SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yt2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4yt2 H(2)-FORMING
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE-RELATE
D PROTEIN MJ1338
(Methanocaldococc
us
jannaschii) 		4 / 5 ASP A  86
PRO A 101
ALA A 105
ILE A 109
 None
 0.96A 2aofB-4yt2A:
undetectable		 2aofB-4yt2A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 4yt2 H(2)-FORMING
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE-RELATE
D PROTEIN MJ1338
(Methanocaldococc
us
jannaschii) 		4 / 9 ILE A 264
ALA A 256
VAL A 259
GLU A 260
 None
 0.70A 2vufA-4yt2A:
3.1		 2vufA-4yt2A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_A_GW6A1_1
(GLUCOCORTICOID
RECEPTOR)		 4yt2 H(2)-FORMING
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE-RELATE
D PROTEIN MJ1338
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  20
GLN A  22
LEU A  31
CYH A 127
THR A 128
 None
None
None
PEG  A 404 (-3.6A)
None
 1.20A 3cldA-4yt2A:
undetectable		 3cldA-4yt2A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 4yt2 H(2)-FORMING
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE-RELATE
D PROTEIN MJ1338
(Methanocaldococc
us
jannaschii) 		5 / 12 HIS A 155
SER A 153
THR A 126
PHE A 351
LEU A 134
 None
 1.19A 3fzgA-4yt2A:
undetectable		 3fzgA-4yt2A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 4yt2 H(2)-FORMING
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE-RELATE
D PROTEIN MJ1338
(Methanocaldococc
us
jannaschii) 		4 / 7 TYR A  41
LYS A  34
GLU A  33
PRO A  32
 None
 1.19A 3hs4A-4yt2A:
undetectable		 3hs4A-4yt2A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 4yt2 H(2)-FORMING
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE-RELATE
D PROTEIN MJ1338
(Methanocaldococc
us
jannaschii) 		4 / 6 PHE A 102
PHE A  99
HIS A 155
THR A 128
 None
 1.23A 3lb3A-4yt2A:
undetectable		 3lb3A-4yt2A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4yt2 H(2)-FORMING
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE-RELATE
D PROTEIN MJ1338
(Methanocaldococc
us
jannaschii) 		5 / 12 GLU A  49
GLY A 161
THR A 162
VAL A  75
GLY A  43
 None
 1.01A 3sglA-4yt2A:
4.4		 3sglA-4yt2A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 4yt2 H(2)-FORMING
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE-RELATE
D PROTEIN MJ1338
(Methanocaldococc
us
jannaschii) 		4 / 8 ILE A 123
ALA A 110
VAL A 117
PRO A 118
 None
None
None
PEG  A 402 ( 4.6A)
 0.77A 4jltA-4yt2A:
undetectable		 4jltA-4yt2A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4yt2 H(2)-FORMING
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE-RELATE
D PROTEIN MJ1338
(Methanocaldococc
us
jannaschii) 		5 / 9 THR A 126
THR A 106
ALA A 110
GLY A  18
ASP A  86
 None
 1.07A 4qvmK-4yt2A:
undetectable
4qvmL-4yt2A:
undetectable		 4qvmK-4yt2A:
19.94
4qvmL-4yt2A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4yt2 H(2)-FORMING
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE-RELATE
D PROTEIN MJ1338
(Methanocaldococc
us
jannaschii) 		5 / 11 THR A 126
THR A 106
ALA A 110
GLY A  18
ASP A  86
 None
 1.07A 4qvwK-4yt2A:
undetectable
4qvwL-4yt2A:
undetectable		 4qvwK-4yt2A:
19.94
4qvwL-4yt2A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4yt2 H(2)-FORMING
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE-RELATE
D PROTEIN MJ1338
(Methanocaldococc
us
jannaschii) 		5 / 11 THR A 126
THR A 106
ALA A 110
GLY A  18
ASP A  86
 None
 1.07A 4qvwY-4yt2A:
undetectable
4qvwZ-4yt2A:
undetectable		 4qvwY-4yt2A:
19.94
4qvwZ-4yt2A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4yt2 H(2)-FORMING
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE-RELATE
D PROTEIN MJ1338
(Methanocaldococc
us
jannaschii) 		5 / 10 THR A 126
THR A 106
ALA A 110
GLY A  18
ASP A  86
 None
 1.07A 4qw3K-4yt2A:
undetectable
4qw3L-4yt2A:
undetectable		 4qw3K-4yt2A:
19.94
4qw3L-4yt2A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4yt2 H(2)-FORMING
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE-RELATE
D PROTEIN MJ1338
(Methanocaldococc
us
jannaschii) 		4 / 5 ALA A 200
TYR A 168
HIS A  92
PHE A  50
 None
 1.15A 4ze2A-4yt2A:
undetectable		 4ze2A-4yt2A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4yt2 H(2)-FORMING
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE-RELATE
D PROTEIN MJ1338
(Methanocaldococc
us
jannaschii) 		5 / 9 SER A 208
GLY A 172
ALA A 200
VAL A 202
ILE A 186
 None
 1.05A 5i3cA-4yt2A:
undetectable		 5i3cA-4yt2A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_A_ACTA305_0
(CARBONIC ANHYDRASE 4)		 4yt2 H(2)-FORMING
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE-RELATE
D PROTEIN MJ1338
(Methanocaldococc
us
jannaschii) 		4 / 4 GLN A 185
VAL A 122
GLU A  94
ILE A  95
 None
None
PEG  A 402 ( 4.5A)
None
 1.16A 5jncA-4yt2A:
undetectable		 5jncA-4yt2A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4yt2 H(2)-FORMING
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE-RELATE
D PROTEIN MJ1338
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 113
PHE A  50
SER A 195
ILE A 170
ALA A 189
 None
 1.26A 5oy02-4yt2A:
undetectable		 5oy02-4yt2A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 4yt2 H(2)-FORMING
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE-RELATE
D PROTEIN MJ1338
(Methanocaldococc
us
jannaschii) 		4 / 8 GLU A  61
THR A 100
PRO A 101
ILE A 109
 None
 0.94A 6a4iA-4yt2A:
undetectable		 6a4iA-4yt2A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 4yt2 H(2)-FORMING
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE-RELATE
D PROTEIN MJ1338
(Methanocaldococc
us
jannaschii) 		5 / 10 GLY A  18
GLY A  20
GLU A  61
THR A 100
ILE A 109
 None
 0.96A 6exiA-4yt2A:
8.3		 6exiA-4yt2A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 4yt2 H(2)-FORMING
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE-RELATE
D PROTEIN MJ1338
(Methanocaldococc
us
jannaschii) 		5 / 10 GLY A  18
GLY A  20
GLU A  61
THR A 100
ILE A 109
 None
 0.98A 6exiB-4yt2A:
4.8		 6exiB-4yt2A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 4yt2 H(2)-FORMING
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE-RELATE
D PROTEIN MJ1338
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  18
GLY A  20
GLU A  61
THR A 100
ILE A 109
 None
 0.97A 6exiC-4yt2A:
4.8
6exiD-4yt2A:
4.8		 6exiC-4yt2A:
15.86
6exiD-4yt2A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 4yt2 H(2)-FORMING
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE-RELATE
D PROTEIN MJ1338
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  18
GLY A  20
GLU A  61
THR A 100
ILE A 109
 None
 0.98A 6exiC-4yt2A:
4.8
6exiD-4yt2A:
4.8		 6exiC-4yt2A:
15.86
6exiD-4yt2A:
15.86