SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yte'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	13GS_A_SASA211_1 (GLUTATHIONE S-TRANSFERASE)	4yte	H(2)-FORMING METHYLENETETRAHYDROM ETHANOPTERIN DEHYDROGENASE-RELATE D PROTEIN MJ0715 (Methanocaldococc us jannaschii)	5 / 10	TYR A 157 PRO A 189 VAL A 182 VAL A 191 ILE A 3	None	1.41A	13gsA-4yteA: undetectable	13gsA-4yteA: 20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QCA_A_FUAA221_1 (TYPE III CHLORAMPHENICOL ACETYLTRANSFERASE)	4yte	H(2)-FORMING METHYLENETETRAHYDROM ETHANOPTERIN DEHYDROGENASE-RELATE D PROTEIN MJ0715 (Methanocaldococc us jannaschii)	4 / 7	CYH A 113 THR A 115 SER A 141 LEU A 48	None	0.92A	1qcaA-4yteA: undetectable	1qcaA-4yteA: 22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1U72_A_MTXA188_1 (DIHYDROFOLATE REDUCTASE)	4yte	H(2)-FORMING METHYLENETETRAHYDROM ETHANOPTERIN DEHYDROGENASE-RELATE D PROTEIN MJ0715 (Methanocaldococc us jannaschii)	5 / 12	ALA A 99 LEU A 123 GLN A 174 LEU A 178 VAL A 86	None	1.16A	1u72A-4yteA: undetectable	1u72A-4yteA: 20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2H42_C_VIAC903_2 (CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE)	4yte	H(2)-FORMING METHYLENETETRAHYDROM ETHANOPTERIN DEHYDROGENASE-RELATE D PROTEIN MJ0715 (Methanocaldococc us jannaschii)	3 / 3	ASN A 176 ILE A 84 MET A 143	None	0.62A	2h42C-4yteA: undetectable	2h42C-4yteA: 18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IJ7_C_TPFC2471_1 (CYTOCHROME P450 121)	4yte	H(2)-FORMING METHYLENETETRAHYDROM ETHANOPTERIN DEHYDROGENASE-RELATE D PROTEIN MJ0715 (Methanocaldococc us jannaschii)	4 / 8	THR A 192 VAL A 191 ASN A 176 ALA A 170	None	1.16A	2ij7C-4yteA: undetectable	2ij7C-4yteA: 20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GWX_A_EPAA1_2 (PROTEIN (PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR-DELTA)))	4yte	H(2)-FORMING METHYLENETETRAHYDROM ETHANOPTERIN DEHYDROGENASE-RELATE D PROTEIN MJ0715 (Methanocaldococc us jannaschii)	5 / 12	THR A 115 THR A 89 ILE A 111 ILE A 84 LEU A 123	None	1.35A	3gwxA-4yteA: undetectable	3gwxA-4yteA: 20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KW2_B_ADNB300_1 (PROBABLE R-RNA METHYLTRANSFERASE)	4yte	H(2)-FORMING METHYLENETETRAHYDROM ETHANOPTERIN DEHYDROGENASE-RELATE D PROTEIN MJ0715 (Methanocaldococc us jannaschii)	5 / 11	ALA A 8 GLY A 31 SER A 49 LEU A 48 ALA A 36	None	1.13A	3kw2B-4yteA: 2.2	3kw2B-4yteA: 23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TNE_B_RITB401_2 (SECRETED ASPARTIC PROTEASE)	4yte	H(2)-FORMING METHYLENETETRAHYDROM ETHANOPTERIN DEHYDROGENASE-RELATE D PROTEIN MJ0715 (Methanocaldococc us jannaschii)	4 / 7	SER A 141 VAL A 182 ILE A 159 THR A 115	None	0.96A	3tneB-4yteA: undetectable	3tneB-4yteA: 18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W9T_B_W9TB504_1 (HEMOLYTIC LECTIN CEL-III)	4yte	H(2)-FORMING METHYLENETETRAHYDROM ETHANOPTERIN DEHYDROGENASE-RELATE D PROTEIN MJ0715 (Methanocaldococc us jannaschii)	4 / 5	GLU A 38 GLY A 34 TYR A 30 GLN A 11	None	1.34A	3w9tB-4yteA: undetectable	3w9tB-4yteA: 16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W9T_D_W9TD506_1 (HEMOLYTIC LECTIN CEL-III)	4yte	H(2)-FORMING METHYLENETETRAHYDROM ETHANOPTERIN DEHYDROGENASE-RELATE D PROTEIN MJ0715 (Methanocaldococc us jannaschii)	4 / 5	GLU A 38 GLY A 34 TYR A 30 GLN A 11	None	1.38A	3w9tD-4yteA: undetectable	3w9tD-4yteA: 16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HFP_B_15UB402_1 (PROTHROMBIN)	4yte	H(2)-FORMING METHYLENETETRAHYDROM ETHANOPTERIN DEHYDROGENASE-RELATE D PROTEIN MJ0715 (Methanocaldococc us jannaschii)	5 / 12	LEU A 87 ALA A 78 ILE A 94 GLY A 7 GLY A 9	None	1.17A	4hfpB-4yteA: undetectable	4hfpB-4yteA: 19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JLT_A_8PRA505_1 (CYTOCHROME P450 2B4)	4yte	H(2)-FORMING METHYLENETETRAHYDROM ETHANOPTERIN DEHYDROGENASE-RELATE D PROTEIN MJ0715 (Methanocaldococc us jannaschii)	4 / 8	ILE A 112 ALA A 99 VAL A 106 PRO A 107	None	0.80A	4jltA-4yteA: undetectable	4jltA-4yteA: 17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVL_K_BO2K301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	4yte	H(2)-FORMING METHYLENETETRAHYDROM ETHANOPTERIN DEHYDROGENASE-RELATE D PROTEIN MJ0715 (Methanocaldococc us jannaschii)	5 / 11	THR A 115 THR A 95 ALA A 99 GLY A 7 ASP A 75	None	1.02A	4qvlK-4yteA: undetectable 4qvlL-4yteA: undetectable	4qvlK-4yteA: 19.82 4qvlL-4yteA: 21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVL_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	4yte	H(2)-FORMING METHYLENETETRAHYDROM ETHANOPTERIN DEHYDROGENASE-RELATE D PROTEIN MJ0715 (Methanocaldococc us jannaschii)	5 / 11	THR A 115 THR A 95 ALA A 99 GLY A 7 ASP A 75	None	1.02A	4qvlY-4yteA: undetectable 4qvlZ-4yteA: undetectable	4qvlY-4yteA: 19.82 4qvlZ-4yteA: 21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVM_K_BO2K301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	4yte	H(2)-FORMING METHYLENETETRAHYDROM ETHANOPTERIN DEHYDROGENASE-RELATE D PROTEIN MJ0715 (Methanocaldococc us jannaschii)	5 / 9	THR A 115 THR A 95 ALA A 99 GLY A 7 ASP A 75	None	1.03A	4qvmK-4yteA: undetectable 4qvmL-4yteA: undetectable	4qvmK-4yteA: 19.82 4qvmL-4yteA: 21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVM_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	4yte	H(2)-FORMING METHYLENETETRAHYDROM ETHANOPTERIN DEHYDROGENASE-RELATE D PROTEIN MJ0715 (Methanocaldococc us jannaschii)	5 / 10	THR A 115 THR A 95 ALA A 99 GLY A 7 ASP A 75	None	1.03A	4qvmY-4yteA: undetectable 4qvmZ-4yteA: undetectable	4qvmY-4yteA: 19.82 4qvmZ-4yteA: 21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVP_K_BO2K301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	4yte	H(2)-FORMING METHYLENETETRAHYDROM ETHANOPTERIN DEHYDROGENASE-RELATE D PROTEIN MJ0715 (Methanocaldococc us jannaschii)	5 / 10	THR A 115 THR A 95 ALA A 99 GLY A 7 ASP A 75	None	1.04A	4qvpK-4yteA: undetectable 4qvpL-4yteA: undetectable	4qvpK-4yteA: 19.82 4qvpL-4yteA: 21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVP_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	4yte	H(2)-FORMING METHYLENETETRAHYDROM ETHANOPTERIN DEHYDROGENASE-RELATE D PROTEIN MJ0715 (Methanocaldococc us jannaschii)	5 / 10	THR A 115 THR A 95 ALA A 99 GLY A 7 ASP A 75	None	1.03A	4qvpY-4yteA: undetectable 4qvpZ-4yteA: undetectable	4qvpY-4yteA: 19.82 4qvpZ-4yteA: 21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVV_K_BO2K301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	4yte	H(2)-FORMING METHYLENETETRAHYDROM ETHANOPTERIN DEHYDROGENASE-RELATE D PROTEIN MJ0715 (Methanocaldococc us jannaschii)	4 / 8	THR A 115 THR A 95 GLY A 7 ASP A 75	None	0.72A	4qvvK-4yteA: undetectable 4qvvL-4yteA: undetectable	4qvvK-4yteA: 19.82 4qvvL-4yteA: 21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVV_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	4yte	H(2)-FORMING METHYLENETETRAHYDROM ETHANOPTERIN DEHYDROGENASE-RELATE D PROTEIN MJ0715 (Methanocaldococc us jannaschii)	4 / 8	THR A 115 THR A 95 GLY A 7 ASP A 75	None	0.71A	4qvvY-4yteA: undetectable 4qvvZ-4yteA: undetectable	4qvvY-4yteA: 19.82 4qvvZ-4yteA: 21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVW_K_BO2K301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	4yte	H(2)-FORMING METHYLENETETRAHYDROM ETHANOPTERIN DEHYDROGENASE-RELATE D PROTEIN MJ0715 (Methanocaldococc us jannaschii)	5 / 11	THR A 115 THR A 95 ALA A 99 GLY A 7 ASP A 75	None	1.02A	4qvwK-4yteA: undetectable 4qvwL-4yteA: undetectable	4qvwK-4yteA: 19.82 4qvwL-4yteA: 21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVW_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	4yte	H(2)-FORMING METHYLENETETRAHYDROM ETHANOPTERIN DEHYDROGENASE-RELATE D PROTEIN MJ0715 (Methanocaldococc us jannaschii)	5 / 11	THR A 115 THR A 95 ALA A 99 GLY A 7 ASP A 75	None	1.02A	4qvwY-4yteA: undetectable 4qvwZ-4yteA: undetectable	4qvwY-4yteA: 19.82 4qvwZ-4yteA: 21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVY_K_BO2K301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	4yte	H(2)-FORMING METHYLENETETRAHYDROM ETHANOPTERIN DEHYDROGENASE-RELATE D PROTEIN MJ0715 (Methanocaldococc us jannaschii)	5 / 10	THR A 115 THR A 95 ALA A 99 GLY A 7 ASP A 75	None	1.00A	4qvyK-4yteA: undetectable 4qvyL-4yteA: undetectable	4qvyK-4yteA: 19.82 4qvyL-4yteA: 21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVY_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	4yte	H(2)-FORMING METHYLENETETRAHYDROM ETHANOPTERIN DEHYDROGENASE-RELATE D PROTEIN MJ0715 (Methanocaldococc us jannaschii)	5 / 10	THR A 115 THR A 95 ALA A 99 GLY A 7 ASP A 75	None	0.99A	4qvyY-4yteA: undetectable 4qvyZ-4yteA: undetectable	4qvyY-4yteA: 19.82 4qvyZ-4yteA: 21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QW1_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	4yte	H(2)-FORMING METHYLENETETRAHYDROM ETHANOPTERIN DEHYDROGENASE-RELATE D PROTEIN MJ0715 (Methanocaldococc us jannaschii)	5 / 10	THR A 115 THR A 95 ALA A 99 GLY A 7 ASP A 75	None	1.04A	4qw1Y-4yteA: undetectable 4qw1Z-4yteA: undetectable	4qw1Y-4yteA: 19.82 4qw1Z-4yteA: 21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QW3_K_BO2K301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	4yte	H(2)-FORMING METHYLENETETRAHYDROM ETHANOPTERIN DEHYDROGENASE-RELATE D PROTEIN MJ0715 (Methanocaldococc us jannaschii)	5 / 10	THR A 115 THR A 95 ALA A 99 GLY A 7 ASP A 75	None	1.01A	4qw3K-4yteA: undetectable 4qw3L-4yteA: undetectable	4qw3K-4yteA: 19.82 4qw3L-4yteA: 21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QW3_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	4yte	H(2)-FORMING METHYLENETETRAHYDROM ETHANOPTERIN DEHYDROGENASE-RELATE D PROTEIN MJ0715 (Methanocaldococc us jannaschii)	5 / 10	THR A 115 THR A 95 ALA A 99 GLY A 7 ASP A 75	None	1.01A	4qw3Y-4yteA: undetectable 4qw3Z-4yteA: undetectable	4qw3Y-4yteA: 19.82 4qw3Z-4yteA: 21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5B6I_A_ADNA302_1 (FLUORINASE)	4yte	H(2)-FORMING METHYLENETETRAHYDROM ETHANOPTERIN DEHYDROGENASE-RELATE D PROTEIN MJ0715 (Methanocaldococc us jannaschii)	4 / 7	THR A 117 PRO A 119 THR A 120 SER A 142	None	1.20A	5b6iA-4yteA: undetectable	5b6iA-4yteA: 20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BXN_K_BO2K301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	4yte	H(2)-FORMING METHYLENETETRAHYDROM ETHANOPTERIN DEHYDROGENASE-RELATE D PROTEIN MJ0715 (Methanocaldococc us jannaschii)	5 / 11	THR A 115 THR A 95 ALA A 99 GLY A 7 ASP A 75	None	0.99A	5bxnK-4yteA: undetectable 5bxnL-4yteA: undetectable	5bxnK-4yteA: 19.82 5bxnL-4yteA: 21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BXN_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	4yte	H(2)-FORMING METHYLENETETRAHYDROM ETHANOPTERIN DEHYDROGENASE-RELATE D PROTEIN MJ0715 (Methanocaldococc us jannaschii)	5 / 11	THR A 115 THR A 95 ALA A 99 GLY A 7 ASP A 75	None	1.01A	5bxnY-4yteA: undetectable 5bxnZ-4yteA: undetectable	5bxnY-4yteA: 19.82 5bxnZ-4yteA: 21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ENT_C_MIYC901_1 (MULTIDRUG EFFLUX PUMP SUBUNIT ACRB,MULTIDRUG EFFLUX PUMP SUBUNIT ACRB)	4yte	H(2)-FORMING METHYLENETETRAHYDROM ETHANOPTERIN DEHYDROGENASE-RELATE D PROTEIN MJ0715 (Methanocaldococc us jannaschii)	5 / 9	SER A 184 GLN A 154 GLY A 34 ILE A 5 ALA A 8	None	1.33A	5entC-4yteA: undetectable	5entC-4yteA: 14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UAN_B_REAB503_1 (RETINOIC ACID RECEPTOR BETA)	4yte	H(2)-FORMING METHYLENETETRAHYDROM ETHANOPTERIN DEHYDROGENASE-RELATE D PROTEIN MJ0715 (Methanocaldococc us jannaschii)	5 / 12	ALA A 160 LEU A 123 ILE A 112 ILE A 111 LEU A 131	None	1.29A	5uanB-4yteA: undetectable	5uanB-4yteA: 17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EXI_A_ADNA503_0 (ADENOSYLHOMOCYSTEINA SE)	4yte	H(2)-FORMING METHYLENETETRAHYDROM ETHANOPTERIN DEHYDROGENASE-RELATE D PROTEIN MJ0715 (Methanocaldococc us jannaschii)	5 / 10	GLY A 7 GLY A 9 SER A 49 GLU A 50 ILE A 98	None	0.85A	6exiA-4yteA: 5.3	6exiA-4yteA: 21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EXI_B_ADNB503_1 (ADENOSYLHOMOCYSTEINA SE)	4yte	H(2)-FORMING METHYLENETETRAHYDROM ETHANOPTERIN DEHYDROGENASE-RELATE D PROTEIN MJ0715 (Methanocaldococc us jannaschii)	5 / 10	GLY A 7 GLY A 9 SER A 49 GLU A 50 ILE A 98	None	0.83A	6exiB-4yteA: 8.3	6exiB-4yteA: 21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EXI_C_ADNC503_0 (ADENOSYLHOMOCYSTEINA SE)	4yte	H(2)-FORMING METHYLENETETRAHYDROM ETHANOPTERIN DEHYDROGENASE-RELATE D PROTEIN MJ0715 (Methanocaldococc us jannaschii)	5 / 12	GLY A 7 GLY A 9 SER A 49 GLU A 50 ILE A 98	None	0.86A	6exiC-4yteA: 8.7 6exiD-4yteA: 8.5	6exiC-4yteA: 21.60 6exiD-4yteA: 21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EXI_D_ADND503_0 (ADENOSYLHOMOCYSTEINA SE)	4yte	H(2)-FORMING METHYLENETETRAHYDROM ETHANOPTERIN DEHYDROGENASE-RELATE D PROTEIN MJ0715 (Methanocaldococc us jannaschii)	5 / 12	GLY A 7 GLY A 9 SER A 49 GLU A 50 ILE A 98	None	0.84A	6exiC-4yteA: 8.7 6exiD-4yteA: 8.5	6exiC-4yteA: 21.60 6exiD-4yteA: 21.60

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["13GS_A_SASA211_1","GLUTATHIONE S-TRANSFERASE","4yte","H(2)-FORMING METHYLENETETRAHYDROMETHANOPTERIN DEHYDROGENASE-RELATED PROTEIN MJ0715","Methanocaldococcus jannaschii",5,"TYR A 157;PRO A 189;VAL A 182;VAL A 191;ILE A   3","None","1.41A","13gsA-4yteA:undetectable","13gsA-4yteA:20.45"],["1QCA_A_FUAA221_1","TYPE III CHLORAMPHENICOL ACETYLTRANSFERASE","4yte","H(2)-FORMING METHYLENETETRAHYDROMETHANOPTERIN DEHYDROGENASE-RELATED PROTEIN MJ0715","Methanocaldococcus jannaschii",4,"CYH A 113;THR A 115;SER A 141;LEU A  48","None","0.92A","1qcaA-4yteA:undetectable","1qcaA-4yteA:22.03"],["1U72_A_MTXA188_1","DIHYDROFOLATE REDUCTASE","4yte","H(2)-FORMING METHYLENETETRAHYDROMETHANOPTERIN DEHYDROGENASE-RELATED PROTEIN MJ0715","Methanocaldococcus jannaschii",5,"ALA A  99;LEU A 123;GLN A 174;LEU A 178;VAL A  86","None","1.16A","1u72A-4yteA:undetectable","1u72A-4yteA:20.48"],["2H42_C_VIAC903_2","CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE","4yte","H(2)-FORMING METHYLENETETRAHYDROMETHANOPTERIN DEHYDROGENASE-RELATED PROTEIN MJ0715","Methanocaldococcus jannaschii",3,"ASN A 176;ILE A  84;MET A 143","None","0.62A","2h42C-4yteA:undetectable","2h42C-4yteA:18.15"],["2IJ7_C_TPFC2471_1","CYTOCHROME P450 121","4yte","H(2)-FORMING METHYLENETETRAHYDROMETHANOPTERIN DEHYDROGENASE-RELATED PROTEIN MJ0715","Methanocaldococcus jannaschii",4,"THR A 192;VAL A 191;ASN A 176;ALA A 170","None","1.16A","2ij7C-4yteA:undetectable","2ij7C-4yteA:20.84"],["3GWX_A_EPAA1_2","PROTEIN (PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR-DELTA))","4yte","H(2)-FORMING METHYLENETETRAHYDROMETHANOPTERIN DEHYDROGENASE-RELATED PROTEIN MJ0715","Methanocaldococcus jannaschii",5,"THR A 115;THR A  89;ILE A 111;ILE A  84;LEU A 123","None","1.35A","3gwxA-4yteA:undetectable","3gwxA-4yteA:20.22"],["3KW2_B_ADNB300_1","PROBABLE R-RNA METHYLTRANSFERASE","4yte","H(2)-FORMING METHYLENETETRAHYDROMETHANOPTERIN DEHYDROGENASE-RELATED PROTEIN MJ0715","Methanocaldococcus jannaschii",5,"ALA A   8;GLY A  31;SER A  49;LEU A  48;ALA A  36","None","1.13A","3kw2B-4yteA:2.2","3kw2B-4yteA:23.46"],["3TNE_B_RITB401_2","SECRETED ASPARTIC PROTEASE","4yte","H(2)-FORMING METHYLENETETRAHYDROMETHANOPTERIN DEHYDROGENASE-RELATED PROTEIN MJ0715","Methanocaldococcus jannaschii",4,"SER A 141;VAL A 182;ILE A 159;THR A 115","None","0.96A","3tneB-4yteA:undetectable","3tneB-4yteA:18.29"],["3W9T_B_W9TB504_1","HEMOLYTIC LECTIN CEL-III","4yte","H(2)-FORMING METHYLENETETRAHYDROMETHANOPTERIN DEHYDROGENASE-RELATED PROTEIN MJ0715","Methanocaldococcus jannaschii",4,"GLU A  38;GLY A  34;TYR A  30;GLN A  11","None","1.34A","3w9tB-4yteA:undetectable","3w9tB-4yteA:16.74"],["3W9T_D_W9TD506_1","HEMOLYTIC LECTIN CEL-III","4yte","H(2)-FORMING METHYLENETETRAHYDROMETHANOPTERIN DEHYDROGENASE-RELATED PROTEIN MJ0715","Methanocaldococcus jannaschii",4,"GLU A  38;GLY A  34;TYR A  30;GLN A  11","None","1.38A","3w9tD-4yteA:undetectable","3w9tD-4yteA:16.74"],["4HFP_B_15UB402_1","PROTHROMBIN","4yte","H(2)-FORMING METHYLENETETRAHYDROMETHANOPTERIN DEHYDROGENASE-RELATED PROTEIN MJ0715","Methanocaldococcus jannaschii",5,"LEU A  87;ALA A  78;ILE A  94;GLY A   7;GLY A   9","None","1.17A","4hfpB-4yteA:undetectable","4hfpB-4yteA:19.53"],["4JLT_A_8PRA505_1","CYTOCHROME P450 2B4","4yte","H(2)-FORMING METHYLENETETRAHYDROMETHANOPTERIN DEHYDROGENASE-RELATED PROTEIN MJ0715","Methanocaldococcus jannaschii",4,"ILE A 112;ALA A  99;VAL A 106;PRO A 107","None","0.80A","4jltA-4yteA:undetectable","4jltA-4yteA:17.92"],["4QVL_K_BO2K301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","4yte","H(2)-FORMING METHYLENETETRAHYDROMETHANOPTERIN DEHYDROGENASE-RELATED PROTEIN MJ0715","Methanocaldococcus jannaschii",5,"THR A 115;THR A  95;ALA A  99;GLY A   7;ASP A  75","None","1.02A","4qvlK-4yteA:undetectable;4qvlL-4yteA:undetectable","4qvlK-4yteA:19.82;4qvlL-4yteA:21.34"],["4QVL_Y_BO2Y301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","4yte","H(2)-FORMING METHYLENETETRAHYDROMETHANOPTERIN DEHYDROGENASE-RELATED PROTEIN MJ0715","Methanocaldococcus jannaschii",5,"THR A 115;THR A  95;ALA A  99;GLY A   7;ASP A  75","None","1.02A","4qvlY-4yteA:undetectable;4qvlZ-4yteA:undetectable","4qvlY-4yteA:19.82;4qvlZ-4yteA:21.34"],["4QVM_K_BO2K301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","4yte","H(2)-FORMING METHYLENETETRAHYDROMETHANOPTERIN DEHYDROGENASE-RELATED PROTEIN MJ0715","Methanocaldococcus jannaschii",5,"THR A 115;THR A  95;ALA A  99;GLY A   7;ASP A  75","None","1.03A","4qvmK-4yteA:undetectable;4qvmL-4yteA:undetectable","4qvmK-4yteA:19.82;4qvmL-4yteA:21.34"],["4QVM_Y_BO2Y301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","4yte","H(2)-FORMING METHYLENETETRAHYDROMETHANOPTERIN DEHYDROGENASE-RELATED PROTEIN MJ0715","Methanocaldococcus jannaschii",5,"THR A 115;THR A  95;ALA A  99;GLY A   7;ASP A  75","None","1.03A","4qvmY-4yteA:undetectable;4qvmZ-4yteA:undetectable","4qvmY-4yteA:19.82;4qvmZ-4yteA:21.34"],["4QVP_K_BO2K301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","4yte","H(2)-FORMING METHYLENETETRAHYDROMETHANOPTERIN DEHYDROGENASE-RELATED PROTEIN MJ0715","Methanocaldococcus jannaschii",5,"THR A 115;THR A  95;ALA A  99;GLY A   7;ASP A  75","None","1.04A","4qvpK-4yteA:undetectable;4qvpL-4yteA:undetectable","4qvpK-4yteA:19.82;4qvpL-4yteA:21.34"],["4QVP_Y_BO2Y301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","4yte","H(2)-FORMING METHYLENETETRAHYDROMETHANOPTERIN DEHYDROGENASE-RELATED PROTEIN MJ0715","Methanocaldococcus jannaschii",5,"THR A 115;THR A  95;ALA A  99;GLY A   7;ASP A  75","None","1.03A","4qvpY-4yteA:undetectable;4qvpZ-4yteA:undetectable","4qvpY-4yteA:19.82;4qvpZ-4yteA:21.34"],["4QVV_K_BO2K301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","4yte","H(2)-FORMING METHYLENETETRAHYDROMETHANOPTERIN DEHYDROGENASE-RELATED PROTEIN MJ0715","Methanocaldococcus jannaschii",4,"THR A 115;THR A  95;GLY A   7;ASP A  75","None","0.72A","4qvvK-4yteA:undetectable;4qvvL-4yteA:undetectable","4qvvK-4yteA:19.82;4qvvL-4yteA:21.34"],["4QVV_Y_BO2Y301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","4yte","H(2)-FORMING METHYLENETETRAHYDROMETHANOPTERIN DEHYDROGENASE-RELATED PROTEIN MJ0715","Methanocaldococcus jannaschii",4,"THR A 115;THR A  95;GLY A   7;ASP A  75","None","0.71A","4qvvY-4yteA:undetectable;4qvvZ-4yteA:undetectable","4qvvY-4yteA:19.82;4qvvZ-4yteA:21.34"],["4QVW_K_BO2K301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","4yte","H(2)-FORMING METHYLENETETRAHYDROMETHANOPTERIN DEHYDROGENASE-RELATED PROTEIN MJ0715","Methanocaldococcus jannaschii",5,"THR A 115;THR A  95;ALA A  99;GLY A   7;ASP A  75","None","1.02A","4qvwK-4yteA:undetectable;4qvwL-4yteA:undetectable","4qvwK-4yteA:19.82;4qvwL-4yteA:21.34"],["4QVW_Y_BO2Y301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","4yte","H(2)-FORMING METHYLENETETRAHYDROMETHANOPTERIN DEHYDROGENASE-RELATED PROTEIN MJ0715","Methanocaldococcus jannaschii",5,"THR A 115;THR A  95;ALA A  99;GLY A   7;ASP A  75","None","1.02A","4qvwY-4yteA:undetectable;4qvwZ-4yteA:undetectable","4qvwY-4yteA:19.82;4qvwZ-4yteA:21.34"],["4QVY_K_BO2K301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","4yte","H(2)-FORMING METHYLENETETRAHYDROMETHANOPTERIN DEHYDROGENASE-RELATED PROTEIN MJ0715","Methanocaldococcus jannaschii",5,"THR A 115;THR A  95;ALA A  99;GLY A   7;ASP A  75","None","1.00A","4qvyK-4yteA:undetectable;4qvyL-4yteA:undetectable","4qvyK-4yteA:19.82;4qvyL-4yteA:21.34"],["4QVY_Y_BO2Y301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","4yte","H(2)-FORMING METHYLENETETRAHYDROMETHANOPTERIN DEHYDROGENASE-RELATED PROTEIN MJ0715","Methanocaldococcus jannaschii",5,"THR A 115;THR A  95;ALA A  99;GLY A   7;ASP A  75","None","0.99A","4qvyY-4yteA:undetectable;4qvyZ-4yteA:undetectable","4qvyY-4yteA:19.82;4qvyZ-4yteA:21.34"],["4QW1_Y_BO2Y301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","4yte","H(2)-FORMING METHYLENETETRAHYDROMETHANOPTERIN DEHYDROGENASE-RELATED PROTEIN MJ0715","Methanocaldococcus jannaschii",5,"THR A 115;THR A  95;ALA A  99;GLY A   7;ASP A  75","None","1.04A","4qw1Y-4yteA:undetectable;4qw1Z-4yteA:undetectable","4qw1Y-4yteA:19.82;4qw1Z-4yteA:21.34"],["4QW3_K_BO2K301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","4yte","H(2)-FORMING METHYLENETETRAHYDROMETHANOPTERIN DEHYDROGENASE-RELATED PROTEIN MJ0715","Methanocaldococcus jannaschii",5,"THR A 115;THR A  95;ALA A  99;GLY A   7;ASP A  75","None","1.01A","4qw3K-4yteA:undetectable;4qw3L-4yteA:undetectable","4qw3K-4yteA:19.82;4qw3L-4yteA:21.34"],["4QW3_Y_BO2Y301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","4yte","H(2)-FORMING METHYLENETETRAHYDROMETHANOPTERIN DEHYDROGENASE-RELATED PROTEIN MJ0715","Methanocaldococcus jannaschii",5,"THR A 115;THR A  95;ALA A  99;GLY A   7;ASP A  75","None","1.01A","4qw3Y-4yteA:undetectable;4qw3Z-4yteA:undetectable","4qw3Y-4yteA:19.82;4qw3Z-4yteA:21.34"],["5B6I_A_ADNA302_1","FLUORINASE","4yte","H(2)-FORMING METHYLENETETRAHYDROMETHANOPTERIN DEHYDROGENASE-RELATED PROTEIN MJ0715","Methanocaldococcus jannaschii",4,"THR A 117;PRO A 119;THR A 120;SER A 142","None","1.20A","5b6iA-4yteA:undetectable","5b6iA-4yteA:20.65"],["5BXN_K_BO2K301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","4yte","H(2)-FORMING METHYLENETETRAHYDROMETHANOPTERIN DEHYDROGENASE-RELATED PROTEIN MJ0715","Methanocaldococcus jannaschii",5,"THR A 115;THR A  95;ALA A  99;GLY A   7;ASP A  75","None","0.99A","5bxnK-4yteA:undetectable;5bxnL-4yteA:undetectable","5bxnK-4yteA:19.82;5bxnL-4yteA:21.34"],["5BXN_Y_BO2Y301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","4yte","H(2)-FORMING METHYLENETETRAHYDROMETHANOPTERIN DEHYDROGENASE-RELATED PROTEIN MJ0715","Methanocaldococcus jannaschii",5,"THR A 115;THR A  95;ALA A  99;GLY A   7;ASP A  75","None","1.01A","5bxnY-4yteA:undetectable;5bxnZ-4yteA:undetectable","5bxnY-4yteA:19.82;5bxnZ-4yteA:21.34"],["5ENT_C_MIYC901_1","MULTIDRUG EFFLUX PUMP SUBUNIT ACRB,MULTIDRUG EFFLUX PUMP SUBUNIT ACRB","4yte","H(2)-FORMING METHYLENETETRAHYDROMETHANOPTERIN DEHYDROGENASE-RELATED PROTEIN MJ0715","Methanocaldococcus jannaschii",5,"SER A 184;GLN A 154;GLY A  34;ILE A   5;ALA A   8","None","1.33A","5entC-4yteA:undetectable","5entC-4yteA:14.31"],["5UAN_B_REAB503_1","RETINOIC ACID RECEPTOR BETA","4yte","H(2)-FORMING METHYLENETETRAHYDROMETHANOPTERIN DEHYDROGENASE-RELATED PROTEIN MJ0715","Methanocaldococcus jannaschii",5,"ALA A 160;LEU A 123;ILE A 112;ILE A 111;LEU A 131","None","1.29A","5uanB-4yteA:undetectable","5uanB-4yteA:17.38"],["6EXI_A_ADNA503_0","ADENOSYLHOMOCYSTEINASE","4yte","H(2)-FORMING METHYLENETETRAHYDROMETHANOPTERIN DEHYDROGENASE-RELATED PROTEIN MJ0715","Methanocaldococcus jannaschii",5,"GLY A   7;GLY A   9;SER A  49;GLU A  50;ILE A  98","None","0.85A","6exiA-4yteA:5.3","6exiA-4yteA:21.60"],["6EXI_B_ADNB503_1","ADENOSYLHOMOCYSTEINASE","4yte","H(2)-FORMING METHYLENETETRAHYDROMETHANOPTERIN DEHYDROGENASE-RELATED PROTEIN MJ0715","Methanocaldococcus jannaschii",5,"GLY A   7;GLY A   9;SER A  49;GLU A  50;ILE A  98","None","0.83A","6exiB-4yteA:8.3","6exiB-4yteA:21.60"],["6EXI_C_ADNC503_0","ADENOSYLHOMOCYSTEINASE","4yte","H(2)-FORMING METHYLENETETRAHYDROMETHANOPTERIN DEHYDROGENASE-RELATED PROTEIN MJ0715","Methanocaldococcus jannaschii",5,"GLY A   7;GLY A   9;SER A  49;GLU A  50;ILE A  98","None","0.86A","6exiC-4yteA:8.7;6exiD-4yteA:8.5","6exiC-4yteA:21.60;6exiD-4yteA:21.60"],["6EXI_D_ADND503_0","ADENOSYLHOMOCYSTEINASE","4yte","H(2)-FORMING METHYLENETETRAHYDROMETHANOPTERIN DEHYDROGENASE-RELATED PROTEIN MJ0715","Methanocaldococcus jannaschii",5,"GLY A   7;GLY A   9;SER A  49;GLU A  50;ILE A  98","None","0.84A","6exiC-4yteA:8.7;6exiD-4yteA:8.5","6exiC-4yteA:21.60;6exiD-4yteA:21.60"]]