SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yrp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_A_HISA450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		6 / 10 GLU A 126
THR A 128
GLN A 170
TYR A 318
TYR A 319
GLY A 339
 HIS  A 501 (-3.8A)
HIS  A 501 (-3.7A)
HIS  A 501 (-3.4A)
None
HIS  A 501 (-4.9A)
HIS  A 501 ( 4.3A)
 0.59A 1httA-4yrpA:
33.6		 1httA-4yrpA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		5 / 12 GLU A 126
GLN A 170
ARG A 314
GLY A 339
GLY A 359
 HIS  A 501 (-3.8A)
HIS  A 501 (-3.4A)
None
HIS  A 501 ( 4.3A)
HIS  A 501 (-3.5A)
 1.11A 1httB-4yrpA:
32.9		 1httB-4yrpA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		9 / 12 GLU A 126
THR A 128
GLN A 170
LEU A 316
TYR A 318
TYR A 319
GLY A 339
TYR A 342
GLY A 359
 HIS  A 501 (-3.8A)
HIS  A 501 (-3.7A)
HIS  A 501 (-3.4A)
HIS  A 501 (-4.6A)
None
HIS  A 501 (-4.9A)
HIS  A 501 ( 4.3A)
HIS  A 501 (-4.6A)
HIS  A 501 (-3.5A)
 0.65A 1httB-4yrpA:
32.9		 1httB-4yrpA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		7 / 12 GLU A 126
THR A 128
GLN A 170
LEU A 316
TYR A 318
TYR A 319
GLY A 359
 HIS  A 501 (-3.8A)
HIS  A 501 (-3.7A)
HIS  A 501 (-3.4A)
HIS  A 501 (-4.6A)
None
HIS  A 501 (-4.9A)
HIS  A 501 (-3.5A)
 1.40A 1httB-4yrpA:
32.9		 1httB-4yrpA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		5 / 12 THR A 128
LEU A 316
TYR A 318
GLY A 340
GLY A 359
 HIS  A 501 (-3.7A)
HIS  A 501 (-4.6A)
None
None
HIS  A 501 (-3.5A)
 1.24A 1httB-4yrpA:
32.9		 1httB-4yrpA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		6 / 12 GLU A 126
THR A 128
GLN A 170
LEU A 316
TYR A 318
GLY A 359
 HIS  A 501 (-3.8A)
HIS  A 501 (-3.7A)
HIS  A 501 (-3.4A)
HIS  A 501 (-4.6A)
None
HIS  A 501 (-3.5A)
 1.13A 1httC-4yrpA:
33.6		 1httC-4yrpA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		9 / 12 GLU A 126
THR A 128
GLN A 170
LEU A 316
TYR A 318
TYR A 319
GLY A 339
TYR A 342
GLY A 359
 HIS  A 501 (-3.8A)
HIS  A 501 (-3.7A)
HIS  A 501 (-3.4A)
HIS  A 501 (-4.6A)
None
HIS  A 501 (-4.9A)
HIS  A 501 ( 4.3A)
HIS  A 501 (-4.6A)
HIS  A 501 (-3.5A)
 0.60A 1httC-4yrpA:
33.6		 1httC-4yrpA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		6 / 12 THR A 128
LEU A 316
TYR A 318
TYR A 319
GLY A 340
GLY A 359
 HIS  A 501 (-3.7A)
HIS  A 501 (-4.6A)
None
HIS  A 501 (-4.9A)
None
HIS  A 501 (-3.5A)
 1.28A 1httC-4yrpA:
33.6		 1httC-4yrpA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		6 / 12 GLU A 126
GLN A 170
ARG A 314
LEU A 316
GLY A 339
GLY A 359
 HIS  A 501 (-3.8A)
HIS  A 501 (-3.4A)
None
HIS  A 501 (-4.6A)
HIS  A 501 ( 4.3A)
HIS  A 501 (-3.5A)
 1.10A 1httD-4yrpA:
33.0		 1httD-4yrpA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		5 / 12 GLU A 126
GLN A 170
LEU A 316
TYR A 318
GLY A 359
 HIS  A 501 (-3.8A)
HIS  A 501 (-3.4A)
HIS  A 501 (-4.6A)
None
HIS  A 501 (-3.5A)
 1.01A 1httD-4yrpA:
33.0		 1httD-4yrpA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		8 / 12 GLU A 126
THR A 128
GLN A 170
LEU A 316
TYR A 318
TYR A 319
GLY A 339
GLY A 359
 HIS  A 501 (-3.8A)
HIS  A 501 (-3.7A)
HIS  A 501 (-3.4A)
HIS  A 501 (-4.6A)
None
HIS  A 501 (-4.9A)
HIS  A 501 ( 4.3A)
HIS  A 501 (-3.5A)
 0.67A 1httD-4yrpA:
33.0		 1httD-4yrpA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		6 / 12 THR A 128
LEU A 316
TYR A 318
TYR A 319
GLY A 340
GLY A 359
 HIS  A 501 (-3.7A)
HIS  A 501 (-4.6A)
None
HIS  A 501 (-4.9A)
None
HIS  A 501 (-3.5A)
 1.25A 1httD-4yrpA:
33.0		 1httD-4yrpA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		4 / 8 LEU A 377
SER A 197
ASP A  73
THR A  78
 None
DMS  A 503 (-3.6A)
None
None
 1.05A 1ig3A-4yrpA:
undetectable
1ig3B-4yrpA:
2.2		 1ig3A-4yrpA:
19.47
1ig3B-4yrpA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		5 / 10 GLY A 361
ILE A 367
GLY A 326
ILE A 207
ALA A 194
 HIS  A 501 (-3.8A)
None
None
None
None
 1.04A 1sh9B-4yrpA:
undetectable		 1sh9B-4yrpA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		4 / 8 TYR A  87
THR A 128
TRP A 148
LEU A 346
 None
HIS  A 501 (-3.7A)
None
None
 1.20A 1uw6A-4yrpA:
undetectable
1uw6B-4yrpA:
undetectable		 1uw6A-4yrpA:
19.47
1uw6B-4yrpA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		4 / 8 TYR A  87
THR A 128
TRP A 148
LEU A 346
 None
HIS  A 501 (-3.7A)
None
None
 1.22A 1uw6D-4yrpA:
undetectable
1uw6E-4yrpA:
undetectable		 1uw6D-4yrpA:
19.47
1uw6E-4yrpA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		4 / 8 TYR A  87
THR A 128
TRP A 148
LEU A 346
 None
HIS  A 501 (-3.7A)
None
None
 1.19A 1uw6G-4yrpA:
undetectable
1uw6H-4yrpA:
undetectable		 1uw6G-4yrpA:
19.47
1uw6H-4yrpA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		4 / 8 TYR A  87
THR A 128
TRP A 148
LEU A 346
 None
HIS  A 501 (-3.7A)
None
None
 1.17A 1uw6P-4yrpA:
undetectable
1uw6Q-4yrpA:
undetectable		 1uw6P-4yrpA:
19.47
1uw6Q-4yrpA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		4 / 8 TRP A 148
LEU A 346
TYR A  87
THR A 128
 None
None
None
HIS  A 501 (-3.7A)
 1.18A 1uw6P-4yrpA:
undetectable
1uw6T-4yrpA:
undetectable		 1uw6P-4yrpA:
19.47
1uw6T-4yrpA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_SAMB293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		5 / 12 TYR A 342
ALA A 190
ASN A 172
TYR A 318
TYR A  87
 HIS  A 501 (-4.6A)
None
HIS  A 501 (-4.4A)
None
None
 1.15A 1xvaB-4yrpA:
0.2		 1xvaB-4yrpA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		5 / 11 THR A 267
THR A 266
THR A 265
SER A 272
ALA A 310
 None
 1.23A 2f16N-4yrpA:
undetectable		 2f16N-4yrpA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		4 / 5 LEU A 345
ILE A 355
SER A 351
GLY A 350
 None
 0.93A 2otfA-4yrpA:
undetectable		 2otfA-4yrpA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		5 / 12 GLY A 340
GLY A 359
ILE A 322
ASP A 343
THR A 128
 None
HIS  A 501 (-3.5A)
None
None
HIS  A 501 (-3.7A)
 1.24A 2vdvE-4yrpA:
undetectable		 2vdvE-4yrpA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		5 / 11 GLY A 340
GLY A 359
ILE A 322
ASP A 343
THR A 128
 None
HIS  A 501 (-3.5A)
None
None
HIS  A 501 (-3.7A)
 1.24A 2vdvF-4yrpA:
undetectable		 2vdvF-4yrpA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		4 / 8 GLY A 338
GLY A 339
GLY A 340
ILE A 322
 None
HIS  A 501 ( 4.3A)
None
None
 0.66A 3d41A-4yrpA:
undetectable		 3d41A-4yrpA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		5 / 11 GLY A 321
ILE A 175
SER A 180
VAL A 181
ALA A 183
 None
 0.79A 3dcmX-4yrpA:
undetectable		 3dcmX-4yrpA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		3 / 3 SER A 150
ASP A  88
ASP A 174
 None
None
HIS  A 501 (-2.9A)
 0.94A 3iv6C-4yrpA:
undetectable		 3iv6C-4yrpA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		5 / 8 TYR A 149
MET A 173
PHE A 360
ALA A 191
ALA A 194
 None
 1.50A 3khmA-4yrpA:
undetectable		 3khmA-4yrpA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		4 / 7 GLY A 363
PHE A 360
GLY A 338
PHE A 324
 SO4  A 506 (-3.5A)
None
None
None
 0.86A 3ko0M-4yrpA:
1.5
3ko0P-4yrpA:
1.6		 3ko0M-4yrpA:
13.82
3ko0P-4yrpA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		4 / 8 MET A 173
PHE A 360
ALA A 191
ALA A 194
 None
 1.06A 3l4dD-4yrpA:
undetectable		 3l4dD-4yrpA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		4 / 6 ARG A 100
THR A 107
ALA A 230
ALA A 317
 None
 1.22A 3ns1C-4yrpA:
undetectable		 3ns1C-4yrpA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		5 / 9 ASP A 364
ILE A 367
GLY A 363
VAL A 205
GLY A 326
 SO4  A 506 (-4.8A)
None
SO4  A 506 (-3.5A)
None
None
 1.40A 4acaB-4yrpA:
undetectable
4acaC-4yrpA:
undetectable		 4acaB-4yrpA:
23.97
4acaC-4yrpA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		5 / 11 THR A 267
THR A 266
THR A 265
SER A 272
ALA A 310
 None
 1.24A 4qvyV-4yrpA:
undetectable
4qvyb-4yrpA:
0.0		 4qvyV-4yrpA:
19.04
4qvyb-4yrpA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		5 / 11 THR A 267
THR A 266
THR A 265
SER A 272
ALA A 310
 None
 1.24A 4qvyH-4yrpA:
0.0
4qvyN-4yrpA:
0.0		 4qvyH-4yrpA:
19.04
4qvyN-4yrpA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		4 / 7 THR A 128
GLY A 339
TYR A 342
GLY A 359
 HIS  A 501 (-3.7A)
HIS  A 501 ( 4.3A)
HIS  A 501 (-4.6A)
HIS  A 501 (-3.5A)
 0.42A 4rdxA-4yrpA:
31.6		 4rdxA-4yrpA:
29.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		4 / 7 ARG A 196
ASP A 304
GLY A 301
GLU A 298
 SO4  A 508 ( 4.0A)
None
None
None
 0.80A 5bs8A-4yrpA:
undetectable
5bs8C-4yrpA:
undetectable
5bs8D-4yrpA:
undetectable		 5bs8A-4yrpA:
22.02
5bs8C-4yrpA:
22.02
5bs8D-4yrpA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		4 / 7 ARG A 196
ASP A 304
GLY A 301
GLU A 298
 SO4  A 508 ( 4.0A)
None
None
None
 0.80A 5btaA-4yrpA:
1.2
5btaC-4yrpA:
undetectable
5btaD-4yrpA:
undetectable		 5btaA-4yrpA:
22.02
5btaC-4yrpA:
22.02
5btaD-4yrpA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		4 / 7 ALA A 230
ASP A 343
GLY A 340
GLU A 184
 None
 0.95A 5btdA-4yrpA:
1.1
5btdB-4yrpA:
undetectable
5btdC-4yrpA:
1.3		 5btdA-4yrpA:
22.02
5btdB-4yrpA:
22.25
5btdC-4yrpA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		4 / 7 ASP A 304
GLY A 301
GLU A 298
ARG A 196
 None
None
None
SO4  A 508 ( 4.0A)
 0.88A 5btfA-4yrpA:
1.2
5btfB-4yrpA:
undetectable
5btfC-4yrpA:
1.1		 5btfA-4yrpA:
22.02
5btfB-4yrpA:
22.25
5btfC-4yrpA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		4 / 7 ARG A 196
ASP A 304
GLY A 301
GLU A 298
 SO4  A 508 ( 4.0A)
None
None
None
 0.85A 5btgA-4yrpA:
undetectable
5btgC-4yrpA:
undetectable
5btgD-4yrpA:
undetectable		 5btgA-4yrpA:
22.02
5btgC-4yrpA:
22.02
5btgD-4yrpA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		9 / 12 GLU A 126
THR A 128
GLN A 170
LEU A 316
TYR A 318
TYR A 319
GLY A 339
TYR A 342
GLY A 359
 HIS  A 501 (-3.8A)
HIS  A 501 (-3.7A)
HIS  A 501 (-3.4A)
HIS  A 501 (-4.6A)
None
HIS  A 501 (-4.9A)
HIS  A 501 ( 4.3A)
HIS  A 501 (-4.6A)
HIS  A 501 (-3.5A)
 0.59A 5e3iA-4yrpA:
33.9		 5e3iA-4yrpA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		5 / 12 GLU A 126
THR A 128
GLN A 170
TYR A 318
GLY A 359
 HIS  A 501 (-3.8A)
HIS  A 501 (-3.7A)
HIS  A 501 (-3.4A)
None
HIS  A 501 (-3.5A)
 1.13A 5e3iA-4yrpA:
33.9		 5e3iA-4yrpA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		6 / 12 THR A 128
LEU A 316
TYR A 318
TYR A 319
GLY A 340
GLY A 359
 HIS  A 501 (-3.7A)
HIS  A 501 (-4.6A)
None
HIS  A 501 (-4.9A)
None
HIS  A 501 (-3.5A)
 1.27A 5e3iA-4yrpA:
33.9		 5e3iA-4yrpA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		5 / 11 GLU A 126
THR A 128
GLN A 170
TYR A 318
GLY A 359
 HIS  A 501 (-3.8A)
HIS  A 501 (-3.7A)
HIS  A 501 (-3.4A)
None
HIS  A 501 (-3.5A)
 1.10A 5e3iB-4yrpA:
33.7		 5e3iB-4yrpA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		8 / 11 GLU A 126
THR A 128
GLN A 170
TYR A 318
TYR A 319
GLY A 339
TYR A 342
GLY A 359
 HIS  A 501 (-3.8A)
HIS  A 501 (-3.7A)
HIS  A 501 (-3.4A)
None
HIS  A 501 (-4.9A)
HIS  A 501 ( 4.3A)
HIS  A 501 (-4.6A)
HIS  A 501 (-3.5A)
 0.57A 5e3iB-4yrpA:
33.7		 5e3iB-4yrpA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		5 / 11 THR A 267
THR A 266
THR A 265
SER A 272
ALA A 310
 None
 1.27A 5l5fV-4yrpA:
0.0
5l5fb-4yrpA:
undetectable		 5l5fV-4yrpA:
19.04
5l5fb-4yrpA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		5 / 11 THR A 267
THR A 266
THR A 265
SER A 272
ALA A 310
 None
 1.27A 5l5fH-4yrpA:
0.0
5l5fN-4yrpA:
0.0		 5l5fH-4yrpA:
19.04
5l5fN-4yrpA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		5 / 12 THR A 267
THR A 266
THR A 265
SER A 272
ALA A 310
 None
 1.26A 5l5zV-4yrpA:
undetectable
5l5zb-4yrpA:
undetectable		 5l5zV-4yrpA:
19.04
5l5zb-4yrpA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		5 / 12 THR A 267
THR A 266
THR A 265
SER A 272
ALA A 310
 None
 1.26A 5l5zH-4yrpA:
undetectable
5l5zN-4yrpA:
undetectable		 5l5zH-4yrpA:
19.04
5l5zN-4yrpA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		4 / 6 ARG A  69
ARG A  68
LEU A  71
ALA A 194
 SO4  A 507 (-3.3A)
None
None
None
 1.03A 6b89B-4yrpA:
undetectable		 6b89B-4yrpA:
11.90