SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yu9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A 347
LEU A 351
ASN A 348
LEU A 170
MET A  65
 None
 1.20A 1a28B-4yu9A:
undetectable		 1a28B-4yu9A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		5 / 11 LEU A 238
ILE A 124
ILE A 196
MET A 241
GLN A 237
 EDO  A 404 (-4.1A)
None
None
None
None
 1.37A 1gx9A-4yu9A:
0.7		 1gx9A-4yu9A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		5 / 9 PHE A 260
LEU A 318
PHE A 261
ASN A 263
TYR A 358
 None
 1.37A 1i00B-4yu9A:
undetectable		 1i00B-4yu9A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		4 / 7 LEU A 356
ILE A  62
THR A  60
MET A  65
 None
 0.99A 1kglA-4yu9A:
undetectable		 1kglA-4yu9A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		5 / 10 LEU A 271
ALA A 273
ILE A 274
ALA A  46
LEU A 359
 None
 0.95A 1xp0A-4yu9A:
undetectable		 1xp0A-4yu9A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XPQ_A_SPMA924_1
(FMS1 PROTEIN)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		5 / 11 ASP A 107
ASN A 122
LEU A 246
PHE A 310
LEU A 244
 None
 1.40A 1xpqA-4yu9A:
0.0		 1xpqA-4yu9A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XPQ_C_SPMC921_1
(FMS1 PROTEIN)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		5 / 11 ASP A 107
ASN A 122
LEU A 246
PHE A 310
LEU A 244
 None
 1.41A 1xpqC-4yu9A:
0.0		 1xpqC-4yu9A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		5 / 12 PHE A 197
LEU A 195
VAL A 355
LEU A 361
LEU A 191
 None
 0.92A 2hc4A-4yu9A:
undetectable		 2hc4A-4yu9A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		4 / 8 LEU A 244
ARG A 313
SER A 160
GLY A 215
 None
SO4  A 402 ( 3.8A)
None
None
 1.07A 2qd5B-4yu9A:
undetectable		 2qd5B-4yu9A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		4 / 6 LEU A  73
LEU A  70
ILE A  91
ARG A  94
 None
 0.94A 2rlfA-4yu9A:
undetectable
2rlfB-4yu9A:
undetectable		 2rlfA-4yu9A:
9.88
2rlfB-4yu9A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		4 / 6 LEU A  73
LEU A  70
ILE A  91
ARG A  94
 None
 0.98A 2rlfC-4yu9A:
undetectable
2rlfD-4yu9A:
undetectable		 2rlfC-4yu9A:
9.88
2rlfD-4yu9A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		5 / 12 SER A 323
GLY A 251
ASP A 340
THR A 343
ASN A 335
 None
 1.36A 3a25A-4yu9A:
undetectable		 3a25A-4yu9A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		4 / 5 SER A  50
LEU A 284
GLY A 282
GLU A 277
 None
 1.14A 3aiaA-4yu9A:
undetectable
3aiaB-4yu9A:
1.8		 3aiaA-4yu9A:
21.86
3aiaB-4yu9A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		3 / 3 LEU A 284
GLU A 277
ILE A 274
 None
 0.53A 3czhA-4yu9A:
undetectable		 3czhA-4yu9A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		4 / 4 GLU A 117
GLY A 116
THR A 113
GLU A 115
 None
 1.13A 3e9xA-4yu9A:
undetectable		 3e9xA-4yu9A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		5 / 9 LEU A 356
HIS A 360
HIS A  43
ILE A  47
LEU A  48
 None
 1.35A 3hy7A-4yu9A:
undetectable		 3hy7A-4yu9A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		4 / 8 ASP A 159
LEU A 249
ASP A 305
ASP A 306
 ZN  A 401 (-2.1A)
None
None
None
 1.21A 3n2oC-4yu9A:
undetectable
3n2oD-4yu9A:
undetectable		 3n2oC-4yu9A:
20.06
3n2oD-4yu9A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O5R_A_FK5A1001_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		5 / 11 ASP A 345
VAL A 162
ILE A 250
LYS A 349
ILE A 350
 None
 1.44A 3o5rA-4yu9A:
undetectable		 3o5rA-4yu9A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		4 / 6 HIS A 330
PRO A 326
LEU A 249
ASP A 305
 ZN  A 401 (-3.2A)
None
None
None
 1.19A 3oi8A-4yu9A:
undetectable		 3oi8A-4yu9A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		4 / 6 ILE A 350
HIS A 287
PRO A 255
LEU A 347
 None
 1.14A 3oi8A-4yu9A:
undetectable		 3oi8A-4yu9A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		5 / 10 PHE A 260
LEU A 318
PHE A 261
ASN A 263
TYR A 358
 None
 1.33A 4eb4D-4yu9A:
undetectable		 4eb4D-4yu9A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		3 / 3 SER A 323
TYR A 299
PRO A 326
 None
 0.93A 4k8cA-4yu9A:
undetectable		 4k8cA-4yu9A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		3 / 3 SER A 323
TYR A 299
PRO A 326
 None
 0.90A 4kahA-4yu9A:
undetectable		 4kahA-4yu9A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		3 / 3 SER A 323
TYR A 299
PRO A 326
 None
 0.90A 4kahB-4yu9A:
undetectable		 4kahB-4yu9A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		3 / 3 SER A 323
TYR A 299
PRO A 326
 None
 0.92A 4kanA-4yu9A:
undetectable		 4kanA-4yu9A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		3 / 3 SER A 323
TYR A 299
PRO A 326
 None
 0.94A 4kanB-4yu9A:
undetectable		 4kanB-4yu9A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		3 / 3 SER A 323
TYR A 299
PRO A 326
 None
 0.94A 4kbeA-4yu9A:
undetectable		 4kbeA-4yu9A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		3 / 3 SER A 323
TYR A 299
PRO A 326
 None
 0.93A 4kbeB-4yu9A:
undetectable		 4kbeB-4yu9A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		3 / 3 SER A 323
TYR A 299
PRO A 326
 None
 0.91A 4lbgA-4yu9A:
undetectable		 4lbgA-4yu9A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		3 / 3 SER A 323
TYR A 299
PRO A 326
 None
 0.90A 4lbgB-4yu9A:
undetectable		 4lbgB-4yu9A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		4 / 8 LEU A 271
MET A 166
LEU A 247
ILE A 303
 None
 1.03A 4ok1A-4yu9A:
undetectable		 4ok1A-4yu9A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		5 / 11 HIS A 140
ASP A 159
GLU A 201
GLU A 202
HIS A 330
 None
ZN  A 401 (-2.1A)
ZN  A 401 ( 4.9A)
ZN  A 401 (-2.2A)
ZN  A 401 (-3.2A)
 0.36A 4pqaA-4yu9A:
21.1		 4pqaA-4yu9A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A 247
LEU A 137
ALA A 138
LEU A 244
LEU A 318
 None
 1.12A 4pxmA-4yu9A:
undetectable		 4pxmA-4yu9A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_F_PARF500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		5 / 11 PHE A 146
ASP A 248
ASP A 306
TYR A 214
GLY A 200
 None
 1.44A 4qb9F-4yu9A:
0.5		 4qb9F-4yu9A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5H_C_ACTC1742_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SUBUNIT)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		4 / 5 ASP A 248
TRP A 329
THR A 158
ASP A 159
 None
None
None
ZN  A 401 (-2.1A)
 1.47A 5g5hC-4yu9A:
0.0		 5g5hC-4yu9A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		4 / 5 LEU A 249
LEU A 246
PHE A 325
HIS A 140
 None
 1.01A 5gtrA-4yu9A:
undetectable		 5gtrA-4yu9A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		5 / 12 TYR A 141
TYR A  85
THR A 108
ILE A 106
ILE A 123
 None
 1.25A 5ifuA-4yu9A:
undetectable		 5ifuA-4yu9A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_1
(-)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A 213
GLU A 201
ASP A 248
LEU A 244
HIS A 319
 None
ZN  A 401 ( 4.9A)
None
None
None
 1.47A 6gbnB-4yu9A:
undetectable		 6gbnB-4yu9A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens) 		4 / 5 LEU A 191
ILE A 123
MET A 241
GLY A 240
 None
 1.05A 6hd6A-4yu9A:
undetectable		 6hd6A-4yu9A:
10.94