SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yrd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4yrd CAPSULAR
POLYSACCHARIDE
SYNTHESIS ENZYME
CAP5F
(Staphylococcus
aureus) 		5 / 10 ASN A 277
ILE A 278
GLY A 260
GLU A 340
GLY A 282
 3IT  A 402 ( 4.2A)
None
None
None
None
 1.21A 1mehA-4yrdA:
undetectable		 1mehA-4yrdA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4yrd CAPSULAR
POLYSACCHARIDE
SYNTHESIS ENZYME
CAP5F
(Staphylococcus
aureus) 		5 / 12 PHE A 231
LEU A 212
ILE A 146
PHE A 134
GLY A 206
 None
 1.29A 2lbdA-4yrdA:
undetectable		 2lbdA-4yrdA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4yrd CAPSULAR
POLYSACCHARIDE
SYNTHESIS ENZYME
CAP5F
(Staphylococcus
aureus) 		3 / 3 LEU A 133
TRP A 137
TYR A 172
 None
 0.87A 3aicA-4yrdA:
undetectable		 3aicA-4yrdA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4yrd CAPSULAR
POLYSACCHARIDE
SYNTHESIS ENZYME
CAP5F
(Staphylococcus
aureus) 		3 / 3 LEU A 133
TRP A 137
TYR A 172
 None
 0.83A 3aicB-4yrdA:
undetectable		 3aicB-4yrdA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4yrd CAPSULAR
POLYSACCHARIDE
SYNTHESIS ENZYME
CAP5F
(Staphylococcus
aureus) 		3 / 3 LEU A 133
TRP A 137
TYR A 172
 None
 0.82A 3aicE-4yrdA:
undetectable		 3aicE-4yrdA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4yrd CAPSULAR
POLYSACCHARIDE
SYNTHESIS ENZYME
CAP5F
(Staphylococcus
aureus) 		3 / 3 LEU A 133
TRP A 137
TYR A 172
 None
 0.82A 3aicF-4yrdA:
undetectable		 3aicF-4yrdA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4yrd CAPSULAR
POLYSACCHARIDE
SYNTHESIS ENZYME
CAP5F
(Staphylococcus
aureus) 		3 / 3 LEU A 133
TRP A 137
TYR A 172
 None
 0.83A 3aicG-4yrdA:
undetectable		 3aicG-4yrdA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4yrd CAPSULAR
POLYSACCHARIDE
SYNTHESIS ENZYME
CAP5F
(Staphylococcus
aureus) 		3 / 3 LEU A 133
TRP A 137
TYR A 172
 None
 0.81A 3aicH-4yrdA:
undetectable		 3aicH-4yrdA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4yrd CAPSULAR
POLYSACCHARIDE
SYNTHESIS ENZYME
CAP5F
(Staphylococcus
aureus) 		3 / 3 THR A 284
ASN A 338
GLU A 340
 None
 0.72A 3v4tA-4yrdA:
undetectable
3v4tC-4yrdA:
1.0		 3v4tA-4yrdA:
23.01
3v4tC-4yrdA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 4yrd CAPSULAR
POLYSACCHARIDE
SYNTHESIS ENZYME
CAP5F
(Staphylococcus
aureus) 		4 / 5 ASP A 363
ASP A 330
ASN A 354
GLU A 355
 None
 1.38A 3vywD-4yrdA:
undetectable		 3vywD-4yrdA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4yrd CAPSULAR
POLYSACCHARIDE
SYNTHESIS ENZYME
CAP5F
(Staphylococcus
aureus) 		4 / 6 LYS A 181
ILE A 184
VAL A  51
LEU A  90
 None
 0.93A 4em2A-4yrdA:
undetectable		 4em2A-4yrdA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 4yrd CAPSULAR
POLYSACCHARIDE
SYNTHESIS ENZYME
CAP5F
(Staphylococcus
aureus) 		4 / 4 ILE A 316
VAL A 311
VAL A 369
ARG A 307
 None
 1.27A 4m6tA-4yrdA:
undetectable		 4m6tA-4yrdA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4yrd CAPSULAR
POLYSACCHARIDE
SYNTHESIS ENZYME
CAP5F
(Staphylococcus
aureus) 		4 / 7 ILE A   5
LEU A  53
GLY A  10
GLY A  13
 None
 0.84A 5a06B-4yrdA:
8.0		 5a06B-4yrdA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 4yrd CAPSULAR
POLYSACCHARIDE
SYNTHESIS ENZYME
CAP5F
(Staphylococcus
aureus) 		3 / 3 ASN A 277
SER A 279
ARG A 259
 3IT  A 402 ( 4.2A)
None
None
 0.66A 5b2qA-4yrdA:
undetectable		 5b2qA-4yrdA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4yrd CAPSULAR
POLYSACCHARIDE
SYNTHESIS ENZYME
CAP5F
(Staphylococcus
aureus) 		4 / 4 GLN A  34
THR A  35
GLU A  30
LEU A  53
 None
 1.26A 5m66A-4yrdA:
6.4		 5m66A-4yrdA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 4yrd CAPSULAR
POLYSACCHARIDE
SYNTHESIS ENZYME
CAP5F
(Staphylococcus
aureus) 		5 / 12 ILE A   5
LEU A  16
TRP A 130
GLY A   7
GLY A  10
 None
 1.24A 5nnaB-4yrdA:
undetectable		 5nnaB-4yrdA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4yrd CAPSULAR
POLYSACCHARIDE
SYNTHESIS ENZYME
CAP5F
(Staphylococcus
aureus) 		4 / 5 TYR A 250
ARG A 222
THR A 223
LEU A 224
 None
 1.25A 5w97J-4yrdA:
undetectable		 5w97J-4yrdA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 4yrd CAPSULAR
POLYSACCHARIDE
SYNTHESIS ENZYME
CAP5F
(Staphylococcus
aureus) 		3 / 3 HIS A 288
HIS A 337
HIS A 290
 ZN  A 401 ( 3.4A)
ZN  A 401 ( 3.7A)
None
 0.59A 5zrdA-4yrdA:
undetectable		 5zrdA-4yrdA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 4yrd CAPSULAR
POLYSACCHARIDE
SYNTHESIS ENZYME
CAP5F
(Staphylococcus
aureus) 		3 / 3 LYS A 296
VAL A 328
ASP A 330
 None
 0.70A 6fgdA-4yrdA:
3.3		 6fgdA-4yrdA:
23.29