SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ysj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		8 / 12 LEU A  34
GLY A  35
VAL A  42
ALA A  55
GLU A 112
ASN A 156
LEU A 158
ASP A 172
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.5A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-3.5A)
MG  A 505 ( 2.7A)
ADP  A 506 (-4.7A)
ADP  A 506 ( 2.4A)
 0.52A 1fmoE-4ysjA:
30.8		 1fmoE-4ysjA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		5 / 10 ALA A 276
VAL A 135
ILE A 132
GLY A 214
ILE A 139
 None
 0.98A 1hsgA-4ysjA:
undetectable		 1hsgA-4ysjA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		7 / 12 LEU A  34
VAL A  42
ALA A  55
GLU A  76
THR A 105
GLY A 111
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
None
ADP  A 506 ( 4.6A)
None
ADP  A 506 (-4.7A)
 0.84A 1iepA-4ysjA:
22.4		 1iepA-4ysjA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 12 LEU A  34
VAL A  42
ALA A  55
GLU A  76
THR A 105
GLY A 110
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
None
ADP  A 506 ( 4.6A)
None
 0.77A 1iepB-4ysjA:
22.5		 1iepB-4ysjA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 12 LEU A  34
VAL A  42
ALA A  55
GLU A  76
THR A 105
GLY A 111
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
None
ADP  A 506 ( 4.6A)
None
 0.71A 1iepB-4ysjA:
22.5		 1iepB-4ysjA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2S_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 7 ARG A 263
VAL A 254
TRP A 251
PHE A 246
 None
 1.47A 1k2sA-4ysjA:
undetectable
1k2sB-4ysjA:
undetectable		 1k2sA-4ysjA:
20.99
1k2sB-4ysjA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2S_B_H4BB2760_1
(NITRIC-OXIDE
SYNTHASE)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 6 TRP A 251
PHE A 246
ARG A 263
VAL A 254
 None
 1.46A 1k2sA-4ysjA:
undetectable
1k2sB-4ysjA:
undetectable		 1k2sA-4ysjA:
20.99
1k2sB-4ysjA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		5 / 12 LEU A 481
LEU A 478
PHE A 444
ALA A 320
LEU A 414
 None
 1.38A 1kt5A-4ysjA:
undetectable		 1kt5A-4ysjA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		8 / 12 LEU A  34
ALA A  55
LYS A  57
GLU A  76
LEU A 103
THR A 105
GLY A 111
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
ADP  A 506 ( 4.6A)
None
ADP  A 506 (-4.7A)
 0.90A 1m17A-4ysjA:
25.2		 1m17A-4ysjA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM5_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 8 ARG A 263
VAL A 254
TRP A 251
PHE A 246
 None
 1.49A 1om5A-4ysjA:
undetectable
1om5B-4ysjA:
undetectable		 1om5A-4ysjA:
21.18
1om5B-4ysjA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_A_BEZA1501_0
(RAS-RELATED PROTEIN
RAB-9A)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 5 ILE A 262
TRP A 251
LEU A 266
PRO A 226
 None
 1.24A 1s8fA-4ysjA:
undetectable
1s8fB-4ysjA:
undetectable		 1s8fA-4ysjA:
17.96
1s8fB-4ysjA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		9 / 12 LEU A  34
VAL A  42
ALA A  55
GLU A  76
LEU A  80
THR A 105
GLY A 111
LEU A 158
ASP A 172
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
None
None
ADP  A 506 ( 4.6A)
None
ADP  A 506 (-4.7A)
ADP  A 506 ( 2.4A)
 0.94A 1t46A-4ysjA:
22.7		 1t46A-4ysjA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		9 / 12 LEU A  34
VAL A  42
ALA A  55
LYS A  57
GLU A  76
LEU A  80
THR A 105
GLY A 111
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
ADP  A 506 ( 4.6A)
None
ADP  A 506 (-4.7A)
 0.74A 1t46A-4ysjA:
22.7		 1t46A-4ysjA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		5 / 12 ALA A  55
GLU A  76
LEU A  80
THR A 105
HIS A 149
 ADP  A 506 (-3.3A)
None
None
ADP  A 506 ( 4.6A)
None
 0.57A 1uwhA-4ysjA:
24.6		 1uwhA-4ysjA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 12 ALA A  55
LYS A  57
GLU A  76
LEU A  80
THR A 105
HIS A 149
 ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
ADP  A 506 ( 4.6A)
None
 0.64A 1uwhB-4ysjA:
24.3		 1uwhB-4ysjA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 7 LYS A  57
LEU A  80
ILE A  88
ILE A 147
 ADP  A 506 (-2.4A)
None
None
None
 0.53A 1uwjA-4ysjA:
7.0		 1uwjA-4ysjA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		3 / 3 ILE A 307
ASP A 392
PHE A 393
 None
CA  A 502 (-3.1A)
None
 0.60A 1uwjB-4ysjA:
24.3		 1uwjB-4ysjA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 12 ALA A  55
THR A 105
GLY A 111
ASP A 115
LEU A 158
PHE A 173
 ADP  A 506 (-3.3A)
ADP  A 506 ( 4.6A)
None
None
ADP  A 506 (-4.7A)
None
 1.06A 1xkkA-4ysjA:
23.5		 1xkkA-4ysjA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		5 / 9 LEU A  34
VAL A  42
LYS A  57
LEU A  91
LEU A 103
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-2.4A)
None
None
 0.64A 1xkkA-4ysjA:
23.5		 1xkkA-4ysjA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		5 / 12 ILE A 132
ILE A 219
PHE A 114
LEU A 113
ILE A 131
 None
 1.05A 2cd2A-4ysjA:
undetectable		 2cd2A-4ysjA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		7 / 12 LEU A  34
GLY A  35
VAL A  42
ALA A  55
ASP A 151
LYS A 153
ASN A 156
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.5A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
None
None
MG  A 505 ( 2.7A)
 0.55A 2fumA-4ysjA:
29.9		 2fumA-4ysjA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		7 / 12 LEU A  34
VAL A  42
ALA A  55
ASP A 151
LYS A 153
ASN A 156
ASP A 172
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
None
None
MG  A 505 ( 2.7A)
ADP  A 506 ( 2.4A)
 0.63A 2fumA-4ysjA:
29.9		 2fumA-4ysjA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		7 / 12 LEU A  34
GLY A  35
GLY A  37
VAL A  42
ALA A  55
LYS A 153
ASN A 156
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.5A)
ADP  A 506 (-2.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
None
MG  A 505 ( 2.7A)
 0.76A 2fumD-4ysjA:
27.9		 2fumD-4ysjA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 12 VAL A  42
ALA A  55
GLU A  76
THR A 105
GLY A 111
LEU A 158
 ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
None
ADP  A 506 ( 4.6A)
None
ADP  A 506 (-4.7A)
 0.80A 2hyyA-4ysjA:
23.0		 2hyyA-4ysjA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 12 VAL A  42
ALA A  55
GLU A  76
THR A 105
GLY A 111
LEU A 158
 ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
None
ADP  A 506 ( 4.6A)
None
ADP  A 506 (-4.7A)
 0.79A 2hyyB-4ysjA:
22.9		 2hyyB-4ysjA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		8 / 12 LEU A  34
ALA A  55
LYS A  57
GLU A  76
LEU A 103
THR A 105
GLY A 111
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
ADP  A 506 ( 4.6A)
None
ADP  A 506 (-4.7A)
 1.00A 2itoA-4ysjA:
24.4		 2itoA-4ysjA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		7 / 12 LEU A  34
ALA A  55
LYS A  57
THR A 105
GLY A 111
ASP A 115
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
ADP  A 506 ( 4.6A)
None
None
ADP  A 506 (-4.7A)
 1.00A 2itoA-4ysjA:
24.4		 2itoA-4ysjA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		8 / 12 LEU A  34
GLY A  35
VAL A  42
ALA A  55
LYS A  57
GLU A  76
LEU A 103
THR A 105
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.5A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
ADP  A 506 ( 4.6A)
 0.81A 2ityA-4ysjA:
24.4		 2ityA-4ysjA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		8 / 12 LEU A  34
VAL A  42
ALA A  55
LYS A  57
GLU A  76
THR A 105
GLY A 111
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
ADP  A 506 ( 4.6A)
None
ADP  A 506 (-4.7A)
 1.09A 2itzA-4ysjA:
24.3		 2itzA-4ysjA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		8 / 12 LEU A  34
VAL A  42
ALA A  55
LYS A  57
THR A 105
GLY A 111
ASP A 115
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
ADP  A 506 ( 4.6A)
None
None
ADP  A 506 (-4.7A)
 1.09A 2itzA-4ysjA:
24.3		 2itzA-4ysjA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		7 / 12 LEU A  34
GLY A  35
VAL A  42
LYS A  57
GLU A  76
LEU A  80
LEU A 103
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.5A)
ADP  A 506 (-4.3A)
ADP  A 506 (-2.4A)
None
None
None
 0.54A 2ivuA-4ysjA:
26.8		 2ivuA-4ysjA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 7 GLY A 214
VAL A 135
SER A 212
LEU A 152
 None
 0.79A 2oa1B-4ysjA:
undetectable		 2oa1B-4ysjA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 5 LEU A 420
ALA A 423
LEU A 328
MET A 409
 None
 1.23A 2oaxA-4ysjA:
undetectable		 2oaxA-4ysjA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		5 / 12 ILE A 168
THR A 105
VAL A  42
LEU A 158
LEU A  80
 None
ADP  A 506 ( 4.6A)
ADP  A 506 (-4.3A)
ADP  A 506 (-4.7A)
None
 1.38A 2rctA-4ysjA:
undetectable		 2rctA-4ysjA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 6 ALA A 320
ALA A 317
THR A 313
PHE A 310
 None
 1.04A 2xfhA-4ysjA:
undetectable		 2xfhA-4ysjA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 10 ARG A  32
LEU A  34
ALA A  55
LYS A  57
GLY A 111
LEU A 158
 None
ADP  A 506 ( 3.8A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
ADP  A 506 (-4.7A)
 0.94A 3aoxA-4ysjA:
23.4		 3aoxA-4ysjA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3P_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 7 ARG A 263
VAL A 254
TRP A 251
PHE A 246
 None
 1.48A 3b3pA-4ysjA:
undetectable
3b3pB-4ysjA:
undetectable		 3b3pA-4ysjA:
20.98
3b3pB-4ysjA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		7 / 12 VAL A  42
ALA A  55
LEU A 103
THR A 105
GLY A 111
LEU A 158
PHE A 173
 ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
None
ADP  A 506 ( 4.6A)
None
ADP  A 506 (-4.7A)
None
 0.98A 3bbtD-4ysjA:
23.7		 3bbtD-4ysjA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		7 / 12 VAL A  42
ALA A  55
LYS A  57
LEU A 103
THR A 105
GLY A 111
LEU A 158
 ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
ADP  A 506 ( 4.6A)
None
ADP  A 506 (-4.7A)
 1.01A 3bbtD-4ysjA:
23.7		 3bbtD-4ysjA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		5 / 12 ILE A 132
ILE A 219
PHE A 114
LEU A 113
ILE A 131
 None
 1.05A 3cd2A-4ysjA:
undetectable		 3cd2A-4ysjA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		5 / 11 VAL A 135
ALA A 276
ILE A 274
ILE A 262
ILE A 132
 None
 1.01A 3clbA-4ysjA:
undetectable		 3clbA-4ysjA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		5 / 10 VAL A 135
ALA A 276
ILE A 274
ILE A 262
ILE A 132
 None
 1.09A 3clbD-4ysjA:
undetectable		 3clbD-4ysjA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 6 LEU A  34
VAL A  42
LYS A  57
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-2.4A)
ADP  A 506 (-4.7A)
 0.82A 3cs9D-4ysjA:
21.9		 3cs9D-4ysjA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		8 / 12 LEU A  34
GLY A  35
GLY A  37
VAL A  42
ALA A  55
LYS A  57
ASN A 156
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.5A)
ADP  A 506 (-2.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
MG  A 505 ( 2.7A)
ADP  A 506 (-4.7A)
 0.68A 3eygA-4ysjA:
26.5		 3eygA-4ysjA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		7 / 12 LEU A  34
GLY A  35
GLY A  37
VAL A  42
ALA A  55
LYS A  57
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.5A)
ADP  A 506 (-2.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
ADP  A 506 (-4.7A)
 0.50A 3fupB-4ysjA:
26.3		 3fupB-4ysjA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 11 LEU A  34
VAL A  42
ALA A  55
THR A 105
GLY A 111
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 ( 4.6A)
None
ADP  A 506 (-4.7A)
 0.42A 3g0eA-4ysjA:
21.5		 3g0eA-4ysjA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 11 LEU A  34
VAL A  42
ALA A  55
THR A 105
GLY A 111
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 ( 4.6A)
None
ADP  A 506 (-4.7A)
 0.47A 3g0fA-4ysjA:
22.2		 3g0fA-4ysjA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 10 LEU A  34
VAL A  42
ALA A  55
THR A 105
GLY A 111
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 ( 4.6A)
None
ADP  A 506 (-4.7A)
 0.44A 3g0fB-4ysjA:
22.5		 3g0fB-4ysjA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 12 ALA A  55
GLU A  76
LEU A  80
THR A 105
HIS A 149
ASP A 172
 ADP  A 506 (-3.3A)
None
None
ADP  A 506 ( 4.6A)
None
ADP  A 506 ( 2.4A)
 1.25A 3gp0A-4ysjA:
23.4		 3gp0A-4ysjA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		7 / 12 VAL A  42
ALA A  55
GLU A  76
LEU A  79
LEU A  80
THR A 105
HIS A 149
 ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
None
None
None
ADP  A 506 ( 4.6A)
None
 0.78A 3gp0A-4ysjA:
23.4		 3gp0A-4ysjA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		5 / 10 VAL A 135
ALA A 276
ILE A 274
ILE A 262
ILE A 132
 None
 1.02A 3hbbA-4ysjA:
undetectable		 3hbbA-4ysjA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		5 / 11 VAL A 135
ALA A 276
ILE A 274
ILE A 262
ILE A 132
 None
 1.06A 3hbbC-4ysjA:
undetectable		 3hbbC-4ysjA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		5 / 10 VAL A 135
ALA A 276
ILE A 274
ILE A 262
ILE A 132
 None
 1.07A 3hbbD-4ysjA:
undetectable		 3hbbD-4ysjA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		5 / 12 ALA A  55
LYS A  57
GLU A  76
LEU A  80
THR A 105
 ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
ADP  A 506 ( 4.6A)
 0.77A 3hecA-4ysjA:
15.2		 3hecA-4ysjA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		5 / 12 LYS A  57
GLU A  76
LEU A  79
LEU A  80
THR A 105
 ADP  A 506 (-2.4A)
None
None
None
ADP  A 506 ( 4.6A)
 1.01A 3hecA-4ysjA:
15.2		 3hecA-4ysjA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 12 VAL A  42
ALA A  55
LYS A  57
GLU A  76
LEU A  80
THR A 105
 ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
ADP  A 506 ( 4.6A)
 1.04A 3hegA-4ysjA:
22.0		 3hegA-4ysjA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		5 / 12 GLY A 350
ILE A 147
ASP A  84
LEU A  83
PHE A 173
 None
 1.03A 3ihtA-4ysjA:
undetectable		 3ihtA-4ysjA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 12 VAL A  42
ALA A  55
GLU A  76
THR A 105
GLY A 111
LEU A 158
 ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
None
ADP  A 506 ( 4.6A)
None
ADP  A 506 (-4.7A)
 0.70A 3k5vA-4ysjA:
16.6		 3k5vA-4ysjA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 12 VAL A  42
ALA A  55
GLU A  76
THR A 105
GLY A 111
LEU A 158
 ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
None
ADP  A 506 ( 4.6A)
None
ADP  A 506 (-4.7A)
 0.73A 3k5vB-4ysjA:
22.2		 3k5vB-4ysjA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		5 / 8 ALA A  55
LYS A  57
GLU A  76
LEU A 103
THR A 105
 ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
ADP  A 506 ( 4.6A)
 0.59A 3lfaA-4ysjA:
20.7		 3lfaA-4ysjA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		7 / 12 LEU A  34
GLY A  35
GLY A  37
VAL A  42
ALA A  55
LYS A  57
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.5A)
ADP  A 506 (-2.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
ADP  A 506 (-4.7A)
 0.61A 3lxnA-4ysjA:
26.5		 3lxnA-4ysjA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 12 LEU A  34
VAL A  42
ALA A  55
GLU A  76
THR A 105
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
None
ADP  A 506 ( 4.6A)
ADP  A 506 (-4.7A)
 0.86A 3ms9A-4ysjA:
22.4		 3ms9A-4ysjA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		7 / 12 LEU A  34
VAL A  42
ALA A  55
GLU A  76
THR A 105
GLY A 111
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
None
ADP  A 506 ( 4.6A)
None
ADP  A 506 (-4.7A)
 0.79A 3ms9B-4ysjA:
22.4		 3ms9B-4ysjA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 12 LEU A  34
VAL A  42
ALA A  55
GLU A  76
THR A 105
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
None
ADP  A 506 ( 4.6A)
ADP  A 506 (-4.7A)
 0.85A 3mssA-4ysjA:
22.6		 3mssA-4ysjA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 12 LEU A  34
VAL A  42
ALA A  55
GLU A  76
THR A 105
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
None
ADP  A 506 ( 4.6A)
ADP  A 506 (-4.7A)
 0.87A 3mssC-4ysjA:
22.5		 3mssC-4ysjA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 12 ALA A  55
GLU A  76
THR A 105
GLY A 111
LEU A 158
ASP A 172
 ADP  A 506 (-3.3A)
None
ADP  A 506 ( 4.6A)
None
ADP  A 506 (-4.7A)
ADP  A 506 ( 2.4A)
 1.07A 3mssD-4ysjA:
22.8		 3mssD-4ysjA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 12 LEU A  34
ALA A  55
GLU A  76
THR A 105
GLY A 111
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.3A)
None
ADP  A 506 ( 4.6A)
None
ADP  A 506 (-4.7A)
 0.80A 3mssD-4ysjA:
22.8		 3mssD-4ysjA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 12 VAL A  42
ALA A  55
LYS A  57
LEU A  80
THR A 105
PHE A 173
 ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
ADP  A 506 ( 4.6A)
None
 0.97A 3og7A-4ysjA:
25.5		 3og7A-4ysjA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 12 GLY A  35
VAL A  42
ALA A  55
LYS A  57
LEU A  80
THR A 105
 ADP  A 506 (-3.5A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
ADP  A 506 ( 4.6A)
 0.71A 3ohtA-4ysjA:
18.7		 3ohtA-4ysjA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 12 GLY A  35
VAL A  42
ALA A  55
LYS A  57
LEU A  80
THR A 105
 ADP  A 506 (-3.5A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
ADP  A 506 ( 4.6A)
 0.68A 3ohtB-4ysjA:
18.7		 3ohtB-4ysjA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 12 LEU A  34
VAL A  42
ALA A  55
GLU A  76
THR A 105
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
None
ADP  A 506 ( 4.6A)
ADP  A 506 (-4.7A)
 0.70A 3pyyB-4ysjA:
22.9		 3pyyB-4ysjA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		5 / 8 ILE A 435
LEU A 440
ALA A 317
ALA A 318
MET A 477
 None
 1.34A 3r9tA-4ysjA:
undetectable		 3r9tA-4ysjA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 7 ILE A 262
PHE A 227
LYS A 241
GLY A 242
 None
 1.23A 3sj0X-4ysjA:
undetectable		 3sj0X-4ysjA:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 8 VAL A  42
LYS A  57
ILE A 171
ASP A 172
 ADP  A 506 (-4.3A)
ADP  A 506 (-2.4A)
ADP  A 506 (-4.5A)
ADP  A 506 ( 2.4A)
 0.62A 3warA-4ysjA:
27.6		 3warA-4ysjA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 12 LEU A  34
VAL A  42
ALA A  55
GLU A  76
LEU A  80
GLY A 111
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
None
None
None
 0.66A 3wzdA-4ysjA:
22.2		 3wzdA-4ysjA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		8 / 12 LEU A  34
VAL A  42
ALA A  55
LYS A  57
GLU A  76
LEU A  80
GLY A 111
HIS A 149
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
None
None
 0.57A 3wzeA-4ysjA:
22.3		 3wzeA-4ysjA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		8 / 12 LEU A  34
ALA A  55
LYS A  57
GLU A  76
THR A 105
HIS A 149
ARG A 150
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
ADP  A 506 ( 4.6A)
None
None
ADP  A 506 (-4.7A)
 0.84A 3zosA-4ysjA:
22.4		 3zosA-4ysjA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		7 / 12 ALA A  55
LYS A  57
GLU A  76
THR A 105
HIS A 149
ARG A 150
LEU A 158
 ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
ADP  A 506 ( 4.6A)
None
None
ADP  A 506 (-4.7A)
 0.82A 3zosB-4ysjA:
22.5		 3zosB-4ysjA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		5 / 12 LEU A 321
LEU A 478
LEU A 479
GLN A 476
THR A 313
 None
 1.39A 3zqtA-4ysjA:
undetectable		 3zqtA-4ysjA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		7 / 12 LEU A  34
VAL A  42
ALA A  55
LYS A  57
GLU A  76
GLY A 111
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
ADP  A 506 (-4.7A)
 0.52A 4ag8A-4ysjA:
22.3		 4ag8A-4ysjA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		8 / 12 LEU A  34
VAL A  42
ALA A  55
LYS A  57
GLU A  76
LEU A  80
GLY A 111
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
None
ADP  A 506 (-4.7A)
 0.53A 4agcA-4ysjA:
21.9		 4agcA-4ysjA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		8 / 12 LEU A  34
VAL A  42
ALA A  55
LYS A  57
GLU A  76
LEU A  80
GLY A 111
HIS A 149
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
None
None
 0.58A 4asdA-4ysjA:
22.2		 4asdA-4ysjA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 6 HIS A  85
SER A 137
GLU A 281
ASP A 345
 None
None
None
CA  A 501 (-3.1A)
 0.96A 4blvA-4ysjA:
undetectable		 4blvA-4ysjA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		7 / 12 ALA A  55
LYS A  57
GLU A  76
LEU A  80
THR A 105
HIS A 149
LEU A 158
 ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
ADP  A 506 ( 4.6A)
None
ADP  A 506 (-4.7A)
 0.76A 4c8bA-4ysjA:
24.3		 4c8bA-4ysjA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		8 / 12 ALA A  55
LYS A  57
GLU A  76
LEU A  80
ILE A  88
THR A 105
HIS A 149
LEU A 158
 ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
None
ADP  A 506 ( 4.6A)
None
ADP  A 506 (-4.7A)
 0.81A 4c8bB-4ysjA:
24.1		 4c8bB-4ysjA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		5 / 12 THR A 140
LEU A 285
LEU A 280
VAL A 210
ILE A 139
 None
 0.97A 4c9lA-4ysjA:
undetectable		 4c9lA-4ysjA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		5 / 12 THR A 140
LEU A 285
LEU A 280
VAL A 210
ILE A 139
 None
 0.99A 4c9lB-4ysjA:
undetectable		 4c9lB-4ysjA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		5 / 12 THR A 140
LEU A 285
LEU A 280
VAL A 210
ILE A 139
 None
 0.95A 4c9oA-4ysjA:
undetectable		 4c9oA-4ysjA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		5 / 12 THR A 140
LEU A 285
LEU A 280
VAL A 210
ILE A 139
 None
 0.94A 4c9oB-4ysjA:
undetectable		 4c9oB-4ysjA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		7 / 12 LEU A  34
VAL A  42
ALA A  55
LYS A  57
THR A 105
GLY A 111
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
ADP  A 506 ( 4.6A)
None
ADP  A 506 (-4.7A)
 1.03A 4hjoA-4ysjA:
19.3		 4hjoA-4ysjA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		9 / 12 LEU A  34
GLY A  35
VAL A  42
ALA A  55
LYS A  57
GLY A 111
ASP A 115
LEU A 158
ASP A 172
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.5A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
ADP  A 506 (-4.7A)
ADP  A 506 ( 2.4A)
 1.05A 4i22A-4ysjA:
23.2		 4i22A-4ysjA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		9 / 12 LEU A  34
GLY A  35
VAL A  42
ALA A  55
LYS A  57
LEU A 103
GLY A 111
ASP A 115
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.5A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
None
ADP  A 506 (-4.7A)
 1.00A 4i22A-4ysjA:
23.2		 4i22A-4ysjA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		8 / 12 VAL A  42
ALA A  55
ASP A 115
ASP A 151
ASN A 156
LEU A 158
ILE A 171
ASP A 172
 ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
None
None
MG  A 505 ( 2.7A)
ADP  A 506 (-4.7A)
ADP  A 506 (-4.5A)
ADP  A 506 ( 2.4A)
 0.58A 4i41A-4ysjA:
29.5		 4i41A-4ysjA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		8 / 12 VAL A  42
ALA A  55
ASP A 115
ASP A 151
LYS A 153
ASN A 156
LEU A 158
ILE A 171
 ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
None
None
None
MG  A 505 ( 2.7A)
ADP  A 506 (-4.7A)
ADP  A 506 (-4.5A)
 0.57A 4i41A-4ysjA:
29.5		 4i41A-4ysjA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		7 / 11 VAL A  42
ALA A  55
LYS A  57
GLU A 155
LEU A 158
ILE A 171
ASP A 172
 ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
ADP  A 506 (-4.7A)
ADP  A 506 (-4.5A)
ADP  A 506 ( 2.4A)
 0.98A 4iaaA-4ysjA:
29.1		 4iaaA-4ysjA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		8 / 12 GLY A  35
VAL A  42
ALA A  55
LYS A  57
MET A  89
LEU A  91
LEU A 103
ILE A 171
 ADP  A 506 (-3.5A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
None
ADP  A 506 (-4.5A)
 0.70A 4ifgA-4ysjA:
30.4		 4ifgA-4ysjA:
82.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		8 / 12 GLY A  35
VAL A  42
ALA A  55
MET A  89
LEU A  91
LEU A 103
LEU A 158
ILE A 171
 ADP  A 506 (-3.5A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
None
None
None
ADP  A 506 (-4.7A)
ADP  A 506 (-4.5A)
 0.65A 4ifgA-4ysjA:
30.4		 4ifgA-4ysjA:
82.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		9 / 12 VAL A  42
ALA A  55
LYS A  57
MET A  89
LEU A  91
LEU A 103
GLY A 111
GLU A 112
ILE A 171
 ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
None
None
ADP  A 506 (-3.5A)
ADP  A 506 (-4.5A)
 0.75A 4ifgA-4ysjA:
30.4		 4ifgA-4ysjA:
82.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		9 / 12 VAL A  42
ALA A  55
MET A  89
LEU A  91
LEU A 103
GLY A 111
GLU A 112
LEU A 158
ILE A 171
 ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
None
None
None
None
ADP  A 506 (-3.5A)
ADP  A 506 (-4.7A)
ADP  A 506 (-4.5A)
 0.63A 4ifgA-4ysjA:
30.4		 4ifgA-4ysjA:
82.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 7 TRP A 251
PHE A 246
ARG A 263
VAL A 254
 None
 1.49A 4imtA-4ysjA:
undetectable
4imtB-4ysjA:
undetectable		 4imtA-4ysjA:
20.98
4imtB-4ysjA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 5 LEU A 113
PRO A 154
LEU A 157
ILE A 168
 None
 0.95A 4klrA-4ysjA:
undetectable		 4klrA-4ysjA:
22.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		7 / 11 LEU A  34
GLY A  35
VAL A  42
ALA A  55
LYS A  57
ASN A 156
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.5A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
MG  A 505 ( 2.7A)
ADP  A 506 (-4.7A)
 0.64A 4o0sA-4ysjA:
32.6		 4o0sA-4ysjA:
31.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		5 / 6 LEU A  34
GLY A  35
VAL A  42
ALA A  55
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.5A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-4.7A)
 0.26A 4o0wA-4ysjA:
26.9		 4o0wA-4ysjA:
30.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		8 / 12 LEU A  34
GLY A  35
GLY A  37
GLY A  40
VAL A  42
ALA A  55
LYS A  57
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.5A)
ADP  A 506 (-2.8A)
None
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
ADP  A 506 (-4.7A)
 0.63A 4otiA-4ysjA:
24.1		 4otiA-4ysjA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		5 / 12 ILE A 168
THR A 105
VAL A  42
LEU A 158
LEU A  80
 None
ADP  A 506 ( 4.6A)
ADP  A 506 (-4.3A)
ADP  A 506 (-4.7A)
None
 1.33A 4qynA-4ysjA:
undetectable		 4qynA-4ysjA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 12 VAL A  42
ALA A  55
LYS A  57
GLU A  76
THR A 105
LEU A 158
 ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
ADP  A 506 ( 4.6A)
ADP  A 506 (-4.7A)
 0.51A 4r7iA-4ysjA:
22.4		 4r7iA-4ysjA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_A_TFPA203_1
(CALMODULIN)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 8 PHE A 427
ILE A 435
LEU A 440
MET A 477
 None
 0.67A 4rjdA-4ysjA:
10.4		 4rjdA-4ysjA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_A_TFPA203_1
(CALMODULIN)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 8 PHE A 427
ILE A 435
VAL A 469
MET A 477
 None
 0.30A 4rjdA-4ysjA:
10.4		 4rjdA-4ysjA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 6 LEU A  34
VAL A  42
ILE A  88
ILE A 170
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
None
None
 0.49A 4tyjA-4ysjA:
22.7		 4tyjA-4ysjA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 6 LEU A  34
VAL A  42
LYS A  57
ILE A  88
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-2.4A)
None
 0.72A 4tyjA-4ysjA:
22.7		 4tyjA-4ysjA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 10 LEU A  34
VAL A  42
GLU A  76
LEU A  83
ILE A  88
ILE A 170
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
None
None
None
None
 0.72A 4u0iA-4ysjA:
22.6		 4u0iA-4ysjA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 10 LEU A  34
VAL A  42
LEU A  83
ILE A  88
ARG A 150
ILE A 170
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
None
None
None
None
 0.79A 4u0iA-4ysjA:
22.6		 4u0iA-4ysjA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		7 / 12 ALA A  55
LYS A  57
LEU A  80
THR A 105
GLY A 111
HIS A 149
LEU A 158
 ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
ADP  A 506 ( 4.6A)
None
None
ADP  A 506 (-4.7A)
 0.68A 4u0iA-4ysjA:
22.6		 4u0iA-4ysjA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 6 ARG A  32
LEU A  34
ALA A  55
LEU A 158
 None
ADP  A 506 ( 3.8A)
ADP  A 506 (-3.3A)
ADP  A 506 (-4.7A)
 0.74A 4wboC-4ysjA:
27.1		 4wboC-4ysjA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		9 / 12 LEU A  34
ALA A  55
LYS A  57
GLU A  76
LEU A 103
THR A 105
GLY A 111
ASP A 115
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
ADP  A 506 ( 4.6A)
None
None
ADP  A 506 (-4.7A)
 0.99A 4wkqA-4ysjA:
25.2		 4wkqA-4ysjA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 5 LYS A 339
ARG A 343
LEU A 300
ASP A 296
 None
 1.45A 4xdtA-4ysjA:
undetectable		 4xdtA-4ysjA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 12 VAL A  42
ALA A  55
LYS A  57
THR A 105
ASP A 172
PHE A 173
 ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
ADP  A 506 ( 4.6A)
ADP  A 506 ( 2.4A)
None
 0.85A 4xv2A-4ysjA:
25.2		 4xv2A-4ysjA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 12 ALA A  55
LYS A  57
LEU A  80
THR A 105
ASP A 172
PHE A 173
 ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
ADP  A 506 ( 4.6A)
ADP  A 506 ( 2.4A)
None
 0.85A 4xv2B-4ysjA:
25.0		 4xv2B-4ysjA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 7 TRP A 251
PHE A 246
ARG A 263
VAL A 254
 None
 1.50A 5ad4A-4ysjA:
undetectable
5ad4B-4ysjA:
undetectable		 5ad4A-4ysjA:
20.98
5ad4B-4ysjA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD8_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 6 TRP A 251
PHE A 246
ARG A 263
VAL A 254
 None
 1.50A 5ad8A-4ysjA:
undetectable
5ad8B-4ysjA:
undetectable		 5ad8A-4ysjA:
20.98
5ad8B-4ysjA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADB_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 6 TRP A 251
PHE A 246
ARG A 263
VAL A 254
 None
 1.48A 5adbA-4ysjA:
undetectable
5adbB-4ysjA:
undetectable		 5adbA-4ysjA:
20.98
5adbB-4ysjA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ARF_A_SAMA1002_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		5 / 12 GLY A 348
ARG A 133
HIS A  85
ASN A 167
TYR A 401
 None
 1.30A 5arfA-4ysjA:
1.8		 5arfA-4ysjA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		8 / 12 LEU A  34
VAL A  42
ALA A  55
LYS A  57
GLU A  76
THR A 105
GLY A 111
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
ADP  A 506 ( 4.6A)
None
ADP  A 506 (-4.7A)
 0.80A 5bvwA-4ysjA:
22.7		 5bvwA-4ysjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 12 VAL A  42
ALA A  55
LYS A  57
LEU A  80
THR A 105
PHE A 173
 ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
ADP  A 506 ( 4.6A)
None
 0.82A 5cswA-4ysjA:
24.9		 5cswA-4ysjA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 12 VAL A  42
ALA A  55
LYS A  57
LEU A  80
THR A 105
PHE A 173
 ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
ADP  A 506 ( 4.6A)
None
 0.85A 5cswB-4ysjA:
25.0		 5cswB-4ysjA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0O_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 7 TRP A 251
PHE A 246
ARG A 263
VAL A 254
 None
 1.49A 5g0oA-4ysjA:
undetectable
5g0oB-4ysjA:
undetectable		 5g0oA-4ysjA:
20.00
5g0oB-4ysjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 12 LEU A  34
VAL A  42
ALA A  55
THR A 105
GLY A 111
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 ( 4.6A)
None
ADP  A 506 (-4.7A)
 1.09A 5h2uA-4ysjA:
23.8		 5h2uA-4ysjA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 12 VAL A  42
ALA A  55
LYS A  57
THR A 105
ASP A 115
GLY A 174
 ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
ADP  A 506 ( 4.6A)
None
None
 1.07A 5hesB-4ysjA:
23.8		 5hesB-4ysjA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 12 ALA A  55
LYS A  57
GLU A  76
LEU A  80
THR A 105
HIS A 149
 ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
ADP  A 506 ( 4.6A)
None
 0.80A 5hi2A-4ysjA:
25.1		 5hi2A-4ysjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 8 THR A 245
CYH A 224
TYR A 218
LEU A 248
 None
 1.47A 5kxiA-4ysjA:
2.1
5kxiB-4ysjA:
2.1		 5kxiA-4ysjA:
20.48
5kxiB-4ysjA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 11 LEU A  34
GLY A  35
VAL A  42
ALA A  55
GLU A 112
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.5A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-3.5A)
ADP  A 506 (-4.7A)
 0.48A 5lvnA-4ysjA:
31.5		 5lvnA-4ysjA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		8 / 12 GLY A  35
VAL A  42
ALA A  55
LYS A  57
GLU A  76
GLY A 111
GLU A 112
ILE A 171
 ADP  A 506 (-3.5A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
ADP  A 506 (-3.5A)
ADP  A 506 (-4.5A)
 0.63A 5mafA-4ysjA:
31.2		 5mafA-4ysjA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		5 / 10 LEU A  34
VAL A  42
LYS A  57
GLU A  76
GLY A 111
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-2.4A)
None
None
 0.70A 5mo4A-4ysjA:
19.0		 5mo4A-4ysjA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 8 ALA A  55
GLU A  76
LEU A 158
ASP A 172
 ADP  A 506 (-3.3A)
None
ADP  A 506 (-4.7A)
ADP  A 506 ( 2.4A)
 0.60A 5owrA-4ysjA:
24.7		 5owrA-4ysjA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 7 TRP A 251
PHE A 246
ARG A 263
VAL A 254
 None
 1.50A 5untA-4ysjA:
undetectable
5untB-4ysjA:
undetectable		 5untA-4ysjA:
20.98
5untB-4ysjA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNU_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 7 TRP A 251
PHE A 246
ARG A 263
VAL A 254
 None
 1.49A 5unuA-4ysjA:
undetectable
5unuB-4ysjA:
undetectable		 5unuA-4ysjA:
20.98
5unuB-4ysjA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 7 TRP A 251
PHE A 246
ARG A 263
VAL A 254
 None
 1.49A 5unwA-4ysjA:
1.1
5unwB-4ysjA:
undetectable		 5unwA-4ysjA:
20.98
5unwB-4ysjA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 6 TRP A 251
PHE A 246
ARG A 263
VAL A 254
 None
 1.48A 5unxA-4ysjA:
1.0
5unxB-4ysjA:
undetectable		 5unxA-4ysjA:
20.98
5unxB-4ysjA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO4_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 7 TRP A 251
PHE A 246
ARG A 263
VAL A 254
 None
 1.50A 5uo4A-4ysjA:
undetectable
5uo4B-4ysjA:
undetectable		 5uo4A-4ysjA:
19.41
5uo4B-4ysjA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 12 LEU A  34
ALA A  55
LYS A  57
GLU A  76
LEU A 103
GLY A 111
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
None
 1.33A 5vcvA-4ysjA:
27.9		 5vcvA-4ysjA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 12 LEU A  34
ALA A  55
LYS A  57
GLU A  76
LEU A 103
THR A 105
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
ADP  A 506 ( 4.6A)
 0.64A 5vcvA-4ysjA:
27.9		 5vcvA-4ysjA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		7 / 12 LEU A  34
VAL A  42
ALA A  55
LYS A  57
GLU A  76
LEU A 103
THR A 105
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
ADP  A 506 ( 4.6A)
 0.63A 5vcyA-4ysjA:
27.6		 5vcyA-4ysjA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUR_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 7 TRP A 251
PHE A 246
ARG A 263
VAL A 254
 None
 1.50A 5vurA-4ysjA:
undetectable
5vurB-4ysjA:
undetectable		 5vurA-4ysjA:
20.98
5vurB-4ysjA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUV_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 7 ARG A 263
VAL A 254
TRP A 251
PHE A 246
 None
 1.50A 5vuvA-4ysjA:
undetectable
5vuvB-4ysjA:
undetectable		 5vuvA-4ysjA:
19.41
5vuvB-4ysjA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 6 TRP A 251
PHE A 246
ARG A 263
VAL A 254
 None
 1.49A 5vuxA-4ysjA:
undetectable
5vuxB-4ysjA:
undetectable		 5vuxA-4ysjA:
19.41
5vuxB-4ysjA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUY_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 7 TRP A 251
PHE A 246
ARG A 263
VAL A 254
 None
 1.44A 5vuyA-4ysjA:
undetectable
5vuyB-4ysjA:
undetectable		 5vuyA-4ysjA:
19.41
5vuyB-4ysjA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		8 / 12 ARG A  32
LEU A  34
VAL A  42
ALA A  55
LYS A  57
GLU A  76
GLY A 111
LEU A 158
 None
ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
ADP  A 506 (-4.7A)
 0.98A 5y7zA-4ysjA:
25.9		 5y7zA-4ysjA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		8 / 12 ARG A  32
LEU A  34
VAL A  42
ALA A  55
LYS A  57
GLU A  76
GLY A 111
LEU A 158
 None
ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
ADP  A 506 (-4.7A)
 0.98A 5y7zA-4ysjA:
25.9		 5y7zA-4ysjA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		7 / 12 LEU A  34
ALA A  55
LYS A  57
GLU A  76
GLY A 111
LEU A 158
ASP A 172
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
ADP  A 506 (-4.7A)
ADP  A 506 ( 2.4A)
 0.90A 5y7zB-4ysjA:
18.7		 5y7zB-4ysjA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		9 / 12 LEU A  34
VAL A  42
ALA A  55
LYS A  57
GLU A  76
THR A 105
GLY A 111
LEU A 158
ASP A 172
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
ADP  A 506 ( 4.6A)
None
ADP  A 506 (-4.7A)
ADP  A 506 ( 2.4A)
 0.84A 5y80A-4ysjA:
25.1		 5y80A-4ysjA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 8 VAL A  42
LYS A  57
ILE A 171
ASP A 172
 ADP  A 506 (-4.3A)
ADP  A 506 (-2.4A)
ADP  A 506 (-4.5A)
ADP  A 506 ( 2.4A)
 0.46A 5y9mX-4ysjA:
27.1		 5y9mX-4ysjA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 7 VAL A  42
LYS A  57
ILE A 171
ASP A 172
 ADP  A 506 (-4.3A)
ADP  A 506 (-2.4A)
ADP  A 506 (-4.5A)
ADP  A 506 ( 2.4A)
 0.62A 5yf9B-4ysjA:
20.2		 5yf9B-4ysjA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 7 VAL A  42
LYS A  57
ILE A 171
ASP A 172
 ADP  A 506 (-4.3A)
ADP  A 506 (-2.4A)
ADP  A 506 (-4.5A)
ADP  A 506 ( 2.4A)
 0.54A 5ywmX-4ysjA:
27.6		 5ywmX-4ysjA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		6 / 12 LEU A  34
VAL A  42
ALA A  55
LYS A  57
GLU A  76
GLY A 111
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
 0.49A 5zv2B-4ysjA:
22.5		 5zv2B-4ysjA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV1_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		4 / 7 TRP A 251
PHE A 246
ARG A 263
VAL A 254
 None
 1.49A 6av1A-4ysjA:
undetectable
6av1B-4ysjA:
undetectable		 6av1A-4ysjA:
9.31
6av1B-4ysjA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		5 / 12 ILE A 139
SER A 212
LEU A  83
ILE A 216
LEU A 157
 None
 1.07A 6dwnC-4ysjA:
undetectable		 6dwnC-4ysjA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE
(Eimeria
tenella) 		3 / 3 TYR A 141
ASP A 349
GLN A 351
 None
CA  A 501 (-2.7A)
None
 0.97A 6g1pA-4ysjA:
undetectable		 6g1pA-4ysjA:
21.63