
undetectable
1gtfT-4yraA:
undetectable
1gtfS-4yraA:
12.91
1gtfT-4yraA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus
musculus)
5 / 11 ALA A 326
THR A 236
GLY A 172
THR A 193
SER A 330
None
1.04A 1gtnT-4yraA:
undetectable
1gtnU-4yraA:
undetectable
1gtnT-4yraA:
12.91
1gtnU-4yraA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus
musculus)
5 / 12 GLY A 172
THR A 193
SER A 330
ALA A 326
THR A 236
None
1.00A 1gtnL-4yraA:
undetectable
1gtnV-4yraA:
undetectable
1gtnL-4yraA:
12.91
1gtnV-4yraA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_E_TRPE81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus
musculus)
5 / 10 ALA A 326
THR A 236
GLY A 172
THR A 193
SER A 330
None
1.06A 1utdE-4yraA:
undetectable
1utdF-4yraA:
undetectable
1utdE-4yraA:
12.91
1utdF-4yraA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_H_TRPH81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus
musculus)
5 / 10 ALA A 326
THR A 236
GLY A 172
THR A 193
SER A 330
None
1.07A 1utdH-4yraA:
undetectable
1utdI-4yraA:
undetectable
1utdH-4yraA:
12.91
1utdI-4yraA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus
musculus)
5 / 12 ALA A 326
THR A 236
GLY A 172
THR A 193
SER A 330
None
1.01A 1utdL-4yraA:
undetectable
1utdM-4yraA:
undetectable
1utdL-4yraA:
12.91
1utdM-4yraA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus
musculus)
5 / 12 ALA A 326
THR A 236
GLY A 172
THR A 193
SER A 330
None
1.02A 1utdO-4yraA:
undetectable
1utdP-4yraA:
undetectable
1utdO-4yraA:
12.91
1utdP-4yraA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus
musculus)
5 / 11 ALA A 326
THR A 236
GLY A 172
THR A 193
SER A 330
None
1.01A 1utdP-4yraA:
undetectable
1utdQ-4yraA:
undetectable
1utdP-4yraA:
12.91
1utdQ-4yraA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_S_TRPS81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus
musculus)
5 / 11 ALA A 326
THR A 236
GLY A 172
THR A 193
SER A 330
None
1.02A 1utdS-4yraA:
undetectable
1utdT-4yraA:
undetectable
1utdS-4yraA:
12.91
1utdT-4yraA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_U_TRPU81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus
musculus)
5 / 10 ALA A 326
THR A 236
GLY A 172
THR A 193
SER A 330
None
1.04A 1utdU-4yraA:
undetectable
1utdV-4yraA:
undetectable
1utdU-4yraA:
12.91
1utdV-4yraA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_V_TRPV81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus
musculus)
5 / 11 GLY A 172
THR A 193
SER A 330
ALA A 326
THR A 236
None
1.01A 1utdL-4yraA:
undetectable
1utdV-4yraA:
undetectable
1utdL-4yraA:
12.91
1utdV-4yraA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus
musculus)
3 / 3 THR A 275
PRO A 168
TYR A 128
None
0.90A 2dxrA-4yraA:
undetectable
2dxrA-4yraA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus
musculus)
4 / 6 ARG A 289
TYR A 291
ALA A 281
ARG A 218
None
1.41A 2ql8A-4yraA:
undetectable
2ql8B-4yraA:
undetectable
2ql8A-4yraA:
18.73
2ql8B-4yraA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus
musculus)
4 / 7 GLN A 315
ILE A 243
TYR A 318
CYH A 255
None
1.34A 2xz5D-4yraA:
undetectable
2xz5E-4yraA:
undetectable
2xz5D-4yraA:
22.09
2xz5E-4yraA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus
musculus)
3 / 3 PRO A 300
GLU A 254
TYR A 318
None
0.75A 2zmbA-4yraA:
undetectable
2zmbA-4yraA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus
musculus)
3 / 3 HIS A 152
HIS A 201
MET A 205
None
0.83A 3mihA-4yraA:
undetectable
3mihA-4yraA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus
musculus)
3 / 3 LYS A 111
TYR A 110
ARG A 114
None
1.20A 4gc9A-4yraA:
2.8
4gc9A-4yraA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus
musculus)
5 / 10 GLY A 172
THR A 193
SER A 330
ALA A 326
THR A 236
None
1.09A 5eevA-4yraA:
undetectable
5eevB-4yraA:
undetectable
5eevA-4yraA:
12.91
5eevB-4yraA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus
musculus)
5 / 10 GLY A 172
THR A 193
SER A 330
ALA A 326
THR A 236
None
1.08A 5eewA-4yraA:
undetectable
5eewB-4yraA:
undetectable
5eewA-4yraA:
12.91
5eewB-4yraA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus
musculus)
5 / 10 GLY A 172
THR A 193
SER A 330
ALA A 326
THR A 236
None
1.08A 5eexA-4yraA:
undetectable
5eexB-4yraA:
undetectable
5eexA-4yraA:
12.91
5eexB-4yraA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus
musculus)
5 / 10 GLY A 172
THR A 193
SER A 330
ALA A 326
THR A 236
None
1.08A 5eeyA-4yraA:
undetectable
5eeyB-4yraA:
undetectable
5eeyA-4yraA:
12.91
5eeyB-4yraA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus
musculus)
5 / 10 GLY A 172
THR A 193
SER A 330
ALA A 326
THR A 236
None
1.08A 5eezA-4yraA:
undetectable
5eezB-4yraA:
undetectable
5eezA-4yraA:
12.91
5eezB-4yraA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus
musculus)
5 / 10 GLY A 172
THR A 193
SER A 330
ALA A 326
THR A 236
None
1.08A 5ef0A-4yraA:
undetectable
5ef0B-4yraA:
undetectable
5ef0A-4yraA:
12.91
5ef0B-4yraA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus
musculus)
5 / 10 GLY A 172
THR A 193
SER A 330
ALA A 326
THR A 236
None
1.08A 5ef1A-4yraA:
undetectable
5ef1B-4yraA:
undetectable
5ef1A-4yraA:
12.91
5ef1B-4yraA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus
musculus)
5 / 10 GLY A 172
THR A 193
SER A 330
ALA A 326
THR A 236
None
1.08A 5ef2A-4yraA:
undetectable
5ef2B-4yraA:
undetectable
5ef2A-4yraA:
12.91
5ef2B-4yraA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus
musculus)
5 / 10 GLY A 172
THR A 193
SER A 330
ALA A 326
THR A 236
None
1.08A 5ef3A-4yraA:
undetectable
5ef3B-4yraA:
undetectable
5ef3A-4yraA:
12.91
5ef3B-4yraA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus
musculus)
3 / 3 PRO A 223
LEU A 355
SER A 294
None
0.82A 5fsaB-4yraA:
undetectable
5fsaB-4yraA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus
musculus)
5 / 10 ILE A 293
ASN A 292
ILE A 225
ILE A 226
LEU A 355
None
1.44A 5vkqA-4yraA:
undetectable
5vkqB-4yraA:
undetectable
5vkqA-4yraA:
11.52
5vkqB-4yraA:
11.52