SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ytw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O7O_A_DXTA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4ytw MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
35
PROTEIN UPS1,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 SER B  41
ASN B  43
PRO A  74
THR B  53
VAL B  81
 None
 1.28A 2o7oA-4ytwB:
undetectable		 2o7oA-4ytwB:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPV_A_MIYA1209_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4ytw MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
35
PROTEIN UPS1,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 SER B  41
ASN B  43
PRO A  74
THR B  53
VAL B  81
 None
 1.38A 2xpvA-4ytwB:
undetectable		 2xpvA-4ytwB:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4ytw MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
35
PROTEIN UPS1,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 SER B  41
ASN B  43
PRO A  74
THR B  53
VAL B  81
 None
 1.23A 2xrlA-4ytwB:
undetectable		 2xrlA-4ytwB:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 4ytw MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
35
PROTEIN UPS1,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 8 ILE B  40
ILE B  79
LEU B  98
ASP A  67
 None
 0.80A 4dtaB-4ytwB:
undetectable		 4dtaB-4ytwB:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2G_B_CTCB222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4ytw MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
35
PROTEIN UPS1,
MITOCHONDRIAL
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 SER B  41
ASN B  43
PRO A  74
THR B  53
VAL B  81
 None
 1.32A 4v2gB-4ytwB:
undetectable		 4v2gB-4ytwB:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 4ytw MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
35
PROTEIN UPS1,
MITOCHONDRIAL
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 5 VAL B  84
VAL B  44
GLY B  48
PHE A  32
 None
 1.00A 5d4nA-4ytwB:
undetectable
5d4nC-4ytwB:
undetectable		 5d4nA-4ytwB:
19.89
5d4nC-4ytwB:
19.89