SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ywo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 4ywo MERCURIC REDUCTASE
(Metallosphaera
sedula) 		4 / 8 VAL A  40
ASN A  41
GLY A  31
LEU A  29
 None
None
FAD  A 501 (-3.5A)
None
 0.88A 1dzmA-4ywoA:
undetectable		 1dzmA-4ywoA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 4ywo MERCURIC REDUCTASE
(Metallosphaera
sedula) 		5 / 12 VAL A 377
ILE A 196
ILE A 426
VAL A 330
ILE A 210
 None
 1.35A 1r5lA-4ywoA:
undetectable		 1r5lA-4ywoA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4ywo MERCURIC REDUCTASE
(Metallosphaera
sedula) 		5 / 11 VAL A  99
ILE A   6
ILE A  35
LEU A  94
PHE A  14
 None
 1.00A 1z11A-4ywoA:
undetectable		 1z11A-4ywoA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4ywo MERCURIC REDUCTASE
(Metallosphaera
sedula) 		5 / 11 VAL A  99
ILE A   6
ILE A  35
LEU A  94
PHE A  14
 None
 0.98A 1z11B-4ywoA:
undetectable		 1z11B-4ywoA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4ywo MERCURIC REDUCTASE
(Metallosphaera
sedula) 		5 / 10 VAL A  99
ILE A   6
ILE A  35
LEU A  94
PHE A  14
 None
 1.05A 1z11D-4ywoA:
undetectable		 1z11D-4ywoA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 4ywo MERCURIC REDUCTASE
(Metallosphaera
sedula) 		4 / 8 GLY A 304
GLY A 291
ALA A 129
ALA A 290
 None
FAD  A 501 (-3.3A)
None
None
 0.57A 2ej3A-4ywoA:
undetectable		 2ej3A-4ywoA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 4ywo MERCURIC REDUCTASE
(Metallosphaera
sedula) 		5 / 12 LEU A 430
ILE A 407
ALA A 403
VAL A 340
VAL A 377
 None
 1.10A 2g78A-4ywoA:
undetectable		 2g78A-4ywoA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 4ywo MERCURIC REDUCTASE
(Metallosphaera
sedula) 		4 / 5 LEU A 416
LEU A 432
MET A 399
THR A 381
 None
 1.19A 2oaxD-4ywoA:
undetectable		 2oaxD-4ywoA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4ywo MERCURIC REDUCTASE
(Metallosphaera
sedula) 		5 / 12 ALA A 303
GLY A   8
LYS A  32
GLU A 105
LEU A 259
 FAD  A 501 (-3.6A)
FAD  A 501 (-2.8A)
FAD  A 501 (-4.7A)
None
FAD  A 501 (-4.4A)
 0.94A 2plwA-4ywoA:
undetectable		 2plwA-4ywoA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 4ywo MERCURIC REDUCTASE
(Metallosphaera
sedula) 		5 / 12 ARG A 438
HIS A 414
ILE A 417
VAL A 413
GLU A 355
 None
 1.21A 2qeoA-4ywoA:
undetectable		 2qeoA-4ywoA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 4ywo MERCURIC REDUCTASE
(Metallosphaera
sedula) 		3 / 3 MET A 382
VAL A 433
GLU A 200
 None
 0.77A 2x9gA-4ywoA:
5.7		 2x9gA-4ywoA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 4ywo MERCURIC REDUCTASE
(Metallosphaera
sedula) 		5 / 9 VAL A  28
GLY A   8
GLY A  31
LEU A   4
ILE A 121
 None
FAD  A 501 (-2.8A)
FAD  A 501 (-3.5A)
None
None
 0.98A 2z0yA-4ywoA:
3.2		 2z0yA-4ywoA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4ywo MERCURIC REDUCTASE
(Metallosphaera
sedula) 		3 / 3 TRP A 148
VAL A 216
ARG A 208
 None
 0.97A 3b0wA-4ywoA:
undetectable		 3b0wA-4ywoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 4ywo MERCURIC REDUCTASE
(Metallosphaera
sedula) 		4 / 8 THR A 130
GLY A 291
LEU A 294
ILE A 274
 FAD  A 501 (-3.8A)
FAD  A 501 (-3.3A)
GOL  A 506 (-4.2A)
None
 0.90A 3nbqB-4ywoA:
undetectable		 3nbqB-4ywoA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 4ywo MERCURIC REDUCTASE
(Metallosphaera
sedula) 		4 / 8 THR A 130
GLY A 291
LEU A 294
ILE A 274
 FAD  A 501 (-3.8A)
FAD  A 501 (-3.3A)
GOL  A 506 (-4.2A)
None
 0.92A 3nbqC-4ywoA:
undetectable		 3nbqC-4ywoA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 4ywo MERCURIC REDUCTASE
(Metallosphaera
sedula) 		3 / 3 THR A 333
ASP A 214
GLU A  62
 None
None
GOL  A 504 ( 4.0A)
 0.81A 3qowA-4ywoA:
2.8		 3qowA-4ywoA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ywo MERCURIC REDUCTASE
(Metallosphaera
sedula) 		5 / 12 ILE A   7
ALA A 129
ALA A 290
VAL A 116
ILE A 121
 FAD  A 501 ( 4.9A)
None
None
None
None
 1.29A 3uvvB-4ywoA:
undetectable		 3uvvB-4ywoA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 4ywo MERCURIC REDUCTASE
(Metallosphaera
sedula) 		4 / 8 GLN A 177
ASN A 213
GLN A 334
ASN A 336
 None
None
GOL  A 504 (-3.8A)
GOL  A 503 (-3.3A)
 1.42A 4d1yA-4ywoA:
undetectable
4d1yB-4ywoA:
3.2		 4d1yA-4ywoA:
20.48
4d1yB-4ywoA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 4ywo MERCURIC REDUCTASE
(Metallosphaera
sedula) 		4 / 8 GLN A 334
ASN A 336
GLN A 177
ASN A 213
 GOL  A 504 (-3.8A)
GOL  A 503 (-3.3A)
None
None
 1.43A 4d1yA-4ywoA:
undetectable
4d1yB-4ywoA:
3.2		 4d1yA-4ywoA:
20.48
4d1yB-4ywoA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4ywo MERCURIC REDUCTASE
(Metallosphaera
sedula) 		5 / 11 PHE A 108
LEU A 259
GLY A 260
ILE A  35
LEU A  94
 None
FAD  A 501 (-4.4A)
None
None
None
 0.99A 4kt0A-4ywoA:
undetectable
4kt0J-4ywoA:
undetectable		 4kt0A-4ywoA:
20.57
4kt0J-4ywoA:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4ywo MERCURIC REDUCTASE
(Metallosphaera
sedula) 		5 / 11 GLY A 388
GLY A 341
LEU A 342
GLU A 346
HIS A 390
 None
 1.09A 4l8fB-4ywoA:
undetectable		 4l8fB-4ywoA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4ywo MERCURIC REDUCTASE
(Metallosphaera
sedula) 		5 / 11 GLY A 388
GLY A 341
LEU A 342
GLU A 346
HIS A 390
 None
 1.11A 4l8fD-4ywoA:
undetectable		 4l8fD-4ywoA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 4ywo MERCURIC REDUCTASE
(Metallosphaera
sedula) 		5 / 9 ALA A 187
ILE A 166
GLY A 167
THR A 237
VAL A 242
 None
 0.93A 4nptA-4ywoA:
undetectable		 4nptA-4ywoA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4ywo MERCURIC REDUCTASE
(Metallosphaera
sedula) 		5 / 11 GLY A  31
GLY A 104
ILE A 102
GLY A  13
ILE A   7
 FAD  A 501 (-3.5A)
None
None
None
FAD  A 501 ( 4.9A)
 1.02A 4qoiA-4ywoA:
undetectable
4qoiB-4ywoA:
undetectable		 4qoiA-4ywoA:
19.38
4qoiB-4ywoA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 4ywo MERCURIC REDUCTASE
(Metallosphaera
sedula) 		5 / 9 ALA A 310
ILE A   7
GLY A  13
ALA A  12
VAL A 293
 None
FAD  A 501 ( 4.9A)
None
FAD  A 501 (-3.8A)
None
 1.17A 4r1zA-4ywoA:
undetectable		 4r1zA-4ywoA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4ywo MERCURIC REDUCTASE
(Metallosphaera
sedula) 		4 / 4 GLY A 273
VAL A 276
PHE A 126
ILE A 287
 None
 1.15A 4xv2B-4ywoA:
undetectable		 4xv2B-4ywoA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1008_1
(SERUM ALBUMIN)		 4ywo MERCURIC REDUCTASE
(Metallosphaera
sedula) 		5 / 9 SER A 363
ALA A 367
SER A 429
LEU A 359
VAL A 377
 None
 1.46A 4z69A-4ywoA:
undetectable		 4z69A-4ywoA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 4ywo MERCURIC REDUCTASE
(Metallosphaera
sedula) 		4 / 8 ALA A 290
GLY A 307
ALA A  16
GLY A  13
 None
 0.66A 4zjzA-4ywoA:
undetectable		 4zjzA-4ywoA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZP0_A_DXCA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 4ywo MERCURIC REDUCTASE
(Metallosphaera
sedula) 		5 / 10 MET A  17
LEU A  29
LEU A  94
GLY A 104
GLN A 103
 None
 1.26A 4zp0A-4ywoA:
undetectable		 4zp0A-4ywoA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4ywo MERCURIC REDUCTASE
(Metallosphaera
sedula) 		4 / 6 GLU A  91
GLY A 291
ASP A 292
GLY A 304
 None
FAD  A 501 (-3.3A)
FAD  A 501 (-2.7A)
None
 0.88A 5cdnR-4ywoA:
undetectable
5cdnS-4ywoA:
undetectable		 5cdnR-4ywoA:
25.19
5cdnS-4ywoA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4ywo MERCURIC REDUCTASE
(Metallosphaera
sedula) 		4 / 6 GLU A  91
GLY A 291
ASP A 292
GLY A 304
 None
FAD  A 501 (-3.3A)
FAD  A 501 (-2.7A)
None
 0.88A 5cdnT-4ywoA:
undetectable
5cdnU-4ywoA:
undetectable		 5cdnT-4ywoA:
25.19
5cdnU-4ywoA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ywo MERCURIC REDUCTASE
(Metallosphaera
sedula) 		5 / 10 ALA A 310
THR A 311
GLU A 312
ALA A 303
GLY A 304
 None
None
None
FAD  A 501 (-3.6A)
None
 1.01A 5lf3H-4ywoA:
undetectable
5lf3I-4ywoA:
undetectable		 5lf3H-4ywoA:
18.87
5lf3I-4ywoA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ywo MERCURIC REDUCTASE
(Metallosphaera
sedula) 		5 / 10 ALA A 310
THR A 311
GLU A 312
ALA A 303
GLY A 304
 None
None
None
FAD  A 501 (-3.6A)
None
 1.02A 5lf3V-4ywoA:
undetectable
5lf3W-4ywoA:
undetectable		 5lf3V-4ywoA:
18.87
5lf3W-4ywoA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 4ywo MERCURIC REDUCTASE
(Metallosphaera
sedula) 		5 / 11 ALA A 310
THR A 311
GLU A 312
ALA A 303
GLY A 304
 None
None
None
FAD  A 501 (-3.6A)
None
 1.02A 5lf7H-4ywoA:
undetectable
5lf7I-4ywoA:
undetectable		 5lf7H-4ywoA:
18.87
5lf7I-4ywoA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 4ywo MERCURIC REDUCTASE
(Metallosphaera
sedula) 		5 / 11 ALA A 310
THR A 311
GLU A 312
ALA A 303
GLY A 304
 None
None
None
FAD  A 501 (-3.6A)
None
 1.02A 5lf7V-4ywoA:
undetectable
5lf7W-4ywoA:
undetectable		 5lf7V-4ywoA:
18.87
5lf7W-4ywoA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 4ywo MERCURIC REDUCTASE
(Metallosphaera
sedula) 		4 / 7 GLN A 103
PHE A  14
GLY A  36
VAL A  40
 None
 0.95A 6ekzA-4ywoA:
undetectable		 6ekzA-4ywoA:
11.65