SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yru'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 4yru NEURONAL CALCIUM
SENSOR 1
(Rattus
norvegicus) 		3 / 3 PRO A  61
MET A 131
TYR A  52
 None
 1.01A 4qa0A-4yruA:
undetectable		 4qa0A-4yruA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 4yru NEURONAL CALCIUM
SENSOR 1
(Rattus
norvegicus) 		3 / 3 PRO A  61
MET A 131
TYR A  52
 None
 1.04A 4qa2B-4yruA:
undetectable		 4qa2B-4yruA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 4yru NEURONAL CALCIUM
SENSOR 1
(Rattus
norvegicus) 		4 / 8 ASP A 161
ASP A 157
ILE A 152
TYR A 108
 CA  A 203 (-2.4A)
CA  A 203 (-3.3A)
None
None
 1.04A 4xjeA-4yruA:
undetectable		 4xjeA-4yruA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 4yru NEURONAL CALCIUM
SENSOR 1
(Rattus
norvegicus) 		4 / 8 ASP A 161
ASP A 157
ILE A 152
TYR A 108
 CA  A 203 (-2.4A)
CA  A 203 (-3.3A)
None
None
 0.96A 5cfsA-4yruA:
undetectable		 5cfsA-4yruA:
16.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 4yru NEURONAL CALCIUM
SENSOR 1
(Rattus
norvegicus) 		5 / 6 ILE A  51
TYR A  52
PHE A  72
THR A  92
TRP A 103
 None
 0.54A 5g08A-4yruA:
21.0		 5g08A-4yruA:
70.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_0
(REGULATORY PROTEIN
TETR)		 4yru NEURONAL CALCIUM
SENSOR 1
(Rattus
norvegicus) 		5 / 12 MET A 156
MET A 155
GLU A 120
LEU A 164
VAL A 125
 None
None
CA  A 202 (-2.2A)
None
None
 1.41A 5vlmC-4yruA:
undetectable		 5vlmC-4yruA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4yru NEURONAL CALCIUM
SENSOR 1
(Rattus
norvegicus) 		5 / 10 LYS A 100
VAL A  91
GLY A  95
TRP A  30
LEU A  89
 None
 1.37A 6bsgA-4yruA:
undetectable		 6bsgA-4yruA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4yru NEURONAL CALCIUM
SENSOR 1
(Rattus
norvegicus) 		5 / 10 LYS A 100
VAL A  91
GLY A  95
TRP A  30
LEU A  89
 None
 1.44A 6bsiA-4yruA:
undetectable		 6bsiA-4yruA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4yru NEURONAL CALCIUM
SENSOR 1
(Rattus
norvegicus) 		5 / 10 LYS A 100
VAL A  91
GLY A  95
TRP A  30
LEU A  89
 None
 1.38A 6bsjA-4yruA:
undetectable		 6bsjA-4yruA:
21.59