SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ys4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4ys4 MEROZOITE SURFACE
PROTEIN P41
(Plasmodium
falciparum) 		4 / 8 ILE A  52
LEU A  87
LEU A  86
PHE A 109
 None
 0.82A 2vctA-4ys4A:
undetectable		 2vctA-4ys4A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4ys4 MEROZOITE SURFACE
PROTEIN P41
(Plasmodium
falciparum) 		4 / 8 ILE A  52
LEU A  87
LEU A  86
PHE A 109
 None
 0.79A 2vctB-4ys4A:
undetectable		 2vctB-4ys4A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4ys4 MEROZOITE SURFACE
PROTEIN P41
(Plasmodium
falciparum) 		4 / 8 ILE A  52
LEU A  87
LEU A  86
PHE A 109
 None
 0.84A 2vctC-4ys4A:
undetectable		 2vctC-4ys4A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 4ys4 MEROZOITE SURFACE
PROTEIN P41
(Plasmodium
falciparum) 		4 / 7 TYR A 328
SER A 325
PHE A 286
GLU A 288
 None
None
GOL  A 406 ( 3.7A)
None
 1.28A 4xzkA-4ys4A:
undetectable		 4xzkA-4ys4A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4ys4 MEROZOITE SURFACE
PROTEIN P41
(Plasmodium
falciparum) 		5 / 10 ILE A 334
ILE A 314
LEU A 313
HIS A 257
ILE A 272
 None
None
None
MLY  A 264 ( 3.8A)
None
 1.28A 5vkqA-4ys4A:
undetectable
5vkqD-4ys4A:
undetectable		 5vkqA-4ys4A:
11.28
5vkqD-4ys4A:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4ys4 MEROZOITE SURFACE
PROTEIN P41
(Plasmodium
falciparum) 		5 / 10 HIS A 257
ILE A 272
ILE A 334
ILE A 314
LEU A 313
 MLY  A 264 ( 3.8A)
None
None
None
None
 1.26A 5vkqA-4ys4A:
undetectable
5vkqB-4ys4A:
undetectable		 5vkqA-4ys4A:
11.28
5vkqB-4ys4A:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4ys4 MEROZOITE SURFACE
PROTEIN P41
(Plasmodium
falciparum) 		5 / 10 HIS A 257
ILE A 272
ILE A 334
ILE A 314
LEU A 313
 MLY  A 264 ( 3.8A)
None
None
None
None
 1.28A 5vkqC-4ys4A:
undetectable
5vkqD-4ys4A:
undetectable		 5vkqC-4ys4A:
11.28
5vkqD-4ys4A:
11.28