SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yvd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4yvd PLEIOTROPIC
REGULATOR 1
(Homo
sapiens) 		5 / 8 SER A 263
ILE A 228
GLY A 222
CYH A 209
GLY A 293
 None
None
None
None
NA  A 601 (-3.6A)
 1.31A 1me7A-4yvdA:
undetectable		 1me7A-4yvdA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 4yvd PLEIOTROPIC
REGULATOR 1
(Homo
sapiens) 		3 / 3 SER A 404
HIS A 381
ASP A 440
 CL  A 606 (-2.9A)
UNX  A 607 ( 4.6A)
None
 0.53A 2wa2B-4yvdA:
undetectable		 2wa2B-4yvdA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_2
(PROTEASE)		 4yvd PLEIOTROPIC
REGULATOR 1
(Homo
sapiens) 		5 / 11 LEU A 478
GLY A 236
ILE A 230
ILE A 210
ILE A 486
 None
 0.78A 3s45B-4yvdA:
undetectable		 3s45B-4yvdA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4yvd PLEIOTROPIC
REGULATOR 1
(Homo
sapiens) 		4 / 4 GLY A 251
GLY A 293
THR A 305
LEU A 303
 NA  A 601 ( 4.4A)
NA  A 601 (-3.6A)
None
None
 0.85A 3si7C-4yvdA:
undetectable
3si7D-4yvdA:
undetectable		 3si7C-4yvdA:
21.52
3si7D-4yvdA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 4yvd PLEIOTROPIC
REGULATOR 1
(Homo
sapiens) 		5 / 9 PHE A 387
LEU A 356
THR A 364
THR A 353
ILE A 354
 None
 1.06A 3tbgD-4yvdA:
undetectable		 3tbgD-4yvdA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4yvd PLEIOTROPIC
REGULATOR 1
(Homo
sapiens) 		5 / 10 ILE A 406
ILE A 395
GLY A 444
THR A 386
PHE A 387
 None
None
None
UNX  A 607 ( 3.5A)
None
 0.97A 4fakA-4yvdA:
undetectable		 4fakA-4yvdA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 4yvd PLEIOTROPIC
REGULATOR 1
(Homo
sapiens) 		5 / 12 THR A 435
GLY A 464
ILE A 416
SER A 429
HIS A 437
 None
 1.20A 4pooB-4yvdA:
undetectable		 4pooB-4yvdA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 4yvd PLEIOTROPIC
REGULATOR 1
(Homo
sapiens) 		5 / 12 VAL A 450
THR A 420
VAL A 379
ILE A 416
HIS A 412
 None
UNX  A 615 ( 3.8A)
UNX  A 617 ( 4.1A)
None
None
 1.33A 4s0vA-4yvdA:
undetectable		 4s0vA-4yvdA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_1
(PROTEASE)		 4yvd PLEIOTROPIC
REGULATOR 1
(Homo
sapiens) 		5 / 12 LEU A 478
GLY A 236
ILE A 230
ILE A 210
ILE A 486
 None
 0.71A 5e5jA-4yvdA:
undetectable		 5e5jA-4yvdA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4yvd PLEIOTROPIC
REGULATOR 1
(Homo
sapiens) 		5 / 12 ALA A 431
ASP A 393
GLY A 390
SER A 389
SER A 429
 None
 1.30A 5hfjE-4yvdA:
undetectable		 5hfjE-4yvdA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 4yvd PLEIOTROPIC
REGULATOR 1
(Homo
sapiens) 		5 / 12 HIS A 287
GLY A 251
GLY A 265
ILE A 253
LEU A 294
 None
NA  A 601 ( 4.4A)
None
None
None
 1.05A 6b3aA-4yvdA:
undetectable		 6b3aA-4yvdA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 4yvd PLEIOTROPIC
REGULATOR 1
(Homo
sapiens) 		5 / 12 HIS A 287
GLY A 251
GLY A 265
ILE A 253
LEU A 294
 None
NA  A 601 ( 4.4A)
None
None
None
 1.14A 6b3bA-4yvdA:
undetectable		 6b3bA-4yvdA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4yvd PLEIOTROPIC
REGULATOR 1
(Homo
sapiens) 		4 / 7 ALA A 312
THR A 311
VAL A 304
TRP A 315
 None
 0.94A 6cduA-4yvdA:
undetectable
6cduE-4yvdA:
undetectable		 6cduA-4yvdA:
22.41
6cduE-4yvdA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4yvd PLEIOTROPIC
REGULATOR 1
(Homo
sapiens) 		4 / 6 VAL A 304
TRP A 315
ALA A 312
THR A 311
 None
 0.87A 6cduB-4yvdA:
undetectable
6cduC-4yvdA:
undetectable		 6cduB-4yvdA:
22.41
6cduC-4yvdA:
22.41