SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yvs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 4yvs CAPSID PROTEIN VP0
(Enterovirus
A) 		4 / 5 LEU C 215
PRO C 218
VAL C 217
ASP C 167
 None
 1.13A 3ufnA-4yvsC:
undetectable
3ufnB-4yvsC:
undetectable		 3ufnA-4yvsC:
17.04
3ufnB-4yvsC:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 4yvs CAPSID PROTEIN VP0
(Enterovirus
A) 		5 / 12 TYR C 148
GLY C 213
TYR C 130
ALA C  96
LEU C 207
 None
 1.12A 3vywC-4yvsC:
undetectable		 3vywC-4yvsC:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA502_1
(CHITINASE)		 4yvs CAPSID PROTEIN VP0
(Enterovirus
A) 		4 / 5 GLY C 154
TRP C  80
ALA C 155
PHE C 106
 None
 1.30A 3wqwA-4yvsC:
undetectable		 3wqwA-4yvsC:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4yvs CAPSID PROTEIN VP0
(Enterovirus
A) 		3 / 3 TYR C 148
ASP C  84
ASP C 156
 None
 0.81A 4a6eA-4yvsC:
undetectable		 4a6eA-4yvsC:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4yvs CAPSID PROTEIN VP0
(Enterovirus
A) 		4 / 5 THR C  68
THR C 229
HIS C 118
LEU C 222
 None
 1.35A 4lvcA-4yvsC:
undetectable		 4lvcA-4yvsC:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4yvs CAPSID PROTEIN VP0
(Enterovirus
A) 		4 / 5 THR C  68
THR C 229
HIS C 118
LEU C 222
 None
 1.35A 4lvcC-4yvsC:
undetectable		 4lvcC-4yvsC:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4yvs CAPSID PROTEIN VP0
(Enterovirus
A) 		3 / 3 ALA C 239
TYR C  64
PRO C  56
 None
 0.65A 4zdyA-4yvsC:
undetectable		 4zdyA-4yvsC:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 4yvs CAPSID PROTEIN VP0
(Enterovirus
A) 		4 / 4 VAL C 110
ALA C 191
ASN C  30
GLN C 181
 None
 1.37A 4zgfA-4yvsC:
undetectable		 4zgfA-4yvsC:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 4yvs CAPSID PROTEIN VP0
(Enterovirus
A) 		4 / 4 VAL C 110
ALA C 191
ASN C 188
GLN C 181
 None
 1.27A 4zgfA-4yvsC:
undetectable		 4zgfA-4yvsC:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4yvs CAPSID PROTEIN VP0
(Enterovirus
A) 		3 / 3 SER C 205
ALA C 206
THR C  87
 None
 0.68A 5n0xB-4yvsC:
undetectable		 5n0xB-4yvsC:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4yvs CAPSID PROTEIN VP0
(Enterovirus
A) 		4 / 6 ARG C  55
ARG C 103
ALA C 246
PRO C  53
 None
 1.34A 5odqA-4yvsC:
undetectable		 5odqA-4yvsC:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 4yvs CAPSID PROTEIN VP0
(Enterovirus
A) 		4 / 5 THR C  68
THR C 229
HIS C 118
LEU C 222
 None
 1.37A 6gbnA-4yvsC:
undetectable		 6gbnA-4yvsC:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 4yvs CAPSID PROTEIN VP0
(Enterovirus
A) 		4 / 5 THR C  68
THR C 229
HIS C 118
LEU C 222
 None
 1.35A 6gbnD-4yvsC:
undetectable		 6gbnD-4yvsC:
19.34