SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yry'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG
DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 8 THR B 259
THR B 237
ASP B 433
GLY A 223
 None
None
FAD  B 503 (-2.8A)
FES  A 501 (-3.4A)
 1.01A 1bu5B-4yryB:
4.0		 1bu5B-4yryB:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 12 VAL B 261
LEU B 258
ILE B 388
ALA B 298
LEU B 301
 None
 0.92A 1cqeA-4yryB:
undetectable		 1cqeA-4yryB:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 12 VAL B 261
LEU B 258
ILE B 388
ALA B 298
LEU B 301
 None
 0.93A 1cqeB-4yryB:
undetectable		 1cqeB-4yryB:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG
(Thermotoga
maritima) 		4 / 6 LEU A 136
ASP A 161
MET A 175
LEU A 107
 None
 1.12A 1errB-4yryA:
undetectable		 1errB-4yryA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG
(Thermotoga
maritima) 		4 / 6 LEU A 136
ASP A 162
MET A 175
LEU A 107
 None
NAD  A 503 ( 3.7A)
None
None
 0.98A 1errB-4yryA:
undetectable		 1errB-4yryA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 8 TYR B 458
ILE B 455
GLY B 427
GLU B 141
 None
 0.87A 1mrjA-4yryB:
undetectable		 1mrjA-4yryB:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 12 GLY B 432
ALA B 444
ALA B 430
ASP B 433
ILE B 434
 FAD  B 503 (-3.2A)
FAD  B 503 (-3.2A)
None
FAD  B 503 (-2.8A)
None
 1.11A 1nt2A-4yryB:
undetectable		 1nt2A-4yryB:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 8 THR B 233
GLY B 431
ILE B 434
VAL B 435
 FAD  B 503 (-3.8A)
None
None
None
 0.84A 1rxcB-4yryB:
undetectable		 1rxcB-4yryB:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 8 THR B 233
GLY B 431
ILE B 434
VAL B 435
 FAD  B 503 (-3.8A)
None
None
None
 0.83A 1rxcE-4yryB:
undetectable		 1rxcE-4yryB:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 8 THR B 233
GLY B 432
ILE B 434
VAL B 435
 FAD  B 503 (-3.8A)
FAD  B 503 (-3.2A)
None
None
 0.97A 1rxcE-4yryB:
undetectable		 1rxcE-4yryB:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 8 THR B 233
GLY B 431
ILE B 434
VAL B 435
 FAD  B 503 (-3.8A)
None
None
None
 0.90A 1rxcI-4yryB:
undetectable		 1rxcI-4yryB:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 8 THR B 233
GLY B 431
ILE B 434
VAL B 435
 FAD  B 503 (-3.8A)
None
None
None
 0.87A 1rxcK-4yryB:
undetectable		 1rxcK-4yryB:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 12 ASP B 158
MET B 445
ASP B 433
ILE B 442
THR B 154
 None
None
FAD  B 503 (-2.8A)
SF4  B 502 ( 4.2A)
None
 1.30A 1s14A-4yryB:
undetectable		 1s14A-4yryB:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG
(Thermotoga
maritima) 		4 / 8 LEU A 178
VAL A 208
GLY A 207
LEU A 107
 None
 1.04A 1s1xA-4yryA:
undetectable		 1s1xA-4yryA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG
DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima;
Thermotoga
maritima) 		4 / 8 LEU B 263
THR A 222
VAL A  91
ASP A  89
 None
 0.82A 1uyuA-4yryB:
undetectable		 1uyuA-4yryB:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG
DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima;
Thermotoga
maritima) 		4 / 8 LEU B 263
THR A 222
VAL A  91
ASP A  89
 None
 0.83A 1uyuB-4yryB:
undetectable		 1uyuB-4yryB:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 12 VAL B 261
LEU B 258
ILE B 388
ALA B 298
LEU B 301
 None
 0.92A 2aylB-4yryB:
undetectable		 2aylB-4yryB:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG
DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima;
Thermotoga
maritima) 		3 / 3 LYS A 197
ASP B 346
ASP A 254
 None
 0.98A 2br4D-4yryA:
3.6		 2br4D-4yryA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 8 GLY B 147
THR B 154
ALA B 155
ALA B 156
 FAD  B 503 (-2.9A)
None
None
None
 0.55A 2ej3A-4yryB:
undetectable		 2ej3A-4yryB:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG
(Thermotoga
maritima) 		4 / 7 ARG A  65
LYS A 123
PRO A  35
ALA A 124
 None
 1.29A 2ejgA-4yryA:
undetectable		 2ejgA-4yryA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG
(Thermotoga
maritima) 		4 / 5 LEU A 136
ASP A 161
MET A 175
LEU A 107
 None
 1.17A 2jfaA-4yryA:
undetectable		 2jfaA-4yryA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG
(Thermotoga
maritima) 		4 / 5 LEU A 136
ASP A 162
MET A 175
LEU A 107
 None
NAD  A 503 ( 3.7A)
None
None
 0.93A 2jfaA-4yryA:
undetectable		 2jfaA-4yryA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG
(Thermotoga
maritima) 		4 / 5 LEU A 136
ASP A 161
MET A 175
LEU A 107
 None
 1.09A 2qxsA-4yryA:
undetectable		 2qxsA-4yryA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG
(Thermotoga
maritima) 		4 / 5 LEU A 136
ASP A 162
MET A 175
LEU A 107
 None
NAD  A 503 ( 3.7A)
None
None
 0.96A 2qxsA-4yryA:
undetectable		 2qxsA-4yryA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG
(Thermotoga
maritima) 		4 / 5 LEU A 136
ASP A 161
MET A 175
LEU A 107
 None
 1.10A 2qxsB-4yryA:
undetectable		 2qxsB-4yryA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG
(Thermotoga
maritima) 		4 / 5 LEU A 136
ASP A 162
MET A 175
LEU A 107
 None
NAD  A 503 ( 3.7A)
None
None
 0.94A 2qxsB-4yryA:
undetectable		 2qxsB-4yryA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 9 ILE B 113
GLY B  87
PRO B  52
VAL B  53
ILE B  55
 SF4  B 502 ( 4.8A)
None
SF4  B 502 ( 4.9A)
None
SF4  B 502 ( 4.4A)
 1.18A 2r5qA-4yryB:
undetectable		 2r5qA-4yryB:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 9 ILE B 113
GLY B  87
PRO B  52
VAL B  53
ILE B  55
 SF4  B 502 ( 4.8A)
None
SF4  B 502 ( 4.9A)
None
SF4  B 502 ( 4.4A)
 1.18A 2r5qC-4yryB:
undetectable		 2r5qC-4yryB:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG
(Thermotoga
maritima) 		3 / 3 TRP A 188
VAL A 208
TRP A 211
 None
 1.32A 2xdcC-4yryA:
undetectable
2xdcD-4yryA:
undetectable		 2xdcC-4yryA:
4.33
2xdcD-4yryA:
4.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG
(Thermotoga
maritima) 		3 / 3 TRP A 188
VAL A 208
TRP A 211
 None
 1.28A 2xdcE-4yryA:
undetectable
2xdcF-4yryA:
undetectable		 2xdcE-4yryA:
4.33
2xdcF-4yryA:
4.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG
(Thermotoga
maritima) 		3 / 3 TRP A 188
VAL A 208
TRP A 211
 None
 1.31A 2y5mE-4yryA:
undetectable
2y5mF-4yryA:
undetectable		 2y5mE-4yryA:
4.33
2y5mF-4yryA:
4.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG
(Thermotoga
maritima) 		3 / 3 TRP A 188
VAL A 208
TRP A 211
 None
 1.30A 2y6nC-4yryA:
undetectable
2y6nD-4yryA:
undetectable		 2y6nC-4yryA:
4.33
2y6nD-4yryA:
4.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG
(Thermotoga
maritima) 		3 / 3 TRP A 188
VAL A 208
TRP A 211
 None
 1.32A 2y6nE-4yryA:
undetectable
2y6nF-4yryA:
undetectable		 2y6nE-4yryA:
4.33
2y6nF-4yryA:
4.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAX_A_CAMA422_0
(CYTOCHROME P450-CAM)		 4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG
DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima;
Thermotoga
maritima) 		4 / 7 LEU B 263
THR A 222
VAL A  91
ASP A  89
 None
 0.80A 2zaxA-4yryB:
undetectable		 2zaxA-4yryB:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 12 ALA B 155
ALA B 156
ASN B 206
ALA B 452
VAL B 213
 None
None
None
None
FAD  B 503 (-3.9A)
 1.00A 3e00A-4yryB:
undetectable		 3e00A-4yryB:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 12 ILE B 442
GLU B 117
GLU B 196
PRO B 189
LEU B 179
 SF4  B 502 ( 4.2A)
SF4  B 502 (-2.5A)
None
None
None
 1.42A 3eigA-4yryB:
undetectable		 3eigA-4yryB:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 12 GLY B 232
GLY B 446
GLY B 448
GLY B 152
VAL B  53
 FAD  B 503 (-4.9A)
None
None
None
None
 0.90A 3embA-4yryB:
3.4		 3embA-4yryB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG
(Thermotoga
maritima) 		5 / 9 ILE A  41
ILE A  50
GLU A  77
LEU A  78
LYS A  81
 None
FAD  A 502 ( 4.4A)
None
None
None
 1.33A 3f78A-4yryA:
3.0		 3f78A-4yryA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		 4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG
(Thermotoga
maritima) 		5 / 9 ILE A  41
ILE A  50
GLU A  77
LEU A  78
LYS A  81
 None
FAD  A 502 ( 4.4A)
None
None
None
 1.37A 3f78B-4yryA:
3.2		 3f78B-4yryA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG
DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima;
Thermotoga
maritima) 		4 / 7 LEU B 263
THR A 222
VAL A  91
ASP A  89
 None
 0.78A 3fwgB-4yryB:
undetectable		 3fwgB-4yryB:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 11 VAL B 261
LEU B 258
ILE B 388
ALA B 298
LEU B 301
 None
 1.09A 3n8yA-4yryB:
undetectable		 3n8yA-4yryB:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 5 VAL B 261
LEU B 258
ILE B 388
ALA B 298
 None
 0.79A 3n8yB-4yryB:
undetectable		 3n8yB-4yryB:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 12 VAL B 261
LEU B 258
ILE B 388
ALA B 298
LEU B 301
 None
 0.92A 3n8zB-4yryB:
undetectable		 3n8zB-4yryB:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 10 ILE B 113
GLY B  87
PRO B  52
VAL B  53
ILE B  55
 SF4  B 502 ( 4.8A)
None
SF4  B 502 ( 4.9A)
None
SF4  B 502 ( 4.4A)
 0.99A 3nu6A-4yryB:
undetectable		 3nu6A-4yryB:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 9 ILE B 113
GLY B  87
PRO B  52
VAL B  53
ILE B  55
 SF4  B 502 ( 4.8A)
None
SF4  B 502 ( 4.9A)
None
SF4  B 502 ( 4.4A)
 1.02A 3nuoA-4yryB:
undetectable		 3nuoA-4yryB:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 11 ILE B 113
VAL B  89
PRO B  52
VAL B  53
ILE B  55
 SF4  B 502 ( 4.8A)
FAD  B 503 (-4.1A)
SF4  B 502 ( 4.9A)
None
SF4  B 502 ( 4.4A)
 1.00A 3oxvD-4yryB:
undetectable		 3oxvD-4yryB:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 8 ILE B  61
GLN B  37
ALA B 112
LEU B  76
 None
 0.67A 3ozwA-4yryB:
4.4		 3ozwA-4yryB:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG
DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima;
Thermotoga
maritima) 		4 / 7 LEU B 263
VAL A  91
ASP A  89
VAL A  40
 None
 0.84A 4cp4A-4yryB:
undetectable		 4cp4A-4yryB:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 8 THR B 233
GLY B 431
ILE B 434
VAL B 435
 FAD  B 503 (-3.8A)
None
None
None
 0.82A 4e1vA-4yryB:
undetectable		 4e1vA-4yryB:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 8 THR B 233
GLY B 432
ILE B 434
VAL B 435
 FAD  B 503 (-3.8A)
FAD  B 503 (-3.2A)
None
None
 0.97A 4e1vA-4yryB:
undetectable		 4e1vA-4yryB:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 8 THR B 233
GLY B 431
ILE B 434
VAL B 435
 FAD  B 503 (-3.8A)
None
None
None
 0.83A 4e1vC-4yryB:
undetectable		 4e1vC-4yryB:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 8 THR B 233
GLY B 432
ILE B 434
VAL B 435
 FAD  B 503 (-3.8A)
FAD  B 503 (-3.2A)
None
None
 0.98A 4e1vC-4yryB:
undetectable		 4e1vC-4yryB:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 8 THR B 233
GLY B 431
ILE B 434
VAL B 435
 FAD  B 503 (-3.8A)
None
None
None
 0.84A 4e1vD-4yryB:
undetectable		 4e1vD-4yryB:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 8 THR B 233
GLY B 431
ILE B 434
VAL B 435
 FAD  B 503 (-3.8A)
None
None
None
 0.82A 4e1vE-4yryB:
undetectable		 4e1vE-4yryB:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 8 THR B 233
GLY B 432
ILE B 434
VAL B 435
 FAD  B 503 (-3.8A)
FAD  B 503 (-3.2A)
None
None
 0.97A 4e1vE-4yryB:
undetectable		 4e1vE-4yryB:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 8 THR B 233
GLY B 431
ILE B 434
VAL B 435
 FAD  B 503 (-3.8A)
None
None
None
 0.84A 4e1vG-4yryB:
undetectable		 4e1vG-4yryB:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 8 THR B 233
GLY B 432
ILE B 434
VAL B 435
 FAD  B 503 (-3.8A)
FAD  B 503 (-3.2A)
None
None
 0.94A 4e1vG-4yryB:
undetectable		 4e1vG-4yryB:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 8 THR B 233
GLY B 431
ILE B 434
VAL B 435
 FAD  B 503 (-3.8A)
None
None
None
 0.82A 4e1vH-4yryB:
undetectable		 4e1vH-4yryB:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 8 THR B 233
GLY B 432
ILE B 434
VAL B 435
 FAD  B 503 (-3.8A)
FAD  B 503 (-3.2A)
None
None
 0.95A 4e1vH-4yryB:
undetectable		 4e1vH-4yryB:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4B_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG
DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima;
Thermotoga
maritima) 		4 / 8 LEU B 263
VAL A  91
ASP A  89
VAL A  40
 None
 0.80A 4l4bA-4yryB:
undetectable		 4l4bA-4yryB:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG
DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 9 ILE B 243
GLY B 242
ILE A 236
ILE B 388
VAL B 387
 None
 1.12A 4nptA-4yryB:
undetectable		 4nptA-4yryB:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 12 ALA B 155
GLY B 432
PHE B 429
ALA B 439
ALA B 444
 None
FAD  B 503 (-3.2A)
None
FAD  B 503 (-4.5A)
FAD  B 503 (-3.2A)
 1.20A 4pclA-4yryB:
3.6		 4pclA-4yryB:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 7 ILE B 442
VAL B  53
ILE B  55
GLU B 117
 SF4  B 502 ( 4.2A)
None
SF4  B 502 ( 4.4A)
SF4  B 502 (-2.5A)
 1.01A 4zzbC-4yryB:
undetectable
4zzbD-4yryB:
undetectable		 4zzbC-4yryB:
20.52
4zzbD-4yryB:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 12 GLY B 232
GLY B 446
GLY B 448
GLY B 152
VAL B  53
 FAD  B 503 (-4.9A)
None
None
None
None
 1.00A 5ehiA-4yryB:
3.5		 5ehiA-4yryB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 12 GLY B 232
GLY B 446
GLY B 448
GLY B 152
VAL B  53
 FAD  B 503 (-4.9A)
None
None
None
None
 1.02A 5eiwA-4yryB:
3.4		 5eiwA-4yryB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 12 GLY B 232
GLY B 446
GLY B 448
GLY B 152
VAL B  53
 FAD  B 503 (-4.9A)
None
None
None
None
 0.99A 5ekxA-4yryB:
3.4		 5ekxA-4yryB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		3 / 3 ARG B 300
HIS B 326
ARG B 296
 None
 1.04A 5iaoC-4yryB:
undetectable		 5iaoC-4yryB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		3 / 3 ARG B 300
HIS B 326
ARG B 296
 None
 1.10A 5iaoF-4yryB:
undetectable		 5iaoF-4yryB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG
(Thermotoga
maritima) 		5 / 12 VAL A  39
LEU A  43
ILE A  87
GLY A  92
PRO A  93
 None
 0.77A 5ienA-4yryA:
undetectable		 5ienA-4yryA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 12 GLY B 232
GLY B 446
GLY B 448
GLY B 152
VAL B  53
 FAD  B 503 (-4.9A)
None
None
None
None
 0.93A 5kqrA-4yryB:
3.5		 5kqrA-4yryB:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 9 ILE B 113
GLY B  87
PRO B  52
VAL B  53
ILE B  55
 SF4  B 502 ( 4.8A)
None
SF4  B 502 ( 4.9A)
None
SF4  B 502 ( 4.4A)
 1.04A 5kr0A-4yryB:
undetectable		 5kr0A-4yryB:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_1
(PROTEASE PR5-SQV)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 9 ALA B 294
ASP B 293
GLY B 286
ILE B 285
PRO B 238
 None
 1.11A 5kr2A-4yryB:
undetectable		 5kr2A-4yryB:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_1
(PROTEASE PR5-SQV)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 9 ALA B 294
ASP B 293
GLY B 286
ILE B 285
PRO B 238
 None
 1.19A 5kr2C-4yryB:
undetectable		 5kr2C-4yryB:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 12 GLY B 232
GLY B 446
GLY B 448
GLY B 152
VAL B  53
 FAD  B 503 (-4.9A)
None
None
None
None
 0.94A 5m5bA-4yryB:
3.3		 5m5bA-4yryB:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 12 GLY B 232
GLY B 446
GLY B 448
GLY B 152
VAL B  53
 FAD  B 503 (-4.9A)
None
None
None
None
 0.96A 5vimA-4yryB:
3.3		 5vimA-4yryB:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 12 GLY B 232
GLY B 446
GLY B 448
GLY B 152
VAL B  53
 FAD  B 503 (-4.9A)
None
None
None
None
 0.93A 5vimB-4yryB:
3.3		 5vimB-4yryB:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		3 / 3 ASN B 289
VAL B  23
HIS B 326
 FAD  B 503 (-3.8A)
None
None
 0.80A 6a5yD-4yryB:
undetectable		 6a5yD-4yryB:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 12 VAL B 213
VAL B 229
ALA B 451
GLU B 402
ASN B 396
 FAD  B 503 (-3.9A)
None
None
None
None
 1.10A 6bqgA-4yryB:
1.4		 6bqgA-4yryB:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG
DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima;
Thermotoga
maritima) 		4 / 8 LEU B 263
THR A 222
VAL A  91
ASP A  89
 None
 0.76A 6cp4A-4yryB:
undetectable		 6cp4A-4yryB:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG
DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A
(Thermotoga
maritima;
Thermotoga
maritima) 		4 / 8 LEU B 263
VAL A  91
ASP A  89
VAL A  40
 None
 0.82A 6cp4A-4yryB:
undetectable		 6cp4A-4yryB:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG
(Thermotoga
maritima) 		3 / 3 LYS A  69
VAL A  71
ASP A  18
 NAD  A 503 ( 3.3A)
FAD  A 502 (-4.8A)
None
 0.52A 6fgdA-4yryA:
3.1		 6fgdA-4yryA:
22.53