SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ys8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 4ys8 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Burkholderia
thailandensis) 		3 / 3 LEU A  39
PHE A  67
ARG A  27
 None
 0.86A 1xdkF-4ys8A:
undetectable		 1xdkF-4ys8A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 4ys8 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Burkholderia
thailandensis) 		5 / 12 LEU A 176
PHE A 171
LEU A  90
PRO A  10
VAL A  54
 None
 1.32A 2qd4B-4ys8A:
2.6		 2qd4B-4ys8A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4ys8 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Burkholderia
thailandensis) 		4 / 4 LEU A 211
ALA A 140
VAL A 139
PRO A 138
 None
 1.23A 3gv1B-4ys8A:
1.4		 3gv1B-4ys8A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 4ys8 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Burkholderia
thailandensis) 		5 / 10 VAL A  54
GLY A  78
VAL A 106
ASN A  88
GLY A  89
 None
 1.18A 3km6A-4ys8A:
undetectable		 3km6A-4ys8A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 4ys8 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Burkholderia
thailandensis) 		5 / 9 VAL A  54
GLY A  78
VAL A 106
ASN A  88
GLY A  89
 None
 1.20A 3kmoA-4ys8A:
undetectable		 3kmoA-4ys8A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4ys8 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Burkholderia
thailandensis) 		5 / 12 LEU A 105
ILE A 119
GLY A 124
ALA A 125
VAL A 135
 None
 1.11A 4nkxC-4ys8A:
undetectable		 4nkxC-4ys8A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 4ys8 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Burkholderia
thailandensis) 		3 / 3 THR A  99
ASP A 100
ALA A 101
 None
 0.00A 5g5gB-4ys8A:
undetectable		 5g5gB-4ys8A:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGJ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4ys8 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Burkholderia
thailandensis) 		3 / 3 VAL A  74
VAL A  53
GLN A  25
 None
 0.41A 5qgjA-4ys8A:
undetectable		 5qgjA-4ys8A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGM_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4ys8 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Burkholderia
thailandensis) 		3 / 3 VAL A  74
VAL A  53
GLN A  25
 None
 0.46A 5qgmA-4ys8A:
undetectable		 5qgmA-4ys8A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGN_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4ys8 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Burkholderia
thailandensis) 		3 / 3 VAL A  74
VAL A  53
GLN A  25
 None
 0.40A 5qgnA-4ys8A:
undetectable		 5qgnA-4ys8A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGY_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4ys8 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Burkholderia
thailandensis) 		3 / 3 VAL A  74
VAL A  53
GLN A  25
 None
 0.50A 5qgyA-4ys8A:
undetectable		 5qgyA-4ys8A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGZ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4ys8 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Burkholderia
thailandensis) 		3 / 3 VAL A  74
VAL A  53
GLN A  25
 None
 0.52A 5qgzA-4ys8A:
undetectable		 5qgzA-4ys8A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH0_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4ys8 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Burkholderia
thailandensis) 		3 / 3 VAL A  74
VAL A  53
GLN A  25
 None
 0.51A 5qh0A-4ys8A:
undetectable		 5qh0A-4ys8A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH2_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4ys8 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Burkholderia
thailandensis) 		3 / 3 VAL A  74
VAL A  53
GLN A  25
 None
 0.52A 5qh2A-4ys8A:
undetectable		 5qh2A-4ys8A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH3_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4ys8 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Burkholderia
thailandensis) 		3 / 3 VAL A  74
VAL A  53
GLN A  25
 None
 0.52A 5qh3A-4ys8A:
undetectable		 5qh3A-4ys8A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH5_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4ys8 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Burkholderia
thailandensis) 		3 / 3 VAL A  74
VAL A  53
GLN A  25
 None
 0.47A 5qh5A-4ys8A:
undetectable		 5qh5A-4ys8A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH6_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4ys8 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Burkholderia
thailandensis) 		3 / 3 VAL A  74
VAL A  53
GLN A  25
 None
 0.51A 5qh6A-4ys8A:
undetectable		 5qh6A-4ys8A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH7_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4ys8 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Burkholderia
thailandensis) 		3 / 3 VAL A  74
VAL A  53
GLN A  25
 None
 0.49A 5qh7A-4ys8A:
undetectable		 5qh7A-4ys8A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHA_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4ys8 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Burkholderia
thailandensis) 		3 / 3 VAL A  74
VAL A  53
GLN A  25
 None
 0.56A 5qhaA-4ys8A:
undetectable		 5qhaA-4ys8A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHH_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4ys8 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Burkholderia
thailandensis) 		3 / 3 VAL A  74
VAL A  53
GLN A  25
 None
 0.51A 5qhhA-4ys8A:
undetectable		 5qhhA-4ys8A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 4ys8 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Burkholderia
thailandensis) 		3 / 3 ARG A 212
PHE A 214
GLY A 113
 None
 0.81A 6fgdA-4ys8A:
undetectable		 6fgdA-4ys8A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 4ys8 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Burkholderia
thailandensis) 		3 / 3 ILE A 114
THR A 115
PRO A 168
 None
 0.55A 6ncsA-4ys8A:
2.4		 6ncsA-4ys8A:
24.35