SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yue'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 4yue S4B6 FAB HEAVY CHAIN
(Mus
musculus) 		5 / 12 VAL H 122
ARG H  85
GLU H  49
ILE H  51
LEU H  84
 None
 0.94A 1d1gB-4yueH:
undetectable		 1d1gB-4yueH:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4yue S4B6 FAB HEAVY CHAIN
(Mus
musculus) 		5 / 12 THR H 120
GLU H  13
LEU H  84
LEU H  23
GLY H  11
 None
 1.13A 1d4fA-4yueH:
undetectable		 1d4fA-4yueH:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 4yue S4B6 FAB LIGHT CHAIN
(Mus
musculus) 		4 / 8 VAL L   7
TYR L  99
GLY L 102
TYR L  74
 None
 0.94A 1jlfA-4yueL:
undetectable
1jlfB-4yueL:
undetectable		 1jlfA-4yueL:
17.85
1jlfB-4yueL:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4yue S4B6 FAB LIGHT CHAIN
(Mus
musculus) 		4 / 6 LEU L 182
ALA L 133
HIS L 192
ASP L 154
 None
 1.28A 2dpzA-4yueL:
undetectable		 2dpzA-4yueL:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4yue S4B6 FAB LIGHT CHAIN
(Mus
musculus) 		4 / 8 ILE L  88
ASP L 168
LEU L  43
GLY L  44
 None
 0.91A 2qqdB-4yueL:
undetectable
2qqdC-4yueL:
undetectable		 2qqdB-4yueL:
19.49
2qqdC-4yueL:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4yue INTERLEUKIN-2
S4B6 FAB LIGHT CHAIN
(Mus
musculus) 		5 / 10 ASP C  75
SER L  56
THR L  25
GLN L  27
LEU L  36
 None
 1.48A 3j6gB-4yueC:
undetectable		 3j6gB-4yueC:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_D_TA1D502_1
(TUBULIN BETA CHAIN)		 4yue INTERLEUKIN-2
S4B6 FAB LIGHT CHAIN
(Mus
musculus) 		5 / 10 ASP C  75
SER L  56
THR L  25
GLN L  27
LEU L  36
 None
 1.48A 3j6gD-4yueC:
undetectable		 3j6gD-4yueC:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_F_TA1F502_1
(TUBULIN BETA CHAIN)		 4yue INTERLEUKIN-2
S4B6 FAB LIGHT CHAIN
(Mus
musculus) 		5 / 10 ASP C  75
SER L  56
THR L  25
GLN L  27
LEU L  36
 None
 1.48A 3j6gF-4yueC:
undetectable		 3j6gF-4yueC:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_H_TA1H502_1
(TUBULIN BETA CHAIN)		 4yue INTERLEUKIN-2
S4B6 FAB LIGHT CHAIN
(Mus
musculus) 		5 / 10 ASP C  75
SER L  56
THR L  25
GLN L  27
LEU L  36
 None
 1.48A 3j6gH-4yueC:
undetectable		 3j6gH-4yueC:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_J_TA1J502_1
(TUBULIN BETA CHAIN)		 4yue INTERLEUKIN-2
S4B6 FAB LIGHT CHAIN
(Mus
musculus) 		5 / 10 ASP C  75
SER L  56
THR L  25
GLN L  27
LEU L  36
 None
 1.48A 3j6gJ-4yueC:
undetectable		 3j6gJ-4yueC:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_L_TA1L502_1
(TUBULIN BETA CHAIN)		 4yue INTERLEUKIN-2
S4B6 FAB LIGHT CHAIN
(Mus
musculus) 		5 / 10 ASP C  75
SER L  56
THR L  25
GLN L  27
LEU L  36
 None
 1.48A 3j6gL-4yueC:
undetectable		 3j6gL-4yueC:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_N_TA1N502_1
(TUBULIN BETA CHAIN)		 4yue INTERLEUKIN-2
S4B6 FAB LIGHT CHAIN
(Mus
musculus) 		5 / 10 ASP C  75
SER L  56
THR L  25
GLN L  27
LEU L  36
 None
 1.48A 3j6gN-4yueC:
undetectable		 3j6gN-4yueC:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_P_TA1P502_1
(TUBULIN BETA CHAIN)		 4yue INTERLEUKIN-2
S4B6 FAB LIGHT CHAIN
(Mus
musculus) 		5 / 10 ASP C  75
SER L  56
THR L  25
GLN L  27
LEU L  36
 None
 1.48A 3j6gP-4yueC:
undetectable		 3j6gP-4yueC:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_R_TA1R502_1
(TUBULIN BETA CHAIN)		 4yue INTERLEUKIN-2
S4B6 FAB LIGHT CHAIN
(Mus
musculus) 		5 / 10 ASP C  75
SER L  56
THR L  25
GLN L  27
LEU L  36
 None
 1.48A 3j6gR-4yueC:
undetectable		 3j6gR-4yueC:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4yue S4B6 FAB HEAVY CHAIN
(Mus
musculus) 		5 / 11 ALA H  71
ILE H  51
GLY H  52
LEU H  86
LEU H  23
 None
 0.86A 3kw2B-4yueH:
undetectable		 3kw2B-4yueH:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 4yue S4B6 FAB LIGHT CHAIN
(Mus
musculus) 		5 / 11 LEU L 182
THR L 181
VAL L 162
SER L 211
VAL L 199
 None
 1.34A 3tbgA-4yueL:
undetectable		 3tbgA-4yueL:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 4yue S4B6 FAB HEAVY CHAIN
(Mus
musculus) 		5 / 9 ALA H  75
ALA H  82
LEU H  84
LEU H  37
SER H  60
 None
 1.08A 4or0B-4yueH:
undetectable		 4or0B-4yueH:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 4yue S4B6 FAB HEAVY CHAIN
S4B6 FAB LIGHT CHAIN
(Mus
musculus;
Mus
musculus) 		5 / 12 ILE L  51
GLN L   9
TYR L  89
GLN H  42
LEU H  48
 None
 1.39A 4qztA-4yueL:
undetectable		 4qztA-4yueL:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 4yue S4B6 FAB LIGHT CHAIN
(Mus
musculus) 		3 / 3 THR L  55
ASN L  34
SER L  53
 None
 0.78A 4tvtA-4yueL:
undetectable		 4tvtA-4yueL:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4yue S4B6 FAB HEAVY CHAIN
(Mus
musculus) 		4 / 4 TYR H  63
THR H  61
GLY H  52
LEU H  84
 None
 1.43A 4w5nA-4yueH:
undetectable		 4w5nA-4yueH:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4yue S4B6 FAB HEAVY CHAIN
S4B6 FAB LIGHT CHAIN
(Mus
musculus;
Mus
musculus) 		5 / 12 TYR L  99
HIS L  94
THR L  55
PHE H 113
SER H 107
 None
 1.37A 5iwuA-4yueL:
undetectable		 5iwuA-4yueL:
20.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MTH_A_ACTA302_0
(ANTIBODY FAB HEAVY
CHAIN)		 4yue S4B6 FAB HEAVY CHAIN
(Mus
musculus) 		4 / 5 SER H 125
ALA H 127
PHE H 159
LEU H 183
 None
 0.26A 5mthA-4yueH:
28.0		 5mthA-4yueH:
73.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 4yue S4B6 FAB HEAVY CHAIN
S4B6 FAB LIGHT CHAIN
(Mus
musculus;
Mus
musculus) 		5 / 12 PRO L 116
MET L 178
VAL L 118
ILE L 120
LEU H 137
 None
 1.30A 5tiwB-4yueL:
undetectable		 5tiwB-4yueL:
20.61