SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ys6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 4ys6 PUTATIVE
SOLUTE-BINDING
COMPONENT OF ABC
TRANSPORTER
(Lachnoclostridiu
m
phytofermentans) 		4 / 6 GLN A  28
TYR A 333
ASP A 253
VAL A 257
 None
 0.97A 1ekjC-4ys6A:
2.9
1ekjD-4ys6A:
2.8		 1ekjC-4ys6A:
21.02
1ekjD-4ys6A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 4ys6 PUTATIVE
SOLUTE-BINDING
COMPONENT OF ABC
TRANSPORTER
(Lachnoclostridiu
m
phytofermentans) 		4 / 6 ASP A 253
VAL A 257
GLN A  28
TYR A 333
 None
 0.97A 1ekjC-4ys6A:
2.9
1ekjD-4ys6A:
2.8		 1ekjC-4ys6A:
21.02
1ekjD-4ys6A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 4ys6 PUTATIVE
SOLUTE-BINDING
COMPONENT OF ABC
TRANSPORTER
(Lachnoclostridiu
m
phytofermentans) 		4 / 8 GLY A  82
ILE A 106
SER A  79
GLN A  60
 None
 1.04A 2a8tB-4ys6A:
undetectable		 2a8tB-4ys6A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4ys6 PUTATIVE
SOLUTE-BINDING
COMPONENT OF ABC
TRANSPORTER
(Lachnoclostridiu
m
phytofermentans) 		4 / 7 GLY A 164
ALA A 165
MET A 166
LEU A 169
 None
 0.64A 2wekB-4ys6A:
undetectable		 2wekB-4ys6A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 4ys6 PUTATIVE
SOLUTE-BINDING
COMPONENT OF ABC
TRANSPORTER
(Lachnoclostridiu
m
phytofermentans) 		3 / 3 CYH A 313
ASN A 120
LYS A 271
 None
None
BGC  A 403 (-2.9A)
 1.28A 4k50A-4ys6A:
undetectable		 4k50A-4ys6A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4ys6 PUTATIVE
SOLUTE-BINDING
COMPONENT OF ABC
TRANSPORTER
(Lachnoclostridiu
m
phytofermentans) 		3 / 3 ASP A 226
LYS A 258
LEU A 338
 None
 0.93A 4ptjA-4ys6A:
undetectable		 4ptjA-4ys6A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 4ys6 PUTATIVE
SOLUTE-BINDING
COMPONENT OF ABC
TRANSPORTER
(Lachnoclostridiu
m
phytofermentans) 		4 / 7 PRO A 309
SER A 300
ASP A 167
THR A 125
 None
 1.32A 4uacA-4ys6A:
undetectable		 4uacA-4ys6A:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ys6 PUTATIVE
SOLUTE-BINDING
COMPONENT OF ABC
TRANSPORTER
(Lachnoclostridiu
m
phytofermentans) 		5 / 11 THR A 248
SER A 224
GLY A 128
THR A 125
ALA A 165
 None
 1.32A 5bxnV-4ys6A:
undetectable
5bxnW-4ys6A:
undetectable		 5bxnV-4ys6A:
21.15
5bxnW-4ys6A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 4ys6 PUTATIVE
SOLUTE-BINDING
COMPONENT OF ABC
TRANSPORTER
(Lachnoclostridiu
m
phytofermentans) 		4 / 6 PHE A 118
ARG A  29
ASP A 226
GLY A 249
 None
BGC  A 403 (-4.0A)
None
None
 1.21A 5mraA-4ys6A:
undetectable
5mraB-4ys6A:
undetectable		 5mraA-4ys6A:
21.64
5mraB-4ys6A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 4ys6 PUTATIVE
SOLUTE-BINDING
COMPONENT OF ABC
TRANSPORTER
(Lachnoclostridiu
m
phytofermentans) 		4 / 8 LEU A 218
TYR A 212
THR A 216
VAL A 179
 None
 0.99A 5ov9B-4ys6A:
undetectable		 5ov9B-4ys6A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 4ys6 PUTATIVE
SOLUTE-BINDING
COMPONENT OF ABC
TRANSPORTER
(Lachnoclostridiu
m
phytofermentans) 		5 / 12 ILE A 208
GLY A 231
ALA A 235
TYR A 240
ALA A 200
 None
 1.02A 5zw4A-4ys6A:
undetectable		 5zw4A-4ys6A:
21.61