SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yu5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		4 / 4 GLY A 693
ASP A 683
GLY A 687
THR A 718
 None
 1.02A 1hxbB-4yu5A:
undetectable		 1hxbB-4yu5A:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		5 / 9 THR A 718
GLY A 399
SER A 409
GLU A 403
GLY A 696
 None
 1.34A 1jhyA-4yu5A:
undetectable		 1jhyA-4yu5A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		5 / 9 THR A 718
GLY A 399
SER A 409
GLU A 403
GLY A 696
 None
 1.31A 1l4nA-4yu5A:
undetectable		 1l4nA-4yu5A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		5 / 9 THR A 718
GLY A 399
SER A 409
GLU A 403
GLY A 696
 None
 1.30A 1l5kA-4yu5A:
undetectable		 1l5kA-4yu5A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		5 / 9 THR A 718
GLY A 399
SER A 409
GLU A 403
GLY A 696
 None
 1.29A 1l5lA-4yu5A:
undetectable		 1l5lA-4yu5A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		5 / 9 THR A 718
GLY A 399
SER A 409
GLU A 403
GLY A 696
 None
 1.28A 1l5mA-4yu5A:
undetectable		 1l5mA-4yu5A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		3 / 3 ALA A 404
VAL A 402
TRP A 675
 None
 0.90A 1micA-4yu5A:
undetectable
1micB-4yu5A:
undetectable		 1micA-4yu5A:
1.95
1micB-4yu5A:
1.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		5 / 10 PHE A 756
SER A 700
LEU A 672
VAL A 795
VAL A 674
 None
 1.27A 1q23E-4yu5A:
undetectable		 1q23E-4yu5A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		5 / 11 PHE A 756
SER A 700
LEU A 672
VAL A 795
VAL A 674
 None
 1.32A 1q23F-4yu5A:
undetectable		 1q23F-4yu5A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		4 / 8 PHE A 193
ARG A  56
ALA A 373
LEU A 210
 None
 1.12A 1x8vA-4yu5A:
undetectable		 1x8vA-4yu5A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		4 / 7 THR A 423
GLU A 225
SER A 465
VAL A 474
 None
 1.22A 2fb2B-4yu5A:
undetectable		 2fb2B-4yu5A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		4 / 7 ASP A 329
ASP A 259
GLY A  89
ILE A  84
 None
CA  A1004 (-3.3A)
None
None
 0.93A 2fxdB-4yu5A:
undetectable		 2fxdB-4yu5A:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		4 / 4 SER A 230
GLY A 439
HIS A 310
ASP A 288
 None
None
None
CA  A1003 (-3.5A)
 1.34A 2oxtC-4yu5A:
undetectable		 2oxtC-4yu5A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		4 / 7 SER A 337
HIS A 258
HIS A 335
ARG A 267
 None
 1.31A 2vmyA-4yu5A:
undetectable
2vmyB-4yu5A:
undetectable		 2vmyA-4yu5A:
20.16
2vmyB-4yu5A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		4 / 8 SER A 337
HIS A 258
HIS A 335
ARG A 267
 None
 1.32A 2vmyA-4yu5A:
undetectable
2vmyB-4yu5A:
undetectable		 2vmyA-4yu5A:
20.16
2vmyB-4yu5A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		3 / 3 PRO A 666
GLY A 719
TYR A 668
 None
 0.62A 2vouA-4yu5A:
undetectable		 2vouA-4yu5A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		3 / 3 PRO A 666
GLY A 719
TYR A 668
 None
 0.59A 2vouB-4yu5A:
undetectable		 2vouB-4yu5A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		3 / 3 PRO A 666
GLY A 719
TYR A 668
 None
 0.57A 2vouC-4yu5A:
undetectable		 2vouC-4yu5A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		5 / 12 GLY A 257
LEU A  57
GLU A 321
ASP A 329
ASP A 259
 None
None
None
None
CA  A1004 (-3.3A)
 1.41A 2vqyA-4yu5A:
undetectable		 2vqyA-4yu5A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		4 / 5 VAL A 674
TYR A 646
VAL A 774
ASP A 758
 None
 1.22A 2x45A-4yu5A:
undetectable		 2x45A-4yu5A:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		5 / 9 ASP A 463
ILE A 462
VAL A 795
VAL A 783
GLN A 786
 None
 1.36A 3fi0O-4yu5A:
undetectable		 3fi0O-4yu5A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		6 / 12 GLY A 691
GLY A 693
PRO A 401
ASN A 684
ALA A 770
SER A 680
 None
 1.33A 3mteA-4yu5A:
undetectable		 3mteA-4yu5A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		6 / 12 GLY A 693
PRO A 690
ALA A 768
ALA A 770
LEU A 695
THR A 398
 None
 1.43A 3p2kA-4yu5A:
undetectable		 3p2kA-4yu5A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		5 / 12 GLY A 691
GLY A 693
PRO A 401
ALA A 770
SER A 680
 None
 1.01A 3p2kD-4yu5A:
undetectable		 3p2kD-4yu5A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		5 / 12 GLY A 411
SER A 424
GLY A 659
ASN A 429
ASP A 389
 None
None
None
None
ZN  A1001 (-2.4A)
 1.12A 3r24A-4yu5A:
undetectable		 3r24A-4yu5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		5 / 11 VAL A 795
ALA A 794
GLY A 785
ALA A 152
LEU A 648
 None
KH2  A1006 (-3.7A)
None
None
None
 1.18A 3rc0A-4yu5A:
undetectable		 3rc0A-4yu5A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		5 / 12 VAL A 795
ALA A 794
GLY A 785
ALA A 152
LEU A 648
 None
KH2  A1006 (-3.7A)
None
None
None
 1.18A 3rc0B-4yu5A:
undetectable		 3rc0B-4yu5A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		4 / 8 ALA A 770
PHE A 745
PHE A 705
THR A 714
 None
 1.07A 3t3sE-4yu5A:
undetectable		 3t3sE-4yu5A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		5 / 10 PHE A 756
SER A 700
LEU A 672
VAL A 795
VAL A 674
 None
 1.32A 3u9fI-4yu5A:
undetectable		 3u9fI-4yu5A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		5 / 12 PHE A 756
SER A 700
LEU A 672
VAL A 795
VAL A 674
 None
 1.33A 3u9fJ-4yu5A:
undetectable
3u9fK-4yu5A:
undetectable		 3u9fJ-4yu5A:
14.31
3u9fK-4yu5A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		5 / 10 PHE A 756
SER A 700
LEU A 672
VAL A 795
VAL A 674
 None
 1.33A 3u9fR-4yu5A:
undetectable		 3u9fR-4yu5A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		5 / 9 ASP A 259
ASP A 330
GLY A 323
PRO A 369
ILE A 332
 CA  A1004 (-3.3A)
None
None
None
None
 1.21A 4ll3B-4yu5A:
undetectable		 4ll3B-4yu5A:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		5 / 10 LEU A 169
HIS A 275
LEU A 274
ALA A 277
LEU A 241
 None
 1.18A 4p65A-4yu5A:
undetectable
4p65B-4yu5A:
undetectable
4p65F-4yu5A:
undetectable
4p65H-4yu5A:
undetectable		 4p65A-4yu5A:
2.58
4p65B-4yu5A:
3.94
4p65F-4yu5A:
3.94
4p65H-4yu5A:
3.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		5 / 11 LEU A 169
HIS A 275
LEU A 274
ALA A 277
LEU A 241
 None
 1.13A 4p65C-4yu5A:
undetectable
4p65D-4yu5A:
undetectable
4p65J-4yu5A:
undetectable
4p65L-4yu5A:
undetectable		 4p65C-4yu5A:
2.58
4p65D-4yu5A:
3.94
4p65J-4yu5A:
3.94
4p65L-4yu5A:
3.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		5 / 11 LEU A 169
HIS A 275
LEU A 274
ALA A 277
LEU A 241
 None
 1.07A 4p65E-4yu5A:
undetectable
4p65F-4yu5A:
undetectable
4p65J-4yu5A:
undetectable
4p65L-4yu5A:
undetectable		 4p65E-4yu5A:
2.58
4p65F-4yu5A:
3.94
4p65J-4yu5A:
3.94
4p65L-4yu5A:
3.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		5 / 11 LEU A 241
LEU A 169
HIS A 275
LEU A 274
ALA A 277
 None
 1.09A 4p65B-4yu5A:
undetectable
4p65D-4yu5A:
undetectable
4p65G-4yu5A:
undetectable
4p65H-4yu5A:
undetectable		 4p65B-4yu5A:
3.94
4p65D-4yu5A:
3.94
4p65G-4yu5A:
2.58
4p65H-4yu5A:
3.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		4 / 5 PHE A 381
PHE A 203
PHE A 219
VAL A 166
 None
 1.20A 5a1rA-4yu5A:
undetectable		 5a1rA-4yu5A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		5 / 12 ALA A  60
GLY A 319
GLY A 323
GLY A 328
LEU A 327
 None
 0.97A 5c0oG-4yu5A:
undetectable		 5c0oG-4yu5A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		3 / 3 TRP A 405
GLU A 649
ASP A 657
 None
 0.94A 5gqbA-4yu5A:
undetectable		 5gqbA-4yu5A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		3 / 3 VAL A 673
LEU A 387
MET A 408
 None
 0.87A 5ikrA-4yu5A:
undetectable		 5ikrA-4yu5A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		3 / 3 GLY A 397
ASP A 769
ASN A 764
 None
 0.51A 5jglA-4yu5A:
undetectable		 5jglA-4yu5A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		5 / 12 ALA A 704
GLY A 719
TYR A 715
ALA A 404
ALA A 723
 None
 1.05A 5n5dA-4yu5A:
undetectable		 5n5dA-4yu5A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		4 / 8 ASP A 758
LEU A 777
VAL A 477
TYR A 646
 None
 1.13A 5ov9B-4yu5A:
undetectable		 5ov9B-4yu5A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		3 / 3 SER A 190
HIS A 197
TYR A 208
 None
 0.92A 5y2tA-4yu5A:
undetectable		 5y2tA-4yu5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		3 / 3 MET A 437
ASP A 164
ARG A 292
 None
 1.21A 5z6kA-4yu5A:
undetectable		 5z6kA-4yu5A:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		3 / 3 ASN A 764
VAL A 753
HIS A 701
 None
 0.87A 6a5yD-4yu5A:
undetectable		 6a5yD-4yu5A:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		4 / 6 GLY A 317
ASP A 182
GLY A 319
GLY A 323
 None
 0.77A 6ag0C-4yu5A:
undetectable		 6ag0C-4yu5A:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		5 / 7 SER A 334
PHE A 377
GLY A 317
ALA A 316
LEU A 170
 None
 1.42A 6dwnB-4yu5A:
undetectable		 6dwnB-4yu5A:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE
(Bacillus
cereus) 		5 / 12 ILE A 181
PHE A 193
GLY A 372
ALA A 373
PHE A 377
 None
 1.11A 6dwnD-4yu5A:
undetectable		 6dwnD-4yu5A:
8.04