SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ywh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4ywh ABC TRANSPORTER
SOLUTE BINDING
PROTEIN
(Actinobacillus
succinogenes) 		5 / 12 GLY A 154
ALA A 197
GLY A 243
ALA A 226
ILE A 241
 None
 0.99A 1gtnL-4ywhA:
undetectable
1gtnV-4ywhA:
undetectable		 1gtnL-4ywhA:
12.05
1gtnV-4ywhA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ywh ABC TRANSPORTER
SOLUTE BINDING
PROTEIN
(Actinobacillus
succinogenes) 		5 / 12 GLY A 243
ALA A 226
ILE A 241
GLY A 154
ALA A 197
 None
 1.01A 1utdO-4ywhA:
undetectable
1utdP-4ywhA:
undetectable		 1utdO-4ywhA:
12.05
1utdP-4ywhA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ywh ABC TRANSPORTER
SOLUTE BINDING
PROTEIN
(Actinobacillus
succinogenes) 		5 / 11 GLY A 243
ALA A 226
ILE A 241
GLY A 154
ALA A 197
 None
 1.01A 1utdP-4ywhA:
undetectable
1utdQ-4ywhA:
undetectable		 1utdP-4ywhA:
12.05
1utdQ-4ywhA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_1
(PROTEASE)		 4ywh ABC TRANSPORTER
SOLUTE BINDING
PROTEIN
(Actinobacillus
succinogenes) 		5 / 12 ALA A 246
ASP A 245
ASP A 247
VAL A 255
ILE A 251
 None
XYP  A 401 (-2.4A)
None
None
None
 1.14A 2o4lA-4ywhA:
undetectable		 2o4lA-4ywhA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4ywh ABC TRANSPORTER
SOLUTE BINDING
PROTEIN
(Actinobacillus
succinogenes) 		4 / 5 SER A 126
PHE A 127
VAL A 132
TYR A 124
 None
 1.30A 2x7hA-4ywhA:
4.4		 2x7hA-4ywhA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4ywh ABC TRANSPORTER
SOLUTE BINDING
PROTEIN
(Actinobacillus
succinogenes) 		4 / 5 SER A 126
PHE A 127
VAL A 132
TYR A 124
 None
 1.31A 2x7hB-4ywhA:
4.5		 2x7hB-4ywhA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 4ywh ABC TRANSPORTER
SOLUTE BINDING
PROTEIN
(Actinobacillus
succinogenes) 		4 / 7 GLY A  92
ASP A 113
TRP A  40
ARG A  39
 None
XYP  A 401 (-3.3A)
None
XYP  A 401 (-3.9A)
 1.27A 3arrA-4ywhA:
undetectable		 3arrA-4ywhA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 4ywh ABC TRANSPORTER
SOLUTE BINDING
PROTEIN
(Actinobacillus
succinogenes) 		3 / 3 MET A 261
VAL A 216
GLU A 143
 None
 0.68A 3c6gA-4ywhA:
undetectable		 3c6gA-4ywhA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ywh ABC TRANSPORTER
SOLUTE BINDING
PROTEIN
(Actinobacillus
succinogenes) 		4 / 7 GLY A  29
VAL A  82
ILE A  87
GLN A  61
 None
 0.88A 3fi0P-4ywhA:
undetectable		 3fi0P-4ywhA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 4ywh ABC TRANSPORTER
SOLUTE BINDING
PROTEIN
(Actinobacillus
succinogenes) 		3 / 3 ALA A 217
VAL A 216
GLN A 168
 None
 0.56A 3of4B-4ywhA:
undetectable		 3of4B-4ywhA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_A_ACRA701_1
(ALPHA-GLUCOSIDASE)		 4ywh ABC TRANSPORTER
SOLUTE BINDING
PROTEIN
(Actinobacillus
succinogenes) 		5 / 12 ASP A 158
ASP A 113
ARG A  39
TRP A  40
ASP A 245
 XYP  A 401 (-2.8A)
XYP  A 401 (-3.3A)
XYP  A 401 (-3.9A)
None
XYP  A 401 (-2.4A)
 1.15A 3phaA-4ywhA:
undetectable		 3phaA-4ywhA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_A_SALA201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4ywh ABC TRANSPORTER
SOLUTE BINDING
PROTEIN
(Actinobacillus
succinogenes) 		5 / 10 VAL A 330
ALA A 246
VAL A 310
ILE A 254
ILE A 320
 None
 1.24A 3retA-4ywhA:
undetectable
3retB-4ywhA:
undetectable		 3retA-4ywhA:
16.55
3retB-4ywhA:
16.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Y9T_A_PA1A401_1
(ABC TRANSPORTER,
SOLUTE BINDING
PROTEIN)		 4ywh ABC TRANSPORTER
SOLUTE BINDING
PROTEIN
(Actinobacillus
succinogenes) 		5 / 12 ASP A 245
ASP A 113
ARG A 114
ASP A 158
TRP A 192
 XYP  A 401 (-2.4A)
XYP  A 401 (-3.3A)
XYP  A 401 (-3.9A)
XYP  A 401 (-2.8A)
XYP  A 401 (-3.2A)
 1.17A 4y9tA-4ywhA:
35.8		 4y9tA-4ywhA:
31.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BR1_A_X6XA401_1
(ABC TRANSPORTER,
BINDING PROTEIN)		 4ywh ABC TRANSPORTER
SOLUTE BINDING
PROTEIN
(Actinobacillus
succinogenes) 		5 / 11 ASP A 245
ASP A 113
ARG A 114
ASP A 158
TRP A 192
 XYP  A 401 (-2.4A)
XYP  A 401 (-3.3A)
XYP  A 401 (-3.9A)
XYP  A 401 (-2.8A)
XYP  A 401 (-3.2A)
 1.12A 5br1A-4ywhA:
35.8		 5br1A-4ywhA:
31.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 4ywh ABC TRANSPORTER
SOLUTE BINDING
PROTEIN
(Actinobacillus
succinogenes) 		3 / 3 TYR A 112
SER A 126
TRP A  40
 None
 1.06A 5n8jB-4ywhA:
undetectable		 5n8jB-4ywhA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_0
(HIV-1 PROTEASE)		 4ywh ABC TRANSPORTER
SOLUTE BINDING
PROTEIN
(Actinobacillus
succinogenes) 		5 / 12 ALA A 246
ASP A 245
ASP A 247
VAL A 255
ILE A 251
 None
XYP  A 401 (-2.4A)
None
None
None
 1.12A 6difA-4ywhA:
undetectable		 6difA-4ywhA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 4ywh ABC TRANSPORTER
SOLUTE BINDING
PROTEIN
(Actinobacillus
succinogenes) 		4 / 6 LEU A 304
ALA A 302
LEU A 163
ASN A 117
 None
 0.93A 6f88B-4ywhA:
undetectable		 6f88B-4ywhA:
13.73