SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yu4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 4yu4 HEMOGLOBIN
(Helogale
parvula) 		6 / 6 ALA A  57
LYS A  60
LYS A  61
ASP A  64
ALA A  65
LEU A  83
 None
None
HEM  A 201 (-2.6A)
None
HEM  A 201 (-3.6A)
HEM  A 201 ( 4.7A)
 0.82A 1iwhA-4yu4A:
26.8		 1iwhA-4yu4A:
87.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 4yu4 HEMOGLOBIN
(Helogale
parvula) 		4 / 7 PHE A  43
PHE A  46
VAL A  62
HIS A  87
 HEM  A 201 (-3.8A)
HEM  A 201 ( 4.9A)
HEM  A 201 (-4.2A)
HEM  A 201 (-3.3A)
 0.85A 1lh6A-4yu4A:
12.8		 1lh6A-4yu4A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 4yu4 HEMOGLOBIN
(Helogale
parvula) 		4 / 7 PHE B  42
PHE B  45
VAL B  67
HIS B  92
 HEM  B 201 (-4.4A)
None
OXY  B 202 (-4.1A)
HEM  B 201 (-3.3A)
 0.82A 1lh6A-4yu4B:
13.7		 1lh6A-4yu4B:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4yu4 HEMOGLOBIN
HEMOGLOBIN
(Helogale
parvula;
Helogale
parvula) 		5 / 12 VAL B 126
ALA A  28
GLY B 119
SER A 111
HIS A 112
 None
 1.07A 1nbiA-4yu4B:
undetectable		 1nbiA-4yu4B:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4yu4 HEMOGLOBIN
HEMOGLOBIN
(Helogale
parvula;
Helogale
parvula) 		5 / 12 VAL B 126
ALA A  28
GLY B 119
SER A 111
HIS A 112
 None
 1.07A 1nbiB-4yu4B:
undetectable		 1nbiB-4yu4B:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_C_T44C601_1
(TRANSTHYRETIN)		 4yu4 HEMOGLOBIN
(Helogale
parvula) 		5 / 9 LEU A 136
ALA A  82
LEU A  80
LYS A  61
ALA A  65
 None
None
None
HEM  A 201 (-2.6A)
HEM  A 201 (-3.6A)
 1.32A 1sn0A-4yu4A:
undetectable
1sn0C-4yu4A:
undetectable		 1sn0A-4yu4A:
23.18
1sn0C-4yu4A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4yu4 HEMOGLOBIN
(Helogale
parvula) 		5 / 9 LEU B  68
LEU B 110
VAL B 137
ALA B 140
LEU B  88
 None
None
None
None
HEM  B 201 ( 4.7A)
 1.26A 1tbfA-4yu4B:
undetectable		 1tbfA-4yu4B:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 4yu4 HEMOGLOBIN
(Helogale
parvula) 		4 / 8 ARG A  31
HIS A 112
SER A 111
ALA B 115
 None
 1.24A 2rk8A-4yu4A:
3.7		 2rk8A-4yu4A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 4yu4 HEMOGLOBIN
(Helogale
parvula) 		5 / 9 ASP B  47
LEU B  48
GLY B  46
PHE B  45
THR B  38
 None
None
None
None
HEM  B 201 ( 4.5A)
 1.47A 2tsrD-4yu4B:
undetectable		 2tsrD-4yu4B:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4yu4 HEMOGLOBIN
(Helogale
parvula) 		5 / 12 GLY A  22
GLY A  18
SER A  19
ALA A  28
HIS A 112
 None
 1.15A 3ou7B-4yu4A:
undetectable		 3ou7B-4yu4A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 4yu4 HEMOGLOBIN
(Helogale
parvula) 		4 / 6 LEU A 105
TYR A  24
ALA A  26
LEU A 109
 None
 1.10A 3rd0A-4yu4A:
2.3		 3rd0A-4yu4A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 4yu4 HEMOGLOBIN
(Helogale
parvula) 		3 / 3 PHE A  46
SER A  52
GLN A  54
 HEM  A 201 ( 4.9A)
None
None
 0.84A 3smtA-4yu4A:
undetectable		 3smtA-4yu4A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4yu4 HEMOGLOBIN
(Helogale
parvula) 		5 / 12 LEU A  73
LEU A  76
ILE A  10
SER A 138
THR A 137
 None
 1.04A 4f4dB-4yu4A:
undetectable		 4f4dB-4yu4A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 4yu4 HEMOGLOBIN
(Helogale
parvula) 		3 / 3 HIS A 113
GLY A  18
ILE A  17
 None
 0.64A 4k50A-4yu4A:
undetectable		 4k50A-4yu4A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 4yu4 HEMOGLOBIN
(Helogale
parvula) 		3 / 3 HIS A 113
GLY A  18
ILE A  17
 None
 0.63A 4k50I-4yu4A:
undetectable		 4k50I-4yu4A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L49_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4yu4 HEMOGLOBIN
(Helogale
parvula) 		4 / 5 PHE B 122
LEU B 110
VAL B 134
VAL B  11
 None
 1.18A 4l49A-4yu4B:
undetectable		 4l49A-4yu4B:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 4yu4 HEMOGLOBIN
(Helogale
parvula) 		5 / 10 PRO B 124
VAL B 126
ALA B 128
TYR B 130
GLY B 119
 None
 1.36A 4mmdA-4yu4B:
undetectable		 4mmdA-4yu4B:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4yu4 HEMOGLOBIN
(Helogale
parvula) 		4 / 6 VAL B 137
LEU B  81
LEU B  75
PHE B 122
 None
 1.12A 4o1zA-4yu4B:
undetectable		 4o1zA-4yu4B:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4yu4 HEMOGLOBIN
(Helogale
parvula) 		5 / 12 VAL B 137
LEU B  81
VAL B  11
LEU B  75
PHE B 122
 None
 1.11A 4o1zB-4yu4B:
undetectable		 4o1zB-4yu4B:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 4yu4 HEMOGLOBIN
(Helogale
parvula) 		5 / 12 LEU B  75
VAL B   1
GLY B 136
LEU B   3
SER B  12
 None
 1.50A 4ot2A-4yu4B:
undetectable		 4ot2A-4yu4B:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4yu4 HEMOGLOBIN
(Helogale
parvula) 		4 / 6 ASP B  47
LEU B  48
GLY B  46
PHE B  45
 None
 0.98A 5nooC-4yu4B:
undetectable		 5nooC-4yu4B:
19.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 4yu4 HEMOGLOBIN
(Helogale
parvula) 		4 / 8 PRO A  95
THR A 134
THR A 137
TRP B  37
 None
 0.72A 5x2sI-4yu4A:
25.3
5x2sJ-4yu4A:
20.9
5x2sK-4yu4A:
25.8		 5x2sI-4yu4A:
87.94
5x2sJ-4yu4A:
42.57
5x2sK-4yu4A:
87.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_A_TRPA501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 4yu4 HEMOGLOBIN
(Helogale
parvula) 		5 / 10 TYR B 130
ALA B 129
LEU B  78
VAL B   1
GLY B 136
 None
 1.41A 5zbdA-4yu4B:
undetectable		 5zbdA-4yu4B:
16.70