SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ysh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 4ysh GLYCINE OXIDASE
(Geobacillus
kaustophilus) 		4 / 5 HIS A 334
LEU A 362
LEU A 221
GLY A 320
 None
 0.99A 1a4lB-4yshA:
undetectable		 1a4lB-4yshA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 4ysh GLYCINE OXIDASE
(Geobacillus
kaustophilus) 		4 / 4 HIS A 334
LEU A 362
LEU A 352
LEU A  23
 None
 1.09A 1a4lD-4yshA:
undetectable		 1a4lD-4yshA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4ysh GLYCINE OXIDASE
(Geobacillus
kaustophilus) 		5 / 12 ILE A 206
GLY A  16
VAL A  10
GLY A 209
HIS A 334
 None
None
None
FAD  A 401 (-3.6A)
None
 1.10A 1nbiA-4yshA:
2.7		 1nbiA-4yshA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4ysh GLYCINE OXIDASE
(Geobacillus
kaustophilus) 		5 / 12 ILE A 206
GLY A  16
VAL A  10
GLY A 209
HIS A 334
 None
None
None
FAD  A 401 (-3.6A)
None
 1.09A 1nbiB-4yshA:
2.8		 1nbiB-4yshA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 4ysh GLYCINE OXIDASE
(Geobacillus
kaustophilus) 		5 / 12 THR A 345
ILE A 206
GLY A 333
ILE A  15
SER A 224
 None
None
None
FAD  A 401 (-3.9A)
None
 0.95A 1sg9B-4yshA:
3.3		 1sg9B-4yshA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 4ysh GLYCINE OXIDASE
(Geobacillus
kaustophilus) 		4 / 5 GLU A  22
THR A 358
LEU A 352
LEU A 348
 None
 1.18A 1u18B-4yshA:
undetectable		 1u18B-4yshA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 4ysh GLYCINE OXIDASE
(Geobacillus
kaustophilus) 		3 / 3 TRP A 115
LEU A 108
LYS A 249
 None
 1.47A 1yajK-4yshA:
undetectable		 1yajK-4yshA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4ysh GLYCINE OXIDASE
(Geobacillus
kaustophilus) 		5 / 12 LEU A 192
GLU A  34
GLY A  11
ALA A 207
ALA A 331
 None
FAD  A 401 (-2.7A)
FAD  A 401 (-3.3A)
None
None
 1.17A 2bm9A-4yshA:
2.9		 2bm9A-4yshA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 4ysh GLYCINE OXIDASE
(Geobacillus
kaustophilus) 		5 / 9 GLY A  12
GLU A 176
ILE A   9
ALA A 207
VAL A 205
 FAD  A 401 ( 4.8A)
None
None
None
None
 1.37A 2drdA-4yshA:
undetectable		 2drdA-4yshA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4ysh GLYCINE OXIDASE
(Geobacillus
kaustophilus) 		5 / 12 ALA A  45
SER A  43
ALA A 160
GLY A 307
TYR A 177
 FAD  A 401 ( 4.5A)
FAD  A 401 (-2.3A)
None
FAD  A 401 ( 4.1A)
None
 1.17A 2igtA-4yshA:
3.4		 2igtA-4yshA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4ysh GLYCINE OXIDASE
(Geobacillus
kaustophilus) 		5 / 12 ALA A  45
SER A  43
ALA A 160
GLY A 307
TYR A 177
 FAD  A 401 ( 4.5A)
FAD  A 401 (-2.3A)
None
FAD  A 401 ( 4.1A)
None
 1.22A 2igtC-4yshA:
3.4		 2igtC-4yshA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 4ysh GLYCINE OXIDASE
(Geobacillus
kaustophilus) 		5 / 11 LEU A  90
GLY A  89
ILE A  88
SER A 155
LEU A  50
 None
 0.95A 2kawA-4yshA:
undetectable		 2kawA-4yshA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 4ysh GLYCINE OXIDASE
(Geobacillus
kaustophilus) 		4 / 7 GLY A  11
GLY A  12
VAL A 180
SER A 208
 FAD  A 401 (-3.3A)
FAD  A 401 ( 4.8A)
FAD  A 401 (-4.0A)
FAD  A 401 (-4.4A)
 0.44A 2oa1B-4yshA:
13.7		 2oa1B-4yshA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4ysh GLYCINE OXIDASE
(Geobacillus
kaustophilus) 		4 / 7 LEU A 174
GLY A  12
GLY A  36
THR A 178
 None
FAD  A 401 ( 4.8A)
None
None
 0.76A 2wd9A-4yshA:
undetectable		 2wd9A-4yshA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4ysh GLYCINE OXIDASE
(Geobacillus
kaustophilus) 		4 / 8 LEU A 174
GLY A  12
GLY A  36
THR A 178
 None
FAD  A 401 ( 4.8A)
None
None
 0.76A 2wd9B-4yshA:
undetectable		 2wd9B-4yshA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4ysh GLYCINE OXIDASE
(Geobacillus
kaustophilus) 		5 / 10 THR A 194
LEU A 174
GLY A  12
GLY A  36
THR A 178
 None
None
FAD  A 401 ( 4.8A)
None
None
 1.09A 2wd9C-4yshA:
undetectable		 2wd9C-4yshA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4ysh GLYCINE OXIDASE
(Geobacillus
kaustophilus) 		5 / 12 GLY A  16
SER A 342
LEU A 347
LEU A  80
LEU A 159
 None
 1.25A 3cs8A-4yshA:
undetectable		 3cs8A-4yshA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4ysh GLYCINE OXIDASE
(Geobacillus
kaustophilus) 		5 / 12 SER A 342
ILE A 339
LEU A  50
LEU A  80
LEU A 163
 None
FAD  A 401 (-3.8A)
None
None
None
 1.32A 3cs8A-4yshA:
undetectable		 3cs8A-4yshA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 4ysh GLYCINE OXIDASE
(Geobacillus
kaustophilus) 		5 / 12 ILE A  15
LEU A 163
PRO A  64
THR A 345
PRO A 317
 FAD  A 401 (-3.9A)
None
None
None
None
 1.20A 3dcjA-4yshA:
2.8
3dcjB-4yshA:
3.4		 3dcjA-4yshA:
20.87
3dcjB-4yshA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4ysh GLYCINE OXIDASE
(Geobacillus
kaustophilus) 		5 / 12 GLY A  16
GLY A  13
ALA A 160
LEU A 163
VAL A 205
 None
FAD  A 401 (-3.3A)
None
None
None
 1.02A 3dmhA-4yshA:
undetectable		 3dmhA-4yshA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 4ysh GLYCINE OXIDASE
(Geobacillus
kaustophilus) 		4 / 5 ARG A 288
ILE A 264
VAL A 293
THR A 100
 SO4  A 402 (-3.0A)
None
None
None
 1.21A 3eigA-4yshA:
undetectable		 3eigA-4yshA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 4ysh GLYCINE OXIDASE
(Geobacillus
kaustophilus) 		6 / 12 LEU A  80
GLY A  20
LEU A  23
ILE A  15
LEU A 159
ILE A 339
 None
None
None
FAD  A 401 (-3.9A)
None
FAD  A 401 (-3.8A)
 1.43A 3ijdA-4yshA:
undetectable		 3ijdA-4yshA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 4ysh GLYCINE OXIDASE
(Geobacillus
kaustophilus) 		6 / 12 LEU A  80
GLY A  20
LEU A  23
ILE A  15
LEU A 159
ILE A 339
 None
None
None
FAD  A 401 (-3.9A)
None
FAD  A 401 (-3.8A)
 1.44A 3ijdB-4yshA:
undetectable		 3ijdB-4yshA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ysh GLYCINE OXIDASE
(Geobacillus
kaustophilus) 		4 / 7 LEU A 352
VAL A 180
ILE A   9
ARG A 184
 None
FAD  A 401 (-4.0A)
None
None
 1.27A 3ik3A-4yshA:
undetectable		 3ik3A-4yshA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4ysh GLYCINE OXIDASE
(Geobacillus
kaustophilus) 		5 / 9 LEU A 352
VAL A 180
ILE A   9
ARG A 184
LEU A 367
 None
FAD  A 401 (-4.0A)
None
None
None
 1.32A 3oxzA-4yshA:
undetectable		 3oxzA-4yshA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4ysh GLYCINE OXIDASE
(Geobacillus
kaustophilus) 		5 / 12 LEU A 367
GLY A 216
ILE A 183
VAL A 219
ALA A 332
 None
 0.99A 4a6dA-4yshA:
undetectable		 4a6dA-4yshA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4ysh GLYCINE OXIDASE
(Geobacillus
kaustophilus) 		5 / 12 LEU A 367
GLY A 216
ILE A 183
VAL A 219
ALA A 332
 None
 1.04A 4a6eA-4yshA:
2.3		 4a6eA-4yshA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4ysh GLYCINE OXIDASE
(Geobacillus
kaustophilus) 		4 / 5 GLY A 216
ILE A 206
VAL A 225
SER A 208
 None
None
None
FAD  A 401 (-4.4A)
 1.17A 4d33B-4yshA:
undetectable		 4d33B-4yshA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4ysh GLYCINE OXIDASE
(Geobacillus
kaustophilus) 		5 / 12 ILE A  86
ALA A 168
ALA A  17
GLY A  13
ALA A 162
 None
None
None
FAD  A 401 (-3.3A)
None
 1.04A 4enhA-4yshA:
undetectable		 4enhA-4yshA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4ysh GLYCINE OXIDASE
(Geobacillus
kaustophilus) 		5 / 10 ILE A 206
ILE A  19
GLY A  16
GLY A  11
PHE A 329
 None
None
None
FAD  A 401 (-3.3A)
None
 1.05A 4fakA-4yshA:
undetectable		 4fakA-4yshA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 4ysh GLYCINE OXIDASE
(Geobacillus
kaustophilus) 		5 / 12 GLY A  48
PHE A 247
SER A 268
TYR A 335
VAL A 228
 FAD  A 401 (-4.1A)
None
SO4  A 402 (-3.8A)
None
None
 1.50A 4ffwB-4yshA:
undetectable		 4ffwB-4yshA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 4ysh GLYCINE OXIDASE
(Geobacillus
kaustophilus) 		3 / 3 ARG A 275
ASP A 274
ARG A 276
 None
 0.67A 4wq4B-4yshA:
undetectable		 4wq4B-4yshA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4ysh GLYCINE OXIDASE
(Geobacillus
kaustophilus) 		4 / 4 ASN A 337
SER A  69
ALA A  66
VAL A  63
 None
 1.39A 4x1kC-4yshA:
undetectable		 4x1kC-4yshA:
23.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 4ysh GLYCINE OXIDASE
(Geobacillus
kaustophilus) 		4 / 6 PHE A 247
GLY A 251
TYR A 253
ALA A 266
 None
None
None
FAD  A 401 (-4.4A)
 0.57A 4yshB-4yshA:
62.9		 4yshB-4yshA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YSH_B_GLYB402_0
(GLYCINE OXIDASE)		 4ysh GLYCINE OXIDASE
(Geobacillus
kaustophilus) 		4 / 5 MET A  49
GLU A  55
TYR A 253
ARG A 309
 FAD  A 401 (-4.3A)
None
None
FAD  A 401 (-3.4A)
 0.98A 4yshB-4yshA:
62.9		 4yshB-4yshA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_B_PQNB2002_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4ysh GLYCINE OXIDASE
(Geobacillus
kaustophilus) 		5 / 9 SER A  43
ILE A  88
ALA A 162
LEU A 163
ALA A  17
 FAD  A 401 (-2.3A)
None
None
None
None
 1.49A 6hqbB-4yshA:
undetectable		 6hqbB-4yshA:
12.50