SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4yw5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_A_ZMRA466_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.71A 1a4gA-4yw5A:
23.8		 1a4gA-4yw5A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 ARG A 290
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.41A 1a4gB-4yw5A:
23.9		 1a4gB-4yw5A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_A_CAMA503_0
(CYTOCHROME P450-CAM)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 9 TYR A 120
LEU A 150
VAL A 148
GLY A 157
VAL A 210
 None
 1.32A 1dz8A-4yw5A:
undetectable		 1dz8A-4yw5A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		4 / 8 GLY A 127
GLY A 234
PHE A 243
GLY A  96
 None
 0.77A 1jhaA-4yw5A:
undetectable		 1jhaA-4yw5A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 GLY A 234
GLY A 233
VAL A  92
LEU A 249
LEU A  94
 None
 0.76A 1mx1F-4yw5A:
undetectable		 1mx1F-4yw5A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 GLY A 234
GLY A  97
VAL A 148
ASP A 147
TYR A 120
 None
 1.21A 1n2xA-4yw5A:
undetectable		 1n2xA-4yw5A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 GLY A 234
GLY A  97
VAL A 148
ASP A 147
VAL A 235
 None
 1.28A 1n2xA-4yw5A:
undetectable		 1n2xA-4yw5A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NNC_A_ZMRA479_1
(NEURAMINIDASE N9)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 ARG A 290
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.52A 1nncA-4yw5A:
20.3		 1nncA-4yw5A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		4 / 5 LEU A 624
TRP A 581
LEU A 636
GLN A 596
 None
 1.17A 1p93D-4yw5A:
undetectable		 1p93D-4yw5A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3E_A_ZMRA1200_1
(HEMAGGLUTININ-NEURAM
INIDASE GLYCOPROTEIN)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 10 TYR A 533
TYR A 553
GLU A 584
ARG A 600
ARG A 662
 G39  A 801 (-4.5A)
None
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
 0.69A 1v3eA-4yw5A:
4.6		 1v3eA-4yw5A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3E_A_ZMRA1200_1
(HEMAGGLUTININ-NEURAM
INIDASE GLYCOPROTEIN)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 10 TYR A 553
PHE A 396
GLU A 584
ARG A 600
ARG A 662
 None
G39  A 801 (-3.9A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
 1.06A 1v3eA-4yw5A:
4.6		 1v3eA-4yw5A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3E_B_ZMRB2200_1
(HEMAGGLUTININ-NEURAM
INIDASE GLYCOPROTEIN)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 10 ARG A 290
TYR A 533
TYR A 553
GLU A 584
ARG A 600
 G39  A 801 (-2.6A)
G39  A 801 (-4.5A)
None
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
 1.04A 1v3eB-4yw5A:
7.7		 1v3eB-4yw5A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3E_B_ZMRB2200_1
(HEMAGGLUTININ-NEURAM
INIDASE GLYCOPROTEIN)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 10 ARG A 290
TYR A 533
TYR A 553
GLU A 584
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-4.5A)
None
G39  A 801 ( 4.7A)
G39  A 801 (-4.4A)
 0.96A 1v3eB-4yw5A:
7.7		 1v3eB-4yw5A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3E_B_ZMRB2200_1
(HEMAGGLUTININ-NEURAM
INIDASE GLYCOPROTEIN)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 10 TYR A 533
TYR A 553
GLU A 584
ARG A 600
ARG A 662
 G39  A 801 (-4.5A)
None
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
 0.68A 1v3eB-4yw5A:
7.7		 1v3eB-4yw5A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3E_B_ZMRB2200_1
(HEMAGGLUTININ-NEURAM
INIDASE GLYCOPROTEIN)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 10 TYR A 553
PHE A 396
GLU A 584
ARG A 600
ARG A 662
 None
G39  A 801 (-3.9A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
 1.09A 1v3eB-4yw5A:
7.7		 1v3eB-4yw5A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 9 TYR A 120
LEU A 150
VAL A 148
GLY A 157
VAL A 210
 None
 1.28A 2a1oB-4yw5A:
undetectable		 2a1oB-4yw5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 ASN A 168
LEU A 170
LEU A 128
ARG A 151
THR A 163
 None
 1.17A 2aa5B-4yw5A:
undetectable		 2aa5B-4yw5A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1477_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.71A 2cmlA-4yw5A:
10.2		 2cmlA-4yw5A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2477_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.71A 2cmlB-4yw5A:
4.5		 2cmlB-4yw5A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.72A 2cmlC-4yw5A:
2.9		 2cmlC-4yw5A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4477_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.72A 2cmlD-4yw5A:
20.4		 2cmlD-4yw5A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 10 TYR A 120
LEU A 150
VAL A 148
GLY A 157
VAL A 210
 None
 1.31A 2cp4A-4yw5A:
undetectable		 2cp4A-4yw5A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F0Z_A_ZMRA381_1
(SIALIDASE 2)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
TYR A 553
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
None
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.37A 2f0zA-4yw5A:
38.1		 2f0zA-4yw5A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F10_A_BCZA382_0
(SIALIDASE 2)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		8 / 12 ARG A 290
ILE A 291
ARG A 309
TYR A 553
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
None
G39  A 801 (-4.3A)
None
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.59A 2f10A-4yw5A:
37.2		 2f10A-4yw5A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTQ_A_ZMRA472_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 ARG A 290
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.69A 2htqA-4yw5A:
10.2		 2htqA-4yw5A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 ASN A 168
LEU A 170
LEU A 128
ARG A 151
THR A 163
 None
 1.21A 2oaxB-4yw5A:
undetectable		 2oaxB-4yw5A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		4 / 5 LEU A 219
ALA A 194
SER A 196
LYS A 167
 None
 1.15A 2othA-4yw5A:
undetectable		 2othA-4yw5A:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		3 / 3 ARG A 662
ASN A 725
THR A 313
 G39  A 801 (-2.9A)
None
None
 0.83A 2q63A-4yw5A:
undetectable		 2q63A-4yw5A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		4 / 7 ILE A 488
TYR A 490
PHE A 343
ASP A 344
 None
None
None
GOL  A 803 ( 4.3A)
 0.89A 2qebB-4yw5A:
undetectable		 2qebB-4yw5A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		3 / 3 ARG A 151
GLU A 155
SER A 658
 None
 0.84A 2xctD-4yw5A:
undetectable		 2xctD-4yw5A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_1
(NEURAMINIDASE A)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 ARG A 290
ASP A 307
ILE A 371
ASP A 388
PHE A 316
 G39  A 801 (-2.6A)
None
None
G39  A 801 ( 4.8A)
GOL  A 802 (-4.9A)
 0.83A 2ya7A-4yw5A:
42.9		 2ya7A-4yw5A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_1
(NEURAMINIDASE A)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ILE A 291
ASP A 307
ILE A 320
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
None
None
None
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 1.32A 2ya7A-4yw5A:
42.9		 2ya7A-4yw5A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_1
(NEURAMINIDASE A)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		10 / 12 ARG A 290
ILE A 291
ASP A 307
ILE A 371
ASP A 372
ASP A 388
TYR A 553
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
None
None
None
G39  A 801 (-2.6A)
G39  A 801 ( 4.8A)
None
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.38A 2ya7A-4yw5A:
42.9		 2ya7A-4yw5A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_1
(NEURAMINIDASE A)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ILE A 291
ASP A 307
ILE A 320
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
None
None
None
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 1.31A 2ya7B-4yw5A:
42.6		 2ya7B-4yw5A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_1
(NEURAMINIDASE A)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		10 / 12 ARG A 290
ILE A 291
ASP A 307
ILE A 371
ASP A 372
ASP A 388
TYR A 553
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
None
None
None
G39  A 801 (-2.6A)
G39  A 801 ( 4.8A)
None
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.36A 2ya7B-4yw5A:
42.6		 2ya7B-4yw5A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_1
(NEURAMINIDASE A)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ILE A 291
ASP A 307
ILE A 371
ASP A 388
PHE A 316
 G39  A 801 (-2.6A)
None
None
None
G39  A 801 ( 4.8A)
GOL  A 802 (-4.9A)
 0.78A 2ya7B-4yw5A:
42.6		 2ya7B-4yw5A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_1
(NEURAMINIDASE A)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 ARG A 290
ASP A 307
ILE A 371
ASP A 388
PHE A 316
 G39  A 801 (-2.6A)
None
None
G39  A 801 ( 4.8A)
GOL  A 802 (-4.9A)
 0.83A 2ya7C-4yw5A:
39.6		 2ya7C-4yw5A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_1
(NEURAMINIDASE A)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ILE A 291
ASP A 307
ILE A 320
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
None
None
None
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 1.30A 2ya7C-4yw5A:
39.6		 2ya7C-4yw5A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_1
(NEURAMINIDASE A)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		10 / 12 ARG A 290
ILE A 291
ASP A 307
ILE A 371
ASP A 372
ASP A 388
TYR A 553
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
None
None
None
G39  A 801 (-2.6A)
G39  A 801 ( 4.8A)
None
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.36A 2ya7C-4yw5A:
39.6		 2ya7C-4yw5A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_1
(NEURAMINIDASE A)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ILE A 291
ASP A 307
ILE A 320
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
None
None
None
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 1.31A 2ya7D-4yw5A:
19.6		 2ya7D-4yw5A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_1
(NEURAMINIDASE A)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		10 / 12 ARG A 290
ILE A 291
ASP A 307
ILE A 371
ASP A 372
ASP A 388
TYR A 553
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
None
None
None
G39  A 801 (-2.6A)
G39  A 801 ( 4.8A)
None
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.35A 2ya7D-4yw5A:
19.6		 2ya7D-4yw5A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_1
(NEURAMINIDASE A)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ILE A 291
ASP A 307
ILE A 371
ASP A 388
PHE A 316
 G39  A 801 (-2.6A)
None
None
None
G39  A 801 ( 4.8A)
GOL  A 802 (-4.9A)
 0.78A 2ya7D-4yw5A:
19.6		 2ya7D-4yw5A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 LEU A 170
ILE A 134
LEU A 105
ILE A 221
PHE A 132
 None
 1.10A 2ygnA-4yw5A:
undetectable		 2ygnA-4yw5A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		4 / 6 VAL A 627
ASP A 685
HIS A 664
TYR A 693
 None
 1.48A 2zs9A-4yw5A:
undetectable		 2zs9A-4yw5A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7E_A_ZMRA1001_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.80A 3b7eA-4yw5A:
20.4		 3b7eA-4yw5A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7E_B_ZMRB1002_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.80A 3b7eB-4yw5A:
20.8		 3b7eB-4yw5A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		4 / 8 HIS A 314
ASN A 318
ILE A 364
TRP A 353
 None
 1.47A 3ccfB-4yw5A:
undetectable		 3ccfB-4yw5A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 ARG A 290
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.43A 3ckzA-4yw5A:
12.1		 3ckzA-4yw5A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		4 / 8 LEU A 232
LEU A  94
ASN A 100
GLY A 234
 None
 0.85A 3dcjB-4yw5A:
undetectable		 3dcjB-4yw5A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_0
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
 0.79A 3k37B-4yw5A:
23.2		 3k37B-4yw5A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_B_BCZB1001_0
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.73A 3k39B-4yw5A:
23.8		 3k39B-4yw5A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_A_ZMRA901_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 ARG A 290
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.44A 3sanA-4yw5A:
3.3		 3sanA-4yw5A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_B_ZMRB901_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 ARG A 290
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.44A 3sanB-4yw5A:
10.3		 3sanB-4yw5A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI5_A_ZMRA1002_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.75A 3ti5A-4yw5A:
4.5		 3ti5A-4yw5A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI5_B_ZMRB1002_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.77A 3ti5B-4yw5A:
9.9		 3ti5B-4yw5A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.69A 3ticA-4yw5A:
7.5		 3ticA-4yw5A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_B_ZMRB1002_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.72A 3ticB-4yw5A:
20.5		 3ticB-4yw5A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_C_ZMRC1002_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.70A 3ticC-4yw5A:
20.4		 3ticC-4yw5A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_D_ZMRD1002_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.70A 3ticD-4yw5A:
20.6		 3ticD-4yw5A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.77A 4b7nA-4yw5A:
11.8		 4b7nA-4yw5A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.87A 4b7qA-4yw5A:
12.5		 4b7qA-4yw5A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_B_ZMRB601_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.80A 4b7qB-4yw5A:
3.0		 4b7qB-4yw5A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.77A 4b7qC-4yw5A:
11.9		 4b7qC-4yw5A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_D_ZMRD601_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.84A 4b7qD-4yw5A:
11.9		 4b7qD-4yw5A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_A_ZMRA700_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.78A 4cpnA-4yw5A:
23.9		 4cpnA-4yw5A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_B_ZMRB700_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.81A 4cpnB-4yw5A:
3.3		 4cpnB-4yw5A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 ARG A 290
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.43A 4cpzA-4yw5A:
24.0		 4cpzA-4yw5A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 ARG A 290
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.41A 4cpzB-4yw5A:
23.9		 4cpzB-4yw5A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.79A 4cpzC-4yw5A:
7.3		 4cpzC-4yw5A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 ARG A 290
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.35A 4cpzD-4yw5A:
24.0		 4cpzD-4yw5A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.81A 4cpzE-4yw5A:
8.3		 4cpzE-4yw5A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.84A 4cpzF-4yw5A:
7.1		 4cpzF-4yw5A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.74A 4cpzG-4yw5A:
23.9		 4cpzG-4yw5A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.81A 4cpzH-4yw5A:
23.8		 4cpzH-4yw5A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		4 / 8 THR A 333
TRP A 334
TYR A 326
PHE A 303
 None
 1.09A 4drjB-4yw5A:
undetectable		 4drjB-4yw5A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		4 / 8 ASP A 388
ASP A 315
GLU A 584
ASP A 307
 G39  A 801 ( 4.8A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
None
 1.21A 4fewD-4yw5A:
undetectable		 4fewD-4yw5A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		4 / 8 ASP A 388
ASP A 315
GLU A 584
ASP A 307
 G39  A 801 ( 4.8A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
None
 1.22A 4gkiA-4yw5A:
undetectable		 4gkiA-4yw5A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.74A 4i00A-4yw5A:
20.6		 4i00A-4yw5A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		3 / 3 TYR A 695
ARG A 662
SER A 694
 G39  A 801 (-4.4A)
G39  A 801 (-2.9A)
None
 1.15A 4lf7I-4yw5A:
undetectable
4lf7J-4yw5A:
undetectable		 4lf7I-4yw5A:
11.95
4lf7J-4yw5A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		3 / 3 TYR A 695
ARG A 662
SER A 694
 G39  A 801 (-4.4A)
G39  A 801 (-2.9A)
None
 1.15A 4lf8I-4yw5A:
undetectable
4lf8J-4yw5A:
undetectable		 4lf8I-4yw5A:
11.95
4lf8J-4yw5A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 ARG A 290
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.44A 4mwrA-4yw5A:
20.3		 4mwrA-4yw5A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.76A 4mwxA-4yw5A:
7.6		 4mwxA-4yw5A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		3 / 3 ARG A 290
ASP A 315
ARG A 662
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 (-2.9A)
 0.77A 4mx0A-4yw5A:
4.5		 4mx0A-4yw5A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_1
(PROTEASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 11 ALA A 387
ILE A 291
GLY A 537
THR A 324
ILE A 322
 None
 0.94A 4njtC-4yw5A:
undetectable		 4njtC-4yw5A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 GLY A 133
SER A 135
ILE A 252
LEU A  87
VAL A 101
 None
 1.04A 4qdjA-4yw5A:
undetectable		 4qdjA-4yw5A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA5_A_ZMRA501_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 ARG A 290
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.44A 4wa5A-4yw5A:
10.3		 4wa5A-4yw5A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		4 / 5 LEU A 150
TYR A 120
ALA A 205
ASN A 206
 None
None
GOL  A 804 (-3.9A)
GOL  A 804 (-3.7A)
 1.09A 4y03B-4yw5A:
undetectable		 4y03B-4yw5A:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		4 / 8 PHE A 452
GLY A 453
THR A 519
TYR A 502
 None
GOL  A 803 (-3.6A)
None
None
 0.92A 5flcB-4yw5A:
undetectable		 5flcB-4yw5A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		4 / 8 PHE A 452
GLY A 453
THR A 519
TYR A 502
 None
GOL  A 803 (-3.6A)
None
None
 0.92A 5flcF-4yw5A:
undetectable		 5flcF-4yw5A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		3 / 3 LEU A 701
TYR A 729
SER A 327
 None
 0.89A 5iktA-4yw5A:
undetectable		 5iktA-4yw5A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 TYR A 608
ILE A 638
TYR A 598
PHE A 626
GLY A 670
 None
 1.03A 5jlcA-4yw5A:
undetectable		 5jlcA-4yw5A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		3 / 3 TYR A 691
TYR A 120
GLN A 122
 None
 1.13A 5jsdA-4yw5A:
undetectable
5jsdB-4yw5A:
undetectable		 5jsdA-4yw5A:
24.12
5jsdB-4yw5A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		3 / 3 TYR A 691
TYR A 120
GLN A 122
 None
 1.14A 5jsdB-4yw5A:
undetectable
5jsdC-4yw5A:
undetectable		 5jsdB-4yw5A:
24.12
5jsdC-4yw5A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L17_A_ZMRA512_1
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ARG A 290
ASP A 315
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.72A 5l17A-4yw5A:
7.7		 5l17A-4yw5A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		3 / 3 HIS A 683
ASP A 685
HIS A 664
 None
 0.78A 5oexA-4yw5A:
0.0		 5oexA-4yw5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		3 / 3 HIS A 683
ASP A 685
HIS A 664
 None
 0.73A 5oexB-4yw5A:
5.8		 5oexB-4yw5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		3 / 3 HIS A 683
ASP A 685
HIS A 664
 None
 0.73A 5oexC-4yw5A:
3.4		 5oexC-4yw5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		3 / 3 HIS A 683
ASP A 685
HIS A 664
 None
 0.73A 5oexD-4yw5A:
10.1		 5oexD-4yw5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		4 / 7 THR A 273
VAL A 148
GLN A 129
GLU A 125
 None
 1.13A 5tudA-4yw5A:
undetectable		 5tudA-4yw5A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 TYR A 608
ILE A 638
TYR A 598
PHE A 626
GLY A 670
 None
 1.35A 5v5zA-4yw5A:
undetectable		 5v5zA-4yw5A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		4 / 6 SER A 696
ARG A 290
GLU A 711
TYR A 695
 None
G39  A 801 (-2.6A)
None
G39  A 801 (-4.4A)
 1.15A 5x7pA-4yw5A:
4.1		 5x7pA-4yw5A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		4 / 6 SER A 696
ARG A 290
GLU A 711
TYR A 695
 None
G39  A 801 (-2.6A)
None
G39  A 801 (-4.4A)
 1.20A 5x7pB-4yw5A:
4.2		 5x7pB-4yw5A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		4 / 6 SER A 696
ARG A 290
GLU A 711
TYR A 695
 None
G39  A 801 (-2.6A)
None
G39  A 801 (-4.4A)
 1.19A 5x7qA-4yw5A:
4.0		 5x7qA-4yw5A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		4 / 6 SER A 696
ARG A 290
GLU A 711
TYR A 695
 None
G39  A 801 (-2.6A)
None
G39  A 801 (-4.4A)
 1.18A 5x7qB-4yw5A:
4.2		 5x7qB-4yw5A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		4 / 6 SER A 696
ARG A 290
GLU A 711
TYR A 695
 None
G39  A 801 (-2.6A)
None
G39  A 801 (-4.4A)
 1.19A 5x7rA-4yw5A:
undetectable		 5x7rA-4yw5A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		7 / 12 ARG A 290
ILE A 291
ARG A 309
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
None
G39  A 801 (-4.3A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.48A 6ekuA-4yw5A:
37.1		 6ekuA-4yw5A:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		6 / 12 ILE A 291
ASP A 372
GLU A 584
ARG A 600
ARG A 662
TYR A 695
 None
G39  A 801 (-2.6A)
G39  A 801 ( 4.7A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.74A 6ekuA-4yw5A:
37.1		 6ekuA-4yw5A:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 GLU A 720
GLY A 692
TYR A 632
PRO A 656
GLY A 665
 None
 1.19A 6gngA-4yw5A:
undetectable		 6gngA-4yw5A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_0
(NEURAMINIDASE)		 4yw5 NEURAMINIDASE C
(Streptococcus
pneumoniae) 		5 / 12 ARG A 290
ASP A 315
ARG A 600
ARG A 662
TYR A 695
 G39  A 801 (-2.6A)
G39  A 801 (-3.2A)
G39  A 801 (-2.9A)
G39  A 801 (-2.9A)
G39  A 801 (-4.4A)
 0.76A 6hcxA-4yw5A:
8.1		 6hcxA-4yw5A:
9.46