SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yrh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4yrh ALPHA-TUBULIN
N-ACETYLTRANSFERASE
1
(Danio
rerio) 		4 / 4 VAL A  17
PHE A 136
PHE A 134
VAL A 115
 None
None
None
ACO  A 201 (-4.5A)
 1.15A 3rv5C-4yrhA:
undetectable
3rv5D-4yrhA:
undetectable		 3rv5C-4yrhA:
21.52
3rv5D-4yrhA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4yrh ALPHA-TUBULIN
N-ACETYLTRANSFERASE
1
(Danio
rerio) 		4 / 4 VAL A 115
PHE A 134
PHE A 136
VAL A  17
 ACO  A 201 (-4.5A)
None
None
None
 1.46A 3rv5C-4yrhA:
undetectable
3rv5D-4yrhA:
undetectable		 3rv5C-4yrhA:
21.52
3rv5D-4yrhA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 4yrh ALPHA-TUBULIN
N-ACETYLTRANSFERASE
1
(Danio
rerio) 		5 / 12 LEU A 158
VAL A 178
PRO A 153
THR A  60
SER A  49
 None
 1.23A 4hvcB-4yrhA:
undetectable		 4hvcB-4yrhA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 4yrh ALPHA-TUBULIN
N-ACETYLTRANSFERASE
1
(Danio
rerio) 		5 / 12 LEU A  45
VAL A  41
PHE A  90
LEU A  75
LEU A   7
 None
 1.17A 4i1rA-4yrhA:
undetectable		 4i1rA-4yrhA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4yrh ALPHA-TUBULIN
N-ACETYLTRANSFERASE
1
(Danio
rerio) 		5 / 12 LEU A 158
VAL A 178
PRO A 153
THR A  60
SER A  49
 None
 1.28A 5xiqB-4yrhA:
undetectable		 5xiqB-4yrhA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 4yrh ALPHA-TUBULIN
N-ACETYLTRANSFERASE
1
(Danio
rerio) 		3 / 3 PHE A 136
ASP A 135
LYS A 139
 None
 0.85A 6awtD-4yrhA:
undetectable		 6awtD-4yrhA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 4yrh ALPHA-TUBULIN
N-ACETYLTRANSFERASE
1
(Danio
rerio) 		5 / 12 LEU A 158
VAL A 178
PRO A 153
THR A  60
SER A  49
 None
 1.20A 6mn8A-4yrhA:
undetectable		 6mn8A-4yrhA:
16.34