SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yv7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_B_CAMB502_0
(CYTOCHROME P450-CAM)		 4yv7 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		4 / 5 PHE A  54
TYR A  55
VAL A 176
VAL A 254
 GOL  A 401 (-3.6A)
GOL  A 401 ( 4.5A)
None
None
 1.41A 1dz6B-4yv7A:
undetectable		 1dz6B-4yv7A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 4yv7 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		4 / 4 ARG A 206
ALA A 234
ALA A 260
GLU A 259
 None
 1.10A 1e7bB-4yv7A:
undetectable		 1e7bB-4yv7A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 4yv7 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ARG A 206
ALA A 234
ALA A 260
GLU A 259
 None
 1.06A 1e7cA-4yv7A:
undetectable		 1e7cA-4yv7A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 4yv7 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 234
VAL A 254
GLY A 253
ALA A 177
ASP A 128
 None
None
None
None
GOL  A 401 (-2.8A)
 1.10A 1kxhA-4yv7A:
undetectable		 1kxhA-4yv7A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4D_A_TOYA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 4yv7 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 10 PHE A 323
ASP A 255
SER A  52
THR A  49
ASP A 128
 None
GOL  A 401 (-2.7A)
GOL  A 401 ( 4.4A)
None
GOL  A 401 (-2.8A)
 1.47A 1m4dA-4yv7A:
undetectable		 1m4dA-4yv7A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 4yv7 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		3 / 3 SER A  46
VAL A 124
LEU A 100
 None
 0.65A 1yajG-4yv7A:
2.7		 1yajG-4yv7A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 4yv7 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ARG A 206
ALA A 237
ALA A 234
GLU A 259
LEU A 241
 None
 1.10A 2bxeB-4yv7A:
undetectable		 2bxeB-4yv7A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 4yv7 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 9 GLY A 253
THR A 273
ALA A 274
LEU A 149
THR A 306
 None
 1.03A 2npnA-4yv7A:
2.8		 2npnA-4yv7A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 4yv7 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 7 ALA A 272
THR A 273
ALA A 274
ARG A 180
TYR A 227
 None
None
None
GOL  A 401 (-3.0A)
None
 1.35A 2ql8A-4yv7A:
undetectable
2ql8B-4yv7A:
undetectable		 2ql8A-4yv7A:
18.39
2ql8B-4yv7A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 4yv7 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ARG A 180
TYR A 227
THR A 273
ALA A 274
 GOL  A 401 (-3.0A)
None
None
None
 1.16A 2ql8A-4yv7A:
undetectable
2ql8B-4yv7A:
undetectable		 2ql8A-4yv7A:
18.39
2ql8B-4yv7A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 4yv7 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 10 TYR A  75
ALA A  78
ALA A  48
LEU A  58
VAL A 127
 None
 1.43A 2wuzB-4yv7A:
undetectable		 2wuzB-4yv7A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_1
(PROTEASE)		 4yv7 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ASP A 203
ASP A 106
VAL A 105
ILE A  82
THR A  49
 None
 1.06A 3el5A-4yv7A:
undetectable		 3el5A-4yv7A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4yv7 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 9 GLY A 236
GLN A 239
VAL A 226
VAL A 251
GLN A 269
 None
 1.40A 3fi0A-4yv7A:
undetectable		 3fi0A-4yv7A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4yv7 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 9 GLY A 236
GLN A 239
VAL A 226
VAL A 251
GLN A 269
 None
 1.39A 3fi0H-4yv7A:
undetectable		 3fi0H-4yv7A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4yv7 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 9 GLY A 236
GLN A 239
VAL A 226
VAL A 251
GLN A 269
 None
 1.45A 3fi0K-4yv7A:
undetectable		 3fi0K-4yv7A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4yv7 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 9 GLY A 236
GLN A 239
VAL A 226
VAL A 251
GLN A 269
 None
 1.41A 3fi0N-4yv7A:
undetectable		 3fi0N-4yv7A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 4yv7 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 154
GLY A 147
GLY A 183
VAL A 271
ASP A 310
 None
 1.10A 3m6vA-4yv7A:
undetectable		 3m6vA-4yv7A:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 4yv7 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 154
GLY A 147
GLY A 183
VAL A 271
ASP A 310
 None
 1.09A 3m6vB-4yv7A:
undetectable		 3m6vB-4yv7A:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 4yv7 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ASP A 266
ARG A 262
ALA A 265
 None
 0.68A 3mbgC-4yv7A:
undetectable		 3mbgC-4yv7A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 4yv7 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		4 / 6 GLU A 281
ASP A 303
ASP A 255
ASN A 143
 None
None
GOL  A 401 (-2.7A)
None
 1.04A 3vywA-4yv7A:
undetectable		 3vywA-4yv7A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 4yv7 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		4 / 6 GLU A 281
ASP A 303
ASP A 255
ASN A 143
 None
None
GOL  A 401 (-2.7A)
None
 1.04A 3vywC-4yv7A:
2.8		 3vywC-4yv7A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIX_A_NIMA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4yv7 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		4 / 4 LEU A  41
ALA A 289
ILE A 286
LYS A  39
 None
 1.24A 4eixA-4yv7A:
undetectable		 4eixA-4yv7A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 4yv7 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ASP A 171
ASN A 230
ALA A 228
TYR A 227
 None
GOL  A 401 (-3.9A)
None
None
 1.20A 4mdbA-4yv7A:
undetectable		 4mdbA-4yv7A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_1
(PROTEASE)		 4yv7 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ASP A 203
ASP A 106
VAL A 105
ILE A  82
THR A  49
 None
 1.05A 4njuC-4yv7A:
undetectable		 4njuC-4yv7A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 4yv7 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ILE A 122
GLY A 121
ALA A 117
LEU A 100
VAL A  89
 None
 1.33A 5hw4B-4yv7A:
3.8		 5hw4B-4yv7A:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4yv7 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		4 / 6 TYR A 201
ASP A 182
ILE A 196
TYR A 227
 None
 1.31A 5igyA-4yv7A:
undetectable		 5igyA-4yv7A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_2
(PROTEASE PR5-SQV)		 4yv7 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ARG A 246
LEU A 241
ILE A 264
GLY A 267
VAL A 249
 None
 1.29A 5kr2B-4yv7A:
undetectable		 5kr2B-4yv7A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 4yv7 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ALA A  61
PHE A  45
GLN A  47
 None
 0.73A 6eceA-4yv7A:
5.1		 6eceA-4yv7A:
22.44