SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ysl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
4 / 6 HIS A 236
GLY A 178
ALA A 180
TYR A 177
None
None
GSH  A 302 (-3.5A)
None
0.89A 1dmaB-4yslA:
undetectable
1dmaB-4yslA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
5 / 12 SER A 155
LEU A 208
VAL A 227
VAL A 166
ALA A 201
None
1.02A 1q23H-4yslA:
undetectable
1q23I-4yslA:
undetectable
1q23H-4yslA:
18.67
1q23I-4yslA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
4 / 6 LEU A 172
GLY A 178
HIS A 236
ILE A 237
None
0.88A 1xf1B-4yslA:
undetectable
1xf1B-4yslA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
5 / 11 ILE A 100
HIS A 149
ASP A 170
HIS A  76
GLY A 169
None
FE  A 301 ( 3.5A)
FE  A 301 ( 3.1A)
None
None
1.17A 1zz1A-4yslA:
undetectable
1zz1A-4yslA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
5 / 12 ILE A  96
HIS A 149
ASP A 170
HIS A  76
GLY A 169
None
FE  A 301 ( 3.5A)
FE  A 301 ( 3.1A)
None
None
1.19A 1zz1B-4yslA:
undetectable
1zz1C-4yslA:
undetectable
1zz1B-4yslA:
27.27
1zz1C-4yslA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
4 / 6 PHE A 124
ILE A 100
VAL A 103
ALA A 152
None
1.01A 2j5mA-4yslA:
undetectable
2j5mA-4yslA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
5 / 12 LEU A 192
ALA A 187
ASP A 254
PHE A 173
HIS A 212
None
None
None
GSH  A 302 ( 4.9A)
GSH  A 302 ( 4.8A)
1.40A 2qo4A-4yslA:
undetectable
2qo4A-4yslA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
4 / 8 ASN A 234
ILE A 235
ASP A 176
ARG A 219
None
1.10A 2v57A-4yslA:
undetectable
2v57A-4yslA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
4 / 8 SER A 233
ASN A 234
ASP A 176
ARG A 219
None
0.92A 2v57A-4yslA:
undetectable
2v57A-4yslA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
4 / 8 ASN A 234
ILE A 235
ASP A 176
ARG A 219
None
1.11A 2v57C-4yslA:
undetectable
2v57C-4yslA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
4 / 8 SER A 233
ASN A 234
ASP A 176
ARG A 219
None
0.93A 2v57C-4yslA:
undetectable
2v57C-4yslA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
5 / 8 HIS A  74
HIS A  76
ASP A 170
HIS A 212
GLY A 169
FE  A 301 (-3.4A)
None
FE  A 301 ( 3.1A)
GSH  A 302 ( 4.8A)
None
1.43A 3c0zB-4yslA:
undetectable
3c0zB-4yslA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
4 / 6 ASP A 183
HIS A  74
HIS A 149
ASP A  78
None
FE  A 301 (-3.4A)
FE  A 301 ( 3.5A)
GSH  A 302 ( 4.4A)
0.85A 3c0zC-4yslA:
undetectable
3c0zC-4yslA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_1
(YAEB-LIKE PROTEIN
RPA0152)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
4 / 5 HIS A 212
SER A  21
ASP A  40
THR A  17
GSH  A 302 ( 4.8A)
None
None
None
1.20A 3okxA-4yslA:
undetectable
3okxA-4yslA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_2
(YAEB-LIKE PROTEIN
RPA0152)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
4 / 5 HIS A 212
SER A  21
ASP A  40
THR A  17
GSH  A 302 ( 4.8A)
None
None
None
1.21A 3okxB-4yslA:
undetectable
3okxB-4yslA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_A_ACRA1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
5 / 12 ASP A  78
ILE A  35
ASP A  36
ASP A 170
PHE A 173
GSH  A 302 ( 4.4A)
None
None
FE  A 301 ( 3.1A)
GSH  A 302 ( 4.9A)
1.42A 3topA-4yslA:
undetectable
3topA-4yslA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
5 / 12 THR A 146
SER A 155
LEU A 208
VAL A 166
ALA A 201
None
1.38A 3u9fD-4yslA:
undetectable
3u9fE-4yslA:
undetectable
3u9fD-4yslA:
18.67
3u9fE-4yslA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
3 / 3 GLU A  15
TYR A  13
SER A  18
None
0.88A 4at0A-4yslA:
undetectable
4at0A-4yslA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
4 / 6 HIS A  79
HIS A  74
ASP A  10
ASP A  36
None
FE  A 301 (-3.4A)
None
None
1.40A 4blvA-4yslA:
undetectable
4blvA-4yslA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
5 / 10 HIS A  74
HIS A  76
ASP A 170
HIS A 212
GLY A 169
FE  A 301 (-3.4A)
None
FE  A 301 ( 3.1A)
GSH  A 302 ( 4.8A)
None
1.45A 4bz6A-4yslA:
undetectable
4bz6A-4yslA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
5 / 12 HIS A  74
HIS A  76
ASP A 170
HIS A 212
GLY A 169
FE  A 301 (-3.4A)
None
FE  A 301 ( 3.1A)
GSH  A 302 ( 4.8A)
None
1.44A 4bz6A-4yslA:
undetectable
4bz6B-4yslA:
undetectable
4bz6A-4yslA:
23.21
4bz6B-4yslA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
5 / 12 HIS A 149
GLY A 169
HIS A  76
ASP A  78
HIS A  79
FE  A 301 ( 3.5A)
None
None
GSH  A 302 ( 4.4A)
None
1.28A 4bz6C-4yslA:
undetectable
4bz6C-4yslA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_D_SHHD700_1
(HISTONE DEACETYLASE
8)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
5 / 10 HIS A  74
HIS A  76
ASP A 170
HIS A 212
GLY A 169
FE  A 301 (-3.4A)
None
FE  A 301 ( 3.1A)
GSH  A 302 ( 4.8A)
None
1.46A 4bz6D-4yslA:
undetectable
4bz6D-4yslA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
4 / 7 ASP A  78
ASP A  40
GLU A  72
ASP A  14
GSH  A 302 ( 4.4A)
None
None
None
1.13A 4feuB-4yslA:
undetectable
4feuB-4yslA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
4 / 8 ASP A  78
ASP A  40
GLU A  72
ASP A  14
GSH  A 302 ( 4.4A)
None
None
None
1.15A 4feuF-4yslA:
undetectable
4feuF-4yslA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
4 / 7 ASP A  78
ASP A  40
GLU A  72
ASP A  14
GSH  A 302 ( 4.4A)
None
None
None
1.16A 4fevD-4yslA:
undetectable
4fevD-4yslA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
4 / 7 ASP A  78
ASP A  40
GLU A  72
ASP A  14
GSH  A 302 ( 4.4A)
None
None
None
1.16A 4fevF-4yslA:
undetectable
4fevF-4yslA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
4 / 8 ASP A  78
ASP A  40
GLU A  72
ASP A  14
GSH  A 302 ( 4.4A)
None
None
None
1.18A 4fewD-4yslA:
undetectable
4fewD-4yslA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
4 / 8 ASP A  78
ASP A  40
GLU A  72
ASP A  14
GSH  A 302 ( 4.4A)
None
None
None
1.16A 4fewF-4yslA:
undetectable
4fewF-4yslA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
4 / 7 ASP A  78
ASP A  40
GLU A  72
ASP A  14
GSH  A 302 ( 4.4A)
None
None
None
1.18A 4fexB-4yslA:
undetectable
4fexB-4yslA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
4 / 8 ASP A  78
ASP A  40
GLU A  72
ASP A  14
GSH  A 302 ( 4.4A)
None
None
None
1.20A 4gkhB-4yslA:
undetectable
4gkhB-4yslA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
4 / 8 ASP A  78
ASP A  40
GLU A  72
ASP A  14
GSH  A 302 ( 4.4A)
None
None
None
1.16A 4gkhF-4yslA:
undetectable
4gkhF-4yslA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
4 / 7 ASP A  78
ASP A  40
GLU A  72
ASP A  14
GSH  A 302 ( 4.4A)
None
None
None
1.17A 4gkhG-4yslA:
undetectable
4gkhG-4yslA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
4 / 8 ASP A  78
ASP A  40
GLU A  72
ASP A  14
GSH  A 302 ( 4.4A)
None
None
None
1.17A 4gkiA-4yslA:
undetectable
4gkiA-4yslA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
4 / 8 ASP A  78
ASP A  40
GLU A  72
ASP A  14
GSH  A 302 ( 4.4A)
None
None
None
1.15A 4gkiE-4yslA:
undetectable
4gkiG-4yslA:
undetectable
4gkiE-4yslA:
21.24
4gkiG-4yslA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
4 / 7 ASP A  78
THR A  17
SER A 266
HIS A  79
GSH  A 302 ( 4.4A)
None
None
None
1.30A 4o4dA-4yslA:
undetectable
4o4dA-4yslA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
5 / 12 PRO A 151
ILE A 263
VAL A 106
VAL A 103
LEU A 264
None
1.23A 5bykA-4yslA:
undetectable
5bykA-4yslA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
4 / 6 GLY A 148
THR A 150
SER A 195
HIS A 145
None
1.06A 5ewuB-4yslA:
undetectable
5ewuB-4yslA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
4 / 5 ILE A 100
LEU A 110
GLY A 108
PHE A 107
None
0.95A 5kmdC-4yslA:
undetectable
5kmdD-4yslA:
undetectable
5kmdC-4yslA:
21.17
5kmdD-4yslA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
5 / 6 ASP A 170
HIS A 149
HIS A  74
HIS A 212
HIS A  79
FE  A 301 ( 3.1A)
FE  A 301 ( 3.5A)
FE  A 301 (-3.4A)
GSH  A 302 ( 4.8A)
None
1.29A 5ncdA-4yslA:
undetectable
5ncdD-4yslA:
undetectable
5ncdA-4yslA:
21.97
5ncdD-4yslA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
5 / 6 HIS A  79
ASP A 170
HIS A 149
HIS A  74
HIS A 212
None
FE  A 301 ( 3.1A)
FE  A 301 ( 3.5A)
FE  A 301 (-3.4A)
GSH  A 302 ( 4.8A)
1.28A 5ncdB-4yslA:
undetectable
5ncdC-4yslA:
undetectable
5ncdB-4yslA:
21.97
5ncdC-4yslA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
3 / 3 HIS A 212
ASP A  78
HIS A  79
GSH  A 302 ( 4.8A)
GSH  A 302 ( 4.4A)
None
0.78A 5oexA-4yslA:
undetectable
5oexA-4yslA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
3 / 3 HIS A 149
HIS A  74
HIS A  76
FE  A 301 ( 3.5A)
FE  A 301 (-3.4A)
None
1.01A 5oexA-4yslA:
undetectable
5oexA-4yslA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
3 / 3 HIS A 212
ASP A  78
HIS A  79
GSH  A 302 ( 4.8A)
GSH  A 302 ( 4.4A)
None
0.77A 5oexB-4yslA:
undetectable
5oexB-4yslA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
3 / 3 HIS A 212
ASP A  78
HIS A  79
GSH  A 302 ( 4.8A)
GSH  A 302 ( 4.4A)
None
0.75A 5oexC-4yslA:
undetectable
5oexC-4yslA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
3 / 3 HIS A 212
ASP A  78
HIS A  79
GSH  A 302 ( 4.8A)
GSH  A 302 ( 4.4A)
None
0.72A 5oexD-4yslA:
undetectable
5oexD-4yslA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida)
3 / 3 ARG A 250
PHE A 184
PHE A 173
GSH  A 302 (-3.3A)
None
GSH  A 302 ( 4.9A)
1.01A 6nknC-4yslA:
undetectable
6nknJ-4yslA:
undetectable
6nknC-4yslA:
20.31
6nknJ-4yslA:
12.01