SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ysb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 4ysb METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Myxococcus
xanthus) 		5 / 10 THR A  64
GLY A  67
VAL A  77
ALA A 222
ALA A  84
 None
 1.04A 1likA-4ysbA:
undetectable		 1likA-4ysbA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_1
(PHOSPHOLIPASE A2)		 4ysb METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Myxococcus
xanthus) 		4 / 5 VAL A  77
PHE A 104
ARG A  70
ARG A 221
 None
 1.32A 3bjwE-4ysbA:
undetectable		 3bjwE-4ysbA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 4ysb METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Myxococcus
xanthus) 		5 / 8 HIS A  57
HIS A  59
ASP A 129
HIS A 170
GLY A 128
 FE  A 301 (-3.4A)
None
FE  A 301 (-3.1A)
None
None
 1.43A 3c0zB-4ysbA:
undetectable		 3c0zB-4ysbA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 4ysb METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Myxococcus
xanthus) 		4 / 6 ASP A 140
HIS A  57
HIS A 112
ASP A  61
 None
FE  A 301 (-3.4A)
FE  A 301 (-3.3A)
None
 0.86A 3c0zC-4ysbA:
undetectable		 3c0zC-4ysbA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 4ysb METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Myxococcus
xanthus) 		4 / 4 ARG A 134
ASP A 151
GLY A 111
THR A 127
 None
 1.39A 3k4vB-4ysbA:
undetectable		 3k4vB-4ysbA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 4ysb METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Myxococcus
xanthus) 		3 / 3 SER A  12
SER A   9
HIS A  62
 None
 0.79A 3mzeA-4ysbA:
undetectable		 3mzeA-4ysbA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 4ysb METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Myxococcus
xanthus) 		5 / 12 GLY A  79
ALA A  87
PHE A  54
ILE A 117
VAL A  91
 None
 1.22A 4azsA-4ysbA:
undetectable		 4azsA-4ysbA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 4ysb METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Myxococcus
xanthus) 		5 / 12 GLY A  79
ALA A  87
PHE A  54
ILE A 117
VAL A  91
 None
 1.22A 4azwA-4ysbA:
undetectable		 4azwA-4ysbA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)		 4ysb METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Myxococcus
xanthus) 		5 / 10 HIS A  57
HIS A  59
ASP A 129
HIS A 170
GLY A 128
 FE  A 301 (-3.4A)
None
FE  A 301 (-3.1A)
None
None
 1.44A 4bz6A-4ysbA:
undetectable		 4bz6A-4ysbA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 4ysb METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Myxococcus
xanthus) 		5 / 12 HIS A  57
HIS A  59
ASP A 129
HIS A 170
GLY A 128
 FE  A 301 (-3.4A)
None
FE  A 301 (-3.1A)
None
None
 1.44A 4bz6A-4ysbA:
undetectable
4bz6B-4ysbA:
undetectable		 4bz6A-4ysbA:
21.21
4bz6B-4ysbA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 4ysb METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Myxococcus
xanthus) 		5 / 12 HIS A 112
GLY A 128
HIS A  59
ASP A  61
HIS A  62
 FE  A 301 (-3.3A)
None
None
None
None
 1.25A 4bz6C-4ysbA:
undetectable		 4bz6C-4ysbA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 4ysb METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Myxococcus
xanthus) 		5 / 11 HIS A  57
HIS A  59
ASP A 129
HIS A 170
GLY A 128
 FE  A 301 (-3.4A)
None
FE  A 301 (-3.1A)
None
None
 1.43A 4lxzB-4ysbA:
undetectable		 4lxzB-4ysbA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 4ysb METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Myxococcus
xanthus) 		3 / 3 HIS A  59
ASN A 220
ALA A  84
 None
 0.64A 5n4tB-4ysbA:
16.0		 5n4tB-4ysbA:
26.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1015_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 4ysb METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Myxococcus
xanthus) 		5 / 12 ASP A  61
ILE A  29
ASP A  30
ASP A 129
LEU A 132
 None
None
None
FE  A 301 (-3.1A)
None
 1.48A 5nn8A-4ysbA:
undetectable		 5nn8A-4ysbA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 4ysb METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Myxococcus
xanthus) 		3 / 3 HIS A 170
ASP A  61
HIS A  62
 None
 0.78A 5oexA-4ysbA:
undetectable		 5oexA-4ysbA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 4ysb METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Myxococcus
xanthus) 		3 / 3 HIS A 170
ASP A 129
HIS A  57
 None
FE  A 301 (-3.1A)
FE  A 301 (-3.4A)
 0.78A 5oexA-4ysbA:
undetectable		 5oexA-4ysbA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 4ysb METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Myxococcus
xanthus) 		3 / 3 HIS A 170
ASP A  61
HIS A  62
 None
 0.75A 5oexB-4ysbA:
undetectable		 5oexB-4ysbA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 4ysb METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Myxococcus
xanthus) 		3 / 3 HIS A 170
ASP A  61
HIS A  62
 None
 0.73A 5oexC-4ysbA:
undetectable		 5oexC-4ysbA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 4ysb METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Myxococcus
xanthus) 		3 / 3 HIS A 170
ASP A  61
HIS A  62
 None
 0.70A 5oexD-4ysbA:
undetectable		 5oexD-4ysbA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 4ysb METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Myxococcus
xanthus) 		4 / 6 ARG A  38
THR A  15
ASP A  30
LEU A  28
 None
 1.16A 5tdzA-4ysbA:
undetectable		 5tdzA-4ysbA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ysb METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Myxococcus
xanthus) 		3 / 3 LEU A 205
ASN A 187
LEU A 149
 None
 0.60A 6exiD-4ysbA:
undetectable		 6exiD-4ysbA:
16.50