SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ywl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_2
(PROTEIN (PROTEASE))		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 GLY A 225
VAL A 221
ILE A 187
GLY A 205
ILE A 206
 None
 0.76A 1c6yB-4ywlA:
undetectable		 1c6yB-4ywlA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 9 GLY A 225
VAL A 221
ILE A 187
GLY A 205
ILE A 206
 None
 1.02A 1hpvA-4ywlA:
undetectable		 1hpvA-4ywlA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 9 VAL A 221
ILE A 187
GLY A 205
ILE A 206
ILE A 249
 None
 1.00A 1hpvA-4ywlA:
undetectable		 1hpvA-4ywlA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 9 VAL A 221
GLY A 205
ILE A 206
VAL A 214
ILE A 249
 None
 1.02A 1hpvB-4ywlA:
undetectable		 1hpvB-4ywlA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 10 VAL A 221
ILE A 187
GLY A 205
VAL A 214
ILE A 249
 None
 0.95A 1hsgA-4ywlA:
undetectable		 1hsgA-4ywlA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 ARG A 228
GLY A  67
GLU A  72
GLU A  65
GLU A 245
 None
 1.44A 1jdvE-4ywlA:
undetectable
1jdvF-4ywlA:
undetectable		 1jdvE-4ywlA:
21.11
1jdvF-4ywlA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		4 / 7 PHE A  95
ALA A  71
PHE A  10
PHE A  13
 None
 1.18A 1lqtA-4ywlA:
undetectable		 1lqtA-4ywlA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		4 / 7 PHE A  95
ALA A  71
PHE A  10
PHE A  13
 None
 1.18A 1lquA-4ywlA:
undetectable		 1lquA-4ywlA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		6 / 9 VAL A 221
ILE A 187
GLY A 205
ILE A 206
VAL A 214
ILE A 249
 None
 0.93A 1ohrB-4ywlA:
undetectable		 1ohrB-4ywlA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		4 / 4 VAL A 221
ALA A 215
LEU A 207
PHE A 185
 None
 1.18A 1q97B-4ywlA:
undetectable		 1q97B-4ywlA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 10 ILE A 187
GLY A 205
ILE A 206
VAL A 214
ILE A 249
 None
 0.97A 1sdtA-4ywlA:
undetectable		 1sdtA-4ywlA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 GLY A 225
VAL A 221
ILE A 187
GLY A 205
ILE A 206
 None
 0.66A 1sdtB-4ywlA:
undetectable		 1sdtB-4ywlA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 11 GLY A 225
VAL A 221
ILE A 187
GLY A 205
ILE A 206
 None
 0.67A 1sdvB-4ywlA:
undetectable		 1sdvB-4ywlA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		3 / 3 ARG A 228
TYR A 153
LYS A 151
 None
 1.06A 1uujB-4ywlA:
undetectable		 1uujB-4ywlA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_2
(HIV-1 PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 11 ILE A 187
GLY A 205
ILE A 206
VAL A 214
ILE A 249
 None
 0.79A 2aquB-4ywlA:
undetectable		 2aquB-4ywlA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 9 ILE A 187
GLY A 205
ILE A 206
VAL A 214
ILE A 249
 None
 0.86A 2avoA-4ywlA:
undetectable		 2avoA-4ywlA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_2
(POL POLYPROTEIN)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 VAL A 221
ILE A 187
GLY A 205
VAL A 214
ILE A 249
 None
 0.82A 2avoB-4ywlA:
undetectable		 2avoB-4ywlA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_2
(POL PROTEIN)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 11 ILE A 187
GLY A 205
ILE A 206
VAL A 214
ILE A 249
 None
 0.89A 2fxeB-4ywlA:
undetectable		 2fxeB-4ywlA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 9 VAL A 221
GLY A 205
ILE A 206
VAL A 214
ILE A 249
 None
 0.98A 2o4pB-4ywlA:
undetectable		 2o4pB-4ywlA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 GLY A 225
VAL A 221
ILE A 187
GLY A 205
ILE A 206
 None
 0.87A 2pynB-4ywlA:
undetectable		 2pynB-4ywlA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 ARG A  94
VAL A 221
ILE A 187
GLY A 205
ILE A 206
 None
 0.88A 2q5kB-4ywlA:
undetectable		 2q5kB-4ywlA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		6 / 12 GLY A 225
VAL A 221
ILE A 187
GLY A 205
ILE A 206
VAL A 214
 None
 1.04A 2q5kB-4ywlA:
undetectable		 2q5kB-4ywlA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 GLY A 225
VAL A 221
ILE A 187
GLY A 205
ILE A 206
 None
 0.85A 2q63B-4ywlA:
undetectable		 2q63B-4ywlA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 GLY A 225
VAL A 221
ILE A 187
GLY A 205
ILE A 206
 None
 0.91A 2qakB-4ywlA:
undetectable		 2qakB-4ywlA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 11 VAL A 221
GLY A 205
ILE A 206
VAL A 214
ILE A 249
 None
 0.95A 2qhcA-4ywlA:
undetectable		 2qhcA-4ywlA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_2
(PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 VAL A 221
ILE A 187
GLY A 205
VAL A 214
ILE A 249
 None
 0.88A 2r5pB-4ywlA:
undetectable		 2r5pB-4ywlA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 9 ILE A 187
GLY A 205
ILE A 206
VAL A 214
ILE A 249
 None
 1.02A 2r5qA-4ywlA:
undetectable		 2r5qA-4ywlA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 9 ILE A 187
GLY A 205
ILE A 206
VAL A 214
ILE A 249
 None
 1.02A 2r5qC-4ywlA:
undetectable		 2r5qC-4ywlA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_2
(HIV-1 PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 ILE A 187
GLY A 205
ILE A 206
VAL A 214
ILE A 249
 None
 0.85A 3d1xB-4ywlA:
undetectable		 3d1xB-4ywlA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 9 ILE A 187
GLY A 205
ILE A 206
VAL A 214
ILE A 249
 None
 0.92A 3d1yB-4ywlA:
undetectable		 3d1yB-4ywlA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_2
(PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 11 ASP A 106
ILE A 203
VAL A 118
GLY A 120
ILE A 121
 None
 0.95A 3ebzB-4ywlA:
undetectable		 3ebzB-4ywlA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 9 VAL A 221
ILE A 187
GLY A 205
ILE A 206
ILE A 249
 None
 1.05A 3ekqB-4ywlA:
undetectable		 3ekqB-4ywlA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		6 / 11 VAL A 221
ILE A 187
GLY A 205
ILE A 206
VAL A 214
ILE A 249
 None
 1.03A 3ekxB-4ywlA:
undetectable		 3ekxB-4ywlA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 9 ILE A 187
GLY A 205
ILE A 206
VAL A 214
ILE A 249
 None
 0.75A 3ekyB-4ywlA:
undetectable		 3ekyB-4ywlA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 10 VAL A 221
ILE A 187
GLY A 205
VAL A 214
ILE A 249
 None
 0.92A 3em3B-4ywlA:
undetectable		 3em3B-4ywlA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 11 ARG A  94
VAL A 221
ILE A 187
GLY A 205
ILE A 206
 None
 0.93A 3lzvB-4ywlA:
undetectable		 3lzvB-4ywlA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 11 VAL A 221
ILE A 187
GLY A 205
ILE A 206
VAL A 214
 None
 0.78A 3lzvB-4ywlA:
undetectable		 3lzvB-4ywlA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 11 VAL A 221
ILE A 187
GLY A 205
VAL A 214
ILE A 249
 None
 0.86A 3lzvB-4ywlA:
undetectable		 3lzvB-4ywlA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 9 ILE A 187
GLY A 205
ILE A 206
VAL A 214
ILE A 249
 None
 0.76A 3ndwB-4ywlA:
undetectable		 3ndwB-4ywlA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_2
(PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 11 ILE A 187
GLY A 205
ILE A 206
VAL A 214
ILE A 249
 None
 0.74A 3ndxB-4ywlA:
undetectable		 3ndxB-4ywlA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		6 / 10 VAL A 221
ILE A 187
GLY A 205
ILE A 206
VAL A 214
ILE A 249
 None
 0.99A 3nu6A-4ywlA:
undetectable		 3nu6A-4ywlA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		6 / 10 VAL A 221
ILE A 187
GLY A 205
ILE A 206
VAL A 214
ILE A 249
 None
 0.94A 3nujA-4ywlA:
undetectable		 3nujA-4ywlA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 10 VAL A 221
ILE A 187
GLY A 205
VAL A 214
ILE A 249
 None
 0.92A 3oxvB-4ywlA:
undetectable		 3oxvB-4ywlA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 11 VAL A 221
ILE A 187
GLY A 205
VAL A 214
ILE A 249
 None
 0.96A 3oxvD-4ywlA:
undetectable		 3oxvD-4ywlA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		4 / 5 ASP A 189
THR A 193
LEU A 194
GLU A 198
 None
 1.37A 4a3pA-4ywlA:
undetectable		 4a3pA-4ywlA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		4 / 6 GLY A  67
VAL A  60
PRO A  64
GLY A 225
 None
 0.75A 4dxuA-4ywlA:
undetectable		 4dxuA-4ywlA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_1
(PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 11 VAL A 221
ILE A 187
GLY A 205
ILE A 206
ILE A 249
 None
 0.98A 4njtA-4ywlA:
undetectable		 4njtA-4ywlA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_1
(PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 11 VAL A 221
ILE A 187
GLY A 205
ILE A 206
ILE A 249
 None
 0.95A 4njtC-4ywlA:
undetectable		 4njtC-4ywlA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 11 GLY A 225
VAL A 221
ILE A 187
GLY A 205
ILE A 206
 None
 0.87A 4njvC-4ywlA:
undetectable		 4njvC-4ywlA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 11 VAL A 221
ILE A 187
GLY A 205
ILE A 206
ILE A 249
 None
 0.94A 4njvC-4ywlA:
undetectable		 4njvC-4ywlA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 GLY A 225
VAL A 221
ILE A 187
GLY A 205
ILE A 206
 None
 0.88A 4njvD-4ywlA:
undetectable		 4njvD-4ywlA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		6 / 11 VAL A 221
ILE A 187
GLY A 205
ILE A 206
VAL A 214
ILE A 249
 None
 1.09A 4qgiB-4ywlA:
undetectable		 4qgiB-4ywlA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		3 / 3 ARG A  94
ILE A  44
PHE A  95
 None
 0.76A 5kirA-4ywlA:
undetectable		 5kirA-4ywlA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 9 VAL A 221
ILE A 187
GLY A 205
ILE A 206
ILE A 249
 None
 1.10A 5kqxB-4ywlA:
undetectable		 5kqxB-4ywlA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 10 ILE A 187
GLY A 205
ILE A 206
VAL A 214
ILE A 249
 None
 0.88A 5kr1A-4ywlA:
undetectable		 5kr1A-4ywlA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 9 ILE A 187
GLY A 205
ILE A 206
VAL A 214
ILE A 249
 None
 0.95A 5kr2D-4ywlA:
undetectable		 5kr2D-4ywlA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 PRO A 217
ILE A 249
LEU A 216
VAL A 125
LEU A 244
 None
 1.09A 5tiwB-4ywlA:
undetectable		 5tiwB-4ywlA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 PRO A 217
ILE A 249
LEU A 216
VAL A 125
LEU A 244
 None
 1.16A 6b52A-4ywlA:
undetectable		 6b52A-4ywlA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_0
(HIV-1 PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 VAL A 221
ILE A 187
GLY A 205
ILE A 206
VAL A 214
 None
 0.80A 6dilA-4ywlA:
undetectable		 6dilA-4ywlA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 ARG A  94
VAL A 221
ILE A 187
GLY A 205
ILE A 206
 None
 0.85A 6dj1B-4ywlA:
undetectable		 6dj1B-4ywlA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 GLY A 225
VAL A 221
ILE A 187
GLY A 205
ILE A 206
 None
 0.75A 6dj1B-4ywlA:
undetectable		 6dj1B-4ywlA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 VAL A 221
ILE A 187
GLY A 205
ILE A 206
VAL A 214
 None
 0.93A 6dj1B-4ywlA:
undetectable		 6dj1B-4ywlA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_0
(HIV-1 PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 10 VAL A 221
ILE A 187
GLY A 205
ILE A 206
VAL A 214
 None
 0.83A 6dj2A-4ywlA:
undetectable		 6dj2A-4ywlA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 ARG A  94
VAL A 221
ILE A 187
GLY A 205
ILE A 206
 None
 0.93A 6dj2B-4ywlA:
undetectable		 6dj2B-4ywlA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 GLY A 225
VAL A 221
ILE A 187
GLY A 205
ILE A 206
 None
 0.74A 6dj2B-4ywlA:
undetectable		 6dj2B-4ywlA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)		 4ywl CELL DIVISION
CONTROL PROTEIN 21
(Pyrococcus
furiosus) 		5 / 12 VAL A 221
ILE A 187
GLY A 205
ILE A 206
VAL A 214
 None
 0.89A 6dj2B-4ywlA:
undetectable		 6dj2B-4ywlA:
17.47