SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yt9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 4yt9 PEPTIDYLARGININE
DEIMINASE
(Porphyromonas
gingivalis) 		4 / 4 ARG A  56
ALA A 136
ALA A 357
GLU A  62
 GOL  A 505 (-4.9A)
None
None
None
 1.23A 1e7bA-4yt9A:
1.8		 1e7bA-4yt9A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 4yt9 PEPTIDYLARGININE
DEIMINASE
(Porphyromonas
gingivalis) 		4 / 4 ARG A  56
ALA A 136
ALA A 357
GLU A  62
 GOL  A 505 (-4.9A)
None
None
None
 1.24A 1e7bB-4yt9A:
undetectable		 1e7bB-4yt9A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFT_B_HSMB177_1
(PROTEIN
(FEMALE-SPECIFIC
HISTAMINE BINDING
PROTEIN 2))		 4yt9 PEPTIDYLARGININE
DEIMINASE
(Porphyromonas
gingivalis) 		5 / 10 TYR A 243
VAL A 284
TYR A 270
ASP A 224
VAL A 193
 None
GOL  A 507 (-4.9A)
GOL  A 503 ( 3.9A)
None
None
 1.47A 1qftB-4yt9A:
0.0		 1qftB-4yt9A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFV_A_HSMA176_1
(PROTEIN
(FEMALE-SPECIFIC
HISTAMINE BINDING
PROTEIN 2))		 4yt9 PEPTIDYLARGININE
DEIMINASE
(Porphyromonas
gingivalis) 		5 / 10 TYR A 243
VAL A 284
TYR A 270
ASP A 224
VAL A 193
 None
GOL  A 507 (-4.9A)
GOL  A 503 ( 3.9A)
None
None
 1.49A 1qfvA-4yt9A:
0.0		 1qfvA-4yt9A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFV_B_HSMB176_1
(PROTEIN
(FEMALE-SPECIFIC
HISTAMINE BINDING
PROTEIN 2))		 4yt9 PEPTIDYLARGININE
DEIMINASE
(Porphyromonas
gingivalis) 		5 / 10 TYR A 243
VAL A 284
TYR A 270
ASP A 224
VAL A 193
 None
GOL  A 507 (-4.9A)
GOL  A 503 ( 3.9A)
None
None
 1.47A 1qfvB-4yt9A:
0.0		 1qfvB-4yt9A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 4yt9 PEPTIDYLARGININE
DEIMINASE
(Porphyromonas
gingivalis) 		5 / 12 TYR A 189
ASN A 247
ILE A 380
ILE A 437
LEU A 370
 None
GOL  A 506 ( 4.9A)
None
None
None
 1.22A 2bjfA-4yt9A:
undetectable		 2bjfA-4yt9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4yt9 PEPTIDYLARGININE
DEIMINASE
(Porphyromonas
gingivalis) 		5 / 7 HIS A 366
TYR A 449
TYR A 436
PRO A 450
TYR A 435
 None
None
None
GOL  A 506 (-4.3A)
None
 1.32A 2oldA-4yt9A:
7.1
2oldB-4yt9A:
6.0		 2oldA-4yt9A:
18.12
2oldB-4yt9A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 4yt9 PEPTIDYLARGININE
DEIMINASE
(Porphyromonas
gingivalis) 		4 / 7 ALA A 277
TYR A 367
TYR A 189
ASP A 187
 None
 1.19A 2pncA-4yt9A:
undetectable		 2pncA-4yt9A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 4yt9 PEPTIDYLARGININE
DEIMINASE
(Porphyromonas
gingivalis) 		3 / 3 TYR A 367
GLU A  62
ASP A 358
 None
 0.86A 3bxoB-4yt9A:
2.0		 3bxoB-4yt9A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G7X_A_HSMA174_1
(FEMALE-SPECIFIC
HISTAMINE-BINDING
PROTEIN 2)		 4yt9 PEPTIDYLARGININE
DEIMINASE
(Porphyromonas
gingivalis) 		5 / 10 TYR A 243
VAL A 284
TYR A 270
ASP A 224
VAL A 193
 None
GOL  A 507 (-4.9A)
GOL  A 503 ( 3.9A)
None
None
 1.47A 3g7xA-4yt9A:
0.0		 3g7xA-4yt9A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G7X_B_HSMB176_1
(FEMALE-SPECIFIC
HISTAMINE-BINDING
PROTEIN 2)		 4yt9 PEPTIDYLARGININE
DEIMINASE
(Porphyromonas
gingivalis) 		5 / 10 TYR A 243
VAL A 284
TYR A 270
ASP A 224
VAL A 193
 None
GOL  A 507 (-4.9A)
GOL  A 503 ( 3.9A)
None
None
 1.49A 3g7xB-4yt9A:
0.0		 3g7xB-4yt9A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4yt9 PEPTIDYLARGININE
DEIMINASE
(Porphyromonas
gingivalis) 		3 / 3 TYR A 367
ASP A 187
ASP A 224
 None
 0.93A 3ou6B-4yt9A:
undetectable		 3ou6B-4yt9A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 4yt9 PEPTIDYLARGININE
DEIMINASE
(Porphyromonas
gingivalis) 		5 / 12 VAL A  93
ALA A  94
PHE A 118
SER A  97
THR A  91
 None
 1.19A 4mm8A-4yt9A:
undetectable		 4mm8A-4yt9A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4yt9 PEPTIDYLARGININE
DEIMINASE
(Porphyromonas
gingivalis) 		4 / 7 VAL A 237
TRP A 240
ILE A 251
HIS A 222
 4GJ  A 239 ( 4.9A)
GOL  A 508 (-3.6A)
None
None
 1.20A 4xo7B-4yt9A:
undetectable		 4xo7B-4yt9A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4yt9 PEPTIDYLARGININE
DEIMINASE
(Porphyromonas
gingivalis) 		4 / 5 ALA A 136
ARG A  56
ALA A 357
GLU A  62
 None
GOL  A 505 (-4.9A)
None
None
 1.31A 5a06C-4yt9A:
undetectable
5a06D-4yt9A:
undetectable		 5a06C-4yt9A:
23.04
5a06D-4yt9A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_1
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 4yt9 PEPTIDYLARGININE
DEIMINASE
(Porphyromonas
gingivalis) 		5 / 12 GLN A 194
LEU A 177
TRP A 134
LEU A 218
ILE A 220
 None
 1.46A 5xprA-4yt9A:
undetectable		 5xprA-4yt9A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4yt9 PEPTIDYLARGININE
DEIMINASE
(Porphyromonas
gingivalis) 		3 / 3 GLN A 179
TRP A 134
VAL A 146
 None
 1.17A 6auuA-4yt9A:
undetectable		 6auuA-4yt9A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 4yt9 PEPTIDYLARGININE
DEIMINASE
(Porphyromonas
gingivalis) 		5 / 9 VAL A 193
HIS A 223
ILE A 300
LEU A 244
ASP A 238
 None
None
None
None
4GJ  A 351 ( 3.4A)
 1.42A 6c2mC-4yt9A:
undetectable		 6c2mC-4yt9A:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4yt9 PEPTIDYLARGININE
DEIMINASE
(Porphyromonas
gingivalis) 		4 / 6 THR A 123
PRO A  72
GLN A  98
ILE A  92
 None
 0.93A 6ef6A-4yt9A:
undetectable		 6ef6A-4yt9A:
21.88