SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yub'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4yub NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		4 / 5 SER A 193
PHE A 191
GLU A 167
GLY A 169
 None
 1.32A 1icvC-4yubA:
undetectable
1icvD-4yubA:
undetectable		 1icvC-4yubA:
17.48
1icvD-4yubA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4yub NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		4 / 8 THR A 210
VAL A 315
GLY A 316
VAL A 375
 None
 0.84A 2a1oA-4yubA:
undetectable		 2a1oA-4yubA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 4yub NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		4 / 7 ASP A 288
HIS A 213
LEU A 324
ILE A 358
 None
 1.02A 3avpA-4yubA:
undetectable		 3avpA-4yubA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 4yub NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		5 / 12 LEU A 121
LEU A 473
ALA A 115
ALA A  55
PRO A  49
 None
 1.25A 3cwkA-4yubA:
undetectable		 3cwkA-4yubA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 4yub NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		5 / 12 GLN A 262
GLY A 260
LEU A 257
GLU A 251
ASN A 299
 None
 0.85A 3kkzA-4yubA:
undetectable		 3kkzA-4yubA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4yub NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		5 / 12 LEU A  56
LEU A 114
ALA A 115
LEU A 109
GLY A  59
 None
 1.07A 3olsA-4yubA:
undetectable		 3olsA-4yubA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 4yub NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		5 / 12 LEU A  56
LEU A 114
ALA A 115
LEU A 109
GLY A  59
 None
 1.02A 3q95B-4yubA:
undetectable		 3q95B-4yubA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 4yub NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		4 / 8 ARG A 203
ALA A 182
ASP A 177
TYR A 144
 None
 0.96A 3qj7A-4yubA:
undetectable
3qj7D-4yubA:
undetectable		 3qj7A-4yubA:
19.30
3qj7D-4yubA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4yub NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		3 / 3 LYS A 407
ARG A  34
LEU A 397
 None
 1.22A 3v4tE-4yubA:
undetectable		 3v4tE-4yubA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 4yub NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		5 / 12 LEU A  56
LEU A 114
ALA A 115
LEU A 109
GLY A  59
 None
 0.99A 4pxmA-4yubA:
undetectable		 4pxmA-4yubA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 4yub NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		5 / 12 VAL A 292
PHE A 272
LEU A 305
ALA A 338
PHE A 335
 None
 1.37A 4rtbA-4yubA:
3.1		 4rtbA-4yubA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4yub NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		4 / 5 ALA A  26
TYR A  29
PRO A 127
PHE A  41
 None
 1.38A 4ze2A-4yubA:
undetectable		 4ze2A-4yubA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 4yub NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		5 / 12 LEU A 121
LEU A 109
SER A 493
LEU A 496
LEU A  56
 None
 1.13A 5mwyA-4yubA:
undetectable		 5mwyA-4yubA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4yub NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		5 / 12 LEU A 157
ALA A 152
GLY A 160
ASP A 192
LEU A  56
 None
 1.13A 5nfjB-4yubA:
undetectable		 5nfjB-4yubA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGO_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4yub NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		4 / 4 VAL A 520
VAL A 519
TYR A 517
GLN A 516
 None
 1.44A 5qgoA-4yubA:
undetectable		 5qgoA-4yubA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDM_A_ADNA904_1
(ATP-CITRATE SYNTHASE)		 4yub NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		4 / 4 THR A  88
ASP A  89
ARG A  31
LEU A  27
 None
 1.08A 5tdmA-4yubA:
2.4		 5tdmA-4yubA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 4yub NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		4 / 6 THR A  88
ASP A  89
ARG A  31
LEU A  27
 None
 1.12A 5tdzA-4yubA:
undetectable		 5tdzA-4yubA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_1
(TETRACYCLINE
DESTRUCTASE TET(50))		 4yub NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		4 / 5 ASP A  62
ARG A  65
LEU A 170
MET A 168
 None
 1.32A 5tuiB-4yubA:
undetectable		 5tuiB-4yubA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 4yub NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens) 		3 / 3 ARG A 466
GLY A 449
GLU A 451
 None
 0.50A 6fgdA-4yubA:
undetectable		 6fgdA-4yubA:
24.08